Patents Assigned to Krebs
  • Patent number: 8673615
    Abstract: A process utilizing enhanced photosynthesis and photocatalysis to purify water and/or utilize CO2 on a large scale by growing biomass in reduced time and space in a closed, continuous-flow system. Added CO2 and balanced nutrients combine with light to increase the growth rate of autotrophic microalgae which require CO2 for growth and produce oxygen. Organic and inorganic compounds and chemical toxins are mineralized in photocatalysis using such produced oxygen, which are then absorbed (metabolized) in the microalgal biomass that is harvested.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: March 18, 2014
    Assignee: Krebs & Sisler L.P.
    Inventor: William P. Krebs
  • Patent number: 8444974
    Abstract: Described is the use of antibodies which are directed against human cellular membrane antigens for the vaccination against cancer diseases.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: May 21, 2013
    Assignee: Igeneon Krebs-Immuntherapie Forschungs-und Entwicklungs-AG
    Inventors: Helmut Eckert, Hans Loibner
  • Publication number: 20120021494
    Abstract: A process utilizing enhanced photosynthesis and photocatalysis to purify water and/or utilize CO2 on a large scale by growing biomass in reduced time and space in a closed, continuous-flow system. Added CO2 and balanced nutrients combine with light to increase the growth rate of autotrophic microalgae which require CO2 for growth and produce oxygen. Organic and inorganic compounds and chemical toxins are mineralized in photocatalysis using such produced oxygen, which are then absorbed (metabolized) in the microalgal biomass that is harvested.
    Type: Application
    Filed: July 13, 2011
    Publication date: January 26, 2012
    Applicant: Krebs & Sisier L.P.
    Inventor: William P. Krebs
  • Publication number: 20120003232
    Abstract: Described is the use of antibodies which are directed against human cellular membrane antigens for the vaccination against cancer diseases.
    Type: Application
    Filed: August 12, 2011
    Publication date: January 5, 2012
    Applicant: IGENEON KREBS-IMMUNTHERAPIE FORSCHUNGS-UND ENTWICKLUNGS-AG
    Inventors: Helmut ECKERT, Hans Loibner
  • Patent number: 8034338
    Abstract: The invention refers to an immunogenic recombinant antibody designed for immunization of primates comprising at least a part of a murine IgG2a subtype amino acid sequence and a mammalian glycosylation.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: October 11, 2011
    Assignee: Igeneon Krebs-Immuntherapie Forschungs-Und Entwicklungs-AG
    Inventors: Hans Loibner, Gottfried Himmler, Günter Waxenecker, Manfred Schuster, Thomas Putz
  • Patent number: 7691372
    Abstract: Described is the use of antibodies which are directed against human cellular membrane antigens for the vaccination against cancer diseases.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: April 6, 2010
    Assignee: Igeneon Krebs-Immuntherapie Forschungs-und Entwickungs-AG
    Inventors: Helmut Eckert, Hans Loibner
  • Publication number: 20090181030
    Abstract: The invention relates to the use of a preparation based on an antibody directed against a tumor-associated glycosylation for preparing a medicament for the prophylactic and/or therapeutic treatment for the reduction or inhibition, respectively, of the growth of tumor cells in a cancer patient, as well as to a pharmaceutical preparation containing an antibody directed against a tumor-associated glycosylation. Moreover, the invention relates to a preparation for pharmaceutical and/or diagnostic use, a diagnostic method and an agent for determining the risk of metastasis formation in a cancer patient, as well as a method of producing a preparation based on a body fluid or tissue, in each case using the antibody directed against a tumor-associated glycosylation.
    Type: Application
    Filed: February 23, 2009
    Publication date: July 16, 2009
    Applicant: IGENEON KREBS-IMMUNTHERAPIE FORSCHUNGS- UND ENTWICKLUNGS-AG
    Inventors: Hans LOIBNER, Gottfried Himmler, Thomas Putz, Michael Freissmuth, Markus Klinger, Hesso Farhan
  • Publication number: 20090130125
    Abstract: The invention relates to a kit for the combined use for the treatment of cancer patients, which set comprises an antigen of a cellular surface protein, or an antibody directed against the cellular surface protein, and an antigen of an aberrant glycosylation, or an antibody directed against the aberrant glycosylation. This kit is destined both for the immunotherapeutic and the diagnostic application. The invention further relates to a selection method for selecting suitable tumor-specific antigens with the assistance of this kit and corresponding specific antibody preparations.
    Type: Application
    Filed: December 11, 2008
    Publication date: May 21, 2009
    Applicant: IGENEONG KREBS-IMMUNTHERAPIE FORSCHUNGS- UND ENTWICKLUNGS-AG
    Inventors: Hans LOIBNER, Gottfried HIMMLER
  • Patent number: 7527789
    Abstract: The invention relates to the use of a preparation based on an antibody directed against a tumor-associated glycosylation for preparing a medicament for the prophylactic and/or therapeutic treatment for the reduction or inhibition, respectively, of the growth of tumor cells in a cancer patient, as well as to a pharmaceutical preparation containing an antibody directed against a tumor-associated glycosylation. Moreover, the invention relates to a preparation for pharmaceutical and/or diagnostic use, a diagnostic method and an agent for determining the risk of metastasis formation in a cancer patient, as well as a method of producing a preparation based on a body fluid or tissue, in each case using the antibody directed against a tumor-associated glycosylation.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: May 5, 2009
    Assignee: Igeneon Krebs-Immuntherapie Forschungs-Und Entwicklungs-AG
    Inventors: Hans Loibner, Gottfried Himmler, Thomas Putz, Michael Freissmuth, Markus Klinger, Hesso Farhan
  • Patent number: 7293657
    Abstract: Hydrocyclone and method for separating and classifying solids in which a slurry is introduced into the cylindrical inlet section of the separation chamber of the hydrocyclone so that the slurry rotates about the axis of the chamber, then passes through a first conically tapered section of the separation chamber, and thereafter through a second conically tapered section which has a smaller cone angle than the first conically tapered section. The finer solids are removed through an overflow outlet toward the upper end of the separation chamber, and the coarser solids are removed through an underflow outlet toward the lower end of the chamber.
    Type: Grant
    Filed: May 2, 2000
    Date of Patent: November 13, 2007
    Assignee: Krebs International
    Inventors: Gerald P. Kelton, Mark E. Hoyack, Timothy J. Olson
  • Publication number: 20070243201
    Abstract: The invention relates to a method for the selection of epitopes for immunotherapy, peptides obtained by said method, the use of said peptides as vaccines and diagnostics and an immune serum obtainable by said method.
    Type: Application
    Filed: June 2, 2004
    Publication date: October 18, 2007
    Applicant: Igeneon Krebs-Immuntherapie Forschungs-und entwicklungs-AG
    Inventors: Hans Loibner, Gottfried Himmler, Alois Jungbauer, Erich Wasserbauer, Manfred Schuster, Rainer Hahn, Astrid Durauer
  • Publication number: 20060246056
    Abstract: Described is the use of an immunotherapeutic agent targeting a human tumor associated antigen for the production of a medicament for immunotherapy of patients with rectal cancer or being at risk of rectal cancer, wherein the immunotherapeutic agent is a vaccine, an antibody or derivative or fragment thereof.
    Type: Application
    Filed: May 24, 2004
    Publication date: November 2, 2006
    Applicant: IGENEON KREBS-IMMUNTHERAPIE FORSCHUNGS-UND ENTWICKLUNGS-AG
    Inventors: Hans Loibner, Helmut Eckert, Gottfried Himmler
  • Publication number: 20060127403
    Abstract: The invention relates to the use of a preparation based on an antibody directed against a tumor-associated antigen, for producing a medicament for the intra-operative treatment of tumor patients, in particular for the prophylactic treatment to prevent the dissemination of tumor cells. The invention further relates to a kit for the intra-operative treatment of tumor patients, comprising the medicament and means for diagnostically determining malignant tumor cells.
    Type: Application
    Filed: July 31, 2003
    Publication date: June 15, 2006
    Applicant: IGENEON KREBS-IMMUNTHERAPIE FORSCHUNGS-UND ENTWICK
    Inventors: Hans Loibner, Gottfried Himmler, Hellmut Samonigg, Eugen Stermetz, Andreas Hauer, Gerda Redl
  • Publication number: 20060062796
    Abstract: Disclosed is a method of producing a polysaccharide-polypeptide conjugate by reacting a polysaccharide with a polypeptide which contains at least one free amino group, wherein a polysaccharide carrier comprising vicinal hydroxyl groups is oxidized under ring opening to create vicinal aldehyde groups and is reacted with one or more base-instable antigenic polypeptide(s) containing at least one free amino group, the polypeptide(s) being bound directly to the polysaccharide carrier via at least one azomethine bond.
    Type: Application
    Filed: September 13, 2005
    Publication date: March 23, 2006
    Applicant: IGENEON KREBS-IMMUNTHERAPIE FORSCHUNGS-UND
    Inventors: Hans Loibner, Helmut Eckert
  • Patent number: 6983850
    Abstract: An ultrasonic sensor is mounted on the splash skirt at the underflow outlet of a hydrocyclone to detect a change in the underflow discharge from the normal conical shape in which the discharge impacts upon the splash skirt to a more cylindrical shape associated with roping.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: January 10, 2006
    Assignee: Krebs Engineers Corporation
    Inventors: Timothy J. Olson, Roger J. Waterman
  • Publication number: 20050255116
    Abstract: The invention relates to a kit for the combined use for the treatment of cancer patients, which set comprises an antigen of a cellular surface protein, or an antibody directed against the cellular surface protein, and an antigen of an aberrant glycosylation, or an antibody directed against the aberrant glycosylation. This kit is destined both for the immunotherapeutic and the diagnostic application. The invention further relates to a selection method for selecting suitable tumor-specific antigens with the assistance of this kit and corresponding specific antibody preparations.
    Type: Application
    Filed: August 12, 2003
    Publication date: November 17, 2005
    Applicant: Igeneon krebs-Immuntherapie Forschungs-UND Entwicklungs-AG
    Inventors: Hans Loibner, Gottfried Himmler
  • Publication number: 20050226880
    Abstract: The invention relates to the use of a preparation based on -an antibody directed against a tumor-associated glycosylation for preparing a medicament for the prophylactic and/or therapeutic treatment for the reduction or inhibition, respectively, of the growth of tumor cells in a cancer patient, as well as to a pharmaceutical preparation containing an antibody directed against a tumor-associated glycosylation. Moreover, the invention relates to a preparation for pharmaceutical and/or diagnostic use, a diagnostic method and an agent for determining the risk of metastasis formation in a cancer patient, as well as a method of producing a preparation based on a body fluid or tissue, in each case using the antibody directed against a tumor-associated glycosylation.
    Type: Application
    Filed: June 30, 2003
    Publication date: October 13, 2005
    Applicant: IGENEON KREBS-IMMNUTHERAPIE FORSCHUNGS-UND ENTWICKLUNGS-AG
    Inventors: Hans Loibner, Gottried Himmler, Thomas Putz, Michael Freissmuth, Markus Klinger, Hesso Farhan
  • Patent number: 6945098
    Abstract: Wear-detection sensor has a body of electrically insulating material with an opening through which a flowable substance can pass, and one or more electrical conductors surrounding the opening and adapted to undergo a discernable change in conductivity as the insulating material is worn away by the flowable substance.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: September 20, 2005
    Assignee: Krebs Engineers Corporation
    Inventor: Timothy Olson
  • Publication number: 20050181475
    Abstract: The invention relates to an immunogenic antibody which comprises at least two different epitopes of a tumor-associated antigen.
    Type: Application
    Filed: May 15, 2003
    Publication date: August 18, 2005
    Applicant: Igeneon Krebs-Immuntherapie Forschungs-Und-Entwicklungs-AG
    Inventors: Hans Loibner, Gunter Waxenecker, Gottfried Himmler, Helmut Eckert, Manfred Schuster, Ralf Kircheis
  • Patent number: 6907845
    Abstract: A method and apparatus to conduct 02/CO2 combustion or oxygen-enriched combustion. The boiler exhaust gas passes through a Gas Primer Sector (GPS) combined with the boiler to effect heat transfer to the combustion gas in indirect counter-flow heat exchange. Sharply reduced gas flows result from using largely moisture-free CO2 as diluent for O2 in the combustion gas which allows long residence time at low velocity for maximum heat transfer from the exhaust gas to the combustion gas. Most particulate drops out and most moisture is condensed from the cooled mostly CO2 exhaust gas. The larger portion is blended with oxygen for the combustion gas and reheated and returned to the boiler through the integrated GPS; the smaller portion is cleaned and separated, the CO2 released or recovered. The complete exhaust gas-combustion gas cycle may be 30 to 90 seconds and preferably about 60 seconds.
    Type: Grant
    Filed: July 7, 2004
    Date of Patent: June 21, 2005
    Assignee: Krebs & Sisler L.P.
    Inventor: William P. Krebs