Patents Assigned to Krebs
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Patent number: 8673615Abstract: A process utilizing enhanced photosynthesis and photocatalysis to purify water and/or utilize CO2 on a large scale by growing biomass in reduced time and space in a closed, continuous-flow system. Added CO2 and balanced nutrients combine with light to increase the growth rate of autotrophic microalgae which require CO2 for growth and produce oxygen. Organic and inorganic compounds and chemical toxins are mineralized in photocatalysis using such produced oxygen, which are then absorbed (metabolized) in the microalgal biomass that is harvested.Type: GrantFiled: July 13, 2011Date of Patent: March 18, 2014Assignee: Krebs & Sisler L.P.Inventor: William P. Krebs
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Patent number: 8444974Abstract: Described is the use of antibodies which are directed against human cellular membrane antigens for the vaccination against cancer diseases.Type: GrantFiled: August 12, 2011Date of Patent: May 21, 2013Assignee: Igeneon Krebs-Immuntherapie Forschungs-und Entwicklungs-AGInventors: Helmut Eckert, Hans Loibner
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Publication number: 20120021494Abstract: A process utilizing enhanced photosynthesis and photocatalysis to purify water and/or utilize CO2 on a large scale by growing biomass in reduced time and space in a closed, continuous-flow system. Added CO2 and balanced nutrients combine with light to increase the growth rate of autotrophic microalgae which require CO2 for growth and produce oxygen. Organic and inorganic compounds and chemical toxins are mineralized in photocatalysis using such produced oxygen, which are then absorbed (metabolized) in the microalgal biomass that is harvested.Type: ApplicationFiled: July 13, 2011Publication date: January 26, 2012Applicant: Krebs & Sisier L.P.Inventor: William P. Krebs
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Patent number: 8034338Abstract: The invention refers to an immunogenic recombinant antibody designed for immunization of primates comprising at least a part of a murine IgG2a subtype amino acid sequence and a mammalian glycosylation.Type: GrantFiled: April 16, 2004Date of Patent: October 11, 2011Assignee: Igeneon Krebs-Immuntherapie Forschungs-Und Entwicklungs-AGInventors: Hans Loibner, Gottfried Himmler, Günter Waxenecker, Manfred Schuster, Thomas Putz
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Patent number: 7691372Abstract: Described is the use of antibodies which are directed against human cellular membrane antigens for the vaccination against cancer diseases.Type: GrantFiled: October 10, 2006Date of Patent: April 6, 2010Assignee: Igeneon Krebs-Immuntherapie Forschungs-und Entwickungs-AGInventors: Helmut Eckert, Hans Loibner
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Patent number: 7527789Abstract: The invention relates to the use of a preparation based on an antibody directed against a tumor-associated glycosylation for preparing a medicament for the prophylactic and/or therapeutic treatment for the reduction or inhibition, respectively, of the growth of tumor cells in a cancer patient, as well as to a pharmaceutical preparation containing an antibody directed against a tumor-associated glycosylation. Moreover, the invention relates to a preparation for pharmaceutical and/or diagnostic use, a diagnostic method and an agent for determining the risk of metastasis formation in a cancer patient, as well as a method of producing a preparation based on a body fluid or tissue, in each case using the antibody directed against a tumor-associated glycosylation.Type: GrantFiled: June 30, 2003Date of Patent: May 5, 2009Assignee: Igeneon Krebs-Immuntherapie Forschungs-Und Entwicklungs-AGInventors: Hans Loibner, Gottfried Himmler, Thomas Putz, Michael Freissmuth, Markus Klinger, Hesso Farhan
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Patent number: 7293657Abstract: Hydrocyclone and method for separating and classifying solids in which a slurry is introduced into the cylindrical inlet section of the separation chamber of the hydrocyclone so that the slurry rotates about the axis of the chamber, then passes through a first conically tapered section of the separation chamber, and thereafter through a second conically tapered section which has a smaller cone angle than the first conically tapered section. The finer solids are removed through an overflow outlet toward the upper end of the separation chamber, and the coarser solids are removed through an underflow outlet toward the lower end of the chamber.Type: GrantFiled: May 2, 2000Date of Patent: November 13, 2007Assignee: Krebs InternationalInventors: Gerald P. Kelton, Mark E. Hoyack, Timothy J. Olson
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Publication number: 20070243201Abstract: The invention relates to a method for the selection of epitopes for immunotherapy, peptides obtained by said method, the use of said peptides as vaccines and diagnostics and an immune serum obtainable by said method.Type: ApplicationFiled: June 2, 2004Publication date: October 18, 2007Applicant: Igeneon Krebs-Immuntherapie Forschungs-und entwicklungs-AGInventors: Hans Loibner, Gottfried Himmler, Alois Jungbauer, Erich Wasserbauer, Manfred Schuster, Rainer Hahn, Astrid Durauer
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Patent number: 6983850Abstract: An ultrasonic sensor is mounted on the splash skirt at the underflow outlet of a hydrocyclone to detect a change in the underflow discharge from the normal conical shape in which the discharge impacts upon the splash skirt to a more cylindrical shape associated with roping.Type: GrantFiled: June 25, 2003Date of Patent: January 10, 2006Assignee: Krebs Engineers CorporationInventors: Timothy J. Olson, Roger J. Waterman
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Publication number: 20050255116Abstract: The invention relates to a kit for the combined use for the treatment of cancer patients, which set comprises an antigen of a cellular surface protein, or an antibody directed against the cellular surface protein, and an antigen of an aberrant glycosylation, or an antibody directed against the aberrant glycosylation. This kit is destined both for the immunotherapeutic and the diagnostic application. The invention further relates to a selection method for selecting suitable tumor-specific antigens with the assistance of this kit and corresponding specific antibody preparations.Type: ApplicationFiled: August 12, 2003Publication date: November 17, 2005Applicant: Igeneon krebs-Immuntherapie Forschungs-UND Entwicklungs-AGInventors: Hans Loibner, Gottfried Himmler
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Patent number: 6945098Abstract: Wear-detection sensor has a body of electrically insulating material with an opening through which a flowable substance can pass, and one or more electrical conductors surrounding the opening and adapted to undergo a discernable change in conductivity as the insulating material is worn away by the flowable substance.Type: GrantFiled: June 25, 2003Date of Patent: September 20, 2005Assignee: Krebs Engineers CorporationInventor: Timothy Olson
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Publication number: 20050181475Abstract: The invention relates to an immunogenic antibody which comprises at least two different epitopes of a tumor-associated antigen.Type: ApplicationFiled: May 15, 2003Publication date: August 18, 2005Applicant: Igeneon Krebs-Immuntherapie Forschungs-Und-Entwicklungs-AGInventors: Hans Loibner, Gunter Waxenecker, Gottfried Himmler, Helmut Eckert, Manfred Schuster, Ralf Kircheis
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Patent number: 6907845Abstract: A method and apparatus to conduct 02/CO2 combustion or oxygen-enriched combustion. The boiler exhaust gas passes through a Gas Primer Sector (GPS) combined with the boiler to effect heat transfer to the combustion gas in indirect counter-flow heat exchange. Sharply reduced gas flows result from using largely moisture-free CO2 as diluent for O2 in the combustion gas which allows long residence time at low velocity for maximum heat transfer from the exhaust gas to the combustion gas. Most particulate drops out and most moisture is condensed from the cooled mostly CO2 exhaust gas. The larger portion is blended with oxygen for the combustion gas and reheated and returned to the boiler through the integrated GPS; the smaller portion is cleaned and separated, the CO2 released or recovered. The complete exhaust gas-combustion gas cycle may be 30 to 90 seconds and preferably about 60 seconds.Type: GrantFiled: July 7, 2004Date of Patent: June 21, 2005Assignee: Krebs & Sisler L.P.Inventor: William P. Krebs
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Publication number: 20040265318Abstract: Described is use of antibodies which are directed against human cellular membrane antigens for the vaccination against cancer diseases.Type: ApplicationFiled: July 28, 2004Publication date: December 30, 2004Applicant: Igeneon Krebs-Immunotherapie Forschungs-und Entwicklungs-AGInventors: Helmut Eckert, Hans Loibner
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Publication number: 20040237909Abstract: A method and apparatus to conduct 02/CO2 combustion or oxygen-enriched combustion. The boiler exhaust gas passes through a Gas Primer Sector (GPS) combined with the boiler to effect heat transfer to the combustion gas in indirect counter-flow heat exchange. Sharply reduced gas flows result from using largely moisture-free CO2 as diluent for O2 in the combustion gas which allows long residence time at low velocity for maximum heat transfer from the exhaust gas to the combustion gas. Most particulate drops out and most moisture is condensed from the cooled mostly CO2 exhaust gas. The larger portion is blended with oxygen for the combustion gas and reheated and returned to the boiler through the integrated GPS; the smaller portion is cleaned and separated, the CO2 released or recovered. The complete exhaust gas-combustion gas cycle may be 30 to 90 seconds and preferably about 60 seconds.Type: ApplicationFiled: July 7, 2004Publication date: December 2, 2004Applicant: Krebs & SislerInventor: William P. Krebs
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Patent number: 6676942Abstract: The invention related to novel Borrelia, and OspA antigens derived therefrom. These antigens show little homology with know OspA's and are therefore useful as vaccine and diagnostic reagents. Multicomponent vaccines based on OspA's from different Borrelia groups are also disclosed.Type: GrantFiled: April 1, 1999Date of Patent: January 13, 2004Assignees: SmithKline Beecham Biologicals (s.a.), Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V., Deutsches Krebs Forschungszentrum Stiftung des Offentlichen RechtsInventors: Yves Lobet, Markus Simon, Ulrich Schaible, Reinhard Wallich, Michael Kramer
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Patent number: 6033575Abstract: The method and apparatus mixes two immiscible liquids A and O to form a dispersion and then pre-separates the dispersion into two fractions (A+o) and (O+a) in a spout. These two fractions are fed separately into a decanter with two separate compartments which continue to maintain the two fractions as separate. Within the two separate compartments the two fractions are further separated into two flows, A, O, a, and o, such that four flows exit the decanter.Type: GrantFiled: May 4, 1998Date of Patent: March 7, 2000Assignee: Krebs & Cie S.A.Inventors: Jean-Claude Perret, Alain Sonntag, David Goodman
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Patent number: 6027607Abstract: A process for extracting salt from brine contained in at least one open evaporation basin. At least part of the brine is heated in a heating unit located outside the evaporation basis and returned to the evaporation basin. The heating unit is driven by waste heat from a recooling industrial plant. According to this process, climatic values and the degree of recooling are measured and evaluated in a control unit. At least part of the heated brine and some non-heated brine are sprayed by a spraying device of the evaporation basin. The amount of sprayed brine is regulated by the control unit depending on the measured data.Type: GrantFiled: July 31, 1998Date of Patent: February 22, 2000Assignee: Krebs & Co. AGInventor: Vicente Gracia Corniel
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Patent number: 5535892Abstract: Coal spiral having a relatively short first stage helix for separating a slurry into clean coal, refuse and middlings splits, and a relatively short second stage helix for recleaning middlings split from the first stage. The first stage has only 3.25 turns, the second stage has only two turns, and a combination separator box and feed box delivers the middlings directly from the first stage to the second. The two helices are aligned coaxially, and are of opposite rotational sense to provide counter-rotation of the middlings in the two stages.Type: GrantFiled: May 3, 1994Date of Patent: July 16, 1996Assignee: Krebs EngineersInventors: Robert G. Moorhead, Peter O. J. Davies
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Patent number: 5389255Abstract: A module having a plurality of chambers which are seated relatively close to each other in a flow-through reservoir having a feed inlet and an oppositely located retentate outlet. The chambers include pervaporation chambers which have a permeation-selective layer and heating chambers. The pervaporation chambers and the heating chambers are alternatingly disposed and supported in cutouts within comb-shaped supports. The flow-through reservoir is box-shaped and has removable, tightly secured longitudinal end walls, one of which supports all pervaporation chambers, the other of which supports all heating chambers. The module is highly efficient due to flow and temperature distribution conditions which remain extremely exact.Type: GrantFiled: May 19, 1993Date of Patent: February 14, 1995Assignee: Krebs & Co. AGInventors: Rene S. Danziger, Claus Gerrath