Abstract: Disclosed are high-throughput vessel supply systems and methods of supplying sample vessels, such as samples stored in test tubes. A system for supplying a plurality of individual vessels that each contains a sample is disclosed.

Abstract: Disclosed are high-throughput vessel sorting systems and methods of sorting sample vessels, such as samples stored in test tubes. A system for sorting a plurality of individual vessels that each contains a sample is disclosed.

Abstract: In certain embodiments, the invention stems from the discovery that analysis of population distribution curves of metabolite levels in blood can be used to facilitate predicting risk of autism spectrum disorder (ASD) and/or to differentiate between ASD and non-ASD developmental delay (DD) in a subject. In certain aspects, information from assessment of the presence, absence, and/or direction (upper or lower) of a tail effect in a metabolite distribution curve is utilized to predict risk of ASD and/or to differentiate between ASD and DD.

Abstract: Disclosed herein are methods for the production of mutant bacteriophages with altered host range. Additionally, disclosed herein are methods and systems for rapid detection of microorganisms such as Listeria spp. in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Listeria-specific bacteriophage, allows detection of a specific microorganism, such as Listeria spp. and an indicator signal may be amplified to optimize assay sensitivity.

Abstract: Methods of LC-MS analysis of oligonucleotides free of ion-pairing reagents are disclosed herein. Historically, ion-pairing reagents have been used for acceptable extraction and chromatography prior to mass spectral analysis. The disclosure herein presents methods free of ion-pairing reagents at each stage, from extraction through the LC-MS endpoint. Also disclosed herein are systems for performing these methods.

Abstract: A self-documenting clinical trial operations system and service suite and method, with a clinical trial operation software, a coordinator application and coordinator portal, providing information for the clinical trial operation software, a trial design services module, examining a trial design provided by a coordinator and automatically generating a software specification for a trial operations service suite, a patient application and patient portal generated from the trial design services module, for providing patient information for the clinical trial operation software, a customization option to customize at least one of the patient application and patient portal, a specification option to generate a specification document describing a design of a coordinator-customized patient application, wherein the customization and specification options are provided to the coordinator via the coordinator portal.

Abstract: Disclosed herein are methods and systems for rapid detection of microorganisms such as bacteria in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene encoding one subunit of an indicator protein. The specificity of the bacteriophage allows detection of a particular bacteria of interest and an indicator signal may be amplified to optimize assay sensitivity.

Abstract: Disclosed are methods and systems and computer program products for determining DPB1 expression without the need for rs9277534 (3? UTR) sequence data. Such methods are useful in assessing HLA sequencing submitted to or already in donor databases for matches that will reduce the risk of hematopoietic transplant rejection (i.e., graft vs. host disease).

Abstract: A system includes a learning filter for deidentified healthcare data. The system provides self-improving data filtering of data for the detection of disorders for engaging patients in observational research to gather additional data. A processor performs operations including obtaining patient information about a patient and current order data. The current order data indicates an order for a laboratory test for the patient and obtaining, from a database, historical data indicating a previous laboratory test for the patient and a result of the previous laboratory test. The operations further include determining that the patient is a subject of interest for a disorder by applying the filter to historical data to produce filtered data and comparing the filtered data to a profile associated with the disorder. Additional laboratory tests can be performed, after which a hash-to-patient identifier (PID) mapping database and the filter can be updated.

Abstract: The present invention relates generally to methods of accurately quantifying HER2 and/or p95 expression in subjects with a HER2 positive cancer and indicating the risk of brain relapse in such patients.

Abstract: A self-documenting clinical trial operations system and service suite and method, with a clinical trial operation software, a coordinator application and coordinator portal, providing information for the clinical trial operation software, a trial design services module, examining a trial design provided by a coordinator and automatically generating a software specification for a trial operations service suite, a patient application and patient portal generated from the trial design services module, for providing patient information for the clinical trial operation software, a customization option to customize at least one of the patient application and patient portal, a specification option to generate a specification document describing a design of a coordinator-customized patient application, wherein the customization and specification options are provided to the coordinator via the coordinator portal.

Abstract: Disclosed herein are methods and systems for rapid detection of microorganisms such as bacteria in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene encoding one subunit of an indicator protein. The specificity of the bacteriophage allows detection of a particular bacteria of interest and an indicator signal may be amplified to optimize assay sensitivity.

Abstract: A method of diagnosing bacterial vaginosis in a woman, which involves determining an amount of each of more than one BV-associated bacterium in a vaginal sample obtained from the female and assessing a BV status of the female based on the amount of each of the more than one BV-associated bacterium in the sample

Abstract: Disclosed are methods, devices and systems for the isolation and detection of biomolecules from a sample. The embodiments, detection of such biomolecules provides for detection of microorganisms. For example, disclosed are methods, devices and systems that use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. The devices, systems and methods of the invention may allow for the detection of certain biomolecules peptides and ions in real time using minute amounts of sample.

Abstract: Disclosed are methods, systems, and computer program products for using liquid chromatography/tandem mass spectrometry (LC-MS/MS) for the analysis of endogenous biomarkers, such as 11-oxo androgens, in a sample. The 11-oxo androgens may comprise at least one of 11-hydroxyandrostendione (11OHA), 11-hydroxytestosterone (11OHT) or 11-ketotestosterone (11KT). More specifically, the methods, systems, and computer program products are described for detecting and quantifying the amount of an 11-oxo-androgen in a sample.

Abstract: Systems, methods, and media for laboratory testing services are disclosed. A request for an electronic form can be received from an electronic device. A customized electronic form can be sent to the electronic device. The electronic form may be customized based at least in part on a healthcare provider associated with the request. At least one laboratory test may be requested to be ordered for at least one patient associated with the healthcare provider. At least one predefined rule may be applied to the requested order to verify that the order is valid. At least one laboratory can be selected to perform the ordered laboratory tests. Specimen collection information may be sent to a collection facility and can be based at least in part on rules or preferences of a lab selected to perform a laboratory test. Customized test reports can be provided to a healthcare provider.

Abstract: A system includes a learning filter for deidentified healthcare data. The system provides self-improving data filtering of data for the detection of disorders for engaging patients in observational research to gather additional data. A processor performs operations including obtaining patient information about a patient and current order data. The current order data indicates an order for a laboratory test for the patient and obtaining, from a database, historical data indicating a previous laboratory test for the patient and a result of the previous laboratory test. The operations further include determining that the patient is a subject of interest for a disorder by applying the filter to historical data to produce filtered data and comparing the filtered data to a profile associated with the disorder. Additional laboratory tests can be performed, after which a hash-to-patient identifier (PID) mapping database and the filter can be updated.

Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).

Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease activity, for prediction of risk for progressive spinal and joint damage, in particular for axial spondyloarthritis (axSpA) and ankylosing spondylitis (AS), and for generating a dataset are provided, along with kits for measuring expression of the biomarkers. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.

Abstract: Disclosed are high-throughput vessel receiving systems and methods of receiving sample vessels, such as samples stored in test tubes. A system for receiving a plurality of individual vessels that each contains a sample, and systems and apparatus for guiding, reorienting, collecting, and transporting a plurality of articles, including vessels, are disclosed.