Abstract: An anthracycline compound, R20X2, of the following formula (II) is produced by a process which comprises subjecting an anthracycline compound, R20X3, of the following formula (I) or a salt thereof to reaction in the co-presence of (1) acetone and/or dimethylformamide and (2) an aqueous solution containing ammonium ion and/or trialkylamine. ##STR1## The anthracycline compound, R20X2, can be produced not only by the cultivation of actinomycetes but also, in accordance with the process as shown above, by chemical conversion of the anthracycline compound, R20X3, in a high yield.

Abstract: A container rotating-transporting device for transporting a plurality of containers while rotating same, which comprises a transport device for transporting the containers straightly, a plurality of container stands each provided rotatably on the transport device to hold a container thereon and having a roller or pulley and a rotation imparting member for rotating each container stand when the roller or pulley contacts the rotation imparting member. This device is used for a container inspecting device.

Abstract: A use of the pyrrolidone derivative represented by the following formula [I] as an anti-amnesitc agent: ##STR1## wherein R represents a group ##STR2## X represents --SO.sub.2 -- or --CO--; R' represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom or a nitro group; n denotes an integer of 1-5; and, when n is an integer of 2 or more, R' may be the same or different, provided that(a) when X is --SO.sub.2 --, there is no case where R' is 3-CF.sub.3, 4-Cl-5-CF.sub.3, 3,5-(CF.sub.3).sub.2 or 3-NO.sub.2 ;(b) when X is --CO--, there is no case where n denotes 1 or 2 and R' is a halogen atom or a nitro group;(c) when X is --SO.sub.2 --, there is no case where n denotes 1 or 2 and R' is a group other than 4-Cl or 3-NO.sub.2 ; and(d) when n denotes 2, there is no case where the groups R' represent the same group which is halogen atom or a nitro group.

Abstract: Disclosed is an anthracycline compound of the following formula (I) or an acid addition salt thereof: ##STR1## These compounds are useful as intermediates in the synthesis of an anthracycline compound, M-R20X or M-R20X2, which has antitumor activity.

Abstract: An apparatus for detecting defects on a bottle mouth having a screw thread has an illuminating unit for applying light to the mouth of a bottle under rotation; a photoelectric conversion unit for photoelectrically converting a light transmitted image of the bottle mouth illuminated with light by the illuminating unit into electric signals; a defect detecing unit for detecting a defect within a predetermined area in the light transmitted image photoelectrically converted by the photoelectric conversion unit, based on the brightness at predtermined at-least two points in a predetermined detection direction within the area; and a judge unit for calculating the number of defects detected by the defect detecting unit and judging the presence of any defect of the bottle mouth based on the number of defects.The apparatus detects defect points from the light transmitted image of the bottle mouth and judges based on the number of defect points whether or not there is a defect of a bottle.

Abstract: There is provided a process for producing an optically active 2-phenoxypropionic acid, which comprises allowing an optically active lactic ester represented by the following formula (I) to react with a phenol represented by the following formula (II) in the copresence of a reagent A and a reagent B defined below to form an optically active 2-phenoxypropionic ester represented by the following formula (III), and liberating an optically active 2-phenoxypropionic acid represented by the following formula (IV) from the optically active 2-phenoxypropionic ester: ##STR1## wherein R.sup.1 represents a group to form a monovalent ester, which can be eliminated from the compound (III) under weakly basic to acidic conditions and R.sup.

Abstract: Cells, particularly animal cells, are cultivated in roller bottles which are handled or processed by a system comprising a decapper, the first liquid sucking and filling machine in which culture medium is sucked and a bottle cleaning liquid is supplied, a bottle rolling mechanism for washing the inner wall of the bottle in a horizontally-reclined state while rolling the same, the second liquid sucking and filling machine in which the cleaning liquid is sucked and culture medium is supplied, and a capper. The decapper, the first liquid sucking and filling machine, the bottle rolling mechanism, the second liquid sucking and filling machine, and the capper are all located in an aseptic chamber in this order along a conveyor which extends between a bottle supply turn table and a bottle collecting turn table.

Abstract: A process for preparing fruit juice beverages capable of being sold in cups via dispensing vending machines which comprises the steps of subjecting a fruit juice containing solid matter to milling, deaeration, homogenization and optional pasteurization, the milled juice being dispensed through a flow quantity control means substantially without clogging at the flow quantity control means.

Abstract: An apparatus for detecting defects on a bottle mouth has an annular illuminator, a reflecting mirror for forming a planar image of the bottle mouth, a CCD camera for detecting the planar image and an operation unit for operating electric signals produced by the CCD camera to judge existence of the defects on the bottle mouth. Detecting operation of defects can be carried out instantly without rotating the bottle.

Abstract: Disclosed is a novel macrolide antibiotic, M 119, of the formula (A): ##STR1## wherein the substituent R designates either (a) or (d): (a) R: H(d) R: OH.The antibiotic M 119 has antimicrobial activity, particularly against Gram-positive bacteria, typical pathogenic bacteria falling under Gram-negative bacteria such as Haemophilus influenzae, and mycoplasmas, and is effective against infections induced by such bacteria.

Abstract: An improved bottle opening machine for smoothly removing crown caps from bottle necks of empty bottles contained in bottle cases which are being conveyed on a conveyance system in a single file, in which the cap removing is carried out by the steps of engaging of cap removing sections on rotary discs with the crown caps on the bottle necks in an area where the circular movement path of the cap removing sections and the linear movement path of the bottle necks mutually converge in the tangential direction, removing of the crown caps from the bottle necks under the influence of a moment which is produced as the former is separated from the latter as the rotary discs are rotated, and releasing of the removed crown caps from the cap removing sections with the aid of cap releasing mechanisms. To ensure that the cap removing sections are positioned correctly with corresponding bottle necks, at least a synchronizing means is rotatably mounted on the frame structure.

Abstract: A promoter comprises a DNA having the same base sequence as that of a DNA fraction having a size of about 1.1 kbp, which is obtained by cleavage by restriction enzyme Bam HI of a DNA fraction comprising all of a 16SrRNA gene and a part of a 23SrRNA gene, said DNA fraction being obtained by cleavage by restriction enzyme Eco RI of chloroplast DNA of Marchantia polymorpha L. The promoter is integrated with a DNA having the same sequence as that of DNA derived from a procaryote into a vector.

Abstract: Disclosed is a modification of production of alcoholic beverages such as beer or wine by subjecting to fermentation by means of a faculative anaerobic microorganism such as a yeast a substrate liquor to the microorganism, which modification comprises conducting at least a part of the fermentation under such an anaerobic condition that the content of the dissolved oxygen in the substrate liquor is held at a restricted level thereby to reduce the content of diacetyls which imparts a disagreeable odor to the alcoholic beverages produced. The anaerobic fermentation makes it possible to use a yeast in high concentration without entailing the increase in the quantity of the diacetyls. Typically, the fermentation is conducted in two zones; one zone being conducted under the conditions that the yeast is proliferating while the other under the conditions that the yeast is not proliferating.

Abstract: An apparatus for discriminating and sorting out defective plastic bottle crates from sound bottle crates comprising driving means for urging an indenter or contact tip provided at the tip of a vibrating rod of an ultrasonic hardness tester into steady contact in indented state with a bottle crate, detecting means for detecting resonant frequency of said vibrating rod which is varied by the urging of said indenter or contact tip into steady contact with said bottle crate, and means for distinguishing and sorting out defective bottle crates from sound bottle crates in response to the resonant frequency detected by the detecting means.

Abstract: A counterpressure liquid filling device for a container (1) comprises a gas discharge passage (9a) for discharging the pressurized gas of the container (1) into the atmosphere, the gas discharge passage (9a) being branched into a first branch discharge conduit (12), one end of which is communicated with the neck of the container (1), and a second branch discharge passage (13), one end of which is communicated with the container at a position where the quantity of the liquid to be filled is determined, the other ends of both the first branch discharge conduit (12) and the second branch discharge passage (13) being communicated with a valve operating chamber (11). A gas flow control valve (10) is housed in the valve operating chamber (11).

Abstract: In glass bottle inspection, a pulse of acoustic wave is injected into a portion of the glass bottle forming a closed path for the propagation of the acoustic wave pulse so that the injected acoustic wave pulse travels round the closed plath, and acoustic wave pulse is detected while it is travelling round the closed path. Whether there is a defect along the closed path is judged in accordance with the magnitude of the detected acoustic wave pulse.

Abstract: A liquid flow controller suitable for a liquid containing numerous solid particles has a casing in which a valve body is slidably accommodated. Between the inner surface of the casing and the outer surface of the valve body is provided a wide space by forming some sliding projections. Furthermore, at least one flexible closing member is provided between the casing and the valve body. This construction enables the valve body to move smoothly without jamming of the solid particles in the liquid in the space.

Abstract: An improved bottle opening machine for removing crown caps from the head portions of empty bottles in bottle cases without any damage or chipping on the bottle heads as the bottle cases are conveyed on a conveyance system in an end-to-end relation. The improvement consists in that cap removing operation is carried out by way of the steps of engaging cap removing parts to the crown caps on the bottle heads in an area where the circular movement track of the cap removing parts is united with the linear movement track of the bottle heads in the tangential relation, removing the crown caps from the bottle heads under the influence of a moment caused when the former is gradually parted away from the latter and releasing the removed crown caps from the cap removing parts.

Abstract: In detection of a defect in a part of an object having a surface which is substantially a surface of revolution, the surface of the inspected part is illuminated by light rays which are emitted through an annular portion coaxially disposed with the surface of the inspected part, and light rays reflected at the surface of the inspected part are received to form an image of the inspected part. The image is constituted of pixels corresponding to the respective portions of the surface of the inspected part. Signals having a value indicative of the brightness of the pixels are stored in relation to the respective positions of the pixels in the image. The stored signals are referred repeatedly to provide, as a set of signals, a predetermined number of the signals of the pixels positioned along an imaginary line extending radially through a central point in the image corresponding to the axis of the surface of the inspected part and positioned and distributed within a radial range extending along the imaginary line.

Abstract: An anthracycline compound, Arugomycin, having the physicochemical properties set forth below is produced by aerobically cultivating an Arugomycin-producing Streptomyces strain in a suitable culture medium, and recovering from the culture the anthracycline compound, Arugomycin.(1) Color and form:Orange powder(2) Melting point:207.degree. to 213.degree. C. (decomposed)(3) Specific rotatory power:[.alpha.].sub.D.sup.25 =+112.degree.(C: 0.1, chloroform:methanol=9:1)(4) Elementary analysis (%):______________________________________ C H O N ______________________________________ Found 56.2 6.9 35.1 1.8 Calcd. 56.7 6.7 34.9 1.7 ______________________________________(5) Ultraviolet and visible absorption spectrum: as shown in FIG. 1. ______________________________________ .lambda..sub.max (E.sup.1% .sub.1cm) ______________________________________ CH.sub.3 OH 235(363), 258(167), 292(61), 476(104) 0.1N HCl + CH.sub.3 OH 235(387), 258(159), 292(61), 468(110) 0.1N NaOH + CH.sub.