Patents Assigned to Korea Institute of Science and Technology
  • Publication number: 20200132672
    Abstract: A method, a composition and a kit for screening an ALK or ROS-1 kinase inhibitor are disclosed in the present specification. In an aspect, by the method, composition and kit for screening an ALK or ROS-1 kinase inhibitor according to the present disclosure, it is possible to conduct simultaneous quantitative and qualitative analysis and faster screening of a larger number of candidate substances as compared with conventional molecular biological experimental methods and to grasp the overall level of change in a plurality of different metabolites in a cell line by candidate substances of ALK or ROS-1 kinase inhibitor and thus the screening efficiency for drugs which exert an ALK or ROS-1 kinase inhibitory effect is excellent. Consequently, the present disclosure has an advantage of being able to be used in various ways in the development of new drugs which exert an ALK or ROS-1 kinase inhibitory effect.
    Type: Application
    Filed: May 10, 2019
    Publication date: April 30, 2020
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Byung Hwa JUNG, Hyun Beom LEE, Naeun YOON
  • Publication number: 20200131199
    Abstract: Provided is a pharmaceutical composition for preventing and treating tumors, the pharmaceutical composition including an imidazooxazole derivative compound, a solvate, a stereoisomer, or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition is administered to an entity which has developed a tumor or is in danger of developing a tumor, and thus tumors can be prevented or treated.
    Type: Application
    Filed: December 31, 2019
    Publication date: April 30, 2020
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Gamal El-din MAHMOUD, Hong Seok CHOI, Kyung Ho YOO, Dong Keun HAN, Chang Hyun OH, Abdel-Maksoud MOHAMMED, I. El-Gamal MOHAMMED, Usama M. AMMAR
  • Patent number: 10635163
    Abstract: Provided is a system and method for interaction analysis of virtual space. The system for interaction analysis of virtual space includes an interaction data collection unit which collects interaction data of at least one user participating in virtual space in which virtual content is implemented, an interaction data storage unit which synchronizes and stores the collected interaction data, and an interaction data analysis unit which provides an analysis mode of the interaction data.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: April 28, 2020
    Assignees: Korea Institute of Science and Technology, Center of Human-Centered Interaction for Coexistence
    Inventors: Jung Min Park, Joong Jae Lee, Jeong Hwa Lee
  • Publication number: 20200124555
    Abstract: The present disclosure relates to an ammonia gas detection sensor including a substrate, a graphene sheet disposed on the substrate, and metal nanoparticles disposed on the graphene sheet, and an ammonia gas detection device comprising the gas detection sensor.
    Type: Application
    Filed: January 23, 2019
    Publication date: April 23, 2020
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Kang Bong LEE, Yun Sik NAM, Yeon Hee LEE, Oleksandr TSYMBALENKO
  • Publication number: 20200121959
    Abstract: Disclosed herein is a non-invasive treatment system using intermedium, and an exemplary treatment system is configured to output high-intensity focused ultrasound to remove bone tissue, inject an acoustically-transparent medium into a part where the bone tissue is removed to generate an intermedium, and output therapeutic ultrasound that passes through the intermedium. Accordingly, the bone tissue is removed in a non-invasive way using high-intensity focused ultrasound, and the intermedium is generated at the bone tissue removed site, to increase the penetration of therapeutic ultrasound or generate ultrasound itself, thereby improving an ultrasound treatment effect while minimizing the side effect (for example, infection of dura mater) of invasive surgery methods.
    Type: Application
    Filed: February 14, 2019
    Publication date: April 23, 2020
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Byung Chul LEE, Hyung Min KIM, Ki Joo PAHK
  • Publication number: 20200123271
    Abstract: Provided is a composition for enhancing the sensitivity of prostate cancer to an anti-cancer drug. The composition may overcome resistance of cancer cells to a target anti-cancer drug and improve not only sensitivity of the cancer cells to the anti-cancer drug but also therapeutic effects on prostate cancer via combined administration with a conventional target anti-cancer drug.
    Type: Application
    Filed: October 7, 2019
    Publication date: April 23, 2020
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Kwan Hyi LEE, Hyojin LEE
  • Patent number: 10629696
    Abstract: A method for forming a hexagonal boron nitride (h-BN) thin film is provided. According to the method, an alumina thin film including amorphous alumina or gamma-alumina is prepared. An h-BN thin film is synthesized at equal to or less than 750° C. on the alumina thin film. A mono-layer thickness of the h-BN film is equal to or less than 0.40 nm.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: April 21, 2020
    Assignee: Korea Institute of Science and Technology
    Inventors: Jaehyun Park, Yumin Sim, Jaikyeong Kim
  • Patent number: 10630045
    Abstract: The present disclosure discloses a double trigger type single pulse laser apparatus configured to suppress additional pulses to increase single pulse energy and improve stability of output as compared to a conventional single trigger type single pulse laser apparatus. According to the present invention, there is provided a single pulse laser apparatus including a resonator which has a first mirror, a second mirror, a gain medium, an electro-optic modulator and an acousto-optic modulator configured to respectively perform Q-switching and mode-locking, the single pulse laser apparatus including a first photodiode configured to measure a laser beam oscillated by the resonator.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: April 21, 2020
    Assignee: Korea Institute of Science and Technology
    Inventors: Young Min Jhon, Hui Dong Yang, Byunghyuck Moon, Minah Seo, Chulki Kim, Taikjin Lee, Yongsang Ryu, Hyunseok Song, Jaehun Kim
  • Publication number: 20200119355
    Abstract: The present disclosure relates to an aqueous binder for a lithium-sulfur secondary battery, a method for preparing the same, and a lithium-sulfur secondary battery including the same. More particularly, it is possible to obtain an aqueous binder (PEI/PVP/CA, PPC) by adding citric acid to a mixed solution of polyethylene imine with polyvinyl pyrrolidone, and to apply the aqueous binder to a lithium-sulfur secondary battery having high discharge capacity, Coulombic efficiency and stable life characteristics through the improvement of adhesion capability even at a sulfur cathode with high energy density, inhibition of a shuttle reaction and inhibition of metal current collector corrosion.
    Type: Application
    Filed: February 14, 2019
    Publication date: April 16, 2020
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Won Il CHO, Van Dung Do, Mun Sek Kim, In Wook Nah, Min Seop Kim
  • Patent number: 10622490
    Abstract: Provided is a reconfigurable logic device using an electrochemical potential. The device includes first and second semiconductor channels, where an effective magnetic field direction of a channel is controlled by a current direction and which are spaced apart from each other, a first ferromagnetic gate contacting the first semiconductor channel and a second ferromagnetic gate contacting the second semiconductor channel, where a magnetization direction is controlled by a gate voltage, and a control unit configured to calculate a difference value corresponding to a difference between a first determination value and a second determination value, and compare the difference value with a reference value to determine an output value.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: April 14, 2020
    Assignee: Korea Institute of Science and Technology
    Inventors: Hyun Cheol Koo, Hyung Jun Kim, Cha Un Jang, Joon Yeon Chang, Suk Hee Han, Joo Hyeon Lee
  • Patent number: 10620343
    Abstract: A metamaterial for an electromagnetic wave filter includes a substrate; and a film disposed on the substrate and having a set of slots arranged to form a rotationally symmetric pattern, which is patterned in an intaglio shape, or a set of structures arranged to form a rotationally symmetric pattern, which is patterned in an embossed shape, to control a transmission rate according to polarization of an electromagnetic wave incident on the film. The set of slots or the set of structures have an array angle that is determined such that the transmission rate and a reflectivity thereof have constant values according to the polarization of the electromagnetic wave incident on the film, and have a chloroplast molecular structure pattern in which the set of slots or the set of structures are arranged in pentagonal and hexagonal shapes.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: April 14, 2020
    Assignee: Korea Institute of Science and Technology
    Inventors: Minah Seo, Sanghun Lee, Deokha Woo, Jaehun Kim, Taikjin Lee, Jaebin Choi, Chulki Kim, Joo-Hiuk Son, Young Min Jhon
  • Patent number: 10610602
    Abstract: Disclosed is a drug conjugate as a prodrug that is degraded by cathepsin B specifically expressed in tumor tissues to release doxorubicin. The drug conjugate can form self-assembled nanoparticles. In addition, the drug conjugate specifically responds to and is activated in tumor cells. Therefore, the use of the drug conjugate eliminates the incidence of side effects (for example, cell damage and apoptosis) during the course of cancer prevention or treatment.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: April 7, 2020
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Kwangmeyung Kim, Ick Chan Kwon, Juho Park
  • Patent number: 10615227
    Abstract: A resistance-switchable material containing: an insulating support; and a complementary resistance switchable filler dispersed in the insulating support, wherein the complementary resistance switchable filler has a spherical core-shell structure containing: a spherical conductive core containing a conductive material; and an insulating shell formed on the surface of the core and containing an insulating material. The resistance-switchable material is capable of exhibiting complementary resistive switching characteristics with improved reliability and stability as symmetrical uniform filament current paths are formed in respective resistive layers adjacent to two electrodes with the conductive core of the complementary resistance-switchable filler at the center due to the electric field control effect by the spherical complementary resistance-switchable filler.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: April 7, 2020
    Assignee: Korea Institute of Science and Technology
    Inventors: Sang-Soo Lee, Jong Hyuk Park, Jeong Gon Son, Minsung Kim, Young Jin Kim, Heesuk Kim
  • Patent number: 10616566
    Abstract: A three-dimensional (3D) image display system includes a profile information provider configured to provide profile information defining a hardware characteristic of a 3D image display device, and a 3D image reproducer configured to collect information of the hardware characteristic of the 3D image display device from the profile information provider and render image content according to the profile information.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: April 7, 2020
    Assignee: Korea Institute of Science and Technology
    Inventors: Dae Il Seo, Byoung Hyun Yoo, Hee Dong Ko
  • Publication number: 20200101194
    Abstract: Provided are a hydrogel composition with high viscoelasticity and a bioink composition including the hydrogel composition. The hydrogel composition according to an embodiment is composed of natural biocompatible substances and thus is not toxic, but has high viscosity, resulting in high mechanical stability or long persistence. Thus, the hydrogel composition may be usefully utilized as a bioink composition for bioprinting, a support in tissue engineering, or a soft tissue filler.
    Type: Application
    Filed: October 19, 2018
    Publication date: April 2, 2020
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sang Heon KIM, Joo Young LEE, Seung Ja OH
  • Publication number: 20200102549
    Abstract: Disclosed herein are a yeast strain capable of utilizing xylose as a carbon source and a method for producing lipids using the same. The yeast strain is obtained by adaptively evolving a wild-type yeast strain which cannot utilize xylose as a carbon source so that it can produce high density lipids and then transforming the adaptively evolved strain to obtain the ability to metabolize xylose. Since the strain does not have the xylose metabolic pathway based on oxidoreductase, it can produce biodiesel and biomaterials based on lipid and lignocellulosic biomass at a high yield without a problem of cofactor imbalance and can greatly improve the economic feasibility and sustainability of the production processes of biodiesel and biomaterials.
    Type: Application
    Filed: November 29, 2018
    Publication date: April 2, 2020
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sun Mi Lee, Sangdo Yook, Youngsoon Um, Gyeongtaek Gong, Jiwon Kim
  • Publication number: 20200107406
    Abstract: A transparent planar heating film is provided. The transparent planar heating film includes a transparent electrode, metal nanoparticles applied to the upper surface of the transparent electrode, and a transparent adhesive film attached to the upper surface of the metal nanoparticles. The heating temperature of the transparent planar heating film is a maximum of at least two times higher at the same power consumption than that of conventional planar heating films. In the transparent planar heating film, the metal nanoparticle film is bonded to a desired location on the surface of the transparent electrode, enabling selective heating. Also provided is a method for manufacturing the transparent planar heating film.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 2, 2020
    Applicants: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, IM Co., Ltd.
    Inventors: Hyungduk KO, Ji Hun Park, Ki-sun Park, Min Ji Park, Kwan Il Lee
  • Patent number: 10603404
    Abstract: The present invention relates to a phosphazene-based polymer comprising an amino acid ester, polyethylene glycol, a group comprising a functional group, and a catechol group linked directly or by a linker to a part of or an entire functional group, in a predetermined ratio. In addition, the present invention relates to a preparation method thereof, and a tissue-adhesive composition comprising the same as an active ingredient.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: March 31, 2020
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Soo Chang Song, Young-Min Kim, ChangHo Kim
  • Publication number: 20200093404
    Abstract: A motion capture system includes a motion sensor having a flexible body and a fiber bragg gratings (FBG) sensor inserted into the body, a fixture configured to fix the motion sensor to a human body of a user, a light source configured to irradiate light to the motion sensor, and a measurer configured to analyze a reflected light output from the motion sensor, wherein the FBG sensor includes an optical fiber extending along a longitudinal direction of the body and a sensing unit formed in a partial region of the optical fiber and having a plurality of gratings, and wherein a change of a wavelength spectrum of the reflected light, caused by the change of an interval of the gratings due to a motion of the user, is detected to measure a motion state of the user.
    Type: Application
    Filed: November 27, 2019
    Publication date: March 26, 2020
    Applicants: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY, CENTER OF HUMAN-CENTERED INTERACTION FOR COEXISTENCE
    Inventors: Jinseok KIM, Hyun Joon SHIN, Bum-Jae YOU, Sungwook YANG, Minsu JANG, Jun Sik KIM
  • Patent number: 10601052
    Abstract: Disclosed are a reversible fuel cell oxygen electrode in which IrO2 is electrodeposited and formed on a porous carbon material and platinum is applied thereon to form a porous platinum layer, a reversible fuel cell including the same, and a method for preparing the same. According to the corresponding reversible fuel cell oxygen electrode, as the loading amounts of IrO2 and platinum used in the reversible fuel cell oxygen electrode can be lowered, it is possible to exhibit excellent reversible fuel cell performances (excellent fuel cell performance and water electrolysis performance) by improving the mass transport of water and oxygen while being capable of reducing the loading amounts of IrO2 and platinum. Further, it is possible to exhibit a good activity of a catalyst when the present disclosure is applied to a reversible fuel cell oxygen electrode and to reduce corrosion of carbon.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: March 24, 2020
    Assignee: Korea Institute of Science and Technology
    Inventors: Jong Hyun Jang, Byungseok Lee, Hee-Young Park, Hyoung-Juhn Kim, Dirk Henkensmeier, Sung Jong Yoo, Jin Young Kim, So Young Lee, Jaeyune Ryu, Sung Pil Yoon, Jonghee Han, Suk Woo Nam