Patents Assigned to KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCE
  • Publication number: 20210085998
    Abstract: The present invention relates to a method, a device, and a program for calculating a brachytherapy plan, and a brachytherapy apparatus. The method comprises: a step in which a computer obtains the number of radiation irradiation spots on the basis of radiation irradiation information (a radiation irradiation spot number obtaining step (S200)); a step in which the computer obtains target area information from a body model of a patient generated on the basis of medical image data of the patient (a target area information obtaining step (S400)); and a therapy plan calculating step (S600) in which the computer calculates, on the basis of the radiation irradiation information and the target area information, the radiation irradiation spots to which radiation is irradiated and the time length of irradiation to each radiation irradiation spot.
    Type: Application
    Filed: December 3, 2020
    Publication date: March 25, 2021
    Applicants: THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION, NATIONAL CANCER CENTER, THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY, KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Ho Jin KIM, Jung Won KWAK, Byung Chul CHO, Sang Wook LEE, Chi Young JEONG, Young Kyung LIM, Ui Jung HWANG, Sang Hyoun CHOI
  • Patent number: 10898126
    Abstract: The present invention provides a triple fusion imaging device for sentinel lymphadenectomy for laparoscopic surgery including: a composite laparoscope for near infrared ray/gamma ray/visible ray acquisition configured to acquire triple images of a gamma ray from a gamma ray radioactive material injected to a diseased part, a visible ray, and a near infrared ray; an optical fiber configured to transmit the triple images acquired from the composite laparoscope; an optical source configured to generate a white light for acquiring a visible image through the optical fiber and a near infrared ray excitation light for acquiring a near infrared ray image by exciting a near infrared ray emitting fluorescence material at the disease part; an optical-to-electrical conversion module configured to separate individual images of the visible ray, near infrared ray and gamma ray from the triple images delivered through the optical fiber and then respectively convert the individual images to electrical signals; a matching uni
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: January 26, 2021
    Assignees: EULJI UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION, SAMSUNG LIFE PUBLIC WELFARE FOUNDATION, KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCE
    Inventors: Seong Jong Hong, Han Gyu Kang, Gun Chul Hong, Hyung Seok Lee, Kyeong Min Kim, Ho Young Lee, Seung Hoon Lee, Jong Hun Lee
  • Patent number: 10760082
    Abstract: A substance inhibiting the expression of CCND3 gene or PAK2 gene, the substance containing a nucleotide such as miR-4779, may be efficiently used for preventing or treating cancer. In addition, by screening the substance that inhibits the expression of CCND3 gene or PAK2 gene, a candidate substance for preventing or treating cancer may be selected.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: September 1, 2020
    Assignee: Korea Institute of Radiological & Medical Sciences
    Inventors: Kyung Hee Koo, Hee Chung Kwon, Jie Young Song
  • Patent number: 10722526
    Abstract: The present invention relates to a pharmaceutical composition for radioprotection or radiomitigation with respect to radiation-induced damage, the composition comprising a compound of Formula 1, or a pharmaceutically acceptable salt thereof or a solvate thereof.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: July 28, 2020
    Assignee: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Yoon Jin Lee, Hae June Lee, Jae Kyung Nam, A Ram Kim, Kyeng Jung Kim
  • Patent number: 10583157
    Abstract: The present invention relates to an artificial cartilage containing mesenchymal stem cell (MSC)-like dedifferentiated cells obtained by passage culturing costal chondrocytes, and a preparation process thereof.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: March 10, 2020
    Assignees: BIO SOLUTION CO., LTD., KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES, UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNGHEE UNIVERSITY
    Inventors: Young Sook Son, Jung Sun Lee, Eun Kyung Lee, Jin Yeon Lee
  • Publication number: 20190329066
    Abstract: The present invention relates to a body insertable device having an outer body being bent; and an inner body positioned inside the outer body, having an accommodation space in which the resource soured is accommodated, and being capable of rotating inside the outer body, wherein a radiation emission direction is continuously adjusted by rotation of the inner body.
    Type: Application
    Filed: June 19, 2017
    Publication date: October 31, 2019
    Applicants: National Cancer Center, Korea Institute of Radiological & Medical Sciences, The Asan Foundation, University of Ulsan Foundation for Industry Cooperation
    Inventors: Young Kyung LIM, Jung Won KWAK, Dae Yong KIM, Yeon Joo KIM, Joo Young KIM, Soon Ki MIN, Young Dae JUNG, Ho Jin JEONG, Sang Hyoun CHOI, Ui Jung HWANG
  • Publication number: 20190256857
    Abstract: A substance inhibiting the expression of CCND3 gene or PAK2 gene, the substance containing a nucleotide such as miR-4779, may be efficiently used for preventing or treating cancer. In addition, by screening the substance that inhibits the expression of CCND3 gene or PAK2 gene, a candidate substance for preventing or treating cancer may be selected.
    Type: Application
    Filed: December 21, 2017
    Publication date: August 22, 2019
    Applicant: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Kyung Hee Koo, Hee Chung Kwon, Jie Young Song
  • Publication number: 20190192701
    Abstract: Provided are a conjugate including an EGFR inhibitor that enables treatment and diagnosis of epidermal growth factor receptor (EGFR)-overexpressing tumors including resistant tumors, a method that enables drug delivery treatment and diagnosis of EGFR-overexpressing tumors using the conjugate, and a method of preparing the conjugate.
    Type: Application
    Filed: December 26, 2018
    Publication date: June 27, 2019
    Applicant: Korea Institute of Radiological & Medical Sciences
    Inventors: Tae Sup Lee, Ik Joon Choi, Joo Hyun Kang
  • Patent number: 10301596
    Abstract: The present invention relates to a method for inhibiting an inflammatory response in chondrocytes, and dedifferentiation or destruction of chondrocytes by irradiating damaged chondrocytes with low-dose radiation, and a method of treating a disease of cartilage by irradiating damaged chondrocytes with low-dose radiation.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: May 28, 2019
    Assignee: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Sang Gu Hwang, Eun Hee Hong
  • Patent number: 9963701
    Abstract: The present invention relates to a pharmaceutical composition for treating a radiation- or drug-resistant cancer, containing an agent capable of inhibiting the expression of hepatoma-derived growth factor (HDGF)-related protein-3 (HRP-3), a method of treating a radiation- or drug-resistant cancer by administering the pharmaceutical composition, and the use of an HRP-3 inhibitor for preparing an agent for treating a radiation- or drug-resistant cancer. The use of the pharmaceutical composition of the present invention enables to treat a resistant cancer in combination with a conventional anticancer chemotherapy or radiotherapy. Accordingly, the pharmaceutical composition of the present invention can reduce both the costs for developing anticancer agents against resistant cancers and the costs for treating cancers in patients, thus being useful for the economic and effective treatment of resistant cancers.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: May 8, 2018
    Assignee: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Sang Gu Hwang, Hong Shik Yun
  • Patent number: 9794521
    Abstract: Provided are apparatuses and methods of resampling event data for quantitative improvement of a PET image, which acquire a quantitatively-improved new PET image by analyzing a storage format of list data prior to conversion into the PET image and nonparametrically resampling event data from the list data based on the analysis results to improve noise and statistical characteristics thereof. The quantitatively improved new PET image may be acquired by analyzing a storage format of list data constituting the PET image and nonparametrically resampling event data to improve noise and statistical characteristics thereof.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: October 17, 2017
    Assignee: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Sang Keun Woo, Kyeong Min Kim, Tae Won Nam, Ji Min Kim, Sang Moo Lim
  • Publication number: 20170274018
    Abstract: The present invention relates to an artificial cartilage containing mesenchymal stem cell (MSC)-like dedifferentiated cells obtained by passage culturing costal chondrocytes, and a preparation process thereof.
    Type: Application
    Filed: June 12, 2017
    Publication date: September 28, 2017
    Applicants: BIO SOLUTION CO., LTD., KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES, UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNGHEE UNIVERSITY
    Inventors: Young Sook SON, Jung Sun LEE, Eun Kyung LEE, Jin Yeon LEE
  • Patent number: 9694034
    Abstract: The present invention relates to an artificial cartilage containing mesenchymal stem cell (MSC)-like dedifferentiated cells obtained by passage culturing costal chondrocytes, and a preparation process thereof.
    Type: Grant
    Filed: October 31, 2006
    Date of Patent: July 4, 2017
    Assignees: BIO SOLUTION CO., LTD., KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES, UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNGHEE UNIVERSITY
    Inventors: Young Sook Son, Jung Sun Lee, Eun Kyung Lee, Jin Yeon Lee
  • Publication number: 20170121368
    Abstract: Provided are a novel compound, in which a bombesin derivative known as having selectivity with respect to prostate cancer bonds with a ligand via aminomethyl galacturonic acid, a complex compound that covalently bonds with a radioactive isotope via the ligand of the novel compound, methods of preparing the compounds, and a nuclear-based molecular imaging agent including the complex compound.
    Type: Application
    Filed: October 29, 2015
    Publication date: May 4, 2017
    Applicant: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Yong Jin Lee, Joo Hyun Kang, Kwang Il Kim, Min Hwan Kim, Byung Il Kim, Ji Ae Park, Sang Keun Woo, Kyo Chul Lee, Tae Sup Lee
  • Patent number: 9588119
    Abstract: Disclosed are increased expression of ERp57, ERp57-STAT3 complex, and ERp57-STAT3-Mcl-1 in laryngeal cancer, especially in radioresistant laryngeal cancer and their regulations on radioresistance of laryngeal cancer. As such, the efficacy of radiotherapy can be enhanced by diagnosing prognosis in laryngeal cancer and radioresistance of laryngeal cancer. Furthermore, provided are a method of screening a therapeutic agent for laryngeal cancer including selecting a candidate drug that inhibits the expression of ERp57 or inactivates ERp57, and a therapeutic method for inhibiting or treating laryngeal cancer or radioresistant laryngeal cancer, thereby being useful in the treatment of laryngeal cancer.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: March 7, 2017
    Assignee: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Jae-Sung Kim, Sang-Gu Hwang, Young-Hoon Han
  • Patent number: 9550995
    Abstract: Provided is a composition for inducing tumor cell senescence and a method for inducing tumor cell senescence using the same. The composition can inhibit a PAPSS2 gene in a tumor cell to thereby induce senescence of the tumor cell, and if the composition is used concurrently with irradiation of the tumor cell, the composition can improve the sensitivity of the tumor cell to radiation.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: January 24, 2017
    Assignees: Korea Institute of Radiological & Medical Sciences, Inha University Research and Business Foundation
    Inventors: Jae-Seon Lee, Seung Hee Jung, Bong Cho Kim, Hyung Chul Lee, Na-Kyung Han, Mi-Na Hong
  • Patent number: 9447054
    Abstract: Disclosed is an anticancer supplement agent including a benzo[d]oxazole derivative as an effective ingredient. The benzo[d]oxazole derivative, which is a nuclear factor E2-related factor 2 (Nrf2) inhibitor, is capable of inhibiting activity of Nrf2 that induces an antioxidant enzyme to remove reactive oxygen species (ROS) that kills a cancer cell, thereby increasing production of ROS. Therefore, the benzo[d]oxazole derivative can be used as an anticancer supplement agent that shows therapeutic effects in anticancer agent therapy or radiation therapy, and in this regard, the benzo[d]oxazole derivative can overcome tolerance of the cancer cell to anticancer agent therapy or radiation therapy and enhance apoptotic effects on the cancer cell.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: September 20, 2016
    Assignee: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Jie Young Song, Ji Yeon Ahn, In Sung Jung, Saelooom Lee, Arang Son, Ky Youb Nam, Hyun Kyung Choi, Seung Yong Seo, Yuan Yue
  • Patent number: 9421193
    Abstract: Provided are a compound represented by Formula I, a pharmaceutically acceptable salt thereof, or a solvate thereof; and a pharmaceutical composition for cancer treatment and a pharmaceutical composition for a radiation sensitizer for cancer treatment, each pharmaceutical composition including the compound of Formula I, the pharmaceutically acceptable salt thereof, or the solvate thereof: wherein, in Formula I, —R1 is a C1-C3 alkoxy, ?O, or —OH, and —R2 is a 5- or 6-membered heteroaryl including 1 to 2 hetero atoms selected from nitrogen and oxygen, wherein a carbon of the 5- or 6-membered heteroaryl is optionally substituted with a C1-C3 alkyl a C1-C3 alkoxy, or hydroxy.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: August 23, 2016
    Assignee: Korea Institute of Radiological & Medical Sciences
    Inventors: Sung Hee Hong, In Seok Hong, Kee Ho Lee
  • Publication number: 20160187501
    Abstract: A thin-layer chromatography type radiation detector includes a plurality of light-emitting members configured to generate visible light due to radiation, each of the light-emitting members including a scintillator having a surface filled with a reflector for reflecting the visible light, and are arranged in parallel to one another in a width direction, light sensors respectively coupled to one end portions of the plurality of light-emitting members and configured to measure a current generated due to the visible light generated by the plurality of light-emitting members, and an output port configured to sequentially output values of the current measured by the light sensors as digital signals.
    Type: Application
    Filed: October 23, 2015
    Publication date: June 30, 2016
    Applicant: Korea Institute of Radiological & Medical Sciences
    Inventors: Jong Guk Kim, Sang June Jeon, Jung Young Kim, Kyeong Min Kim
  • Publication number: 20160120851
    Abstract: Provided are a compound represented by Formula I, a pharmaceutically acceptable salt thereof, or a solvate thereof; and a pharmaceutical composition for cancer treatment and a pharmaceutical composition for a radiation sensitizer for cancer treatment, each pharmaceutical composition including the compound of Formula I, the pharmaceutically acceptable salt thereof, or the solvate thereof: wherein, in Formula I, —R1 is a C1-C3 alkoxy, ?O, or —OH, and —R2 is a 5- or 6-membered heteroaryl including 1 to 2 hetero atoms selected from nitrogen and oxygen, wherein a carbon of the 5- or 6-membered heteroaryl is optionally substituted with a C1-C3 alkyl a C1-C3 alkoxy, or hydroxy.
    Type: Application
    Filed: January 11, 2016
    Publication date: May 5, 2016
    Applicant: Korea Institute of Radiological & Medical Sciences
    Inventors: Sung Hee HONG, In Seok HONG, Kee Ho LEE