Abstract: The invention concerns a composition containing at least an oxazolin, optionally combined with at least a compound such as a metalloprotease inhibitor, a PKC inhibitor, an anti-inflammatory agent, a soothing agent, an immunosuppressor, an ion chelating agent, an alkanolamide, an oxazolidinone and a carbamic acid derivative. The invention also concerns the use of such a composition as medicine, in particular for preventing or treating skin pathologies of allergic and/or inflammatory and/or irritative origin or resulting from a danger signal. The invention further concerns a method for cosmetic treatment of sensitive, irritated, intolerant, allergy-prone, ageing skin and/or mucosa exhibiting skin barrier disorder, or exhibiting non-pathological immunologic imbalance, which consists in applying such composition on the skin and/or mucosa.
Type:
Grant
Filed:
December 27, 2002
Date of Patent:
August 7, 2012
Assignee:
Laboratoires Expanscience
Inventors:
Philippe Msika, Nathalie Piccardi, Antoine Piccirilli
Abstract: The present invention concerns the use of a rice protein hydrolysate in order to pigment the skin and skin appendages. Thus, it is possible to intensify the normal pigmentation of the skin without sunlight. Preferred areas of applications are repigmentation of white patches of the skin, repigmentation of white patches of the skin as a consequence of pityriasis or due to the use of dermocorticoids; acceleration and intensification of the tanning process, stimulation of the constitutive photoprotection and improvement of the phototype, prevention of skin photocarcinogenesis. Advantageously, the rice protein hydrolysate comprises peptides of which at least 50% have a molecular mass in the range of between 300 and 3,500 Da.
Abstract: The invention concerns the use of at least a vegetable oil product selected among the group consisting of vegetable oil oleic distillates, vegetable oil unsaponifiable matters, vegetable oil furan lipids and mixtures thereof, as agents for increasing skin lipid synthesis, in particular lipids of the epidermal skin barrier, in or for preparing a composition containing a pharmaceutically or dermatologically acceptable medium. The use enables to prevent and/or treat deterioration of the skin barrier (dry skin, skin subjected to actinic radiation, ichthyosis, acne, xerosis, atopic dermatitis, sensitive skin, chafing and reactive skin, itching and the like).
Abstract: The present invention relates to the use of a plant oil product as an agent for increasing the synthesis of skin lipids, especially the lipids of the epidermal skin barrier, in or for the preparation of a cosmetic, pharmaceutical or dermatological composition. The invention also relates to a method for cosmetic treatment with a cosmetic, pharmaceutical or dermatological composition for increasing the synthesis of skin lipids, especially the lipids of the epidermal skin barrier, and to the use of the plant product as a food additive.
Abstract: The invention relates to the use of a compound comprising D-mannoheptulose and/or perseitol for producing a drug for treating and/or preventing diseases related to the modification of an innate and/or acquired immunity by increasing the production of antimicrobial peptides, preferably hBD-2 without inducing inflammatory reactions, irritation or intolerance. Said compound can also comprise a peptidic avocado extract and/or a peptidic lupin extract.
Type:
Grant
Filed:
April 29, 2005
Date of Patent:
March 1, 2011
Assignee:
Laboratoires Expanscience
Inventors:
Antoine Piccirilli, Nathalie Piccardi, Philippe Msika, François Paul, Stéphanie Bredif
Abstract: The invention relates to a medicament which comprises a peptide extract of avocado and which can also comprise a composition containing D-mannoheptulose and/or perseitol, such as a water-soluble extract of avocado sugars, and/or a peptide extract of lupine. The inventive medicament is intended for the treatment and/or prevention of illnesses that are linked to an alteration in innate and/or acquired immunity, through an increase in the production of anti-microbial peptides, preferably hBD-2, without inducing inflammatory reactions, irritations or intolerances.
Type:
Grant
Filed:
April 29, 2005
Date of Patent:
November 16, 2010
Assignee:
Laboratoires Expanscience
Inventors:
Antoine Piccirilli, Nathalie Piccardi, Philippe Msika, François Paul, Stéphanie Bredif
Abstract: The present invention concerns a process for producing refined avocado oil rich in triglycerides. The invention also pertains to refined avocado oil rich in triglycerides obtainable by said process. Advantageously, the refined avocado oil of the invention contains a sterols-enriched unsaponifiable fraction. Advantageously, the refined avocado oil of the invention is substantially free of acetogenins and furanic lipids. The invention also concerns compositions containing said oil. The invention also pertains to such compositions for use as a medication, as a dermatological agent, as a cosmetic agent, or as a nutriceutical, for human or animal use.
Abstract: The invention relates to the cosmetic use of a composition containing at least one oxazoline, serving as an active substance, as a slimming product, and to an associated cosmetic treatment method. The invention also relates to the cosmetic use of a composition containing at least one oxazoline, serving as an active substance, for preventing and/or treating cellulite.
Type:
Grant
Filed:
June 17, 2004
Date of Patent:
December 8, 2009
Assignee:
Laboratoires Expanscience
Inventors:
Philippe Msika, Antoine Piccirilli, Nathalie Piccardi
Abstract: The present invention relates to the use of a plant oil product as an agent for increasing the synthesis of skin lipids, especially the lipids of the epidermal skin barrier, in or for the preparation of a cosmetic, pharmaceutical or dermatological composition. The invention also relates to a method for cosmetic treatment with a cosmetic, pharmaceutical or dermatological composition for increasing the synthesis of skin lipids, especially the lipids of the epidermal skin barrier, and to the use of the plant product as a food additive.
Abstract: The invention relates to the use of one or several synthetic or natural furan alkyls for preparing a drug preventing and/or treating obesity or overweight. The use of one or several synthetic or natural furan alkyls for cosmetically treating local excessive weight is also disclosed. Said furan alkyls preferably correspond to formula (I), wherein identical or different R1, R2, R3et R4 are independently of each other a hydrogen atom, a C1-C35alkyl radical, C1-C35 alcenyl radical or a C1-C35 alcynyl radical, preferably C10-C22, wherein said alkyl, alcenyl and alcynyl radicals are substitutable and R1, R2, R3 are preferably a hydrogen atom.
Type:
Grant
Filed:
May 27, 2005
Date of Patent:
September 15, 2009
Assignee:
Laboratoires Expanscience
Inventors:
Antoine Piccirilli, Philippe Msika, Nathalie Piccardi
Abstract: The invention concerns a pharmaceutical or cosmetic composition, characterised in that it comprises at least a compound for inhibiting Langerhans' cell migration, said active compound being selected in the group consisting of protein kinase C (PKC) inhibiting compounds, matrix metalloprotease (MMP) inhibiting compounds, and combinations thereof, and at least a pharmaceutically or cosmetically acceptable carrier. Said composition enables to inhibit considerably Langerhans' cell migration induced by the presence or an allergenic agent.
Type:
Grant
Filed:
November 14, 2001
Date of Patent:
March 31, 2009
Assignee:
Laboratoires Expanscience
Inventors:
Philippe Msika, Nathalie Piccardi, Antoine Piccirilli
Abstract: The invention relates to a method for extracting substances from maca, to the obtained extract, to a cosmetic and pharmaceutical composition containing said extract, and to the use thereof as an anti-aging cosmetic agent. The method is characterized by a step involving the use of an enzymatic hydrolysis of proteins.
Type:
Grant
Filed:
June 17, 2004
Date of Patent:
January 6, 2009
Assignee:
Laboratoires Expanscience
Inventors:
Nathalie Piccardi, Antoine Piccirilli, Philippe Msika, François Paul
Abstract: The invention relates to the use of at least one unsaponifiable component of vegetable oil, in particular of avocado, soya bean and/or lupin oils, for the preparation of a medicament intended to stimulate the expression of TGF-? or the expression of the plasminogen activator inhibitor PAI-1. The invention also relates to a method of cosmetic treatment comprising the application of at least one unsaponifiable component of vegetable oil as well as the use of the latter as additive in a food for human beings and/or for animals.
Type:
Grant
Filed:
July 15, 2003
Date of Patent:
November 11, 2008
Assignee:
Laboratoires Expanscience
Inventors:
Karim Boumediene, Jean-Pierre Pujol, Georges Bernard Guillou, Philippe Msika, Chafik Ghayor
Abstract: The present invention relates to a process for obtaining a furan lipid-rich unsaponifiable material from avocado, which comprises the successive steps (1) of controlled dehydration of fresh avocados or of avocados that have undergone preliminary transformations, (2) of extraction of the oil from dehydrated fruit, (3) of a heat treatment of the extracted oil and of a step of concentration of the unsaponifiable fraction of the oil or alternately, these two operations possibly being carried out successively in this order or in the reverse order, and finally (4) a step of saponification and of extraction of the unsaponifiable material.
Abstract: The invention concerns the use of at least an oil derived from the seeds of the gourd family selected from the group consisting of Lagenaria, Luffa and Momordica, for preparing a composition designed to inhibit 5?-reductase activity, and the use of said oil for preparing a composition for treating prostatic hypertrophy, prostatic adenoma, acne, hyperseborrhea, alopecia, and hirsutism. The invention also concerns cosmetic treatment methods, in particular for greasy skin. The invention further concerns the use of at least an oil derived from seeds of the gourd family in a nutritional food composition for humans and/or animals as additive for inhibiting 5? reductase activity.
Type:
Grant
Filed:
July 1, 2002
Date of Patent:
July 3, 2007
Assignee:
Laboratoires Expanscience
Inventors:
Antoine Piccirilli, Jacqueline Smadja, Philippe Msika, Isabelle Grondin, Nathalie Piccardi
Abstract: The present invention relates to a process for obtaining a furan lipid-rich unsaponifiable material from avocado, which comprises the successive steps (1) of controlled dehydration of fresh avocados or of avocados that have undergone preliminary transformations, (2) of extraction of the oil from dehydrated fruit, (3) of a heat treatment of the extracted oil and of a step of concentration of the unsaponifiable fraction of the oil or alternately, these two operations possibly being carried out successively in this order or in the reverse order, and finally (4) a step of saponification and of extraction of the unsaponifiable material.
Abstract: The invention concerns a cosmetic or dermatological composition for protection against ultraviolet radiation, based on inorganic screening agent, characterized in that it comprises a water-in-oil emulsion containing a combination of at least a particulate inorganic sunscreening agent, selected among the group consisting of titanium dioxide, zinc oxide and mixtures thereof, and at least an emulsifier selected among the group consisting of silicone derivatives with glycosidic constituent, the particulate screening agent being homogeneously dispersed in the water-in-oil emulsion.
Type:
Grant
Filed:
April 4, 2001
Date of Patent:
July 19, 2005
Assignee:
Laboratoires Expanscience
Inventors:
Jean-Christophe Choulot, Nathalie Petit, Philippe Msika, Patricia Ferraris, Delphine Ribes, Jocelyne Hilaire, Bernard Ribes
Abstract: The invention concerns a method for preparing a fatty substance ester, characterised in that it consists in subjecting to an esterification reaction at least a fatty substance with at least an alcohol compound selected from the group consisting of sterols, stanols, 4-methylsterols and their hydrogenated homologous, triterpene alcohols and their hydrogenated homologues, and mixtures thereof, in the presence of at least a solid catalyst selected in the group consisting of lanthanide oxides and the mixtures of said oxides.
Type:
Grant
Filed:
January 21, 2003
Date of Patent:
December 7, 2004
Assignee:
Laboratoires Expanscience
Inventors:
Joë Barrault, Mickaël Boisseau, Yannick Pouilloux, Antoine Piccirilli
Abstract: The invention concerns a method for extracting usaponifiable matters from a vegetable oil comprising at least a saponification step whereby the oil is transformed into a hydro alcoholic solution, a step for extracting the hydro alcoholic solution with a organic solvent such as chloro-1-butane, preferably the treated vegetable oil is avocado or soya oil.
Type:
Grant
Filed:
July 12, 2002
Date of Patent:
July 6, 2004
Assignee:
Laboratoires Expanscience
Inventors:
Sandrine Bardet, Jacques Legrand, Antoine Piccirilli