Patents Assigned to Kaohsiung Medical University
  • Three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes and preparation process and uses of the same
    Patent number: 8470522
    Abstract: Disclosed herein is a three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes, as well as a process for preparing the same. The three-dimensional culture, which was found to mimic the biological characteristics of articular chondrocytes that undergo terminal differentiation in vivo, can be used as a tool in the studies of the molecular and cellular mechanisms of osteoarthritis, and in the screening of candidate drugs for use in treatment of a disorder associated with articular chondrocytes.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: June 25, 2013
    Assignee: Kaohsiung Medical University
    Inventors: Mei-Ling Ho, Gwo-Jaw Wang, Je-Ken Chang
  • Composition for inhibiting melanogenesis and use thereof
    Patent number: 8455023
    Abstract: The present invention provides a Cinnamomum subavenium extract for inhibiting melanogenesis. The present invention also provides a composition for inhibiting melanogenesis including compounds inhibit tyrosinase activity.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: June 4, 2013
    Assignee: Kaohsiung Medical University
    Inventors: Hui-Min Wang, Chung-Yi Chen, Zhi-Hong Wen
  • Microrna-based method for anti-colorectal cancer effects and prognosis of colorectal cancer
    Publication number: 20130137597
    Abstract: The present invention discloses a method of providing anti-oncogenic effects in a subject suffered from colorectal cancer. The present invention also discloses a method for screening an anti-colorectal cancer agent. The present invention further discloses a method of determining the prognosis of a subject with colorectal cancer.
    Type: Application
    Filed: February 5, 2013
    Publication date: May 30, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: KAOHSIUNG MEDICAL UNIVERSITY
  • FUNCTIONALIZED POLYMER NANOPARTICLES AND THE PHARMACEUTICAL USE THEREOF
    Publication number: 20130136714
    Abstract: PEO-PPO-PEO polymers and vinyl monomers are used to prepare several block copolymers via consecutive atom transfer radical polymerization (ATRP). The block copolymers provide good delivery characteristics and can be used as a gene/drug delivery carrier for therapy and diagnosis.
    Type: Application
    Filed: August 10, 2012
    Publication date: May 30, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Li-Fang Wang, Shih-Jer Huang, Zhi-Rong Hsu
  • Hybrid superparamagnetic iron oxide nanoparticles and polyethylenimine as a magnetoplex for gene transfection
    Patent number: 8445025
    Abstract: Disclosed are the nanoparticle and the method for the same, and the preparing method includes steps of mixing polyethylenimine (PEI) with the poly(acrylic acid)-bound iron oxide (PAAIO) to form a PEI-PAAIO polyelectrolyte complex (PEC) and mixing the PEI-PAAIO PEC with genetic material such as plasmid DNA to form the PEI-PAAIO/pDNA magnetic nanoparticle. The PEI-PAAIO/pDNA magnetoplex is highly water dispersible and suitable for long term storage, shows superparamagnetism, low cytotoxicity, high stability and nice transfection efficiency, and thus the PEI-PAAIO PEC can replace PEI as a non-viral gene vector.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: May 21, 2013
    Assignee: Kaohsiung Medical University
    Inventors: Li-Fang Wang, Shuo-Li Sun, Yu-Lun Lo
  • COMPOSITION AND GINGER EXTRACT FOR PROMOTING PROLIFERATION AND/OR MIGRATION OF SKIN CELLS, AND PHARMACEUTICAL COMPOSITION USING THE SAME
    Publication number: 20130123544
    Abstract: A composition for promoting proliferation and/or migration of skin cells includes a compound of formula (I): or a pharmaceutically acceptable salt or ester thereof.
    Type: Application
    Filed: April 12, 2012
    Publication date: May 16, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hui-Min Wang, Chung-Yi Chen, Chien-Chih Chiu, Yi-Ting Chou
  • ANTI-HUMAN UROTHELIAL CARCINOMA OF SUPERCRITICAL CARBON DIOXIDE EXTRACT OF CINNAMOMUM SUBAVENIUM, AND THE PREPARATION PROCESS AND USES
    Publication number: 20130122110
    Abstract: What is disclosed in the invention is a preparation method of a supercritical Cinnamomum subavenium extract, which is made from the material, the dried stem of C. subavenium. The extract is obtained by extracting C. subavenium which is pulverized as particles with supercritical carbon dioxide fluid. The C. subavenium extract or its active ingredient, subamolide A, can be used to inhibit the growth of human urothelial carcinoma cell lines. In addition, the C. subavenium extract (or subamolide A) is able to synergistically inhibit the growth of human urothelial carcinoma cell lines with cisplatin (CDDP) or gemcitabine (Gem). Therefore, the C. subavenium extract (or subamolide A) can be an anticancer drug alone, or forms a pharmaceutical composition with CDDP (or Gem) to treat with cancers in respect of urinary system.
    Type: Application
    Filed: March 21, 2012
    Publication date: May 16, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: JIH-HENG LI, A-MEI HUANG, CHUNG-YI CHEN, PEI-JUNG LIEN, CHIUNG-HUI LIU
  • INHALED NO DONOR KMUPS DERIVATIVE PREVENTING ALLERGIC PULMONARY VASCULAR AND BRONCHIAL INFLAMMATION VIA SUPPRESSED CYTOKINES, INOS AND INFLAMMATORY CELL COUNTS IN ASTHMA MODEL
    Publication number: 20130095059
    Abstract: A method for treating a disease is provided. The method includes steps of: providing a subject in need thereof; and administering one selected from a group consisting of KMUPS compound represented by formula I, a pharmaceutically acceptable salts thereof; and a pharmaceutical composition thereof to the subject in a dosage from 1 to 2.5 milligram per kilogram of body weight, wherein R2 and R4 are each selected independently from a group consisting of a C1˜C5 alkoxy group, a hydrogen, a nitro group and a halogen atom.
    Type: Application
    Filed: April 2, 2012
    Publication date: April 18, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: Ing-Jun CHEN
  • METHOD FOR PREDICTING THE SURVIVAL STATUS AND PROGNOSIS OF ESOPHAGEAL CANCER AND A KIT THEREOF
    Publication number: 20130096018
    Abstract: The present invention provides a method for predicting the survival rate and prognosis of esophageal carcinoma patients, which is characterized in examining the expression level of a specific gene, peptidase inhibitor 3 (PI3) or CD14 antigen (CD14) in a sample, and comparing to the average expression level of said specific gene from patients to determine the survival and prognosis status for esophageal cancer. The present invention further provides a kit for predicting the survival rate and prognosis of esophageal carcinoma patients.
    Type: Application
    Filed: March 21, 2012
    Publication date: April 18, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Ming-Tsang Wu, Deng-Chyang Wu, Hung-Ju Su, Chah-Hwa Chou, Jie-Len Huang, Yu-Kuei Chen, Chun-Chieh Wu
  • Method for Columbidae gender identification, nucleotide sequence for Columbidae gender and nucleotide primer pair for Columbidae gender
    Patent number: 8420316
    Abstract: The invention provides a method for Columbidae gender identification including: providing a DNA sample of a bird belonging to the Columbidae family; performing a polymerase chain reaction to the DNA sample with a first primer pair of a first primer designed within the region of the SEQ ID. NO.: 9 or a complementary sequence thereof and a P2 primer (SEQ ID. NO: 1) or a complementary sequence thereof, and a second primer pair of a second primer designed within the region of the SEQ ID NO.: 10 or a complementary sequence thereof and a P2 primer (SEQ ID. NO: 1) or a complementary sequence thereof; and determining gender by performing a melting curve analysis to a product from the polymerase chain reaction, wherein the result showing two peaks indicate a female gender and showing one peak indicate a male gender.
    Type: Grant
    Filed: August 11, 2010
    Date of Patent: April 16, 2013
    Assignee: Kaohsiung Medical University
    Inventors: Hsueh-Wei Chang, Chien-Chung Cheng, Ying-Fang Su, Yu-Chen Hung
  • MicroRNA-based method for anti-colorectal cancer effects and prognosis of colorectal cancer
    Patent number: 8420618
    Abstract: The present invention discloses a method of providing anti-oncogenic effects in a subject suffered from colorectal cancer. The present invention also discloses a method for screening an anti-colorectal cancer agent. The present invention further discloses a method of determining the prognosis of a subject with colorectal cancer.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: April 16, 2013
    Assignee: Kaohsiung Medical University
    Inventors: Suh-Hang Hank Juo, Jaw-Yuan Wang, I-Ping Yang, Hsiang-Lin Tsai
  • METHOD FOR TREATING ATHEROSCLEROSIS
    Publication number: 20130089601
    Abstract: The invention provides a method for treating atherosclerosis in a subject in need thereof, including administering an effective amount of microRNA-195 to the subject in need thereof. The microRNA-195 may be packaged in a pharmaceutically acceptable carrier. Moreover, the pharmaceutically acceptable carrier may includes a liposome, lipid particle or viral vector.
    Type: Application
    Filed: December 11, 2012
    Publication date: April 11, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: Kaohsiung Medical University
  • 18ß-GLYCYRRHETINIC ACID DERIVATIVES AND SYNTHETIC METHOD THEREOF
    Publication number: 20130072694
    Abstract: The present invention provides a chemical compound having the structure being one selected from a group consisting of wherein R1 is one selected from a group consisting of COOCH3, COOCH2Ph, CONHCH(CH3)2 and CONHC6H5, R2 is one selected from a group consisting of H, CH3 and CH(CH3)2, R3 is one selected from a group consisting of H, CH3, CH(CH3)2 and CH2Ph, and R4 is one of CH(CH3)2 and C6H5.
    Type: Application
    Filed: November 13, 2012
    Publication date: March 21, 2013
    Applicant: Kaohsiung Medical University
    Inventor: Kaohsiung Medical University
  • hnRNP A1 KNOCKOUT ANIMAL MODEL AND USE THEREOF
    Publication number: 20130067605
    Abstract: A nucleic acid construct comprising a genetic engineered heterogeneous nuclear ribonucleoprotein (hnRNP) A1 gene is provided. A transgenic mouse in which the expression of hnRNP A1 gene has been disrupted is also provided. The mouse is useful for studying the role of hnRNP A1 gene in normal and disease states of a neurodegenerative disease or a cancer for developing therapies to treat any of these diseases. Therefore, a method of screening a compound for potential use in prevention and/or treatment of neurodegenerative disease or cancer is further provided.
    Type: Application
    Filed: August 31, 2012
    Publication date: March 14, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yung-Fu Chang, Ting-Yuan Liu, Yuh-Jyh Jong, Jan-Gowth Chang
  • Polyesterification method
    Patent number: 8394915
    Abstract: A polyesterification method comprises steps of mixing, by combining N,N-dialkylformamide dialkyl acetal with a tin catalyst, so as to transfer an alkoxy group from the N,N-dialkylformamide dialkyl acetal to the tin catalyst to obtain a Sn coordination complex; and polymerization, by conducting a ring-opening polymerization of a ester under the catalysis of the Sn coordination complex, and finally to obtain a polyester compound; wherein, the chemical formula of the N,N-dialkylformamide dialkyl acetal is (RO)2CHNR2, with the R being an alkyl group.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: March 12, 2013
    Assignee: Kaohsiung Medical University
    Inventors: Hsuan-Ying Chen, Hsin-Jou Fang
  • APPARATUS AND METHOD FOR PERFORMING PHOTODYNAMIC DIAGNOSIS AND PHOTODYNAMIC THERAPY
    Publication number: 20130053699
    Abstract: An apparatus for performing photodynamic diagnosis and photodynamic therapy on a target region that is pre-given with a photosensitizer precursor includes a display unit, an excitation light source operable to irradiate the target region with exciting light so as to excite emission of fluorescence from the target region as a result of fluorescence response of the photosensitizer precursor, an image capturing unit operable to capture a white light image and a fluorescent image of the target region, an image processing unit operable to superimpose the white light image and the fluorescent image into a synthesized image and to provide at least one of the white light image, the fluorescent image and the synthesized image thereto for display on the display unit, and a curing light source operable to irradiate a specified portion of the target region with curing light for treating the specified portion.
    Type: Application
    Filed: August 30, 2011
    Publication date: February 28, 2013
    Applicants: National Applied Research Laboratories Instrument Technology Research Center, Kaohsiung Medical University
    Inventors: Wen-Hong Wu, Chung-Hsing Chang, Han-Chao Chang, Chun-Li Chang, Kuo-Cheng Huang, Din-Ping Tsai, Hsin-Su Yu
  • Method for preparing a coumarin compound, chromene compound, and method for preparing a chromene compound
    Patent number: 8383843
    Abstract: Disclosed herein is a method for preparing a coumarin compound of formula (F), in which R1, R2, and R3 are independently H, C1˜C7 alkoxy, C1˜C7 alkyl, phenoxy, benzyloxy, or a halogen atom; R4 is an alkyl group; and Ar is an optionally substituted aryl group, the method including: treating a chromene compound having the following formula (E) with an acid in the presence of water. A chromene compound of formula (E) and a method for preparing the chromene compound of formula (E) are also disclosed.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: February 26, 2013
    Assignee: Kaohsiung Medical University
    Inventors: Eng-Chi Wang, Jui-Chi Tsai, Sie-Rong Li, Po-Yuan Chen
  • COMPOSITION FOR TREATING ATHEROSCLEROSIS AND A PREPARATION METHOD THEREOF
    Publication number: 20130040996
    Abstract: Disclosed are a composition for preventing and treating atherosclerosis which includes chalcone compound. In particular, the chalcone compound bound with 2-hydroxyl in ring A and 4?-methyoxy in ring B has versatile therapeutic potentials on anti-atherosclerosis by acting as PPAR? inducer, p44/42 MAPK inhibitor and cell cycle blocker and does not show toxicity to human aortic smooth muscle cells (HASMCs). In addition, the chalcone compound exhibits synergistic effect with the PPAR? ligand (rosiglitazone) to inhibit cell proliferation and the upregulation of cyclin D1, cyclin D3, interleukin-1? (IL-1?) and interleukin-6 (IL-6) induced by oxidized low density lipoprotein (Ox-LDL).
    Type: Application
    Filed: August 9, 2012
    Publication date: February 14, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: YANG-CHANG WU, FANG-RONG CHANG, TUSTY-JIUAN HSIEH, SUH-HANG JUO, AN-SHEN LIN, YING-CHI DU
  • Treatment for spinal muscular atrophy
    Patent number: 8367678
    Abstract: A method of treating spinal muscular atrophy. The method includes administering an effective amount of composition including a sodium-proton exchanger inhibitor and a pharmaceutically acceptable carrier or salt, to a subject with spinal muscular atrophy to ameliorate a symptom of spinal muscular atrophy.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: February 5, 2013
    Assignee: Kaohsiung Medical University
    Inventors: Jan-Gowth Chang, Chung-Yee You, Wen-Kuang Yang
  • POLYSACCHARIDE-GRAFTED POLYETHYLENIMINE AS A GENE CARRIER
    Publication number: 20130030119
    Abstract: The present invention discloses a gene carrier and the preparation method thereof. Chondroitin sulfate (CS) is reacted with methacrylic anhydride (MA) to form chrondroitin sulfate-methacrylate (CSMA), which is further covalently bound with polyethylenimine (PEI) via the Michael addition to produce a CSMA-PEI gene carrier. The CSMA-PEI gene carrier can effectively reduce the cytotoxicity of PEI and enhance the transfection efficiency of PEI.
    Type: Application
    Filed: November 18, 2011
    Publication date: January 31, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: LI-FANG WANG, KUO-HSUN SUNG, YU-LUN LO