Abstract: An inhibiting agent against the proliferation of tumor cells comprises a lower condensation polymer or oligomer of an .alpha.-hydroxy acid, an oligopeptide containing at least one pyroglutamic acid residue, and a stabilizer. The lower condensate and the lower polymer of an .alpha.-hydroxy acid comprise mainly compounds formed by condensing and polymerizing 2 to 10 molecules of an .alpha.-hydroxy acid and their metal salts. The weight ratio of the components is such that the ratio of the lower condensate and the lower polymer of an .alpha.-hydroxy acid is 10, the ratio of the oligopeptide containing at least one pyroglutamic acid residue is 1 to 4, and the ratio of the stabilizer a saccharide or a sugaralcohol comprising is 1 to 3.

Abstract: The present invention relates to a sustained release formulation used for treatment or prevention of the diseases, which contains a therapeutically effective substance as an active ingredient, collagen as a drug carrier, and glycosaminoglycan as an additive. The formulation allows controlled release of the therapeutically effective substance.

Abstract: A method of obstructing the lacrimal canaliculi by infusing therein a solution or liquid dispersion containing a gel forming material, such having collagen as the main ingredient in the range of 1 mg/ml to 70 mg/ml for improving the symptoms of dry eye.

Abstract: Equipment for intracerebral administration of preparations is composed of a preparation-administering device (1) holding a preparation (2), and a plunger (4) removably arranged in the preparation-administering device adapted to push the preparation held therein toward one end of the preparation-administering device. The intracerebral preparation-administration equipment is inserted into a preparation-introducing guide (5) previously implanted in the head of a patient to introduce the preparation into its guide hole (26). The preparation is then guided to a site of administration through a flexible guide tube (23) communicated with the guide hole of the preparation-introducing guide. The equipment for intracerebral administration of preparations may be composed of a tubular preparation-retaining member (30) having a preparation contained therein, and a holder (32) for holding the tubular preparation-retaining member along with a push rod (31) inserted thereinto as an integral part thereof.

Abstract: A non-sliding vacuum gate valve has a valve housing with a valve opening therethrough which is opened and closed by a gate valve body moved by a valve rod. The valve rod moves with linear and tilting movement so that the valve body tilts against the valve seat surrounding the valve opening. The valve rod is moved linearly by cylinder rods extending from a pair of cylinders attached to the valve housing on either side of the valve rod. A cam body having an angular cam slot is attached to a connecting member which spans between the end portions of the cylinder rods above the valve rod. The valve rod has a cam follower engaging the angular cam slot to provide the tilting movement of the valve rod and valve body responsive to the alternate reciprocal vertical movement of the cylinder rods, to open and close the valve opening.

Abstract: The invention relates to a vascular prosthesis wherein, fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells are deposited and captured within the wall of a vascular prosthesis substrate; a manufacturing method comprising the steps of immersing a vascular prosthesis substrate into a dispersed solution of fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells, and depositing and capturing the cells and/or tissue fragments on the inner wall and within the wall of the vascular prosthesis from one side to the other side of the vascular prosthesis substrate wall by providing a pressure differential between the outside and the inside of the vascular prosthesis substrate; and a

Abstract: A deproteinization filler comprises an aggregate of hydroxyapatite fibers having a three dimensional network structure. The mean radius of pores defined by the aggregate is approximately 0.02 .mu.m to approximately 0.08 .mu.m, the specific surface of the aggregate is approximately 25 m.sup.2 /g to approximately 65 m.sup.2 /g and the mean diameter of particles defined by the aggregate is approximately 1 .mu.m to approximately 30 .mu.m. The filler is produced by a given method. The filler may be contained in a throwaway cartridge.

Abstract: The present invention provides an intracorporeally injectable non-toxic composition of atelocollagen having an excellent, long-lasting skin swelling effect due to its low viscosity, good fluidity, easy injectability and low antigenicity (without calcification) properties. The composition is prepared by treating an aqueous suspension of atelocollagen with a buffer for physiological conditions. The suspension can have atelocollagen content of 55 to 75 mg/ml, where approximately 20 to 100% by weight of atelocollagen is cross-linked with a polyepoxy compound.

Abstract: The invention relates to a vascular prosthesis wherein, fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells are deposited and captured within the wall of a vascular prosthesis substrate; a manufacturing method comprising the steps of immersing a vascular prosthesis substrate into a dispersed solution of fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells, and depositing and capturing the cells and/or tissue fragments on the inner wall and within the wall of the vascular prosthesis from one side to the other side of the vascular prosthesis substrate wall by providing a pressure differential between the outside and the inside of the vascular prosthesis substrate; and a

Abstract: A method for drying a wetted molded product of pasty high viscous composition which comprises subjecting the molded product to a dehydration process while wholly or partially contacting the product with an open-cell foamed hydrophobic porous membrane.

Abstract: A hyaluronic acid-containing aqueous solution or aqueous dispersion of collagen having a pH of from about 6.5 to about 8.0 and an osmolality of from about 230 to about 320 mOsm/kgH.sub.2 O. The aqueous solution or the aqueous dispersion of collagen is useful as an agent for correction and reparation of a depressed part of or a void in soft tissue of mammals.

Abstract: A biomaterial excellent in biocompatibility comprising a composite material of an N-acylchitosan and collagen is described. This biomaterial is suitable for used as a wound dressing material, vascular prosthesis, artificial skin or hemostatic agent.

Abstract: A bioprosthetic valve made from a biological tissue containing collagen which has been cross-linked with a polyepoxy compound is disclosed. The valve has excellent biocompatibility and is durable and is free from calcification.

Abstract: An artifical skin comprising an insoluble atelocollagen sheet and an epidermal cell layer cultured only on one surface of the sheet, and a method of producing the same are disclosed, which method includes the steps of: forming an insoluble atelocollagen sheet; inoculating epidermal cells only on one surface of the atelocollagen sheet; and suspending the atelocollagen sheet in a liquid culture medium to culture the epidermal cells, thereby forming an epidermal cell layer.

Abstract: In an adsorbent for use in chromatography comprised of secondary particles formed by aggregation of primary particles in the form of fine crystals of hydroxyapatite, the aggregated primary particles are sintered so as to be bonded together. The adsorbent is produced by heating the secondary particles at a temperature not lower than 300.degree. C. and not higher than the decomposition temperature thereof, and has significantly improved repetitive using properties. In a column system for use in chromatography, there are provided a main column packed with the above described adsorbent and a precolumn packed with a second adsorbent comprised of conventional hydroxyapatite particles. This column has also a significantly improved repetitive using properties.

Abstract: A method for preparing a sustained release formulation utilizing collagen and/or gelatin as a carrier, which comprises the steps:(i) preparing a uniform and high concentrated mixture with respect to the collagen and/or gelatin by blending an active ingredient, said collagen and/or gelatin, and water or an admixture consisting of water and a hydrophilic organic solvent under one of the conditions selected from:(A) the pH of the mixture is kept below 5 and the salt concentration of the mixture is retained below fiber-forming concentration;(B) chemically modified collagen and/or gelatin is employed; and(C) glucose is added to the mixture;(ii) molding the resultant mixture; and(iii) gradually eliminating the solvent from the molded product.

Abstract: This invention relates to a surfactant with less toxicity and irritation against the human body and a production process thereof. The surfactant is produced by the acylation of the side chain amino radicals of collagen or gelatine with an aliphatic acid having 2 to 26 carbon atoms; it is used as an emulsifier and an antiseptic for cosmetics.

Abstract: An antithrombogenic medical material with a remarkable antithrombogenic property and histocompatibility as well as sufficient physical strength, formed by fixing a heparinized collagen to a synthetic polymer material is provided. And a method of preparing an antithrombogenic medical material is provided, wherein a synthetic polymer material is subjected to a coating or impregnating treatment with a collagen-containing solution, followed by heparinization of the collagen, and the heparinized collagen is fixed to the synthetic polymer material. This method allows manufacturing of antithrombogenic medical material with ease.

Abstract: In a method of preparing an antithrombogenic medical material having a heparinized collagen as an antithrombogenic component, there is provided a method comprising the steps of fixing a protamine to a collagen through a polyepoxy compound, and heparinizing the collagen by fixing heparin to the protamine.

Abstract: This invention relates to a hemostatic agent used in surgical operations, which can be produced in two ways: one blending collagen/gelatin with protamine, the other blending collagen/gelatin with protamine and a bi-functional cross-linking agent so as to make said collagen/gelatin have a covalent bond with said protamine. The produced hemostatic agent can stop bleeding within far less time than a conventional hemostatic agent made out of pure collagen.