Abstract: The invention relates to hardly soluble antiphlogistic salts and antiphlogistic-antibiotic pharmaceutical preparations and their use. The hardly water soluble antiphlogistic antibiotics salts have as their cationic component one of the antibiotics gentamicin, clindamycin, neomycin, streptomycin, tetracycline, doxicyline, oxytetracycline and rolitetracycline and as their anionic component one of the antiphlogistics ibuprofen, naproxen, indomethacin, dexamethasone-21-phosphate, dexamethasone-21-sulfate, triamcinolone-21-phosphate and triamcinolone-21-sulfate. The antiphlogistic antibiotics salts are used in pharmaceutical preparations as controlled-release antibiotic/antibiotics drugs.
Type:
Grant
Filed:
June 20, 2003
Date of Patent:
March 18, 2008
Assignee:
Heraeus Kulzer GmbH & Co. KG
Inventors:
Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kühn
Abstract: The present invention relates to an antibiotic(s)-polymer combination, which under physiological conditions guarantees the continuous release of antibiotics over a period of several days and can be used in human and veterinary medicine. The invented antibiotic(s)-polymer combination is wherein in a homogeneous polymer mixture, consisting of one or more hydrophobic polymers from the groups of poly(methacrylic acid esters), the poly(acrylic acid esters) and the poly(methacrylic acid ester-co-acrylic acid esters) and one or more hydrophilic polymers from the group of polyethers, one or more slightly water-soluble antibiotics from the groups of aminoglycoside antibiotics, the lincosamide antibiotics, the tetracycline antibiotics and quinolone antibiotics, possibly an easily water-soluble antibiotic from the groups of aminoglycoside antibiotics, the lincosamide antibiotics and the tetracycline antibiotics, and possibly one or more organic adjuvants are suspended, and that this suspension forms a composite.
Type:
Application
Filed:
October 31, 2007
Publication date:
March 6, 2008
Applicant:
HERAEUS KULZER GMBH & CO. KG
Inventors:
Sebastian Vogt, Matthias Schnabelrauch, Klaus Kuhn
Abstract: A bone replacement material that is, in particular, paste-like and is characterized in that particulate calcium carbonate is suspended in an aqueous solution that contains at least one water-soluble hemostatic agent, whereby the aqueous solution contains an amount of the hemostatic agent at which it is isotonic.
Abstract: A dental implant system component having a coating made of an only slightly water-soluble chlorhexidine fatty acid salt, in which one or more antiphiogistics and/or one or more steroids and/or one or more prostaglandins and/or one or more bisphosphonates and/or one or more statins are dissolved.
Type:
Application
Filed:
July 16, 2007
Publication date:
January 17, 2008
Applicant:
HERAEUS KULZER GMBH
Inventors:
KLAUS-DIETER KUHN, SEBASTIAN VOGT, SANDRA MARTINOVIC
Abstract: A post-shaped element for determining the alignment of an implant (10), or the opening cross-section of an artificial indentation located in a tooth or in the stroma of a human or animal body, relative to the surrounding tissue structures, can be introduced with a receiving section (28, 26A) into an adapted receiving recess (10) in the implant (1) or the artificial indentation, and be affixed therein and removed again. In a connecting position the post-shaped element protrudes with a cantilever section (26K) beyond the opening cross-section of the receiving recess (10) or the artificial indentation.
Type:
Grant
Filed:
April 5, 2001
Date of Patent:
January 1, 2008
Assignee:
Heraeus Kulzer GmbH & Co., KG
Inventors:
Michael Augthun, Manfred Peters, Klaus Haselhuhn, Hubertus Spiekermann
Abstract: The present invention relates to a method for manufacturing dental prostheses according to a digitized virtual model which reflects the maximally situation, comprising the steps providing a data record that reflects the maxillary situation and relationship, digital modeling of the tooth, creating a divided negative mold (rapid manufacturing) from the data from the digital tooth modeling, insertion of the fabricated teeth into the opened negative mold, closing the negative mold, filling the remaining cavity with plastic for the prosthesis.
Abstract: A dental kit made up of: A at least one pre-shaped dental crown made from a plastically deformable dental composite material curable by light, B a container impermeable to light, in which the pre-shaped dental crown is kept before it is applied to a tooth stump, C optionally a film which covers the outer surface of the pre-shaped dental crown.
Type:
Application
Filed:
May 9, 2006
Publication date:
November 15, 2007
Applicant:
Heraeus Kulzer GmbH
Inventors:
Klaus Ruppert, Karl-Heinz Renz, Novica Savic, Chris Holden, Frank Stange, Raquel Neumann
Abstract: One or more substances of the group consisting of gentamicin palmitate, gentamicin myristate, gentamicin laurate, tobramycin palmitate, tobramycin myristate, tobramycin laurate, amikacin palmitate, amikacin myristate, amikacin laurate, vancomycin palmitate, vancomycin laurate, and vancomycin myristate are suitable for providing vascular grafts with an antithrombogenically active principle.
Type:
Application
Filed:
April 4, 2007
Publication date:
November 15, 2007
Applicant:
HERAEUS KULZER GMBH
Inventors:
KLAUS-DIETER KUHN, SEBASTIAN VOGT, MATTHIAS SCHNABELRAUCH
Abstract: Described is a method for producing a dental prosthesis, comprising the following steps: A Producing a model from a material which does not bond with the dental prosthesis material, B Fixing the teeth, C Filling the interspace between the artificial tooth/teeth and the model, wherein in step C melted thermoplastic material is applied in layers and after each layer is hardened by cooling.
Type:
Application
Filed:
April 12, 2007
Publication date:
October 18, 2007
Applicant:
HERAEUS KULZER GMBH
Inventors:
Frank Stange, Novica Savic, Karl-Heinz Renz
Abstract: The invention relates to a self-curing two-component dental material having as its components A powder component containing dicalcium phosphate anhydrate (DCPA) or dicalcium phosphate dihydrate (DCPD) and tetracalcium phosphate (TTCP) and B liquid component containing water and complexing agent, whereby crystalline DCPA having a crystal shape of small plates typical of brushite having an iron (Fe), manganese (Mn), molybdenum (Mo), and tungsten (W) content of less than 0.2 m % (200 ppm) each is used.
Type:
Application
Filed:
March 19, 2007
Publication date:
September 27, 2007
Applicant:
Heraeus Kulzer GmbH
Inventors:
Albert Erdrich, Marcus Hoffmann, Andreas Piotrowski
Abstract: Disclosed are polymerizable dental materials containing silver particles having a primary particles diameter <40 nm as an antimicrobidal additive. The inventive dental materials are suitable as filling composites, basic prosthetic materials, adhesives, coating composites for crowns and bridges, and materials for artificial teeth, for example.
Type:
Application
Filed:
December 13, 2004
Publication date:
September 13, 2007
Applicant:
Heraeus Kulzer GmbH
Inventors:
Klaus Ruppert, Andreas Grundler, Albert Erdrich
Abstract: The invention describes pharmaceutical preparations with retarding active ingredient release, which consist of mixtures of powdery teicoplanin and at least one powdery, water soluble salt form of gentamicin, clindamycin, kanamycin, amikacin, tobramycin, vancomycin, moxifloxacin and ciprofloxacin and an inorganic and/or organic adjuvant. The pharmaceutical preparations are used as permanent or as temporary implants in the form of tablets, molded bodies, fibers and granules.
Type:
Grant
Filed:
June 20, 2003
Date of Patent:
September 4, 2007
Assignee:
Herseus Kulzer GmbH
Inventors:
Sebastian Vogt, Matthias Schnabelrauch, Klaus-Dieter Kühn
Abstract: A local system for the release of active principle is described which consists of approximately spherical or rotation symmetrical bodies which are composed essentially of polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate, zirconium dioxide or barium sulphate and one or more pharmaceutical active principles, in particular antibiotics, and which are produced by radical polymerisation, radical polymerisation activators effective in the temperature range of 10-80° C. or residues of these polymerisation activators from the groups of aromatic amines, heavy metal salts and barbiturates not being contained therein.
Abstract: Form bodies, which can be rotationally-symmetrical or irregularly-shaped, consist of at least one member of the group of the antibiotic salts, gentamicin myristate, gentamicin palmitate, gentamicin stearate, tobramycin myristate, tobramycin palmitate, tobramycin stearate, amikacin myristate, amikacin palmitate, amikacin stearate, vancomycin palmitate, vancomycin stearate, ramoplanin palmitate, ramoplanin stearate, levofloxacin palmitate, levofloxacin stearate, ofloxacin palmitate, ofloxacin stearate, moxifloxacin palmitate, moxifloxacin stearate, clindamycin palmitate, and clindamycin stearate. A medical device for implantation, in which the form bodies are arranged on a biodegradable filament at a distance of 1 mm to 25 mm as well as a method for the manufacture of the medical device and the use of the form bodies or the medical device to treat chronic osteomyelitis are described.
Abstract: A method for producing antibiotic/antibiotics-particles characterized in that an aqueous solution of an amino glycoside-antibiotic or an aqueous solution comprising two or more amino glycoside-antibiotics is mixed under agitation with a solvent mixture comprising isopropanol and at least one additional alcohol, with the volume ratio of the solvent mixture to the aqueous solution being at least 3 to 1 and with the suspension developed being agitated until the primarily yielded coarse antibiotic/antibiotics aggregates disintegrate into particles, which have a grain size smaller than 400 ?m.
Abstract: A self-curing or dual-curing, low viscosity composite is used for the fabrication of a dental liner capable of polymerization in 2 stages with 2 curing times and delayed polymerization characteristics that is designed for use at the cavity wall in the form of a thin layer.
Abstract: A molding paste for use in ceramic molding containing at least one release agent, at least one ion-donating agent, and/or an amphoteric substance has in particular an electrostatically destabilizing effect on ceramic slips.
Abstract: A local system for the liberation of an active principle is described which consists of spherical bodies which are composed of polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate and, if necessary, zirconium dioxide and/or barium sulphate and a pharmaceutical active principle, which contains at least one hemostyptically effective compound stable at least up to 120° C., preferably a calcium salt. The local system for the liberation of an active principle is provided as medical product or drug.
Abstract: A two-component initiator system having accelerators for curing polymerizable materials comprising the following components: (a) a hydroperoxide compound containing one or more hydroperoxide groups that are bound to a tertiary carbon; (b) a thiourea derivative; and (c) as accelerator, a copper compound which is soluble in the preparation is preferably free of amine and is particularly suited for polymerizable dental compositions.
Abstract: A dyed polymethyl methacrylate bone cement is described which is characterised by at least the surface of the polymer particles of the powder component being coated partially or completely with a mixture of one or several dyes and a hydrophobic, low molecular or oligomeric organic coupling agent, such a quantity of coupling agent being present that the polymer particles can be visually recognised as not having swollen.