Abstract: The present invention relates to a heteroaryl derivative, a stereoisomer thereof, a hydrate thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The heteroaryl derivative of the present invention exhibits high inhibitory activity against overexpressed HER2, and thus, a pharmaceutical composition containing the same as an active ingredient can be usefully used for preventing or treating HER-2 positive cancer.

Abstract: A method of regenerating sodium borohydride includes: pretreating reactants including sodium tetraborate hydrate (Na2B4O7·xH2O, 0<x?10), a metal salt, and a reducing agent; and reacting the pretreated reactants by a ball-milling method, wherein the metal salt includes NaHCO2, KHCO2, LiHCO2, NaHCO3, Na2CO3, NaOH, KHCO3, K2CO3, LiHCO3, Li2CO3, Na2O2, NaH, or a combination thereof.

Abstract: Provided is a method for preventing, ameliorating, or treating inflammatory diseases by administering a composition containing extracellular vesicles (EVs) derived from Roseburia spp. strains and/or Bifidobacterium spp. strains, wherein the EVs exhibits effectiveness in improving inflammatory bowel disease (IBD), and additionally, all EVs derived from congeneric strains corresponding to Roseburia spp. strains or Bifidobacterium spp. strains. have been confirmed to exhibit strong anti-inflammatory effect, and the strains and EVs derived therefrom can be provided as a composition for preventing, ameliorating, or treating a variety of inflammatory diseases.

Abstract: The present invention relates to a porous particle composite for PCR, wherein the porous particle composite distributes photothermal nano-elements that generate heat by absorbing light in porous particles in which nucleic acid amplification occurs through temperature control so as not to adjust the temperature of the entire sample by using a hot plate or the like but to adjust the temperature inside the particles by irradiating light to the porous particles to allow nucleic acid amplification inside thereof, thereby reducing energy consumption and shortening diagnostic time.

Abstract: The tissue removal device using focused ultrasound includes a focused ultrasound output unit, a mode setting unit to set an output mode of the focused ultrasound, and a control unit to control output characteristics of the focused ultrasound according to the set mode, wherein the output mode is selected from a first mode for removing a tissue in a local area using a vapor bubble formed by the focused ultrasound, a second mode for removing a tissue in a narrower area than the first mode by controlling the output characteristics of the focused ultrasound immediately after the vapor bubble is formed by the focused ultrasound, and a third mode for obtaining a skin tightening effect by generating heating in a subcutaneous fat layer using focused ultrasound of lower intensity and a longer pulse length than the first mode and the second mode.

Abstract: Disclosed are a method of transmitting image data having a hybrid resolution and a method of generating a hybrid-resolution image. A main region of an original image is transmitted as a high-resolution image and the remaining regions are transmitted as a low-resolution background image. Accordingly, an amount of data to be transmitted is able to be reduced.

Abstract: Disclosed is a disinfection robot capable of autonomous driving and recognition of a disinfection target. The disinfection robot includes: a recognition unit configured to generate recognition information by recognizing a surrounding environment of the disinfection robot; a movement unit configured to move a position of the disinfection robot; a light source unit configured to emit a light of a predetermined wavelength area for disinfection; an injection unit configured to inject a fluid for disinfection; and a control unit configured to move the disinfection robot through the movement unit based on the recognition information, wherein the control unit is configured to identify a disinfection target from the recognition information and control at least one of the light source unit and the injection unit to perform disinfection to at least one of the surrounding environment of the disinfection robot and the disinfection target.

Abstract: A perspiration mapping patch according to the present disclosure is attached to skin of a user to absorb sweat, and includes: a sweat absorbing layer in which a plurality of opening units is arranged; a first support layer which is stacked on a first surface of the sweat absorbing layer and includes an opening opened to correspond to each of the plurality of opening units; and a second support layer stacked on a second surface facing an opposite side of the first surface of the sweat absorbing layer.

Abstract: Provided is a method of manufacturing a stretchable substrate having improved thickness deformation uniformity through control of a spatial crosslinking degree according to various embodiments of the present disclosure to implement the above object. The method includes forming a substrate part of an elastic material, forming an auxetic including a plurality of unit structures on the substrate part, and forming a fixing part on the substrate part on which the auxetic is formed, wherein the fixing part has a different vertical crosslinking density at each position.

Abstract: A high resolution fluorescence imaging device includes a light guide plate having a fluid channel which allows a solution containing a fluorescent sample to pass; a light source disposed on a side of the light guide plate to irradiate light inward the light guide plate; an image sensor disposed under the light guide plate; and a thin film interposed between the light guide plate and the image sensor, wherein the thin film has a first surface having a plurality of pillars and a second surface, the pillars separate the light guide plate and the image sensor apart from each other, and the second surface is bonded to the light guide plate. According to an embodiment, since the light guide plate acts in place of a filter element, it is possible to manufacture in ultrasmall size and achieve multiple fluorescence imaging without replacing a filter.

Abstract: The present disclosure relates to a fiber network operation apparatus for providing a method of determining a physical path in consideration of network performance and resource efficiency in a space division multiplexing-based fiber network and allocating optical resources according thereto, and an operation method thereof.

Abstract: A real-time acoustic simulation method based on artificial intelligence according to an embodiment of the present disclosure includes acquiring medical image data of a target area to be treated; determining ultrasound parameters related to the output of an ultrasonic transducer based on the medical image data; inputting the ultrasound parameters to a numerical model to generate a numerical model based acoustic simulation image for a specific position of the ultrasonic transducer; training an artificial intelligence model using the medical image data and the numerical model based acoustic simulation image; generating an artificial intelligence model based acoustic simulation image for an arbitrary position of the ultrasonic transducer using the trained artificial intelligence model; and outputting a real-time acoustic simulation image with a position change of the ultrasonic transducer.

Abstract: The present disclosure relates to an apparatus for detecting microplastics based on optical technology, more particularly the present disclosure relates to an apparatus for detecting microplastics, which is capable of detecting and analyzing microplastics of various sizes that exist in a fluid in real time regardless of transparency using a microfluidic chip based on optical technology.

Abstract: Provided are astersaponin I, which is a novel triterpene saponin derivative isolated and identified from a Aster koraiensis Nakai (Korean starwort) extract, and a use thereof for preventing or treating a neurodegenerative disorder.

Abstract: Provided is an apparatus for cell particle sorting based on microfluidic-chip flow, by using a design in which Dean flow focusing occurring in a spiral channel and hydrodynamic filtration are coupled. The apparatus comprises a first substrate including a spiral channel having an inner surface and an outer surface based on a radius of curvature, a sample solution inlet, a medium inlet, and a spiral inner-outlet and a spiral outer-outlet both for discharging the particles, and a second substrate including a main channel in which the sample solution discharged from the first substrate and passing through an inter-substrate way flows and a cut-off width WC is set, a side channel allowing a medium introduced into the medium inlet to flow to focus the sample solution on a sidewall of the main channel, a plurality of branch channels connected to the sidewall of main channel and configured to receive the particles from the main channel, a main channel outlet, and at least one branch channel outlet.

Abstract: The present disclosure relates to a polybenzimidazole-based electrolyte membrane for alkaline water electrolysis, which includes a polybenzimidazole-based polymer, wherein the polybenzimidazole-based polymer is a biaxially oriented film. The polybenzimidazole-based electrolyte membrane for alkaline water electrolysis can reduce the concentration of an alkaline solution by improving the crystallinity of a polybenzimidazole-based polymer to increase the resistance against base, significantly improving the long-term stability of alkaline water electrolysis using a polybenzimidazole-based electrolyte membrane through the improved resistance against base, and by increasing the operation temperature to enhance the catalyst activity.

Abstract: A radar-absorbing fiber-reinforced structure includes a fiber composite discharging part. The fiber composite discharging part includes a first electrode part and a second electrode part, which are spaced apart from each other by a dielectric layer and receive different voltages. The fiber composite discharging part is configured to discharge plasma in response to a voltage difference thereby changing a reflected wave or transmitted wave of a radar incident on the radar-absorbing fiber-reinforced structure to reduce reflectivity of the radar. At least one of the first electrode part and the second electrode part include a conductive fiber having a tensile strength equal to or more than 0.5 GPa.

Abstract: Provided is a capacitive micromachined ultrasonic transducer (CMUT) including a substrate, a top electrode provided on the substrate to be spaced apart from the substrate, a supporter made of an insulating material and coupled between the substrate and an edge of the top electrode to support and fix the edge of the top electrode and to define a gap between the substrate and the edge of the top electrode, and a plurality of nanoposts having both ends coupled and fixed to the substrate and the top electrode in the gap, and being compressible and stretchable in a longitudinal direction to at least vertically move the top electrode when power is applied to the top electrode.

Abstract: A non-contact interface device for a vehicle and a method for controlling the same, may display an operation system menu for a driver and passengers to operate various kinds of devices of the vehicle as a hologram, enable a user to operate the displayed operation system menu in a non-contact manner by use of the user's finger or the like, and provide the user with a tactile feedback for a non-contact operation, so that the user can recognize whether to have operated the menu.

Abstract: Embodiments relate to a semiconductor device, which includes: a substrate made of a first material; an insulating layer formed on an upper surface of the substrate; a trench formed at the insulating layer to penetrate the insulating layer toward the substrate; and a seed layer disposed in the trench. The seed layer is made of a second material, the second material lattice-mismatches with respect to the first material, the seed layer includes a threading dislocation extending at least partially in a first direction non-parallel to the upper surface of the substrate and parallel to a <110> direction of a (111) plane and a threading dislocation extending at least partially in a second direction, and the extension of the threading dislocation is terminated at a sidewall of the trench.