Patents Assigned to Labaz
  • Patent number: 4025649
    Abstract: Acetic acid derivatives of the formula: ##STR1## and pharmaceutically acceptable alkali metal salts thereof, wherein R represents the radical ##STR2## in which R.sub.1 and R.sub.2, which may be the same or different, each represent an alkyl radical having from 1 to 4 carbon atoms, R.sub.3 represents a hydrogen atom or a methyl radical and n is an integer in the range of from 0 to 3 inclusive.They possess a competitive inhibitory activity with respect to .gamma.-aminobutyric .alpha.-ketoglutaric transaminase as well as antianoxic and anticonvulsant properties and they are useful for treating central neurological disorders whether resulting or not from cerebral ischemia.
    Type: Grant
    Filed: June 18, 1975
    Date of Patent: May 24, 1977
    Assignee: Labaz
    Inventors: Georges Marcel Taillandier, Jean-Louis Alain Benoit-Guyod, Andre Louis Boucherle, Pierre Luc Eymard, Madeleine Broll, Bernard Ferrandes
  • Patent number: 4024155
    Abstract: New stabilizers of polymers and co-polymers of vinyl chloride, the said stabilizers being 2-phenyl-indole derivatives corresponding to the formula: ##STR1## wherein R.sub.1 and R.sub.2, which are the same or different, each represent a branched- or straight-chain alkyl group containing from 1 to 12 carbon atoms, a cyclohexyl radical, a branched- or straight-chain alkyloxy group containing from 1 to 12 carbon atoms, a benzyloxy radical, a hydroxy radical or R.sub.1 and R.sub.2 represent together an alkylenedioxy radical containing from 1 to 3 carbon atoms, R.sub.3 represents a hydrogen atom, a methyl or methoxy radical, with the proviso that one at least of the substituents R.sub.1 or R.sub.2 does not represent an alkyl radical.
    Type: Grant
    Filed: May 30, 1975
    Date of Patent: May 17, 1977
    Assignee: Labaz
    Inventors: Charles Pigerol, Marie-Madeleine Chandavoine, Paul de Cointet DE Fillain, Souli Nanthavong
  • Patent number: 4012394
    Abstract: 3-Indolyl pyridyl ketones of the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof wherein R.sub.1 representsA straight- or branched-chain saturated or unsaturated alkyl group having not more than 6 carbon atoms, a benzyl group optionally substituted in the aromatic portion by a chlorine atom or a methoxy groupOr ##STR2## wherein A represents an alkylene chain of from 2 to 6 carbon atoms and R.sub.4 and R.sub.5, which may be the same or different, are each an alkyl group having from 1 to 5 carbon atoms, or R.sub.4 and R.sub.5 are joined together to form with the nitrogen atom a piperidino, pyrrolidino or morpholino group,R.sub.2 representsA branched-or straight-chain alkyl group having from 1 to 4 carbon atoms, a phenyl group optionally substituted by a fluorine, chlorine, or bromine atom or a methoxy or cyclohexyl group; andR.sub.3 representsA 2-pyridyl, 3-pyridyl or 4-pyridyl group.They are effective as fibrinolytic and anti-inflammatory agents.
    Type: Grant
    Filed: August 4, 1975
    Date of Patent: March 15, 1977
    Assignee: Labaz
    Inventors: Marcel Descamps, Henri Inion
  • Patent number: 4007204
    Abstract: Novel benzo[b]thiophene derivatives corresponding to the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R represents a branched- or straight-chain alkyl group containing from 1 to 4 carbon atoms, or a cyclohexyl group, n is an integer in the range of from 3 to 6 inclusive, and Am represents a dimethylamino, diethylamino, di-n-propylamino or di-n-butylamino group.These derivatives are useful for the treatment of pathological conditions of the heart and in particular angina pectoris.
    Type: Grant
    Filed: April 21, 1975
    Date of Patent: February 8, 1977
    Assignee: Labaz
    Inventors: Marcel Descamps, Jean Gubin
  • Patent number: 3988472
    Abstract: Tri-n-propylacetamide and tri-n-propylacetic acid salts are useful in the treatment of pathological variations of mood and as anticonvulsants and tranquillizers.
    Type: Grant
    Filed: November 10, 1975
    Date of Patent: October 26, 1976
    Assignee: Labaz
    Inventors: Charles Pigerol, Pierre Luc Eymard
  • Patent number: 3984470
    Abstract: Amidoxime derivatives corresponding to the general formula: ##EQU1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.2, which are the same or different, represent hydrogen or a straight-chain lower alkyl radical containing from 1 to 3 carbon atoms, n is 0, 1 or 2 and R is selected from the groups consisting of: ##SPC1##Wherein X represents oxygen or sulphur, Y . . . Z represents HC--CH or C=C, R.sub.3 and R.sub.4, which are the same or different, represent hydrogen or a branched- or straight-chain lower alkyl radical containing from 1 to 3 carbon atoms with the provisos that:A. when n is 1, R.sub.1 and R.sub.2 are each hydrogen and R is selected from the groups A, B, C and D.b. when n is 2, R.sub.1 and R.sub.2 area each hydrogen and R is selected from the groups A, B, C and the group D when it represents .beta.-naphthyl.They are effective as antidepressive and antiaggressive agents.
    Type: Grant
    Filed: July 28, 1975
    Date of Patent: October 5, 1976
    Assignee: Labaz
    Inventors: Fernand Binon, Pierre Luc Eymard
  • Patent number: 3958011
    Abstract: Tri-n-propylacetic acid and its alkali metal salts are useful in the treatment of central neurological troubles due to or accompanied by cerebral ischemia and as tranquillizers.
    Type: Grant
    Filed: March 31, 1975
    Date of Patent: May 18, 1976
    Assignee: Labaz
    Inventors: Charles Pigerol, Pierre Luc Eymard
  • Patent number: 3952027
    Abstract: Cyclohexanediol derivatives of the general formula: ##SPC1##Wherein R.sub.1 and R.sub.2, which are identical, each represent a N.sub.3 or NH.sub.2 group, and the acid addition salts of the derivative containing two NH.sub.2 groups.These compounds are useful as intermediate products for the preparation, for example, of synthetic antibiotics.
    Type: Grant
    Filed: January 31, 1975
    Date of Patent: April 20, 1976
    Assignee: Labaz
    Inventors: Andre Cier, Stephan Gero, Alain Olesker, Jean Leboul
  • Patent number: 3949087
    Abstract: A method of suppressing seborrhea whereby there is applied to the affected area a composition containing as active principle in a nontoxic vehicle .alpha.,l-carnitine chloride or l-carnitine chloride or a mixture of these two substances.
    Type: Grant
    Filed: August 5, 1974
    Date of Patent: April 6, 1976
    Assignee: Labaz
    Inventors: Zenon Bacq, Fernand Binon
  • Patent number: 3946029
    Abstract: 3-Indolyl pyridyl ketones of the general formula: ##SPC1##And pharmaceutically acceptable acid addition salts thereof wherein R.sub.1 representsA straight- or branched-chain saturated or unsaturated alkyl group having not more than 6 carbon atoms, a benzyl group optionally substituted in the aromatic portion of a chlorine atom or a methoxy groupOr ##EQU1## wherein A represents an alkylene chain of from 2 to 6 carbon atoms and R.sub.4 and R.sub.5, which may be the same or different, are each an alkyl group having from 1 to 5 carbon atoms, or R.sub.4 and R.sub.5 are joined together to form with the nitrogen atom a piperidino, pyrrolidino or morpholino group,R.sub.2 representsA branched- or straight-chain alkyl group having from 1 to 4 carbon atoms, a phenyl group optionally substituted by a fluorine, chlorine, or bromine atom or a methoxy or cyclohexyl group; andR.sub.3 representsA 2-pyridyl, 3-pyridyl or 4-pyridyl group.They are effective as fibrinolytic and anti-inflammatory agents.
    Type: Grant
    Filed: January 31, 1974
    Date of Patent: March 23, 1976
    Assignee: Labaz
    Inventors: Margel Descamps, Henri Inion
  • Patent number: 3931240
    Abstract: Amidoxime derivatives corresponding to the general formula: ##EQU1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.2, which are the same or different, represent hydrogen or a straight- chain lower alkyl radical containing from 1 to 3 carbon atoms, n is 0, 1 or 2 and R is selected from the groups consisting of:Wherein X represents oxygen or sulphur, Y. . .Z represents HC-CH or C=C, R.sub.3 and R.sub.4, which are the same or different, represent hydrogen or a branched- or straight-chain lower alkyl radical containing from 1 to 3 carbon atoms with the provisos that:A. when n is 1, R.sub.1 and R.sub.2 are each hydrogen and R is selected from the groups A, B, C and D.b. when n is 2, R.sub.1 and R.sub.2 are each hydrogen and R is selected from the groups A, B, C and the group D when it represents .beta.-naphthyl.They are effective as antidepressive and antiaggressive agents.
    Type: Grant
    Filed: December 6, 1974
    Date of Patent: January 6, 1976
    Assignee: Labaz
    Inventors: Fernand Binon, Pierre Luc Eymard