Patents Assigned to Laurus Labs Limited
  • Process for the preparation of macitentan
    Patent number: 10669264
    Abstract: The present invention relates to an improved process for the preparation of macitentan and pharmaceutical acceptable salts thereof. Further present invention also relates to methylene chloride solvate of macitentan and their use in the preparation of pure macitentan.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: June 2, 2020
    Assignee: Laurus Labs Limited
    Inventors: Srivardhana Rao Jamjanam, Venkata Ramakrishna Murthy Moturu, Venkata Sunil Kumar Indukuri, Srihari Raju Kalidindi, Satyanarayana Chava
  • Polymorphs of dolutegravir and salts thereof
    Patent number: 10654872
    Abstract: The present invention relates to novel crystalline forms of dolutegravir, process for its preparation and pharmaceutical composition comprising them.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: May 19, 2020
    Assignee: Laurus Labs Limited
    Inventors: Ram Thaimattam, Rajesh Edupuganti, Venkata Sunil Kumar Indukuri, Srihari Raju Kalidindi, Satyanarayana Chava
  • Polymorphs of dolutegravir and salts thereof
    Patent number: 10647729
    Abstract: The present invention relates to novel crystalline forms of dolutegravir, process for its preparation and pharmaceutical composition comprising them.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: May 12, 2020
    Assignee: Laurus Labs Limited
    Inventors: Ram Thaimattam, Rajesh Edupuganti, Venkata Sunil Kumar Indukuri, Srihari Raju Kalidindi, Satyanarayana Chava
  • Process for the preparation of enzalutamide
    Patent number: 10626091
    Abstract: The present invention relates to an improved process for the preparation of enzalutamide by conventional synthesis, which avoids utilization of microwave irradiation and noxious reagents. The present invention also relates to an improved process for preparation of 4-isothiocyanato-2-(trifluoromethyl) benzonitrile, which is an intermediate in the synthesis of Enzalutamide.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: April 21, 2020
    Assignee: Laurus Labs Limited
    Inventors: Kameswar Rao Chivukula, Veera Venkateswara Rao Karuturi, Srinivas Benda, Ramachandra Anke, Dharmapuri Gajula, Venkata Rama Krishna Murthy Moturu, Venkata Sunil Kumar Indukuri, Seeta Rama Anjaneyulu Gorantla, Satyanarayana Chava
  • Process for preparation of Darunavir
    Patent number: 10544157
    Abstract: The present invention provides a process for the preparation of darunavir or solvates or a pharmaceutically acceptable salt thereof substantially free of bisfuranyl impurities, particularly darunavir propionate solvate. The present invention also provides a process for preparation amorphous darunavir using the darunavir propionate solvate.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: January 28, 2020
    Assignee: LAURUS LABS LIMITED
    Inventors: Kameswar R. Chivukula, Venkata R. Murthy, Venkata S. Indukuri, Seeta R. Gorantla
  • Processes for the preparation of ivacaftor
    Patent number: 10501419
    Abstract: The present invention provides processes for the preparation of ivacaftor using novel intermediates and a process for its preparation.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: December 10, 2019
    Assignee: Laurus Labs Limited
    Inventors: Suresh Thatipally, Venkata Krishna Reddy, Venkata Lakshmi Narasimha Rao Dammalapati, Satyanarayana Chava
  • Co-crystals of SGLT2 inhibitors, process for their preparation and pharmaceutical compositions thereof
    Patent number: 10428053
    Abstract: The present invention provides solid forms of SGLT2 inhibitors, to processes for their preparation and their use in the purification of SGLT2 inhibitors and also provided pharmaceutical compositions comprising them and their use in therapy.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: October 1, 2019
    Assignee: LAURUS LABS LIMITED
    Inventors: Kameswar Rao Chivukula, Ram Thaimattam, Veeranarayana Bandlamudi, Durga Visweswar Rao Padala, Narapa Reddy Gade, Nageswar Rao Regandla, Sivarami Reddy Yasam, Venkata RamaKrishnaMurthy Moturu, Venkata Sunil Kumar Indukuri, Uma Maheswar Rao Vasireddi, Srihari Raju Kalidindi, Satyanarayana Chava
  • Processes for the preparation of carfilzomib or pharmaceutically acceptable salts thereof
    Patent number: 10364269
    Abstract: The present invention relates to an improved process for the preparation of carfilzomib or a pharmaceutically acceptable salt thereof. The present invention also relates to a process for the preparation of amorphous form of carfilzomib.
    Type: Grant
    Filed: May 21, 2016
    Date of Patent: July 30, 2019
    Assignee: LAURUS LABS LIMITED
    Inventors: Sanjay Kumar Dehury, Nagaraju Mekala, Jahangeer Baba Shaik, Srinivasa Rao Buddepu, Lakshmi Kanth Kola, Venkata Sunil Kumar Indukuri, Seeta Rama Anjaneyulu Gorantla, Satyanarayana Chava
  • Process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof
    Patent number: 10301321
    Abstract: The present invention relates to a novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof using novel intermediates.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: May 28, 2019
    Assignee: LAURUS LABS LIMITED
    Inventors: Satyanarayana Chava, Seeta Rama Anjaneyulu Gorantla, Venkata Lakshmi Narasimha Dammalapati, Mani Bushan Kotala, Ravindra Aduri
  • Process for the preparation of Enzalutamide
    Patent number: 10131636
    Abstract: The present invention relates to an improved process for the preparation of enzalutamide by conventional synthesis, which avoids utilization of microwave irradiation and noxious reagents. The present invention also relates to an improved process for preparation of 4-isothiocyanato-2-(trifluoromethyl) benzonitrile, which is an intermediate in the synthesis of Enzalutamide.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: November 20, 2018
    Assignee: Laurus Labs Limited
    Inventors: Kameswar R. Chivukula, Veera Venkateswara Rao Karuturi, Srinivas Benda, Ramachandra Anke, Dharmapuri Gajula, Venkata Rama Krishna Murthy Moturu, Venkata S. Indukuri, Seeta Ram Anjaneyulu Gorantla, Satyanarayana Chava
  • Polymorphs of Ivacaftor, process for its preparation and pharmaceutical composition thereof
    Patent number: 9957234
    Abstract: The present invention relates to novel polymorphic forms of ivacaftor, process for its preparation and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: May 1, 2018
    Assignee: Laurus Labs Limited
    Inventors: Ram Thaimattam, Venkata Srinivasa Rao Dama, Venkata Sunil Kumar Indukuri, Seeta Rama Anjaneyulu Gorantla, Satyanarayana Chava
  • Process for the preparation of intermediates useful in the preparation of Hepatitis C virus (HCV) inhibitors
    Patent number: 9957279
    Abstract: The present invention generally relates to a process for preparation of 9-halo-3-(2-haloacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one of Formula I, which is an intermediate in the preparation of Hepatitis C Virus (HCV) inhibitors.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: May 1, 2018
    Assignee: LAURUS LABS LIMITED
    Inventors: Kirshna R. Yalamareddy, Clifton Leigh, Sankar Subramanian, Stephen Mccarron, Omar Depaolis, Lyndon Marble
  • Solid forms of tyrosine kinase inhibitors, process for the preparation and their pharmaceutical composition thereof
    Patent number: 9895377
    Abstract: The present invention generally relates to solid forms of tyrosine kinase inhibitors, in particular combinations of tyrosine kinase inhibitors with anti-oxidative acids, processes for its preparation and a pharmaceutical compositions containing the same.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: February 20, 2018
    Assignee: LAURUS LABS LIMITED
    Inventors: Seeta Ramanjaneyulu Gorantla, Ashwini Nangia, Krishna Sumanth Peraka, Udaya Bhaskara Rao Khandavilli
  • Process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof
    Patent number: 9856271
    Abstract: The present invention relates to a novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof using novel intermediates.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: January 2, 2018
    Assignee: LAURUS LABS LIMITED
    Inventors: Satyanarayana Chava, Seeta Rama Anjaneyulu Gorantla, Venkata Lakshmi Narasimha Dammalapati, Mani Bushan Kotala, Ravindra Aduri
  • Process for preparing eptifibatide
    Patent number: 9850285
    Abstract: The present invention provides processes for preparation of eptifibatide that involve coupling of amino acids in a (2+5), (4+3) and (3+4) sequence method. The invention further provides products produced by the described processes, novel compounds that can be used as synthetic intermediates for the preparation of eptifibatide.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: December 26, 2017
    Assignee: LAURUS LABS LIMITED
    Inventors: Subha Nair Velayudhan, Ravindra Babu Bollu, Venkata S. Indukuri, Seeta R. Gorantla, Venkata S. Kallam, Bala M. Madivada
  • Process for the preparation of gemcitabine-[phenyl(benzoxy-L-alaninyl)] phosphate
    Patent number: 9834577
    Abstract: The present invention provides a process for the preparation of gemcitabine-[phenyl(benzoxy-L-alaninyl)] phosphate of Formula I in high yield and purity.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: December 5, 2017
    Assignee: Laurus Labs Limited
    Inventors: Venkata Lakshmi Narasimha Rao Dammalapati, Mani Bushan Kotala, Shankar Madhavaram