Abstract: Disclosed are methods and systems for the quantification of AngI and/or determination of plasma renin activity in a sample. The methods and systems disclosed herein can be useful for diagnosis of hypertension, aldosteronism and other abnormalities of the renin angiotensin aldosterone system (RAAS).
Type:
Application
Filed:
April 8, 2021
Publication date:
August 12, 2021
Applicant:
Laboratory Corporation of America Holdings
Inventors:
William O. Slade, Jr., Russell Philip Grant, Christopher Michael Shuford
Abstract: Disclosed herein are methods and systems for rapid detection of microorganisms in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as CBA120, allows detection of a specific microorganism, such as E. coli O157:H7, and an indicator signal may be amplified to optimize assay sensitivity.
Type:
Application
Filed:
February 8, 2021
Publication date:
August 5, 2021
Applicant:
Laboratory Corporation of America Holdings
Inventors:
Jose S. Gil, Stephen Erickson, Ben Barrett Hopkins, Minh Mindy Bao Nguyen, Dwight Lyman Anderson
Abstract: Methods are provided for a sensitive and specific assay for the determination of viral load and genotyping of RSV in a biological sample. Compositions and kits for use in the methods also are provided, including optimized primers for the amplification of and detection of the RSV open reading frames from subtypes A and B, and probes for distinguishing between the subtypes. Also provided are methods for amplifying and sequencing an open reading from of an RSV F protein, and compositions and kits for use in the methods.
Type:
Application
Filed:
June 22, 2020
Publication date:
June 17, 2021
Applicant:
Laboratory Corporation of America Holdings
Abstract: Disclosed are methods and systems for the quantification of AngI and/or determination of plasma renin activity in a sample. The methods and systems disclosed herein can be useful for diagnosis of hypertension, aldosteronism and other abnormalities of the renin angiotensin aldosterone system (RAAS).
Type:
Grant
Filed:
November 17, 2017
Date of Patent:
May 18, 2021
Assignee:
Laboratory Corporation of America Holdings
Inventors:
William O. Slade, Jr., Russell Philip Grant, Christopher Michael Shuford
Abstract: Disclosed are methods and systems for the analysis activity of enzyme disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) in a sample. The methods and systems disclosed herein can be useful for diagnosis of thrombotic thrombocytopenic purpura in a patient.
Type:
Application
Filed:
November 4, 2020
Publication date:
March 4, 2021
Applicant:
Laboratory Corporation of America Holdings
Inventors:
Russell Philip Grant, Christopher Michael Shuford, Meghan Norris Bradley
Abstract: Disclosed herein are methods and systems for rapid detection of microorganisms in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as CBA120, allows detection of a specific microorganism, such as E. coli O157:H7, and an indicator signal may be amplified to optimize assay sensitivity.
Type:
Grant
Filed:
January 18, 2017
Date of Patent:
February 9, 2021
Assignee:
Laboratory Corporation of America Holdings
Inventors:
Jose S. Gil, Stephen Erickson, Ben Barrett Hopkins, Minh Mindy Bao Nguyen, Dwight Lyman Anderson
Abstract: The present invention provides novel mutations identified in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that can be used for a more accurate diagnosis of cystic fibrosis (CF) and CF related disorders. Methods for testing a sample obtained from a subject to determine the presence of one or more mutations in the CFTR gene are provided wherein the presence of one or more mutations indicates that the subject has CF or a CF related disorder, or is a carrier of a CFTR mutation.
Type:
Grant
Filed:
January 22, 2019
Date of Patent:
December 15, 2020
Assignee:
Laboratory Corporation of America Holdings
Inventors:
Elizabeth Rohlfs, Deborah Alexa Sirko-Osadsa, Lynne Rosenblum, Narasimhan Nagan, Zhaoqing Zhou, Ruth Heim
Abstract: Disclosed are methods and systems for the analysis activity of enzyme disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) in a sample. The methods and systems disclosed herein can be useful for diagnosis of thrombotic thrombocytopenic purpura in a patient.
Type:
Grant
Filed:
October 11, 2017
Date of Patent:
December 8, 2020
Assignee:
Laboratory Corporation of America Holdings
Inventors:
Russell Philip Grant, Christopher Michael Shuford, Meghan Norris Bradley
Abstract: Disclosed are compositions and methods to detect proteins associated with diseases associated with exposure to inhaled carcinogens. Such markers may be useful to allow individuals susceptible to diseases associated with exposure to inhaled carcinogens to manage their lifestyle and reduce further progression of disease.
Type:
Application
Filed:
May 11, 2018
Publication date:
October 22, 2020
Applicant:
LABORATORY CORPORATION OF AMERICA HOLDINGS
Abstract: The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex in a sample. The invention also provides antibodies specific for Her-3.
Type:
Grant
Filed:
August 21, 2017
Date of Patent:
September 15, 2020
Assignee:
Laboratory Corporation of America Holdings
Inventors:
Michael Bates, Jennifer W. Cook, Gundo Diedrich, Laurie Goodman, Ali Mukherjee, Gordon Parry, Jeff Sperinde, Stephen J. Williams
Abstract: Systems, methods, and media for laboratory testing services are disclosed. A request for an electronic form can be received from an electronic device. A customized electronic form can be sent to the electronic device. The electronic form may be customized based at least in part on a healthcare provider associated with the request. At least one laboratory test may be requested to be ordered for at least one patient associated with the healthcare provider. At least one predefined rule may be applied to the requested order to verify that the order is valid. At least one laboratory can be selected to perform the ordered laboratory tests. Specimen collection information may be sent to a collection facility and can be based at least in part on rules or preferences of a lab selected to perform a laboratory test. Customized test reports can be provided to a healthcare provider.
Type:
Application
Filed:
April 24, 2020
Publication date:
August 6, 2020
Applicant:
Laboratory Corporation of America Holdings
Inventors:
Lidia L. Fonseca, Bill Leister, Suresh Venkatraman, Michael Faisst, George Harter, Kelly Curry, Paul Conlin, Roberto Verrengia, Louis Engel, Andrea Eastman, Piyush Jain
Abstract: Disclosed are methods, devices and systems for the isolation and detection of biomolecules from a sample. The embodiments, detection of such biomolecules provides for detection of microorganisms. For example, disclosed are methods, devices and systems that use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. The devices, systems and methods of the invention may allow for the detection of certain biomolecules peptides and ions in real time using minute amounts of sample.
Type:
Application
Filed:
April 24, 2020
Publication date:
August 6, 2020
Applicant:
Laboratory Corporation of America Holdings
Abstract: The present invention relates to self-contained integrated systems and methods for constructing nucleic acid profiles of human individuals and for identification of the human individuals.
Type:
Grant
Filed:
February 5, 2016
Date of Patent:
July 28, 2020
Assignee:
Laboratory Corporation of America Holdings
Inventors:
Nani M. Grimmer, Michael Neal Parsons, Abigail Bathrick, Donia Palomo Slack
Abstract: Methods are provided for a sensitive and specific assay for the determination of viral load and genotyping of RSV in a biological sample. Compositions and kits for use in the methods also are provided, including optimized primers for the amplification of and detection of the RSV open reading frames from subtypes A and B, and probes for distinguishing between the subtypes. Also provided are methods for amplifying and sequencing an open reading from of an RSV F protein, and compositions and kits for use in the methods.
Type:
Grant
Filed:
August 22, 2016
Date of Patent:
June 23, 2020
Assignee:
Laboratory Corporation of America Holdings
Abstract: The present disclosure relates to a specimen collection device comprising ventilation means for drying a collected specimen. The device further comprises a cassette into which the specimen collected is secured to maintain evidentiary chain of custody requirements while providing unobstructed access to a collected specimen for automated analysis. Methods of using the device are also provided.
Type:
Grant
Filed:
February 13, 2017
Date of Patent:
June 23, 2020
Assignee:
LABORATORY CORPORATION OF AMERICA HOLDINGS
Abstract: Systems, methods, and media for laboratory testing services are disclosed. A request for an electronic form can be received from an electronic device. A customized electronic form can be sent to the electronic device. The electronic form may be customized based at least in part on a healthcare provider associated with the request. At least one laboratory test may be requested to be ordered for at least one patient associated with the healthcare provider. At least one predefined rule may be applied to the requested order to verify that the order is valid. At least one laboratory can be selected to perform the ordered laboratory tests. Specimen collection information may be sent to a collection facility and can be based at least in part on rules or preferences of a lab selected to perform a laboratory test. Customized test reports can be provided to a healthcare provider.
Type:
Grant
Filed:
December 21, 2012
Date of Patent:
May 26, 2020
Assignee:
Laboratory Corporation of America Holdings
Inventors:
Lidia L. Fonesca, Bill Leister, Suresh Venkatraman, Michael Faisst, George Harter, Kelly Curry, Paul Conlin, Roberto Verrengia, Louis Engel, Andrea Eastman, Piyush Jain
Abstract: Disclosed are methods, devices and systems for the isolation and detection of biomolecules from a sample. The embodiments, detection of such biomolecules provides for detection of microorganisms. For example, disclosed are methods, devices and systems that use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. The devices, systems and methods of the invention may allow for the detection of certain biomolecules peptides and ions in real time using minute amounts of sample.
Type:
Grant
Filed:
February 21, 2013
Date of Patent:
May 26, 2020
Assignee:
Laboratory Corporation of America Holdings