Patents Assigned to Kirin Holdings Kabushiki Kaisha
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Publication number: 20250051814Abstract: The present invention relates to a microorganism having a reduced or inactivated activity of a protein according to any one of the following [1] to [3] and improved productivity of lacto-N-triose II or an oligosaccharide having a lacto-N-triose II (LNTII) skeleton as compared with a parent strain: [1] a protein consisting of the amino acid sequence represented by SEQ ID NO: 2 or 4, [2] a mutant protein having an oligosaccharide transporting activity and consisting of an amino acid sequence in which 1 to 20 amino acids are deleted, substituted, inserted, or added in the amino acid sequence represented by SEQ ID NO: 2 or 4, and [3] a homologous protein having an oligosaccharide transporting activity and consisting of an amino acid sequence having an identity of 90% or more with the amino acid sequence represented by SEQ ID NO: 2 or 4.Type: ApplicationFiled: December 21, 2022Publication date: February 13, 2025Applicants: KYOWA HAKKO BIO CO., LTD., KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Tomotoshi SUGITA, Sotaro SANPEI
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Publication number: 20250049058Abstract: It is to provide a fermentation composition comprising live bacteria of lactic acid bacteria, etc. at a certain concentration (cfu/mL) or more and having a pH in a neutral range, in which fermentation composition “an increase in sour taste and odor”, “a decrease in pH”, and/or “a decrease in the live bacteria concentration (cfu/mL) of lactic acid bacteria, etc.” during refrigerated storage after the production are suppressed, and a method of producing the fermentation composition, and so on. It is related to a fermentation composition having a pH of 6.0 to 7.4, the composition comprising: (a) 1×106 cfu/mL or more of live bacteria of one or more types of bacteria selected from the group consisting of lactic acid bacteria and bacteria of the genus Bifidobacterium; (b) a milk raw material and/or a fermented product using a milk raw material; and (c) dead bacterial cells of bacteria of the genus Lactococcus, and a method of producing the fermentation composition, and so on.Type: ApplicationFiled: December 14, 2022Publication date: February 13, 2025Applicant: KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Akiko NAKANO, Haruna KUBO, Hideo KUWAHIRA
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Publication number: 20250034307Abstract: A polymer gel includes a structure derived from a main monomer M1, a crosslinking agent monomer M2, and a radical polymerization initiator I as a constituent element. A monomer reactivity ratio r1 of the main monomer M1 and the monomer reactivity ratio r2 of the crosslinking agent monomer M2 satisfy a condition of r1>r2, a molar ratio of an addition amount of the crosslinking agent monomer M2 to an addition amount of the main monomer M1 is 12% or less, an addition molar ratio CM of the crosslinking agent monomer M2 to an addition amount of the main monomer M1, and an addition molar ratio IM of the initiator to an addition amount of the main monomer M1 satisfy a condition of IM?0.66CM+0.0017, and the radical polymerization initiator I is a compound having a chemical structure of a general formula (I).Type: ApplicationFiled: December 2, 2022Publication date: January 30, 2025Applicants: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYOInventors: Madoka TAKAI, Tsukuru MASUDA, Yui SAEGUSA, Toshikazu TSUJI
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Publication number: 20250026893Abstract: There is disclosed a polymer gel including a structure derived from a main monomer M1, a crosslinking agent monomer M2, and a radical polymerization initiator I as a constituent element. In this polymer gel, a monomer reactivity ratio r1 of the main monomer M1 and a monomer reactivity ratio r2 of the crosslinking agent monomer M2 satisfy a condition of r1>r2, a molar ratio of an addition amount of the crosslinking agent monomer to an addition amount of the main monomer M1 is 1% or less, and a decomposition rate (10?7/s) of the radical polymerization initiator I at 25° C. is 25 or more. This polymer gel has properties of high strength and high viscosity.Type: ApplicationFiled: December 2, 2022Publication date: January 23, 2025Applicants: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYOInventors: Madoka TAKAI, Tsukuru MASUDA, Yui SAEGUSA, Toshikazu TSUJI
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Publication number: 20240415901Abstract: An object of the present invention is to provide a novel agent for inhibiting proliferation of SARS-COV-2 and a novel agent for preventing onset of COVID-19. According to the present invention, there is provided an agent for inhibiting proliferation of SARS-CoV-2 comprising a lactic acid bacterium as an active ingredient. Also, according to the present invention, there is provided an agent for preventing onset of COVID-19 comprising a lactic acid bacterium as an active ingredient. The lactic acid bacterium which is the active ingredient of the present invention is preferably Lactococcus lactis subsp. lactis. The agent of the present invention is preferably in the form of a food composition.Type: ApplicationFiled: October 27, 2022Publication date: December 19, 2024Applicants: Japan as Represented by Director General of National Institute of Infectious Diseases, Kirin Holdings Kabushiki KaishaInventors: Hiroshi ISHII, Tetsuro MATANO, Kenta JONAI, Konomi OHSHIO, Daisuke FUJIWARA
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Patent number: 12168781Abstract: The present invention relates to a method for producing T cells or NK cells including culturing T cells or NK cells in a culture medium containing a CaMKII inhibitor such as a bisbenzylisoquinoline alkaloid compound. The disclosed compounds and methods can be used for maintaining the undifferentiated state of undifferentiated T cells, or for efficiently proliferating T cells or NK cells.Type: GrantFiled: December 6, 2019Date of Patent: December 17, 2024Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, Kyoto UniversityInventors: Shinichiro Takayanagi, Atsushi Kunisato, Sayaka Chuganji, Ken Fukumoto, Kazuki Nakazono, Shin Kaneko, Yohei Kawai
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Publication number: 20240382749Abstract: A taste presentation device may have a first electrode and a second electrode provided to allow an electric circuit to be formed between a food or drink to be taken by a user and a body of the user, and an electric stimulus generation unit that supplies a current for generating an electric stimulation between the first electrode and the second electrode, the electric stimulus generation unit includes a noise reduction unit that reduces a noise component in the current.Type: ApplicationFiled: August 19, 2022Publication date: November 21, 2024Applicants: KIRIN HOLDINGS KABUSHIKI KAISHA, MEIJI UNIVERSITYInventors: Ai SATO, Homei MIYASHITA
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Publication number: 20240290453Abstract: A user terminal includes a transmission/reception unit that acquires first supplement compounding information that indicates compounding of a supplement derived based on a user's information, a display unit that displays the first supplement compounding information acquired by the transmission/reception unit for the user's confirmation, an input reception unit that receives a compounding and preparation input of a supplement that is made by the user regarding the first supplement compounding information displayed by the display unit, a derivation unit that derives second supplement compounding information that indicates compounding of a prepared supplement based on the compounding and preparation input received by the input reception unit, and a transmission/reception unit that outputs the second supplement compounding information derived by the derivation unit.Type: ApplicationFiled: September 15, 2022Publication date: August 29, 2024Applicant: KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Hiroyuki HIDA, Keiji YAMANAKA
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Publication number: 20240277009Abstract: An object of the present invention is to provide a novel lactic acid bacterium-containing beverage and a method for producing the same, a novel lactic acid bacterium bulk powder and a method for producing the same, as well as a novel method for improving the water dispersibility of a lactic acid bacterium in a lactic acid bacterium-containing beverage. The present invention provides a lactic acid bacterium-containing beverage having a pH of 5.0 or higher at 25° C.; and a method for producing a lactic acid bacterium-containing beverage, comprising the steps of: adjusting the pH of the beverage at 25° C. to 5.0 or higher; and/or blending a lactic acid bacterium bulk powder obtained by heat-treating a lactic acid bacterium at a temperature of 90° C. or higher. The present invention also provides a lactic acid bacterium bulk powder obtained by heat treatment at a temperature of 90° C. or higher; and a method for producing the same.Type: ApplicationFiled: July 28, 2022Publication date: August 22, 2024Applicant: KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Yu HIROSE, Yoshihiko SUGIHARA, Takeshi KOKUBO, Toshikazu TSUJI, Hazuki MURAKAWA
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Publication number: 20240254441Abstract: An object of the present invention is to provide a technique for concentrating blood cells having high proliferation ability and/or differentiation ability. The present invention relates to a method for producing a cell composition, the method including: a step of extracting cells expressing a G protein-coupled receptor 56 (GPR56) from a cell aggregate containing immature blood cells, and a cell composition containing an immature blood cell expressing GPR56, in which a proportion of the immature blood cell expressing GPR56 is 50% to 100% of total cells.Type: ApplicationFiled: June 3, 2022Publication date: August 1, 2024Applicant: KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Shinichiro TAKAYANAGI, Ken FUKUMOTO
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Publication number: 20240226194Abstract: This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as Lactococcus garvieae NBRC100934, Lactococcus lactis subsp. cremoris JCM16167, Lactococcus lactis subsp. cremoris NBRC100676, Lactococcus lactis subsp. hordniae JCM1180, Lactococcus lactis subsp. hordniae JCM11040, Lactococcus lactis subsp. lactis NBRC12007, Lactococcus lactis subsp. lactis NRIC1150, Lactococcus lactis subsp. lactis JCM5805, Lactococcus lactis subsp.Type: ApplicationFiled: March 8, 2024Publication date: July 11, 2024Applicant: KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Daisuke FUJIWARA, Kenta JONAI, Tetsu SUGIMURA
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Publication number: 20240191177Abstract: An object of the present invention is to provide a growth promoter for a lactic acid coccus. According to the present invention, there is provided a growth promoter for a lactic acid coccus, comprising a dicarboxylic acid or a salt thereof as an active ingredient. The dicarboxylic acid is preferably an aliphatic dicarboxylic acid having 4 to 6 carbon atoms. The lactic acid coccus is preferably a bacterium belonging to the genus Lactococcus. According to the present invention, the growth of a lactic acid coccus can be promoted by including a dicarboxylic acid in a medium, and, therefore, the present invention is advantageous in that the lactic acid coccus can be cultivated more easily.Type: ApplicationFiled: March 24, 2002Publication date: June 13, 2024Applicant: KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Yu HIROSE, HAZUKI MURAKAWA
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Publication number: 20240180979Abstract: An object of the present invention is to provide a composition for preventing visual dysfunction caused by exposure to light, such as so-called blue light. The present invention provides a composition comprising a lactic acid bacterium as an active ingredient for use in suppressing or improving conditions caused by retinal inflammation resulting from light damage. Eye discomfort is an exemplary condition caused by retinal inflammation resulting from light damage.Type: ApplicationFiled: December 21, 2023Publication date: June 6, 2024Applicant: Kirin Holdings Kabushiki KaishaInventors: Toshihide KURIHARA, Yuji MORITA, Kenta JONAI, Daisuke FUJIWARA
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Publication number: 20240164399Abstract: An object of the present invention is to provide, for example, a packaged tea beverage in which liquid color degradation during heat sterilization is suppressed, and a production method therefor. The method of the present invention comprises the step of including lactic acid bacteria in the production of a heat-sterilized packaged tea beverage having a tea polyphenol concentration of 10 to 200 mg/100 mL and a pH of 4.5 to 7.5.Type: ApplicationFiled: March 14, 2022Publication date: May 23, 2024Applicant: KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Mihoko SUZUKI, Yuko YOTSUMOTO
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Publication number: 20240156122Abstract: An object of the present invention is to provide, for example, a packaged tea beverage in which paper odor is suppressed, and a method for producing the same, as the paper odor occurs in packaged tea beverages containing a JCM5805 strain. The present invention relates to a packaged tea beverage obtainable by a production method comprising a step of including a JCM5805 strain in a tea extract liquid having a tea polyphenol concentration of 10 mg or more/100 mL, and performing a treatment of heating to 100° C. or higher.Type: ApplicationFiled: March 14, 2022Publication date: May 16, 2024Applicant: KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Mihoko SUZUKI, Yuko YOTSUMOTO
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Patent number: 11944657Abstract: This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as Lactococcus garvieae NBRC100934, Lactococcus lactis subsp. cremoris JCM16167, Lactococcus lactis subsp. cremoris NBRC100676, Lactococcus lactis subsp. hordniae JCM1180, Lactococcus lactis subsp. hordniae JCM11040, Lactococcus lactis subsp. lactis NBRC12007, Lactococcus lactis subsp. lactis NRIC1150, Lactococcus lactis subsp. lactis JCM5805, Lactococcus lactis subsp.Type: GrantFiled: December 13, 2021Date of Patent: April 2, 2024Assignee: Kirin Holdings Kabushiki KaishaInventors: Daisuke Fujiwara, Kenta Jonai, Tetsu Sugimura
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Patent number: 11890309Abstract: An object of the present invention is to provide a composition for preventing visual dysfunction caused by exposure to light, such as so-called blue light. The present invention provides a composition comprising a lactic acid bacterium as an active ingredient for use in suppressing or improving conditions caused by retinal inflammation resulting from light damage. Eye discomfort is an exemplary condition caused by retinal inflammation resulting from light damage.Type: GrantFiled: June 13, 2022Date of Patent: February 6, 2024Assignee: Kirin Holdings Kabushiki KaishaInventors: Toshihide Kurihara, Yuji Morita, Kenta Jonai, Daisuke Fujiwara
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Patent number: 11891494Abstract: Disclosed is an additive for imparting antimicrobial properties to a resin. The additive comprises a string polymer, at least one terminal of which has a positive charge, wherein the string polymer is a polymer containing structural units derived from a cationic polymerization initiator and a monomer containing a carbon-carbon double bond. By using this additive, it becomes possible to obtain an antibacterial resin molded body which can be prepared simply and inexpensively and which has high stability and safety.Type: GrantFiled: April 25, 2019Date of Patent: February 6, 2024Assignee: KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Toshikazu Tsuji, Hideki Koizumi, Akiko Jitsuhiro, Yuki Konoeda, Atsushi Hotta, Tomoki Maeda
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Publication number: 20230263735Abstract: An object of the present invention is to provide a film coated tablet that has an excellent tablet slipperiness in an oral cavity and prevents delay in disintegration time of an uncoated tablet.Type: ApplicationFiled: July 13, 2021Publication date: August 24, 2023Applicant: KIRIN HOLDINGS KABUSHIKI KAISHAInventors: Yasuhiro SUZUKI, Toshiki YAMAOKA, Yohei YAMAZOE
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Patent number: D1056621Type: GrantFiled: December 23, 2022Date of Patent: January 7, 2025Assignee: KIRIN HOLDINGS KABUSHIKI KAISHAInventor: Tohru Shirakawa