Abstract: Provided is a method for producing sulfurized olefin, the method including reacting an olefin compound (a) represented by R1R2C?CHR3 . . . (1) (in Formula (1), R1 and R2 each are alkyl groups, respectively, R3 is a hydrogen atom or an alkyl group, and the total number of carbon atoms of R1, R2 and R3 is 2 to 20) with sulfur in the presence of hydrogen to give a dialkyl polysulfide (A).

Abstract: A probe has a base sequence that does not hybridize with a nucleic acid of a mammal under stringent conditions, and has a sequence including a base sequence set forth in any of SEQ ID NOs:1 to 673. A probe set includes two or more kinds of the probes, and the two or more kinds of the probes do not hybridize with each other under stringent conditions.

Abstract: A heat-transfer member (1) is used in a cooling system in which an alcohol serves as a coolant. The heat-transfer member (1) has: a heat-receiving surface (11) configured such that it can receive heat from a heat-generating body; and a heat-dissipating surface (12) configured such that it can dissipate, to the coolant, the heat received at the heat-receiving surface (11). The heat-dissipating surface (12) has a plurality of pores (121) whose average pore diameter is 5 nm or more and 1,000 nm or less. A cooling system can be configured by causing the coolant to contact the heat-dissipating surface (12) of the heat-transfer member (1).

Abstract: The present invention provides a cell adhesion sheet in which the adhesion of platelets is suppressed and the adhesion of cells is excellent. The cell adhesion sheet according to the embodiment of the present invention is formed of a composition containing a compound represented by Formula (1).

Abstract: Methods are disclosed herein for promoting survival of a donor liver in a recipient subject, wherein the donor liver is homozygous for rs738409:G mutation in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene. The method can include administering to the subject glutathione (GSH) and/or a nucleic acid molecule encoding a component of the ferroptosis pathway (such as GPX4).

Abstract: A learning apparatus (500) according to the present invention includes a detection unit (510) that detects, as a candidate region of a learning target, a region detected by one of first detection processing of detecting an object region from a predetermined image and second detection processing of detecting a change region from background image information and the image, and not detected by the other, an output unit (520) that outputs at least a part of the candidate region as a labeling target, and a learning unit (530) that learns a model for performing the first detection processing or a model for performing the second detection processing by using the labeled candidate region as learning data.

Abstract: A laser radiation optical system for laser doping and post-annealing, the laser radiation system including A. a laser apparatus configured to generate pulsed laser light that belongs to an ultraviolet region, B. a stage configured to move a radiation receiving object in an at least one scan direction, the radiation receiving object being an impurity source film containing at least an impurity element as a dopant and formed on a semiconductor substrate, and C. an optical system including a beam homogenizer configured to shape the beam shape of the pulsed laser light into a rectangular shape and generate a beam for laser doping and a beam for post-annealing that differ from each other in terms of a first beam width in the scan direction but have the same second beam width perpendicular to the scan direction.

Abstract: A blood pressure controlling apparatus includes an acquiring part configured to acquire biological information indicating blood pressure of a subject, a producing part configured to produce a frequency modulated pulse train on the basis of the biological information, and a supplying part configured to supply an electrical current on the basis of the frequency modulated pulse train, to an electrode attached on the subject. The electrical current stimulates baroreceptor afferent nerves of the subject.

Abstract: It was found that four nuclease domain mutants have nuclease activity superior to that of a wild-type nuclease domain and are capable of enhancing genome editing efficiency in combination with various nucleic acid binding domains.

Abstract: A machine learning method includes acquiring image data generated from reflected light of illumination light radiated to a first region of a semiconductor film on a substrate, the first region annealed by pulse laser light, acquiring data on a measured semiconductor property of the first region, generating training data including the image data as input and the measured data as output associated with each other, and performing machine learning using a neural network based on the training data to generate a learned model.

Abstract: The object of the present invention is to provide an inexpensive and effective sirtuin activator derived from natural products. The problem can be solved by a sirtuin activator comprising ?-alanine or a salt thereof, or a composition for activating sirtuin comprising the sirtuin activator as an active ingredient, of the present invention.

Abstract: The present disclosure is intended to enhance various effects of a green tea extract such as catechin in the most effective manner. The ratio (B/A) of epigallocatechin gallate (A) contained in the green tea extract and flavanone glycoside (B) contained in the citrus extract is 0.2<B/A<1.6, or a ratio (C/A) of epigallocatechin gallate (A) and eriocitrin (C) contained in the citrus extract is 0.2<C/A<0.5.

Abstract: The present invention discloses a method for diagnosing cancer comprising a step of detecting active protein kinase C? in urine.

Abstract: An organic electroluminescence device in which a polycyclic compound including an electron donor and an electron acceptor is included in an emission layer is provided. The electron donor contains an acridine derivative or a dibenzo-azasiline derivative, and the electron acceptor contains B as a ring-forming atom, O or S directly bonded to B, and a heterocyclic group in which three or five hexagonal rings are condensed. Accordingly, an organic electroluminescence device having high efficiency may be achieved.

Abstract: Provided is a labeling method for nucleic acid including a reaction step for hybridizing a nucleic acid probe that has a nucleotide sequence complementary to that of a nucleic acid to be labeled and contains a reactive nucleobase derivative incorporated at a position complementary to that of a target nucleobase as a target of labeling in the nucleic acid to be labeled, to the nucleic acid to be labeled; a transferring step for transferring a transfer group contained in the reactive nucleobase derivative to the nucleotide residue containing the target nucleobase in the nucleic acid to be labeled; and a labeling step for labeling the transfer group transferred to the nucleotide residue with a radioactive material.

Abstract: The object of the present invention is to provide a pharmaceutical agent which activate mitochondrial function, particularly, an inexpensive pharmaceutical agent. The problem can be solved by a mitochondrial function activator of the present invention, comprising ?-alanine or glycine, or a salt thereof.

Abstract: An object of the present invention is to provide a means for fixing a pancreatic resection stump created during an operation for resecting a portion of the pancreas. The present invention provides a polymeric surgical clip characterized in that the clip comprises a first arm portion, a second arm portion, and a resilient hinge portion joining the first and second arm portions together, both the arm portions are joined to the resilient hinge portion at their bases, the first arm portion has a convex outer surface and a concave inner surface clamping the pancreas, the second arm portion has a convex or flat outer surface and a concave or flat inner surface clamping the pancreas, the first arm portion forms at its distal end a deflectable hook portion curved toward the second arm portion, and the clip is configured so that, in a closed position, a distal end of the second arm portion enters inside the curved hook portion and engages with the hook portion to lock the clip in the closed position.

Abstract: Provided are: a dicyano N-heterocyclic compound represented by formula (I) (in the formula, R3 represents an electron-donating group, and n represents the number of repetitions of the content in brackets and is 0 or 1), the compound having exceptional heat resistance and light emission characteristics; a light-emitting material; and a light-emitting element in which the same is used.

Abstract: A blood pressure controlling apparatus includes an acquiring part configured to acquire biological information indicating blood pressure of a subject, a producing part configured to produce a frequency modulated pulse train on the basis of the biological information, and a supplying part configured to supply an electrical current on the basis of the frequency modulated pulse train, to an electrode attached on the subject. The electrical current stimulates baroreceptor afferent nerves of the subject.

Abstract: A fine work assistance system is configured such that a parallel link mechanism is used for a slave manipulator activated by a master operation, and a precise motion for microsurgery or the like is performed by remote control. In a slave unit of a master-slave manipulator, the parallel link mechanism with multiple degrees of freedom is used for a link mechanism in which an end effector is movable with respect to a base. Moreover, a tip operation part is driving by a hydraulic driving mechanism such that a plurality of linear actuators supported by the base move one ends of links so as to move the end effector, and the slave unit is activated in response to a user operation on the master unit. This achieves the precise motion of the end effector and causes the end effector to perform operations for a precise work.