Abstract: The present invention relates to a liquid immersion micro-channel measurement device and measurement method which are based on trapezoidal incident structure prism incident-type silicon, and according to one embodiment of the present invention, the liquid immersion micro-channel measurement device based on trapezoidal incident structure prism incident-type silicon comprises: a micro-channel structure including a support and at least one micro-channel, which is formed on the support and has a sample detection layer to which a first bioadhesive material for detecting a first sample is fixed; a quadrangular pyramid-shaped prism formed on the upper part of the micro-channel structure; a sample injection unit for injecting, into the micro-channel, a buffer solution containing the first sample; a polarized light generation unit for emitting incident light polarized through the prism on the micro-channel at an incident angle that satisfies a p-wave non-reflection condition; and a polarized light detection unit for d
Type:
Grant
Filed:
December 15, 2016
Date of Patent:
August 8, 2023
Assignee:
KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE
Abstract: The present invention relates to a polar functional group-partially introduced polymer, a preparation method therefor, and an organic electronic element adopting the same. The organic electronic element of the present invention has excellent photoelectric conversion efficiency and stability and is very advantageous in commercialization, by adopting the polar functional group-partially introduced polymer of the present invention.
Type:
Grant
Filed:
November 26, 2018
Date of Patent:
August 1, 2023
Assignee:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Chang Eun Song, Won Suk Shin, Sang Jin Moon, Jong Cheol Lee, Sang Kyu Lee, Hang Ken Lee, Vu Van Doan, Shafket Rasool
Abstract: A clearing pretreatment method of a biological sample having a size of at most 1 mm, that is, a spheroid or organoid, according to the present invention uses a phosphate-buffered saline (PBS) rather than a conventional sucrose solution as a pretreatment solution, thus solving the problem in which the spheroid or organoid floats above the surface of water due to the density difference such that the structure of the sample is damaged. Therefore, there is an effect in that the spheroid or organoid can be transparentized while maintaining the original shape thereof, thus making it possible to image deep parts.
Type:
Application
Filed:
May 28, 2021
Publication date:
July 27, 2023
Applicants:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Inventors:
Sun-Hyun PARK, Ki-Suk KIM, Jae-Meun LEE, Jae-Hyeok LEE, Seong-Hoon PARK, Ji Yeoun LEE, Jinju PARK
Abstract: The present invention relates to an ammonia decomposition catalyst that converts ammonia into hydrogen and nitrogen. The catalyst includes ruthenium (Ru) as an active catalytic component and a composite oxide solid solution (LaxCe1-xOy) including lanthanum oxide and cerium oxide as a catalyst support. The present invention also relates to an ammonia decomposition method using the catalyst and a hydrogen production method using the catalyst.
Type:
Application
Filed:
January 27, 2021
Publication date:
July 27, 2023
Applicant:
Korea Research Institute of Chemical Technology
Inventors:
Ho Jeong Chae, Young-min Kim, Thien An Le, Jeong-Rang Kim, Tae Wan Kim, Youjin Lee, Su Un Lee
Abstract: The present invention provides a target RNA detection method based on a dCas9/gRNA complex. A target RNA detection method according to the present invention can detect target RNA with the naked eye and without separate gene isolation and amplification steps, and, in particular, can rapidly and accurately detect target RNA through excellent target specificity and rapidity, and thus can exhibit excellent effects on the detection of various pathogens and/or viruses.
Type:
Application
Filed:
February 3, 2023
Publication date:
July 27, 2023
Applicants:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY, BIONANO HEALTH GUARD RESEARCH CENTER
Inventors:
Tae Joon KANG, Jeong Moon, Ju Yeon Jung, Kyu Sun Lee, Eun Kyung Lim, Hong Ki Kim, Hyun Ju Kang
Abstract: Disclosed are a natural killer (NK) cell expressing an anti-cotinine chimeric antigen receptor (CAR) specifically binding to cotinine, and a cell therapeutic agent containing the NK cell. The CAR-expressing NK cell which specifically binds cotinine, can effectively move to tumor tissue, regardless of the kind of cancer, depending on the binding substance bound to cotinine. Therefore, the natural killer cell can be usefully employed as a gene therapy exhibiting a highly efficient anticancer effect.
Type:
Grant
Filed:
July 5, 2019
Date of Patent:
July 25, 2023
Assignees:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Inventors:
In Pyo Choi, Tae-Don Kim, Su Ui Lee, Sooyun Lee, Junho Chung, Ki-Hyun Kim, Hyori Kim
Abstract: A method of designing a frequency selective surface (FSS) filter, includes: calculating a candidate solution corresponding to a structure of the FSS filter and an objective-function value corresponding to a difference between a frequency response resulting from the candidate solution and a targeted frequency response; modifying the candidate solution into a trial solution in accordance with a genetic algorithm; and calculating an objective-function value with the trial solution to determine whether to include the trial solution in candidate solutions.
Type:
Application
Filed:
May 11, 2021
Publication date:
July 20, 2023
Applicant:
KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE
Inventors:
Young Pyo HONG, In Ho LEE, In June HWANG, Dal Jae YUN
Abstract: The present invention relates to a nano-dynamic biosensor and a fabrication method therefor. A biosensor according to the present invention comprises a substrate having a hollow structure and a graphene layer formed thereon wherein a probe material is bound to the surface of the graphene layer and the resonance vibration of the hollow structure formed in the substrate is modulated as the probe material increases in weight when a target material to be detected is coupled to the probe material without being labeled, whereby the biosensor is expected to take advantage of the modulation to measure the coupling of the target material including vaccinia virus with high sensitivity on a femtogram (10?15 g) level.
Type:
Grant
Filed:
May 31, 2018
Date of Patent:
July 18, 2023
Assignee:
Korea Research Institute of Standards and Science
Inventors:
Seung Hoon Nahm, Nam Hee Lee, Kwon Sang Ryu, Un Bong Baek
Abstract: The present invention relates to a novel pyrimidine derivative, and a composition for preventing or treating neurodegenerative diseases and cancer, comprising same, the pyrimidine derivative having a LRRK2 protein inhibitory activity, and effectively passing through a blood-brain barrier (BBB) so as to be effectively used as a pharmaceutical composition for preventing or treating neurodegenerative diseases and cancer.
Type:
Application
Filed:
March 12, 2021
Publication date:
July 13, 2023
Applicants:
WHAN IN PHARMACEUTICAL CO., LTD., KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Ge Hyeong LEE, Jee Yeon SEO, Jeong Heon YU, In Hae YE, Ho Chul SHIN, Jee Hee SUH, Seong Hwan KIM, Jin Sook SONG, Seong Hyeon SIM, Chong Hak CHAE, Hee Yeon KANG, Ji Hun LEE, Keon Ha HWANG
Abstract: Provided are a recombinant antigen comprising a cell membrane permeation domain comprising a polypeptide of any one of SEQ ID NOs: 1 to 22 derived from human LRRC24 and a SARS-CoV-2 antigen or a fragment thereof, a vaccine composition comprising the recombinant antigen, a gene construct comprising a polynucleotide encoding the recombinant antigen, a recombinant vector comprising the gene construct, a method for producing the SARS-CoV-2 recombinant antigen, and a kit for preventing or treating SARS-CoV-2 infection comprising the vaccine composition and users' instruction thereof, wherein the antigen exhibited higher immunogenicity against SARS-CoV-2 the neutralizing antibody was better formed in actual animal experiments, excellent protective immunity was induced, and toxicity did not appear in the toxicity test.
Type:
Application
Filed:
May 13, 2021
Publication date:
July 13, 2023
Applicant:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Seong Jun KIM, Chonsaeng KIM, Kyun Do KIM, Dae Gyun AHN, Young Chan KWON, Keunbon KU, Hae Soo KIM, Hye Jin SHIN, Gun Young YOON, In Su HWANG, Gi Uk JEONG, Sun Hee LEE, Mi Hwa KIM, Su Min LEE, Bum Tae KIM
Abstract: Provided are a method for preparing polyhydroxyurethane, polyhydroxyurethane prepared using the method and a pressure-sensitive adhesive comprising the polyhydroxyurethane. According to the present disclosure, it is possible to prepare polyhydroxyurethane in an eco-friendly manner using vegetable oil-derived dimer acid and carbon dioxide and to provide a pressure-sensitive adhesive including the polyhydroxyurethane.
Type:
Application
Filed:
August 29, 2022
Publication date:
July 6, 2023
Applicant:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Ji Hoon SHIN, Jeong Suk YUK, Sae Hume PARK, Nam Kyun KIM
Abstract: The present invention relates to a monolith catalyst for carbon-dioxide/methane reforming and a method of manufacturing the same, and more particularly to a novel monolith catalyst for a reforming reaction having improved thermal durability, configured such that a sintering inhibiting layer is formed by coating the surface of a monolith support with at least one element selected from the group consisting of Group 2, 3, 6, 13, 15 and 16 elements among elements in Period 3 or higher and an active catalyst layer is formed on the sintering inhibiting layer, thereby preventing carbon deposition and catalyst deactivation due to deterioration even upon reaction at high temperatures.
Type:
Grant
Filed:
May 15, 2018
Date of Patent:
July 4, 2023
Assignee:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Tae Sun Chang, Ji Hoon Park, Iljeong Heo, Jung Hyun Park, Young Woo You
Abstract: Disclosed is a catalyst for producing an olefin, the catalyst having an excellent conversion and excellent selectivity, and a method for preparing the catalyst. The catalyst for producing an olefin, according to the present invention, includes: a support including alumina and an auxiliary support component; a main catalyst including an active metal oxide supported on the support; and a co-catalyst including an oxide of an alkali metal and a Group 6B transition metal.
Type:
Grant
Filed:
April 15, 2019
Date of Patent:
June 27, 2023
Assignees:
SK GAS CO., LTD., KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Yong Ki Park, Won Choon Choi, Daesung Park, Hawon Park, Deuk Soo Park, Ung Gi Hong, Byungjun Kang, Miyoung Lee
Abstract: Provided are a methane-selective composite membrane comprising: a UiO-66 type organic-inorganic composite nanoporous material, a MIL-100 type organic-inorganic composite nanoporous material, or a ZIF-8 type organic-inorganic composite nanoporous material to which a methane-selective functional group is introduced for selectively separating methane from a gas mixture containing methane/nitrogen, a use thereof, and a method of preparing the same.
Type:
Grant
Filed:
March 23, 2020
Date of Patent:
June 27, 2023
Assignee:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Jeong Hoon Kim, Chang In Kong, Yang No Yun, Su Young Moon, Bong Jun Chang, Bo Ryoung Park, Youn-Sang Bae, Tea-Hoon Kim
Abstract: The present invention relates to a composition for the prevention, amelioration, or treatment of urination-related disases, comprising cephalotocin. The cephalotocin according to the present invention modulates oxytocin receptors and vasopressin receptors, and has the effect of reducing urine volume by promoting water reabsorption in the kidneys. This means that cephalotocin has a significant antidiuretic effect, and thus, the cephalotocin of the present invention can be variously used in the field of prevention, amelioration, or treatment of urinary disorders or urination-related diseases.
Type:
Application
Filed:
October 7, 2022
Publication date:
June 22, 2023
Applicants:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, NATIONAL MARINE BIODIVERSITY INSTITUTE OF KOREA
Inventors:
Seon Mi JO, Seung Hyun JUNG, Ki Hyun KIM, Dae Sung LEE, Dong Ho WOO, Ye Ji KIM, Chang hoon CHOI, Joung Wook SEO
Abstract: The present disclosure relates to a composition comprising a complex that includes a curcuminoid-based compound and a steviol glycoside, or a curcuminoid-based compound and a licorice extract or a fraction thereof; and a use of the composition for enhancement of immunity according to an enhancement of activity or a cell number of immune cells and/or a use of the composition for prevention, improvement, or treatment of COVID-19. The complex including curcumin and a steviol glycoside, or a licorice extract or a fraction thereof according to the present disclosure, which are food materials that have been registered with the Ministry of Food and Drug Safety and have received the Generally Recognized as Safe (GRAS) rating from the U.S. FDA, and whose safety has already been confirmed, inhibits symptoms of COVID-19 by activating Th1 cells, CD8 T cells, and NK cells. Therefore, the complex can be provided as a food and pharmaceutical composition for preventing, improving, or treating COVID-19.
Type:
Application
Filed:
December 19, 2022
Publication date:
June 22, 2023
Applicants:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY, BIOTEN CO., LTD
Inventors:
Woo Song LEE, Hyung-Jun Kwon, Woo Sik Kim, Young Bae Ryu, In Chul Lee, Hyung Jae Jeong, Ji Young Park
Abstract: The present invention relates to a catalyst for preparing a light olefin, a preparation method therefor, and a method for preparing a light olefin by using same, and can provide a catalyst for preparing a light olefin, a preparation method therefor, and a method for preparing a light olefin by using same, the catalyst comprising a porous zeolite, a clay, an inorganic oxide binder, and Ag2O and P2O5 which are supported in the pores and/or on the surface of the porous zeolite.
Type:
Grant
Filed:
May 2, 2019
Date of Patent:
June 20, 2023
Assignee:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Na Young Kang, Yong Ki Park, Yu Jin Lee
Abstract: A catalyst regenerator for regenerating a coked catalyst produced along with a olefin by mixing naphtha and a catalyst with each other to cause a naphtha cracking reaction, and falling from a cyclone which separates the coked catalyst and the olefin produced from the naphtha cracking reaction, includes: a vessel accommodating a catalyst layer formed by stacking the catalyst; a partial oxidation burner producing a high-temperature gas containing solid carbon; and supply nozzles connected to the partial oxidation burner, installed on a bottom of the vessel toward the falling catalyst and the catalyst layer, and spraying the high-temperature gas containing the solid carbon to the catalyst and the catalyst layer.
Type:
Grant
Filed:
February 1, 2017
Date of Patent:
May 30, 2023
Assignees:
KOREA INSTITUTE OF MACHINERY & MATERIALS, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Inventors:
Dae-hoon Lee, Kwan-Tae Kim, Sungkwon Jo, Yong-Ki Park
Abstract: The present invention relates to an optical fiber BOCDA sensor. A purpose of the present invention is to provide an optical fiber BOCDA sensor which uses two phase codes to control a correlation peak position, thereby further simplifying control design and device configuration and improving spatial resolution to enhance a sensing performance and detection accuracy in comparison with the prior art.
Type:
Grant
Filed:
May 16, 2019
Date of Patent:
May 30, 2023
Assignee:
Korea Research Institute of Standards and Science
Inventors:
Il-Bum Kwon, Dae-Cheol Seo, Chi-Yeop Kim, Bo-Hun Choi
Abstract: Provided are a composition for detecting SARS coronavirus 2, a composition for diagnosing SARS coronavirus 2 infection, a method for detecting SARS coronavirus 2, and a SARS coronavirus 2 infection diagnostic kit, wherein a receptor and an antibody that binds to SARS coronavirus 2 spike protein are used in order to detect SARS coronavirus 2 (SARS-CoV-2) or diagnose SARS coronavirus 2 infection (COVID-19).
Type:
Application
Filed:
June 18, 2021
Publication date:
May 25, 2023
Applicant:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY