Patents Assigned to Labaz
  • Patent number: 4317768
    Abstract: The instant invention relates to compounds of the general formula: ##STR1## wherein R.sub.1 represents an alkyl, alkenyl, phenyl or phenylalkyl radical, R.sub.2 represents an alkyl, alkenyl or alkynyl radical, a .omega.-halogenoethyl radical, an optionally substituted benzyl radical, a phenylalkenyl radical, an optionally substituted phenyl radical, a radical of the formula R.sub.4 --O--(CH.sub.2).sub.n -- wherein n is 2, 3, or 4 and R.sub.4 represents an optionally substituted alkyl radical or a phenyl radical, R.sub.3 represents a hydrogen atom, an alkyl, alkenyl or phenyl radical.The compounds of formula I have been found to be useful as stabilizers for vinyl resins.
    Type: Grant
    Filed: November 13, 1979
    Date of Patent: March 2, 1982
    Assignee: Labaz
    Inventors: Charles Pigerol, Marie-Madeleine Chandavoine, Paul de Cointet de Fillain
  • Patent number: 4299768
    Abstract: 1-Pyrrole- and 1-pyrrolidine-carboxylic acid derivatives corresponding to the general formula: ##STR1## in which R represents an alkyl radical having from 1 to 4 carbon atoms, preferably ethyl, and Am represents a group: ##STR2## wherein R.sub.1 represents a 3-oxo-alkyl radical ##STR3## or a 3-oxo-alkenyl radical ##STR4## and R.sub.2 represents hydrogen or R.sub.1 and R.sub.2, when they are identical, each represent hydrogen, ##STR5## R.sub.3 representing an alkyl radical having from 1 to 5 carbon atoms with the proviso that when R.sub.1 and R.sub.2 are simultaneously hydrogen, Am represents the group A.The novel derivatives are useful as intermediates for synthetizing azaprostaglandines.
    Type: Grant
    Filed: June 11, 1979
    Date of Patent: November 10, 1981
    Assignee: LABAZ
    Inventors: Charles Pigerol, Michel Schaefer, Souli Nanthavong
  • Patent number: 4283420
    Abstract: The chemical compounds of the invention are useful as the active compound in drugs because of their anticonvulsant and/or antianoxic activity. They have the general formula ##STR1## wherein Z is a hydroxyl group; a group--OM wherein M is an alkali metal atom or an equivalent atom fraction of an alkaline-earth metal or an amino group such as --NH.sub.2, and R is a linear or branched alkyl group containing from 1 to 9 carbon atoms, and optionally substituted by one or more halogen atoms; a linear or branched alkenyl or alkynyl, alkoxyalkyl, or acylalkyl group containing from 2 to 9 carbon atoms and optionally substituted by one or more halogen atoms; an aryl or arylalkyl or aryloxyalkyl group comprising at least one aromatic radical and an alkyl chain having from 1 to 4 carbon atoms.
    Type: Grant
    Filed: April 18, 1979
    Date of Patent: August 11, 1981
    Assignee: Labaz
    Inventors: Charles Pigerol, Jean-Claude Vernieres, Pierre Eymard, Jacques Simiand, Madeleine Broll, Jean-Yves Lacolle
  • Patent number: 4264773
    Abstract: The invention relates to 2-(4'-chloro-phenylthio)-benzonitrile, to its process of preparation and to its use for preparing 2-chlorothioxanthone.2-Chloro-thioxanthone prepared from the compound of the invention is useful as a photoinitiator for the reticulation of synthetic resins and as an intermediate for preparing pharmaceuticals.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: April 28, 1981
    Assignee: Labaz
    Inventors: Charles Pigerol, Michel Bouisset, Michel Chignac, Claude Grain
  • Patent number: 4246282
    Abstract: .omega.-Dialkylalkanoic acid derivatives of the formula: ##STR1## in which R.sub.1 and R.sub.2, which can be the same or different, each represent an alkyl radical having from 1 to 4 carbon atoms and n represents 0, 1, 2 or 3.They possess a competitive inhibitory activity with respect to .gamma.-aminobutyric .alpha.-ketoglutaric transaminase as well as antianoxic and anticonvulsant properties and they are useful for treating central neurological disorders, whether resulting or not from cerebral ischemia, and disorders relating to the field of neuropsychiatry.
    Type: Grant
    Filed: June 7, 1979
    Date of Patent: January 20, 1981
    Assignee: Labaz
    Inventors: Michel Chignac, Claude Grain, Fernand Jammot, Charles Pigerol, Pierre L. Eymard, Madeleine Combet (epse Broll)
  • Patent number: 4239893
    Abstract: The instant invention relates to compounds of the general formula: ##STR1## wherein R.sub.1 represents an alkyl, alkenyl, phenylalkyl radical, R.sub.2 represents a straight-chain alkyl, a straight- or branched-chain alkenyl or alkynyl radical, a .omega.-halogenoethyl radical, an optionally substituted benzyl radical, or a radical of the formula R.sub.4 --O--(CH.sub.2).sub.n --wherein n is 2, 3 or 4 and R.sub.4 represents a substituted alkyl radical.The compounds of the foregoing formula have been found to be useful as stabilizers for vinyl resins.
    Type: Grant
    Filed: November 20, 1979
    Date of Patent: December 16, 1980
    Assignee: Labaz
    Inventors: Charles Pigerol, Marie-Madeleine Chandavoine, Paul de C. de Fillain
  • Patent number: 4223041
    Abstract: Urea derivatives of the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which are the same or different, each represent a straight- or branched-chain alkyl, alkenyl or alkynyl radical having from 1 to 5 carbon atoms, R.sub.4 and R.sub.5, which are the same or different, each represent a hydrogen atom or a straight- or branched-chain alkyl, alkenyl or alkynyl radical having from 1 to 5 carbon atoms, R.sub.1, R.sub.2 and R.sub.3 being such that:(a) only one of these radicals can represent an alkenyl or alkynyl group having an unsaturated bond in the .alpha.,.beta.-position with respect to the methylurea radical, in this case, each of the other two substituents represents an alkyl radical,(b) the sum of their carbon atoms is never inferior to 4.They are useful as anxiolytic and antiagressive agents.
    Type: Grant
    Filed: October 25, 1977
    Date of Patent: September 16, 1980
    Assignee: Labaz
    Inventors: Charles Pigerol, Pierre Eymard, Jean-Claude Vernieres, Madeleine Combet epse Broll, Jean-Yves Lacolle
  • Patent number: 4220793
    Abstract: A process for preparing 5-nitro-2-thenoic acid by oxidation of the corresponding aldehyde is described.
    Type: Grant
    Filed: November 14, 1978
    Date of Patent: September 2, 1980
    Assignee: Labaz
    Inventors: Yves Bazile, Paul de Cointet de Fillain, Charles Pigerol
  • Patent number: 4219482
    Abstract: A process for preparing methyl-nitrothenoate and methyl-nitrofuroate by oxidation of the corresponding aldehyde is described.
    Type: Grant
    Filed: November 14, 1978
    Date of Patent: August 26, 1980
    Assignee: Labaz
    Inventors: Yves Bazile, Paul de Cointet de Fillain, Charles Pigerol
  • Patent number: 4209439
    Abstract: Synthetic resin compositions based on vinyl polymers or copolymers are stabilized against degradation by both heat and light by the incorporation therein of a 1,4-dihydropyridine derivative represented by the general formula: ##STR1## wherein R represents a straight or branched-chain saturated or unsaturated alkyl radical containing from 9 to 22 carbon atoms. The stabilizer can be present in an amount of from 0.01 to 0.5 percent by weight, based on the vinyl resin. The vinyl resin may be, for example, polyvinyl chloride, a vinyl chloride-vinyl acetate copolymer or a vinyl chloride-vinylidene chloride copolymer. The stabilized vinyl resins can be used in the manufacture of food packaging materials and containers and also of flooring tiles and recording discs.Some of the dihydropyridine derivatives are novel compounds.
    Type: Grant
    Filed: October 12, 1978
    Date of Patent: June 24, 1980
    Assignee: Labaz
    Inventors: Charles Pigerol, Marie-Madeleine Chandavoine, Paul de Cointet Fillain
  • Patent number: 4209440
    Abstract: This invention relates to new associations of a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 represent a hydrogen atom, an alkyl, alkoxy or hydroxy radical and R represents a hydrogen atom or an alkyl or alkoxy radical, and of a compound of the formula: ##STR2## wherein R.sub.3 represents an alkyl, alkenyl, alkynyl or aralkyl radical or a radical of the formula R.sub.4 --O(CH.sub.2).sub.n --, wherein R.sub.4 represents an alkyl or phenyl radical and n is 2, 3 or 4.The associations according to the invention are stabilizers for vinyl resins.
    Type: Grant
    Filed: October 16, 1978
    Date of Patent: June 24, 1980
    Assignee: Labaz
    Inventors: Charles Pigerol, Marie-Madeleine Chandavoine, Paul de Cointet de Fillain
  • Patent number: 4201725
    Abstract: Methylamine derivatives of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.3 each represent a hydrogen atom or a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 6 carbon atoms, R.sub.2 represents a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 2 to 7 carbon atoms with the proviso that when R.sub.2 represents an alkenyl radical of the formula CH.dbd.CH--R.sub.6 or an alkynyl radical of the formula C.tbd.C--R.sub.6, in which R.sub.6 represents a hydrogen atom or a straight- or branched-chain alkyl radical of 1 to 5 carbon atoms, R.sub.1 and R.sub.3 each represent an atom of hydrogen or an alkyl radical, R.sub.4 and R.sub.5, which are the same or different, each respresent a hydrogen atom, a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 5 carbon atoms or an .omega.-hydroxyalkyl radical containing from 2 to 5 carbon atoms or R.sub.4 and R.sub.
    Type: Grant
    Filed: March 20, 1978
    Date of Patent: May 6, 1980
    Assignee: Labaz
    Inventors: Charles Pigerol, Pierre Eymard, Jean-Claude Vernieres, Jean-Pierre Werbenec, Madeleine C. Epse Broll
  • Patent number: 4186137
    Abstract: 3-Thienyl-acetate derivatives of the general formula: ##STR1## wherein R.sub.1 represents an alkyl, a cycloalkyl or an aralkyl radical, R.sub.2 represents hydrogen or R.sub.1 and R.sub.2, when they are taken together to form a cyclic group with the carbon atom to which they are attached, represent a polymethylene radical having from 2 to 5 carbon atoms, are prepared from a mixture consituted by a compound of the formula: ##STR2## wherein R.sub.3 has the meaning given above and an organic halide of the formula:R.sub.4 Xwherein X represents fluorine, chlorine, bromine or iodine and R.sub.4 represents an alkyl, cycloalkyl or aralkyl radical or --CH.sub.2 (CH.sub.2).sub.n X in which n is an integer in the range of from 1 to 4 inclusive and X has the meaning given above, which mixture is added to an alkali metal hydride in dimethylformamide, at a temperature between -20.degree. C. and -5.degree. C., and allowed to react, in one step, at a temperature between -20.degree. C. and -5.degree. C.
    Type: Grant
    Filed: March 17, 1977
    Date of Patent: January 29, 1980
    Assignee: Labaz
    Inventors: Charles Pigerol, Marie-Madeleine Chandavoine, Michel Chignac, Paul de Cointet de Fillain
  • Patent number: 4173636
    Abstract: The invention relates to decahydroquinoline derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1 represents an alkyl or alkoxy group, a lower dialkylamino group, an optionally substituted phenyl group, a heterocyclic group; R.sup.2 represents an alkyl group, an optionally substituted phenyl group, a naphthyl group, an unsaturated heterocyclic group, an aralkyl group or an alicyclic group; and R.sup.3 represents a substituted furyl group, an aralkyl group or a group represented by the general formula: ##STR2## wherein A represents an alkylene group; Y represents an oxygen or sulphur atom, a carbonyl, carbonyl-hydroxyimino, carbonyl-hydrazono or sulphoxide group, or a group; ##STR3## n is O or an integer of from 1 to 4, with the proviso that when n is O, Y represents a carbonyl group; and R.sup.4 and R.sup.5, which are identical or different, each represent hydrogen, a halogen atom or a methyl, methoxy or acetyl group.
    Type: Grant
    Filed: March 8, 1978
    Date of Patent: November 6, 1979
    Assignee: Labaz
    Inventor: Maurice Prost
  • Patent number: 4170643
    Abstract: Novel aminoglycoside-aminocyclitol derivatives corresponding to the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which are different, represent hydrogen or CH.sub.2 NH.sub.2 and R is selected from the group consisting of: ##STR2## wherein R.sub.3 represents NH.sub.2 or OH and R.sub.4 represents ##STR3## wherein R.sub.5 represents hydrogen or methyl and the pharmaceutically acceptable acid addition salts thereof.They are useful as antibiotics.
    Type: Grant
    Filed: April 13, 1977
    Date of Patent: October 9, 1979
    Assignee: Labaz
    Inventors: Stephan Gero, Daniel Mercier, Alain Olesker, Andre Cier
  • Patent number: 4155929
    Abstract: Process for the preparation of di-n-propyl acetonitrile of the formula: ##STR1## whereby, in a single step, sodium n-propylate in n-propanol medium is added to a reaction medium which is formed of a cyanacetate of general formula: ##STR2## in which R represents an alkyl radical having from 1 to 4 carbon atoms, and n-propyl bromide or iodide, the alkylation reaction taking place under reflux, the crude ester obtained is saponified with a 10 to 20% solution of sodium hydroxide or potassium hydroxide, the resulting salt is acidified with a strong acid, to give crude di-n-propyl cyanacetic acid, which is decarboxylated by heating at a temperature between 140.degree. C. and 190.degree. C., so as to obtain the di-n-propyl acetonitrile.
    Type: Grant
    Filed: May 10, 1978
    Date of Patent: May 22, 1979
    Assignee: Labaz
    Inventors: Michel Chignac, Claude Grain, Charles Pigerol
  • Patent number: 4139634
    Abstract: Indole derivatives of the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl radical, R.sub.2 and R.sub.3, which are the same or different, each represent a hydrogen atom, a methyl or ethyl radical, a benzyl radical or represent together a pentamethylene, hexamethylene, oxydiethylene or N-methylaminodiethylene chain, forming thus a cycle with the nitrogen atom, R.sub.4 represents a phenyl, 2', 4'-dimethyl-phenyl, isopropyl, cyclopropyl, 1-methyl-cyclopropyl, cyclopentyl or cyclohexyl radical, R.sub.5 represents a hydrogen atom, a branched- or straight-chain alkyl radical containing from 1 to 3 carbon atoms, a methylthio or ethylthio radical or a straight-chain acyl radical containing from 2 to 6 carbon atoms, R.sub.6 represents a hydrogen atom or a halogen atom, a methyl, methoxy, hydroxy, carboxy, nitro, amino, methylamino or dimethylamino radical, R.sub.7 represents a hydrogen atom or a halogen atom and n is 1 or 2, with the proviso that two at least of the groups R.sub.5, R.sub.
    Type: Grant
    Filed: May 20, 1977
    Date of Patent: February 13, 1979
    Assignee: Labaz
    Inventors: Charles Pigerol, Paul DE Cointet de Fillain, Pierre Eymard, Jean-Pierre Werbenec, Madeleine Broll
  • Patent number: 4134909
    Abstract: The invention relates to new compounds of the general formula : ##STR1## wherein X represents a hydrogen or halogen atom, R.sub.1 and R.sub.2, which are the same or different, each represent a hydrogen atom or a methoxy radical and R.sub.3 represents an alkyl or aryl radical, with the proviso that at least one of the substituents R.sub.1 and R.sub.2 is not a hydrogen atom.The compounds of formula I are useful for preparing stabilizers for thermoplastic resins.
    Type: Grant
    Filed: June 29, 1977
    Date of Patent: January 16, 1979
    Assignee: Labaz
    Inventors: Charles Pigerol, Paul DE Cointet de Fillain, Yves Bazile, Michel Chignac, Claude Grain
  • Patent number: RE30655
    Abstract: 3-Thienyl-acetate derivatives of the general formula: ##STR1## wherein R.sub.1 represents an alkyl, a cycloalkyl or an aralkyl radical, R.sub.2 represents hydrogen or R.sub.1 and R.sub.2, when they are taken together to form a cyclic group with the carbon atom to which they are attached, represent a polymethylene radical having from 2 to 5 carbon atoms, are prepared from a mixture consituted by a compound of the formula: ##STR2## wherein R.sub.3 has the meaning given above and an organic halide of the formula:R.sub.4 Xwherein X represents fluorine, chlorine, bromine or iodine and R.sub.4 represents an alkyl, cycloalkyl or aralkyl radical or --CH.sub.2 (CH.sub.2).sub.n X in which n is an integer in the range of from 1 to 4 inclusive and X has the meaning given above, which mixture is added to an alkali metal hydride in dimethylformamide, at a temperature between -20.degree. C. and -5.degree. C., and allowed to react, in one step, at a temperature between -20.degree. C. and -5.degree. C.
    Type: Grant
    Filed: June 27, 1980
    Date of Patent: June 23, 1981
    Assignee: Labaz
    Inventors: Charles Pigerol, Marie-Madeleine Chandavoine, Michel Chignac, Paul de Cointet de Fillain
  • Patent number: RE31260
    Abstract: Process for the preparation of di-n-propyl acetonitrile of the formula: ##STR1## whereby, in a single step, sodium n-propylate in n-propanol medium is added to a reaction medium which is formed of a cyanacetate of general formula: ##STR2## in which R represents an alkyl radical having from 1 to 4 carbon atoms, and n-propyl bromide or iodide, the alkylation reaction taking place under reflux, the crude ester obtained is saponified with a 10 to 20% solution of sodium hydroxide or potassium hydroxide, the resulting salt is acidified with a strong acid, to give crude di-n-propyl cyanacetic acid, which is decarboxylated by heating at a temperature between 140.degree. C. and 190.degree. C., so as to obtain the di-n-propyl acetonitrile.
    Type: Grant
    Filed: June 27, 1980
    Date of Patent: May 31, 1983
    Assignee: Labaz
    Inventors: Michel Chignac, Claude Grain, Charles Pigerol