Abstract: A bioFET cell for measuring a time dependent characteristic of an analyte bearing fluid includes a source, a drain, a semiconductive single wall carbon nanotube network layer extending between the source and drain electrodes and electrically coupled there between, a gate insulatively spaced from and disposed over and extending between the source and drain electrodes, a layer of at least one selected antibody disposed on and linked to the polymer layer to functionalize the semiconductive single wall carbon nanotube network layer to a selected target biomarker corresponding to the at least one selected antibody so that electron transport into the semiconductive single wall carbon nanotube network layer is facilitated, where the source, drain and gate electrodes with the carbon nanotube network layer form a defined channel through which the analyte bearing fluid may flow, and a high impedance source follower amplifier coupled to the source electrode.

Abstract: A bioFET cell for measuring a time dependent characteristic of an analyte bearing fluid includes a source, a drain, a semiconductive single wall carbon nanotube network layer extending between the source and drain electrodes and electrically coupled there between, a gate insulatively spaced from and disposed over and extending between the source and drain electrodes, a layer of at least one selected antibody disposed on and linked to the polymer layer to functionalize the semiconductive single wall carbon nanotube network layer to a selected target biomarker corresponding to the at least one selected antibody so that electron transport into the semiconductive single wall carbon nanotube network layer is facilitated, where the source, drain and gate electrodes with the carbon nanotube network layer form a defined channel through which the analyte bearing fluid may flow, and a high impedance source follower amplifier coupled to the source electrode.

Abstract: A bioFET cell for measuring a time dependent characteristic of an analyte bearing fluid includes a source, a drain, a semiconductive single wall carbon nanotube network layer extending between the source and drain electrodes and electrically coupled there between, a gate insulatively spaced from and disposed over and extending between the source and drain electrodes, a layer of at least one selected antibody disposed on and linked to the polymer layer to functionalize the semiconductive single wall carbon nanotube network layer to a selected target biomarker corresponding to the at least one selected antibody so that electron transport into the semiconductive single wall carbon nanotube network layer is facilitated, where the source, drain and gate electrodes with the carbon nanotube network layer form a defined channel through which the analyte bearing fluid may flow, and a high impedance source follower amplifier coupled to the source electrode.

Abstract: A method of reducing the limit of detection in a surface acoustic wave sensor (SAW) includes the steps of: attaching a plurality of DNA segments to a detection surface of a SAW; performing a CRISPR/Cas9 preparation of the DNA segments to cut and splice a selected protein into at least one of a plurality of the DNA segments; conjugating a nanoparticle to the selected protein; and measuring the number of DNA segments with conjugated nanoparticles using a surface acoustic wave sensor (SAW). The nanoparticle may be modified to form a single electron transistor (SET) which generates a detectable signal in response to RF or ultrasonic excitation which is indicative of binding of the corresponding nanoparticle to a selected target analyte.

Abstract: Driverless programmable human interface devices are provided that may be configured using plain text configuration information, such as may be viewed or edited by a user. The human interface device may provide a graphical user interface via one or more software applications accessible via a virtual storage volume provided as part of the human interface device, and which may be executed directly by a user without requiring installation. The user may view and modify textual configuration information directly, or may utilize the provided graphical user interface to do so indirectly.

Abstract: A bioFET cell for measuring a time dependent characteristic of an analyte bearing fluid includes a source, a drain, a semiconductive single wall carbon nanotube network layer extending between the source and drain electrodes and electrically coupled there between, a gate insulatively spaced from and disposed over and extending between the source and drain electrodes, a layer of at least one selected antibody disposed on and linked to the polymer layer to functionalize the semiconductive single wall carbon nanotube network layer to a selected target biomarker corresponding to the at least one selected antibody so that electron transport into the semiconductive single wall carbon nanotube network layer is facilitated, where the source, drain and gate electrodes with the carbon nanotube network layer form a defined channel through which the analyte bearing fluid may flow, and a high impedance source follower amplifier coupled to the source electrode.

Abstract: Driverless programmable human interface devices are provided that may be configured using plain text configuration information, such as may be viewed or edited by a user. The human interface device may provide a graphical user interface via one or more software applications accessible via a virtual storage volume provided as part of the human interface device, and which may be executed directly by a user without requiring installation. The user may view and modify textual configuration information directly, or may utilize the provided graphical user interface to do so indirectly.

Abstract: A bioFET cell for measuring a time dependent characteristic of an analyte bearing fluid includes a source, a drain, a semiconductive single wall carbon nanotube network layer extending between the source and drain electrodes and electrically coupled there between, a gate insulatively spaced from and disposed over and extending between the source and drain electrodes, a layer of at least one selected antibody disposed on and linked to the polymer layer to functionalize the semiconductive single wall carbon nanotube network layer to a selected target biomarker corresponding to the at least one selected antibody so that electron transport into the semiconductive single wall carbon nanotube network layer is facilitated, where the source, drain and gate electrodes with the carbon nanotube network layer form a defined channel through which the analyte bearing fluid may flow, and a high impedance source follower amplifier coupled to the source electrode.

Abstract: An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.

Abstract: An aptamer-based solid-state electrochemical biosensor for label-free detection of Salmonella enterica serovars utilizing immobilized aptamers. The device is realized by forming a matrix array of parallel capacitors, thus allowing the realization of low-cost, portable, fully integrated devices. Protein-aptamer binding modulates the threshold voltage of a circuit, changing the impedance (capacitance) of the circuit. This circuit is further characterized by an electrode coded with a p-Si substrate, enhancing the affinity between the Salmonella outer membrane proteins (OMPs) and the aptamer. An aptamer embedded detection plate is configured within a testing lid device that fits a standard, commercially available polymer specimen jar. A sample is mixed with broth for incubation and cultivation of any present Salmonella bacteria to obtain acceptable concentration of the pathogen for testing. The information obtained can then be transmitted by wireless network.

Abstract: An adjustable keyboard assembly and support mounts and keying layout are provided allowing a user to orient keying modules of the assembly in a variety of desired configurations. In one embodiment, the assembly includes pivoting support plates that allow the flexible adjustments. In another embodiment, at least one lift module is utilized to allow achieving multiple tenting angles expediently. In yet another embodiment, a modular support mount assembly is provided to allow the user to mount keying modules to a structure such as a chair using modular mounts that allow for easy and effective peripheral device supports and reconfiguration of the modular support mount assembly to support keying modules and peripheral devices of various sizes and shapes. Furthermore, a keying layout and assembly is provided to improve efficiency and intuitiveness of using a keying module and for programming the keying modules without use of a separate computer.

Abstract: An adjustable keyboard includes a first keying module situated pivotably with respect to the second keying module for providing a keyboard having improved ergonomics and comfort, and promoting improved productivity of a user. In one embodiment, the first and the second keying modules are pivotably mounted on a base assembly having fixed opposing tenting angles. In one embodiment the first and the second keying modules are mounted on a pivot link assembly configured to pivot the keying modules with respect to each other. In one embodiment, the first and the second keying modules are configured to also laterally separate. In one embodiment, first and second lift modules space a portion of the first and the second keying modules, respectively, from a supporting surface to form opposing tenting angles.

Abstract: A cerebrospinal fluid (CSF) monitoring device for the detection of obstructions in real time through the collection of pressure data from an on-board pressure sensor. This system is designed to integrate into medical devices equipped with a CSF drainage system, such as implantable shunts. CSF analysis data can be transmitted in real-time wirelessly to a physician or can be stored on-board in a memory card and retrieved wirelessly at a later time. Information from the CSF sensors can be used by physicians to monitor CSF conditions known to cause shunt malfunction/obstruction such as elevated protein concentrations, evidence of an on-going or recent hemorrhage such as presence of heme proteins, and concentrations of administered medications/drugs over time. It can be used to monitor for CSF infections, in which increased pressure, increased temperature, CSF high protein and low glucose, would be suggestive of CSF infections.

Abstract: A remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine in order to achieve spinal fusion. A spinal pump is implanted on the vertebrae of a patient and a spinal cage is inserted in between two adjacent vertebrae after removal of the vertebrae disc. A piezoelectric motor drives the pump and pushes osteogenetic agent through the spinal cage and into a sponge disposed within the cage. The pump is charged by an external removable induction belt worn by the patient. Delivery duration and delivery frequency may be changed before implantation of the spine pump according to the specific needs of the patient. The current device employs a mathematical model that enables the regulation as well as attenuation of the bone fusion process by extending and generalizing the model to enhance and optimize the delivery of osteogenetic agent in a regulated manner.

Abstract: A biosensor for detection of vascular endothelial growth factor (VEGF) hybridization uses an array of parallel capacitors to detect electrochemical binding of circulating VEGF to immobilized anti-VEGF monoclonal half-antibodies (a-VEGF mhAb). Binding of a-VEGF mhAb modulates the threshold voltage of a circuit, changing the impedance of the circuit. An electrode coated with a p-Si substrate enhances the affinity between the VEGF molecules. A fluid cell delivers VEGF samples onto the active surface of the chip. An array of parallel capacitors arranged in an interdigitated pattern detects the VEGF in the fluid. The detector provides an accurately measured and quantifiable rate of change of the VEGF molecules in vivo, providing real time feedback which is used to measure response of the tumor to delivered chemotherapeutic agents and biological response modifiers (BRMs) for the purpose of determining tumor burden and efficacy of the chemotherapy as part of a homeostatic loop for chemotherapy.

Abstract: An adjustable keyboard includes a first keying module situated pivotably with respect to the second keying module for providing a keyboard having improved ergonomics and comfort, and promoting improved productivity of a user. In one embodiment, the first and the second keying modules are pivotably mounted on a base assembly having fixed opposing tenting angles. In one embodiment the first and the second keying modules are mounted on a pivot link assembly configured to pivot the keying modules with respect to each other. In one embodiment, the first and the second keying modules are configured to also laterally separate. In one embodiment, first and second lift modules space a portion of the first and the second keying modules, respectively, from a supporting surface to form opposing tenting angles.

Abstract: An adjustable keyboard assembly and support mounts and keying layout are provided allowing a user to orient keying modules of the assembly in a variety of desired configurations. In one embodiment, the assembly includes pivoting support plates that allow the flexible adjustments. In another embodiment, at least one lift module is utilized to allow achieving multiple tenting angles expediently. In yet another embodiment, a modular support mount assembly is provided to allow the user to mount keying modules to a structure such as a chair using modular mounts that allow for easy and effective peripheral device supports and reconfiguration of the modular support mount assembly to support keying modules and peripheral devices of various sizes and shapes. Furthermore, a keying layout and assembly is provided to improve efficiency and intuitiveness of using a keying module and for programming the keying modules without use of a separate computer.

Abstract: A magnetically controlled pump is implanted into the cerebrospinal fluid of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled lumen, intratumoral catheter which will be implanted. Spinal fluid drawn from the patient is analyzed. Medication is delivered on a continuous metronomic basis into the CSF via an internalized pump. CSF is removed and analyzed for VEGF and other cytokines via spectrophotometer analysis or a lab on a chip. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

Abstract: A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents mixed with Avastin at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, the medicating agent Avastin is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. In cases where a tumor resection is not performed, an intratumoral catheter will be implanted. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

Abstract: A peripheral device includes at least one active or trigger element housed in a cartridge that is removably mounted. A user can easily remove the cartridge with the active or trigger elements without using special tools. In some embodiments, the peripheral device can include a leveling member between a detection switch and a triggering interface to facilitate effective actuation of the triggering interface and activation of the detection switch from regions spaced from the detection switch. Some embodiments can include silencing or dampening features or structures to minimize or substantially eliminate sound generated upon activation of the triggering interface.