Abstract: The present invention refers to a process for direct C—H functionalization, the reagents used in the process and the use thereof for the direct C—H functionalization as well as the so-obtained products.
Abstract: The present invention refers to a process for direct C—H functionalization, the reagents used in the process and the use thereof for the direct C—H functionalization as well as the so-obtained products.
Abstract: The present invention concerns a process for removing carbon monoxide and/or gaseous sulphur compounds from hydrogen gas and/or aliphatic hydrocarbons, preferably at low temperatures, with the aid of complex metal aluminium hydrides.
Type:
Application
Filed:
July 26, 2020
Publication date:
August 25, 2022
Applicant:
STUDIENGESELLSCHAFT KOHLE MBH
Inventors:
Michael FELDERHOFF, Kateryna PEINECKE, Bodo ZIBROWIUS, Sun TAI
Abstract: The present invention refers to reagents and methods for preparing a peptide sequence having a [18F]fluoro-aromatic amino acid side which may be further substituted, in particular a 4-[18F]fluoro-phenylalanine side chain in peptide sequences, by chemoselective radio-deoxyfluorination of an aromatic amino acid residue, in particular a tyrosine residue using a traceless-activating group and the reagents used in said process.
Abstract: The present invention refers to a process for direct C—H functionalization, the reagents used in the process and the use thereof for the direct C—H functionalization as well as the so-obtained products.
Abstract: Provided herein are palladium complexes comprising a ligand of Formula (A?) and a ligand of Formula (B), wherein R1-R18 are as defined herein. The palladium complexes are useful in methods of fluorinating aryl and heteroaryl substrates. Further provided are compositions and kits comprising the palladium complexes.
Type:
Grant
Filed:
March 9, 2017
Date of Patent:
November 23, 2021
Assignees:
President and Fellows of Harvard College, Studiengesellschaft Kohle mbH
Abstract: The present invention refers to a process for a transition metal, particularly nickel-catalyzed cyanation reaction of aryl/vinyl halide using organic nitrile compounds. This new reaction provides a strategically distinct approach to the safe preparation of aryl/vinyl cyanides, which are essential compounds in agrochemistry and medicinal chemistry.
Abstract: The present invention relates to chiral phosphoramidimidates, their salts and metal complexes as well as derivatives thereof and their use as catalysts.
Type:
Grant
Filed:
August 31, 2016
Date of Patent:
August 10, 2021
Assignee:
STUDIENGESELLSCHAFT KOHLE MBH
Inventors:
Benjamin List, Philip Stephan Joseph Kaib, Lucas Schreyer, Sunggi Lee, Roberta Properzi, Luping Liu
Abstract: The present invention refers to a process for transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for positron emission tomography (PET) imaging.
Type:
Grant
Filed:
July 10, 2018
Date of Patent:
June 29, 2021
Assignee:
STUDIENGESELLSCHAFT KOHLE MBH
Inventors:
Tobias Ritter, Constanze Neumann, Mohammad Hassan Beyzavi, Martin Georg Strebl-Bantillo, Debashis Mandal
Abstract: Surfactants of the general formula (I) in which R1 is a linear or branched akyl radical having 6 to 20, especially 10 to 16 C atoms, R2 and R3 independently of one another are H or H3CO, and M is hydrogen, an alkali metal or a moiety N+R4R5R6, in which R4, R5 and R6 independently of one another are hydrogen, an alkyl group having 1 to 6 C atoms or a hydroxyalkyl group having 2 to 6 C atoms, are readily incorporated into laundry detergents or cleaning products, possess outstanding performance qualities and can be prepared on the basis of renewable raw materials.
Type:
Grant
Filed:
February 2, 2018
Date of Patent:
April 27, 2021
Assignees:
Henkel AG & Co. KGaA, Studiengesellschaft Kohle mbH
Inventors:
Christian Kropf, Alexander Schulz, Hendrik Hellmuth, Roberto Rinaldi, Hebert Jesus Estevez Rivera
Abstract: Surfactants of general formula (I), in which R1 denotes a linear or branched alkyl residue having 6 to 20, and in particular 8 to 14 carbon atoms, R2 denotes H or CH3, and M denotes hydrogen, an alkali metal or an N+R3R4R5 grouping, in which R3, R4 and R5, independently of one another, denote hydrogen, an alkyl group having 1 to 6 carbon atoms or a hydroxyalkyl group having 2 to 6 carbon atom, can be easily incorporated into washing or cleaning agents, have outstanding application-related properties, and can be produced based on renewable resources.
Type:
Grant
Filed:
February 2, 2018
Date of Patent:
April 27, 2021
Assignees:
Henkel AG & Co. KGaA, Studiengesellschaft Kohle mbH
Inventors:
Christian Kropf, Alexander Schulz, Hendrik Hellmuth, Roberto Rinaldi, Hebert Jesus Estevez Rivera
Abstract: The present invention refers to a process for a Rh-catalyzed Anti-Markovnikov hydrocyanation of terminal alkynes which process discloses, for the first time, the highly stereo- and regio-selective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles and the catalyst used in the present process.
Abstract: The present invention refers to a process for transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for positron emission tomography (PET) imaging.
Type:
Application
Filed:
July 10, 2018
Publication date:
November 26, 2020
Applicants:
STUDIENGESELLSCHAFT KOHLE MBH, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventors:
Tobias RITTER, Constanze NEUMANN, Mohammad Hassan BEYZAVI, Martin Georg STREBL-BANTILLO, Debashis MANDAL
Abstract: The present invention refers to a process for a transition metal, particularly nickel-catalyzed cyanation reaction of aryl/vinyl halide using organic nitrile compounds. This new reaction provides a strategically distinct approach to the safe preparation of aryl/vinyl cyanides, which are essential compounds in agrochemistry and medicinal chemistry.
Abstract: The present invention refers to a process for a Rh-catalyzed Anti-Markovnikov hydrocyanation of terminal alkynes which process discloses, for the first time, the highly stereo- and regio-selective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles and the catalyst used in the present process.