Abstract: A method and apparatus for local infusion of a variety of biological response modifiers (BRMs) and chemotherapeutic agents including tumor necrosis factors (TNF) is described. In one embodiment, the device contains a synthetic pouch compartmentalized into three or more chambers, and an electronic apparatus controlling and modulating the delivery of the agents to the site of the tumor, so as to achieve a desired regimen in support of the elimination of a tumor burden. In one embodiment, an electronic system provides tailored and controlled regulation of the administration of such agents, using sensors to monitor the progress of the treatment. Desired dosing and scheduling of anti-tumor agents in a local setting is provided. In one embodiment, active control and regulation of the administration of medicating agents is attached to a synthetic pouch and with the aid of a piezoelectric valve and pump actuating mechanism. The apparatus provides the desired dose, duration and timing of dose delivery.

Abstract: An artificial tooth apparatus for dispensing medicating agents to the body through the patient's jaw bone comprising a mechanical movement and kinetic mainspring winder, a tourbillon mechanism, a electronic regulator, and a pump mechanism arranged and configured to allow any medicating agent to be dispensed from the apparatus in a highly controlled and regulated manner according to input received by the electronic regulator and the patient's specific pharmacokinetic and pharmacodynamic attributes. Multiple artificial teeth or a comprehensive bridge with several chambers may be used in cases where a polypharmaceutical approach is needed.

Abstract: A method and apparatus for local infusion of a variety of biological response modifiers (BRMs) and chemotherapeutic agents including tumor necrosis factors (TNF) is described. In one embodiment, the device contains a synthetic pouch compartmentalized into three or more chambers, and an electronic apparatus controlling and modulating the delivery of the agents to the site of the tumor, so as to achieve a desired regimen in support of the elimination of a tumor burden. In one embodiment, an electronic system provides tailored and controlled regulation of the administration of such agents, using sensors to monitor the progress of the treatment. Desired dosing and scheduling of anti-tumor agents in a local setting is provided. In one embodiment, active control and regulation of the administration of medicating agents is attached to a synthetic pouch and with the aid of a piezoelectric valve and pump actuating mechanism. The apparatus provides the desired dose, duration and timing of dose delivery.

Abstract: A method and apparatus for local infusion of a variety of biological response modifiers (BRMs) and chemotherapeutic agents including tumor necrosis factors (TNF) is described. In one embodiment, the device contains a synthetic pouch compartmentalized into three or more chambers, and an electronic apparatus controlling and modulating the delivery of the agents to the site of the tumor, so as to achieve a desired regimen in support of the elimination of a tumor burden. In one embodiment, an electronic system provides tailored and controlled regulation of the administration of such agents, using sensors to monitor the progress of the treatment. Desired dosing and scheduling of anti-tumor agents in a local setting is provided In one embodiment, active control and regulation of the administration of medicating agents is attached to a synthetic pouch and with the aid of a piezoelectric valve and pump actuating mechanism. The apparatus provides the desired dose, duration and timing of dose delivery.

Abstract: An adjustable keyboard assembly and support mounts and keying layout are provided allowing a user to orient keying modules of the assembly in a variety of desired configurations. In one embodiment, the assembly includes pivoting support plates that allow the flexible adjustments. In another embodiment, at least one lift module is utilized to allow achieving multiple tenting angles expediently. In yet another embodiment, a modular support mount assembly is provided to allow the user to mount keying modules to a structure such as a chair using modular mounts that allow for easy and effective peripheral device supports and reconfiguration of the modular support mount assembly to support keying modules and peripheral devices of various sizes and shapes. Furthermore, a keying layout and assembly is provided to improve efficiency and intuitiveness of using a keying module and for programming the keying modules without use of a separate computer.

Abstract: An adjustable keyboard includes a first keying module situated pivotably with respect to the second keying module for providing a keyboard having improved ergonomics and comfort, and promoting improved productivity of a user. In one embodiment, the first and the second keying modules are pivotably mounted on a base assembly having fixed opposing tenting angles. In one embodiment the first and the second keying modules are mounted on a pivot link assembly configured to pivot the keying modules with respect to each other. In one embodiment, the first and the second keying modules are configured to also laterally separate. In one embodiment, first and second lift modules space a portion of the first and the second keying modules, respectively, from a supporting surface to form opposing tenting angles.

Abstract: A keyboard for use with a standard personal computer includes an alphanumeric key array having a plurality of alphanumeric keys arranged in a generally orthogonal, concave array. A home row of keys defines a reference position for the fingers of the operator. A liner array of function keys is provided and positioned above the reference position and tilted toward the operator. A generally orthogonal array of auxiliary keys is also positioned above the reference position. The array of auxiliary keys is rotated with respect to the reference position to accommodate the natural angle of the thumb of the operator to the index finger. A palm rest is provided for receiving the palm of the operator while the operator is manipulating the plurality of alphanumeric keys. The palm rest is positioned above the reference position defined by the home row so that during operation of the alphanumeric keys, the fingers of the operator extend downward from the palm rest in a natural curved manner.

Abstract: A keyboard for use with a standard personal computer includes an alphanumeric key array having a plurality of alphanumeric keys arranged in a generally orthogonal, concave array. A home row of keys defines a reference position for the fingers of the operator. A liner array of function keys is provided and positioned above the reference position and tilted toward the operator. A generally orthogonal array of auxiliary keys is also positioned above the reference position. The array of auxiliary keys is rotated with respect to the reference position to accommodate the natural angle of the thumb of the operator to the index finger. A palm rest is provided for receiving the palm of the operator while the operator is manipulating the plurality of alphanumeric keys. The palm rest is positioned above the reference position defined by the home row so that during operation of the alphanumeric keys, the fingers of the operator extend downward from the palm rest in a natural curved manner.

Abstract: A keyboard for use with a standard personal computer includes an alphanumeric key array having a plurality of alphanumeric keys arranged in a generally orthogonal, concave array. A home row of keys defines a reference position for the fingers of the operator. A linear array of function keys is provided and positioned above the reference position and tilted toward the operator. A generally orthogonal array of auxiliary keys is also positioned above the reference position. The array of auxiliary keys is rotated with respect to the reference position to accommodate the natural angle of the thumb of the operator to the index finger. A palm rest is provided for receiving the palm of the operator while the operator is manipulating the plurality of alphanumeric keys. The palm rest is positioned above the reference position defined by the home row so that during operation of the alphanumeric keys, the fingers of the operator extend downward from the palm rest in a natural curved manner.

Abstract: A keyboard having an array of non-planar keys and a method for manufacturing such a keyboard is provided. In one embodiment, the non-planar array is a double-convex array. Electrical connection along the keys and/or from the keys to associated electronics is provided by way of a circuit board. The circuit board has a geometry and flexibility which permits the circuit board to conform to a shape which is non-planar along two non-parallel axes. In one embodiment, the circuit board can be configured in a double-concave shape. The circuit board includes one or more slots defining two or more projections. These projections can be placed in a configured non-coplanar configuration along a first axis and the circuit board can be flexed to a non-planar configuration along a second non-parallel axis.