Patents Assigned to KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCE
  • Patent number: 9266875
    Abstract: Provided are a compound represented by Formula I, a pharmaceutically acceptable salt thereof, or a solvate thereof; and a pharmaceutical composition for cancer treatment and a pharmaceutical composition for a radiation sensitizer for cancer treatment, each pharmaceutical composition including the compound of Formula I, the pharmaceutically acceptable salt thereof, or the solvate thereof: wherein, in Formula I, —R1 is a C1-C3 alkoxy, ?O, or —OH, and —R2 is a 5- or 6-membered heteroaryl including 1 to 2 hetero atoms selected from nitrogen and oxygen, wherein a carbon of the 5- or 6-memberedheteroaryl is optionally substituted with a C1-C3 alkyl a C1-C3 alkoxy, or hydroxy.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: February 23, 2016
    Assignee: Korea Institute of Radiological & Medical Sciences
    Inventors: Sung Hee Hong, In Seok Hong, Kee Ho Lee
  • Patent number: 9254305
    Abstract: The present invention relates to a use of Substance-P for the manufacture of a medicament for mobilization or proliferation of Mesenchymal stem cells (MSCs) from the bone marrow, or facilitating said mobilization or proliferation, and use of Substance-P for the manufacture of a medicament for wound-healing or facilitating wound-healing.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: February 9, 2016
    Assignees: Korea Institute of Radiological & Medical Sciences, Chung-Ang University Industry-Academy Cooperation Foundation
    Inventors: Young Sook Son, Hyun Sook Hong, Jae Chan Kim
  • Publication number: 20160018539
    Abstract: Provided is an apparatus and method for calculating a correction factor, the apparatus including: a counter configured to acquire first data indicating a counted value of a first radiation source according to an activity and an energy window width, and to acquire second data indicating a coincidence value of a second radiation source according to an activity and an energy window width; and a calculator configured to calculate a correction factor for correcting a difference of the coincidence value of the second radiation source having occurred in response to a single gamma photon emission of the first radiation source, based on the first data and the second data.
    Type: Application
    Filed: September 18, 2014
    Publication date: January 21, 2016
    Applicant: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Jin Su KIM, Young Sub LEE, Hee-Joung KIM, Kyeong Min KIM, Sang-Moo LIM
  • Publication number: 20160016943
    Abstract: Provided are a compound represented by Formula I, a pharmaceutically acceptable salt thereof, or a solvate thereof; and a pharmaceutical composition for cancer treatment and a pharmaceutical composition for a radiation sensitizer for cancer treatment, each pharmaceutical composition including the compound of Formula I, the pharmaceutically acceptable salt thereof, or the solvate thereof: wherein, in Formula I, —R1 is a C1-C3 alkoxy, ?O, or —OH, and —R2 is a 5- or 6-membered heteroaryl including 1 to 2 hetero atoms selected from nitrogen and oxygen, wherein a carbon of the 5- or 6-memberedheteroaryl is optionally substituted with a C1-C3 alkyl a C1-C3 alkoxy, or hydroxy.
    Type: Application
    Filed: July 18, 2014
    Publication date: January 21, 2016
    Applicant: Korea Institute of Radiological & Medical Sciences
    Inventors: Sung Hee Hong, In Seok Hong, Eun Jong Han, Kee Ho Lee
  • Publication number: 20160003952
    Abstract: Provided is a polyhedral-shaped radiation counter which measures a radiation level of a radioactive material, in which sensor modules configured to measure the radiation level are disposed at vertexes of a polyhedral shape, respectively, and the sensor modules are connected to each other by rod-shaped frame members disposed in edge positions of the polyhedral shape and face parts of the polyhedral shape form an open space.
    Type: Application
    Filed: June 2, 2015
    Publication date: January 7, 2016
    Applicant: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Jong Guk Kim, Sang June Jeon, Kyo Chul Lee, Eun Ju Kim, Ji Ae Park, Jung Young Kim, Kyeong Min Kim, Sang Moo Lim
  • Patent number: 9175288
    Abstract: Provided are a method of enhancing radiation sensitivity by using miR-499b-5p and a method of treating a radiation resistant cancer including administering miR-499b-5p.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: November 3, 2015
    Assignee: Korea Institute of Radiological & Medical Sciences
    Inventors: Hee Chung Kwon, Eun Sook Kim, Jie Young Song
  • Patent number: 9149505
    Abstract: The present invention provides a pharmaceutical composition for suppressing angiogenesis, containing heat shock protein 27 (HSP27) or a nucleic acid encoding HSP27. In addition, the present invention provides a pharmaceutical composition for treating cancer, containing HSP27 or a nucleic acid encoding HSP27. Additionally, the present invention provides a method of suppressing the in vitro growth of endothelial cells using HSP27. Further, the present invention provides a method of screening an active material for suppressing angiogenesis or an active material for treating cancer, comprising the following steps: processing endothelial cell lines into samples, respectively; measuring the content of HSP27 in an endothelial cell line; and selecting the sample in which the content of HSP27 in an endothelial cell line is increased compared with a control group.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: October 6, 2015
    Assignee: Korea Institute of Radiological & Medical Sciences
    Inventors: Yoon Jin Lee, Yun-Sil Lee, Hae-June Lee, Seo-Hyun Choi, Kyeng-Jung Kim
  • Publication number: 20150185338
    Abstract: An apparatus and method for determining an optimal energy window for optimal positron emission tomography (PET) is disclosed. An optimal energy window determining apparatus may include a data corrector configured to correct data measured from an image quality phantom, an image quality measurer configured to measure an image quality for the corrected data, and an optimal energy window determiner configured to determine the optimal energy window based on the measured image quality. The data corrector may correct the measured data based on a difference between sensitivities measured using different radiopharmaceuticals in at least one energy window.
    Type: Application
    Filed: March 19, 2014
    Publication date: July 2, 2015
    Applicant: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Jin Su KIM, A Ram YU, Hee-Joung KIM, Sang-Moo LIM, Kyeong Min KIM, Gwang Il AN
  • Publication number: 20150186424
    Abstract: Provided are apparatuses and methods of resampling event data for quantitative improvement of a PET image, which acquire a quantitatively-improved new PET image by analyzing a storage format of list data prior to conversion into the PET image and nonparametrically resampling event data from the list data based on the analysis results to improve noise and statistical characteristics thereof. The quantitatively improved new PET image may be acquired by analyzing a storage format of list data constituting the PET image and nonparametrically resampling event data to improve noise and statistical characteristics thereof.
    Type: Application
    Filed: December 22, 2014
    Publication date: July 2, 2015
    Applicant: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Sang Keun Woo, Kyeong Min Kim, Tae Won Nam, Ji Min Kim, Sang Moo Lim
  • Patent number: 9069090
    Abstract: An apparatus and method for determining an optimal energy window for optimal positron emission tomography (PET) is disclosed. An optimal energy window determining apparatus may include a data corrector configured to correct data measured from an image quality phantom, an image quality measurer configured to measure an image quality for the corrected data, and an optimal energy window determiner configured to determine the optimal energy window based on the measured image quality. The data corrector may correct the measured data based on a difference between sensitivities measured using different radiopharmaceuticals in at least one energy window.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: June 30, 2015
    Assignee: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Jin Su Kim, A Ram Yu, Hee-Joung Kim, Sang-Moo Lim, Kyeong Min Kim, Gwang Il An
  • Publication number: 20150170777
    Abstract: A radioactive isotope liquid targeting apparatus having a functional thermosiphon internal flow channel according to the present invention includes a cavity member having a cavity for accommodating a concentrate for a nuclear reaction. The cavity member includes: a front thin film having a front opening and a rear opening; a front cooling member which is coupled to the cavity member; a thermosiphon induction member which is connected to the rear opening and which has a thermosiphon flow channel connected to the cavity so as to enable the concentrate accommodated in the cavity to flow by means of a thermosiphon phenomenon; and a rear cooling member which is coupled to the rear surface of the thermosiphon induction member and which has a cooling water supply space.
    Type: Application
    Filed: August 28, 2012
    Publication date: June 18, 2015
    Applicant: Korea Institute of Radiological & Medical Sciences
    Inventors: Bong Hwan Hong, Won Taek Hwang, Tae Keun Yang, In Su Jung, Joonsun Kang, Yeun Soo Park
  • Publication number: 20150141486
    Abstract: Provided are a method of enhancing radiation sensitivity by using miR-499b-5p and a method of treating a radiation resistant cancer including administering miR-499b-5p.
    Type: Application
    Filed: April 29, 2014
    Publication date: May 21, 2015
    Applicant: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Hee Chung KWON, Eun Sook KIM, Jie Young SONG
  • Patent number: 8917816
    Abstract: A multi-leaf collimator device for radiotherapy, including: a frame that has a box shape and has through-holes formed in top and bottom surfaces thereof; a plurality of collimators that are received in the frame, wherein each of the collimators includes a rack gear formed on the top surface of the collimator, the collimators are symmetrically arranged in a left-right direction about a central portion of the frame, and are slidably provided on the frame; and a motion driving unit that includes a pinion gear that is formed to be detachable from the rack gear formed on the top surface of the collimator, and is provided on the frame to move the pinion gear in a front-back direction of the frame and an up-down direction of the frame.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: December 23, 2014
    Assignee: Korea Institute of Radiological & Medical Sciences
    Inventors: Young Hoon Ji, Hai Jo Jung, Kum Bae Kim, Mun Sik Choi, Seung Woo Park
  • Publication number: 20140357517
    Abstract: The present disclosure provides a composition for radiation exposure diagnosis including an agent for measuring an expression level of an insulin-like growth factor-binding protein-5 (IGFBP-5) gene at an mRNA or the protein and a kit for radiation exposure diagnosis. Methods of diagnosing radiation exposure as well as methods for screening an agent for enhancing radiation sensitivity or for radiation protection are disclosed. Also provided are compositions for enhancing radiation sensitivity and/or radiation protection.
    Type: Application
    Filed: May 9, 2012
    Publication date: December 4, 2014
    Applicant: Korea Institute of Radiological & Medical Sciences
    Inventors: Kwang Seok Kim, Sang Woo Bae, Kyu Jin Choi, Eun Sook Kim
  • Publication number: 20140336439
    Abstract: A portable phantom device according to the present invention is a phantom device which is detachably installed in a bird cage that is coupled to an irradiator, and includes a body provided with an accommodation space having a cylindrical shape and a top of which is open so as to accommodate water, a horizontality adjustment maintaining portion which is detachably coupled to a side wall of the body; and a sensor holding portion which is installed on the side wall of the body so as not to interfere with the horizontality adjustment maintaining portion, so that a sensor for measuring the amount of radiation that is incident on the accommodation space may be inserted from the outside of the body and accommodated in the body (Representative drawing: FIG.
    Type: Application
    Filed: August 28, 2012
    Publication date: November 13, 2014
    Applicant: KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
    Inventors: Young Hoon Ji, Hyun Do Huh, Sang Hyoun Choi, Hai Jo Jung, Kum Bae Kim
  • Patent number: 8815243
    Abstract: The present invention relates to a pharmaceutical composition for promoting angiogenesis, containing an antibody that specifically binds to heat shock protein (HSP) 27. In addition, the present invention relates to a pharmaceutical composition containing an antibody that specifically binds to HSP 27, for treating an angiogenesis-dependent ailment selected from a group consisting of a wound, chronic ulcer, ischemic stroke, myocardial infarction, angina pectoris, and cerebrovascular dementia. In addition, the present invention relates to a method for promoting the in vitro growth of endothelial cells using an antibody that specifically binds to HSP27.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: August 26, 2014
    Assignee: Korea Institute of Radiological & Medical Sciences
    Inventors: Yoon Jin Lee, Yun-Sil Lee, Hae-June Lee, Seo-Hyun Choi, Kyeng-Jung Kim
  • Patent number: 8809297
    Abstract: Disclosed is an anticancer composition, comprising an inhibitor against WIG1 and/or YPEL5 or against a protein encoded by the gene. A composition for screening an anticancer agent comprising a nucleic acid having a sequence complementary to an mRNA of WIG1 and/or YPEL5, or an antibody to a protein encoded by the gene is also provided. Also, a method is provided for screening an anticancer agent, which comprises: (A) quantitatively analyzing expression of WIG1 and/or YPEL5 at an mRNA or protein level in a tumor cell which is not treated with a candidate for an anticancer agent; (B) quantitatively analyzing expression of the gene at an mRNA or protein level in a tumor cell after treatment of the candidate for an anticancer agent; and (C) selecting the candidate if the expression level of the gene is increased in step (B), compared to step (A).
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: August 19, 2014
    Assignee: Korea Institute of Radiological & Medical Sciences
    Inventors: Jae-Seon Lee, Bong Cho Kim, Je-Jung Lee, Su Min Park
  • Patent number: 8697415
    Abstract: The present disclosure relates to a deacetylation hydrolase of a hyaluronic acid a hyaluronic acid deacetylated by same and a derivative thereof. The deacetylated hyaluronic acid and the derivative thereof have the following characteristic: a delayed initial decomposition rate on a living body; minimized decrease of molecular weight and viscosity; accelerated gelation due to a lower gelation temperature than the gelation temperature for a non-deacetylated hyaluronic acid; and an hMSC survival rate that is hardly affected by increased concentration of the deacetylated hyaluronic acid and the derivative thereof in a culture medium. As a result, the deacetylated hyaluronic acid and the derivative thereof can be useful as a bioingredient such a delivery system for a cell, gene, drug, and the like, or a support for tissue engineering, etc.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: April 15, 2014
    Assignee: Korea Institute of Radiological & Medical Sciences
    Inventors: Chun-Ho Kim, Jong-Il Kim
  • Patent number: 8691973
    Abstract: Provided are a method of producing a porous chitosan scaffold, the method including: providing an aqueous acidic solution having chitosan and a solvent which does not dissolve the chitosan; and freeze-drying the aqueous acidic solution, wherein the solvent is selected from the group consisting of a C3-C8 aliphatic alcohol having one hydroxy group, ethylene glycol monoethylether, ethylene glycol monobutylether, dioxane, tetrahydrofuran, dimethylcarbonate, acetone and acetonitrile, and a chitosan scaffold produced using the method.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: April 8, 2014
    Assignee: Korea Institute of Radiological & Medical Sciences
    Inventors: Chun-Ho Kim, Seung-Jae Lee, Jin-Ik Lim, Youngsook Son
  • Publication number: 20140065109
    Abstract: The present invention relates to a use of Substance-P for the manufacture of a medicament for mobilization or proliferation of Mesenchymal stem cells (MSCs) from the bone marrow, or facilitating said mobilization or proliferation, and use of Substance-P for the manufacture of a medicament for wound-healing or facilitating wound-healing.
    Type: Application
    Filed: September 5, 2013
    Publication date: March 6, 2014
    Applicants: Chung-Ang University Industry-Academy Cooperation Foundation, Korea Institute of Radiological & Medical Sciences
    Inventors: Young Sook Son, Hyun Sook Hong, Jae Chan Kim