Patents Assigned to Labsystems Oy
  • Patent number: 4995432
    Abstract: Dosage equipment, which includes a peristaltic pump for the dosage of liquid. The set of hoses (17) of the peristaltic pump includes an upper piece (18) and a lower piece (19). The body of the pump includes an attaching piece (13), to which the upper piece and the lower piece can be attached.
    Type: Grant
    Filed: October 13, 1988
    Date of Patent: February 26, 1991
    Assignee: Labsystems Oy
    Inventors: Jukka Tervamaki, Mauno Heinonen, Matti Priha, Juha Koivisto
  • Patent number: 4988481
    Abstract: The invention relates to a pipette in which a piston is reciprocated in a cylinder by means of an electric motor. The pipette is preferably provided with a volume adjustment nut comprising locking mechanism to prevent accidental volume adjustment. According to another preferable embodiment the pipette is provided with contact switches for automatically stopping the motor. According to a third preferable embodiment the pipette comprises a cylinder assembly comprising a mechanism for ejecting a tip reservoir of the cylinder.
    Type: Grant
    Filed: January 30, 1989
    Date of Patent: January 29, 1991
    Assignee: Labsystems OY
    Inventors: Kari Jarvimaki, Mauno Heinonen, Juha Koivisto
  • Patent number: 4953575
    Abstract: The invention relates to a washing device for cuvette sets. The cuvette set is placed into a holder (11) in a rotor (10). The washing liquid is removed from the cuvettes by rotating the rotor.
    Type: Grant
    Filed: October 2, 1989
    Date of Patent: September 4, 1990
    Assignee: Labsystems Oy
    Inventor: Jukka Tervamaki
  • Patent number: 4849406
    Abstract: A method of determining the presence of epithelial lesions is provided wherein a sample of a body fluid taken from an epithelial region suspected to have said lesions is tested for the presence of a proteolytic activity. The lesion is then treated by applying a therapeutically effective amount of a proteinase inhibitor in the form of a physiologically acceptable preparation, a pharmaceutical preparation of aprotinin being particularly preferred.
    Type: Grant
    Filed: March 11, 1986
    Date of Patent: July 18, 1989
    Assignee: Labsystems Oy
    Inventor: Eeva-Marjatta Salonen
  • Patent number: 4824791
    Abstract: The invention concerns a thermostated cuvette set in which samples placed in the cuvettes are measured photometrically. Cuvettes of uniform wall thickness are permanently fixed to the bottom of a basin-shaped frame. The cuvettes are connected by partition walls to each other and to the walls of the basin to form arrays of cuvettes defining a path for flow of the thermostating medium. In a preferred embodiment the path is serpentine. The cuvette set also includes at least one inlet opening and at least one outlet opening in the wall of the basin for circulation of the thermostating medium.
    Type: Grant
    Filed: March 5, 1987
    Date of Patent: April 25, 1989
    Assignee: Labsystems Oy
    Inventors: Pertti Ekholm, Oili Salmi, Jukka Tuunanen, Erkki Vesanen
  • Patent number: 4777145
    Abstract: Immunological fluorometric assay method, wherein an antigen (1) attached to magnetic particles (3) reacts in a liquid with an antibody (2) present in the sample and with an antibody (4) marked with a fluorescent substance. After the reaction, the particles are pulled by means of a magnetic field through a second (6) liquid layer onto the bottom of the measurement vessel, whereupon the particles are excited, and emitted radiation is collected through the wall of the vessel.
    Type: Grant
    Filed: October 8, 1985
    Date of Patent: October 11, 1988
    Assignee: Labsystems Oy
    Inventors: Juhani E. I. Luotola, Hannu Harjunmaa
  • Patent number: 4777127
    Abstract: A human endogenous retrovirus-related Mv-75,000 protein, containing the decapeptide sequence Glutamic Acid-Asparagine-Proline-Serine-Glutamine-Phenylalanine-Tyrosine-Glutamic Acid-Arginine-Leucine, a synthetic undecapeptide Sp-23 based on the decapeptide, and specific polycolonal and monoclonal antibodies and specific nucleic acid probes are used as specific reagents for the detection and treatment of tumors such as renal cell adenocarcinoma and choriocarcinoma, among others, and placental disorders including blighted ova, hydatiform and destructive moles.
    Type: Grant
    Filed: September 30, 1985
    Date of Patent: October 11, 1988
    Assignee: Labsystems Oy
    Inventors: Jukka Suni, Antti Vaheri
  • Patent number: 4758523
    Abstract: Method for carrying out immunoassays, in which method an antibody (or antigen) labeled with a tracer so as to be fluorescent is attached onto an antigen (or antibody, respectively) present at the inside wall of the measurement vessel, a liquid denser than the sample is added to the measurement vessel, which said denser liquid displaces the liquid from underneath, and both the excitation radiation is passed into the sample and the fluorescent radiation is collected to the detector through the wall or the bottom of the measurement vessel.
    Type: Grant
    Filed: March 14, 1985
    Date of Patent: July 19, 1988
    Assignee: Labsystems Oy
    Inventor: Hannu Harjunmaa
  • Patent number: 4731337
    Abstract: Fluorometric immunological assay method in which an antigen is attached onto magnetic particles, which are, for the time of measurement, pulled against the wall of the measurement vessel by means of the magnetic field. The magnetic particles adhering to the vessel walls are irradiated and the resultant emitted fluorescence is measured.
    Type: Grant
    Filed: July 24, 1985
    Date of Patent: March 15, 1988
    Assignee: Labsystems Oy
    Inventors: Juhani E. I. Luotola, Hannu Harjunmaa
  • Patent number: 4696195
    Abstract: A valve including a valve body having a surface with a plurality of orifices with a resilient closure membrane adjacent thereto is disclosed. The membrane is positioned to yield in response to a pressure differential so as to permit flow between respective ports. A male closure member is mounted to selectively urge the membrane into contact with the periphery of an orifice in order to prevent liquid flow therethrough in accordance with a desired flow arrangement. Further refinements include spring biasing of the closure mechanism, which in one construction has a movable carriage provided with a roller.
    Type: Grant
    Filed: February 28, 1985
    Date of Patent: September 29, 1987
    Assignee: Labsystems Oy
    Inventors: Jukka Savonlahti, Pertti Ekholm, Hannu Harjunmaa
  • Patent number: 4684250
    Abstract: A set of cuvettes wherein the measurement windows (5) are in the bottom of the cuvettes and surrounded by a matt-faced area (8). The matt-faced area eliminates the access of diffused light to the detector of the photometer.
    Type: Grant
    Filed: December 20, 1984
    Date of Patent: August 4, 1987
    Assignee: Labsystems Oy
    Inventors: Aarre Kukka, Jukka Tervamaki, Heikki Nikulin, Olavi Vuorinen
  • Patent number: 4678326
    Abstract: An apparatus for measuring optical properties such as fluorescence, luminescence or absorption by a liquid sample includes collimating lenses disposed adjacent a cuvette so that their optical axes coincide with the central axis of the cuvette. A fiber bundle with an end portion is located adjacent to the lenses and is provided with a plurality of distinct light transmitting paths extending along the length of the fiber bundle to its end portions. The fiber bundle and collimating lenses cooperate to communicate collimated light between the sample and fiber bundle. The lenses are operable to focus light emanating from the sample upon the end portion of the fiber bundle so that an equal proportion from each volume element of the sample is incident on the fiber bundle surface.
    Type: Grant
    Filed: May 17, 1984
    Date of Patent: July 7, 1987
    Assignee: Labsystems Oy
    Inventor: Hannu Harjunmaa
  • Patent number: 4675288
    Abstract: Method for the performance of a mutagenicity test so that a cell population is subjected to a mutagen. As a result of this, a part of the population mutates, whereat the originally uniform cell population is differentiated into sub-populations. The variation of turbidity caused by the increase in the density of the differentiated cell populations is measured as a change in optical density by means of a photometer measuring vertically at a certain wavelength, and the quantity of cells in the sub-populations is determined as optical density. The absorbance values are measured in accordance with a pre-programmed time share system and a growth curve is formed out of the values as a function of time.
    Type: Grant
    Filed: February 27, 1984
    Date of Patent: June 23, 1987
    Assignee: Labsystems Oy
    Inventor: Kai Falck
  • Patent number: 4661711
    Abstract: Fluorometer in whose reference channel (5) there is optical fiber made of a fluorescent material. The optical fiber acts as an internal standard.
    Type: Grant
    Filed: August 12, 1985
    Date of Patent: April 28, 1987
    Assignee: Labsystems Oy
    Inventor: Hannu Harjunmaa
  • Patent number: 4659222
    Abstract: Microcuvette set which comprises several cuvettes (5) in a matrix form, arranged so as to be handled as one whole unit. The frame portion of the microcuvette set (1) consists of a preferably rectangular frame portion (2) designed so that two or more cuvette-set components (3) can be attached to it in the longitudinal or transverse direction one after the other. Each of the said cuvette-set components (3) consists of several cuvettes (5) disposed in a line or matrix form and connected to each other or attached together by means of a support plate (4), and the middle portion of the frame portion (2) is open at least within the area covered by the cuvettes (5) in the cuvette-set components (3). The microcuvette set (1) comprises a rectangular locking frame (6), open at its middle portion at least within the area corresponding to the frame portion (2), which locking frame is arranged so as to be attached to the top face of the frame portion (2), e.g.
    Type: Grant
    Filed: September 5, 1984
    Date of Patent: April 21, 1987
    Assignee: Labsystems Oy
    Inventor: Pertti Ekholm
  • Patent number: 4659656
    Abstract: There is disclosed a method for the quantitative determination of mastitis in a cow. This method comprises decaseinating and delipidating a milk sample from the cow to obtain a clear solution, substantially removing .alpha..sub.2 -macroglobulin from the sample, mixing the clear and substantially .alpha..sub.2 -macroglobulin free sample with a known amount to trypsin, and measuring the activity of the amount of trypsin which is in excess of the amount which is inactivated by the milk's antitrypsin.
    Type: Grant
    Filed: June 13, 1984
    Date of Patent: April 21, 1987
    Assignees: Labsystems Oy, Eflab Oy
    Inventor: Markus Sandholm
  • Patent number: 4652127
    Abstract: A photometer with controllable heating plates both above and below the set of sample cuvettes. The photometer is in particular used so that the upper plate is regulated to be warmer.
    Type: Grant
    Filed: August 24, 1984
    Date of Patent: March 24, 1987
    Assignee: Labsystems Oy
    Inventors: Pertti Ekholm, Hannu Harjunmaa, Esko Kaukanen, Osmo Suovaniemi
  • Patent number: 4652136
    Abstract: Method for the measurement of the difference in the color contents of two samples (1, 2) or of two component areas of a sample, in which method one or several sources of light (3 to 6) as well as one light detector (7) are used. According to the invention, both samples (1, 2), or component areas of a sample, are illuminated simultaneously and, from both samples (1, 2) or component areas of a sample, the light is passed simultaneously to the light detector (7). The lights to be measured from the samples (1, 2) or component areas of a sample are of different colors, as compared with each other, so that the light to be measured from the first sample or component area is absorbed weakly in the coloring agent and the light to be measured from the second sample or component area is absorbed strongly in the coloring agent. The colors of the lights to be measured from the samples (1, 2) or component areas of a sample are alternated with each other at an appropriate frequency, such as, e.g.
    Type: Grant
    Filed: February 3, 1984
    Date of Patent: March 24, 1987
    Assignee: Labsystems Oy
    Inventor: Hannu Harjunmaa
  • Patent number: 4610170
    Abstract: Method for the precise dilution of a liquid sample, in which diluting agent is pumped through a main channel (1) open at its lower tip and, at the same time, sample is pumped through a side channel (2), whose lower tip (11) opens into the main channel. The invention can be used e.g. in photometers.
    Type: Grant
    Filed: November 2, 1984
    Date of Patent: September 9, 1986
    Assignee: Labsystems Oy
    Inventors: Pertti Ekholm, Esko Kaukanen
  • Patent number: 4593563
    Abstract: A method and apparatus for accurately determining the rate of dissolution of solid substances with highly reproducible results is disclosed. The method and apparatus are directed to a system wherein a sample of solid, which may be powdery, is placed in a sample holder which is then immersed in a perfusion chamber. The weight of the sample is measured as a function of time as the sample dissolves. The sample holder has a variable internal volume which adjusts to the amount of sample therein so as to maintain a substantially constant liquid/solid interface area during dissolution rate measurements.
    Type: Grant
    Filed: September 5, 1984
    Date of Patent: June 10, 1986
    Assignee: Labsystems Oy
    Inventors: Ensio Laine, Jarkko Haapaniemi