Abstract: A tissue sample container including a base having a plurality of sample holding sections, which are configured to receive a plurality of tissue samples in a given orientation and are demarcated by section walls; and a lid configured to sealingly engage the base. The sample holding sections are sized and shaped to correspond to a specific tissue sample size and shape such that the base in cooperation with the section walls, maintain the given orientation and identity of the tissue samples within respective sample holding sections.

Abstract: A method for treating a tissue sample including placing at least one tissue sample on an cassette which has: a retaining member, a base and at least one biasing element; placing the at least one tissue sample in the tissue cassette; attaching the base and the retaining member to retain the tissue sample; processing the tissue sample in the tissue cassette with one or more solvents; and embedding the tissue sample in a paraffin to form an portion of paraffin in which the tissue sample is embedded in the tissue cassette, wherein the embedding comprises adding molten paraffin to the interior area of the tissue cassette and allowing the paraffin to become solid.

Abstract: A blade dispenser (100) has a blade supply container (110), a blade disposal container (120), and a detachable and reconnectable connecting means (130, 131, 132) that is embodied to connect the blade supply container (110) and blade disposal container (120) detachably to one another. The blade supply container (110) has a blade supply container upper side and a blade supply container underside, and is embodied to receive a blade stack (111) made up of multiple mutually abutting blades (112, 115). The blade supply container (110) also has a removal opening (116) through which at least one blade (112, 115) of the blade stack (111) is removable from the blade supply container (110). The blade disposal container (120) has a blade disposal container upper side and a blade disposal container underside, and is embodied to receive blades (120) to be disposed of.

Abstract: An apparatus for safety-compliant emptying and filling of a reagent container (24, 40) for a tissue processor (20) comprises a suction line (30, 42) for aspirating a reagent out of the reagent container (24, 40) and a delivery line (32, 44) for filling the reagent container (24, 40) with the reagent, a terminating opening (31, 43) of the suction line (30, 42) being spaced away from a terminating opening (33, 45) of the delivery line (32, 44).

Abstract: The invention relates to a coverslipping module for mounting coverslips onto specimen slides (12) for microscopic investigations, having a transport apparatus (9) for transporting a specimen slide (12) out of a rack (3) or a specimen slide holder to a coverslipping position (13) in which the specimen slide (12) is equipped with a coverslip, and having an alignment device for aligning the specimen slide (12) in the coverslipping position (13) for mounting the coverslip. In order to allow the specimen slide (12) to be reliably and quickly aligned for mounting of the coverslips, thereby ensuring a high level of process dependability with a short processing time, the alignment device are constituted by multiple movable orientation jaws (18) which are arranged so that by closure of the orientation jaws (18), the specimen slide (12) becomes aligned in the coverslipping position (13).

Abstract: A sample holder (100) of a microtome is described, including a basic body (110) and an alignment component (120). A first actuatable retainer (140) can be configured to permit a relative motion between the alignment component (120) and the basic body (110) in an actuated state, and configured to inhibit the relative motion between the alignment component (120) and the basic body (110) in a deactuated state. A clamping subassembly (130) can be arranged on the alignment component (120), and comprise two clamping components (131, 132). A second actuatable retainer (180) can be configured to open the clamping subassembly (130) in an actuated state, and configured to close the clamping subassembly (130) in a deactuated state. An actuation mechanism can be configured to respectively actuate and deactuate the first actuatable retainer (140) and the second actuatable retainer (180).

Abstract: The invention relates to a tissue sample handling apparatus, in particular for grasping histological samples after infiltration of an embedding medium such as, for example, paraffin, which is characterized in that a sample is immobilizable on the handling apparatus, in particular in a sample holding position, by means of negative pressure.

Abstract: The present invention relates to a microtome (10) including a sample holder (12) a cutting unit (16), and a drive unit (22) capable of producing a relative movement between the sample holder (12) and the cutting unit (16) for cutting the sample. In addition, the microtome (10) has a handwheel (32) and an encoder (38). A control unit (40) controls the drive unit (22) as a function of the rotational movement of the handwheel (32) detected by the encoder (38) and in such a way that, in a first operating mode, the relative movement produced between the sample holder (12) and the cutting element (16) by the drive unit (22) when the handwheel (32) is rotated through a full revolution has a maximum first stroke length and that, in a second operating mode, the relative movement has a preset second stroke length shorter than the maximum first stroke length.

Abstract: A freezing microtome for the production of microscopable thin sections of tissue samples (60), comprising a cooling device (24, 34, 36, 38, 40, 42, 46, 48, 50, 52) for freezing the tissue samples (60), a cutting device for cutting the frozen tissue samples (60) and a working chamber, in which the cutting device and at least a part of the cooling device (24, 34, 36, 38, 40, 42, 46, 48, 50, 52) are arranged is described. The part of the cooling device (24, 34, 36, 38, 40, 42, 46, 48, 50, 52) arranged in the working chamber contains a liquid coolant (70), in which the tissue samples (60) can be inserted for freezing.

Abstract: The invention relates to an apparatus for treating histological samples, in particular for detaching and/or isolating a histological sample that, in particular after an infiltration operation, is adhering to another sample and/or to the inside of a cassette (1), having a sample receiving chamber (2) which is embodied and intended to be filled at least partly with a liquid (3), in particular with liquid paraffin. The apparatus according to the present invention is characterized in that a displacement means (5) is provided that is introducible into the liquid (3), in particular under open- and/or closed-loop control, in order to elevate the fill level height (6) of the liquid (3), and/or that a displacement means (5) is provided whose volume is increasable, in particular under open- and/or closed-loop control, in order to elevate the fill level height.

Abstract: A sample cooling device for histological samples is connectable to a power network for supplying electrical voltage to the device. The sample cooling device comprises a measuring apparatus for measuring a magnitude of an input line voltage present at the sample cooling device, and a transformer having a primary coil that comprises at least three coil pickoffs, and a secondary coil. The sample cooling device further comprises a switching means that connects two of the coil pickoffs to the power network as a function of the magnitude of the input line voltage, so that a magnitude of an output voltage present at the secondary coil has a predefined or predefinable voltage value irrespective of the magnitude of the input voltage. A corresponding method for supplying electrical power to a sample cooling device for histological samples is also disclosed.

Abstract: An apparatus (10) for handling specimen slides comprises a first module receiving region (18) in which a coverslipping module (100, 200), for coverslipping thin sections arranged on the specimen slides with a coverslipping medium and a coverslipping element, is receivable. A first electrical interface is provided in the first module receiving region (18) for attachment of a coverslipping module (100, 200), this interface being embodied so that by way of it, both a glass coverslipping module (100) for coverslipping with glass wafers and a tape coverslipping module (200) for coverslipping with tapes is attachable. The first module receiving region (18) is furthermore embodied in such a way that a tape coverslipping module (200) or a glass coverslipping module (100) is selectably receivable in it.

Abstract: The invention relates to an apparatus for treating histological samples, in particular for detaching and/or isolating a histological sample that, in particular after an infiltration operation, is adhering to another sample and/or to the inside of a cassette (1), having a sample receiving chamber (2) which is embodied and intended to be filled at least partly with a liquid (3), in particular with liquid paraffin. The apparatus according to the present invention is characterized in that an apparatus is provided that is introducible into the liquid (3), in particular under open- and/or closed-loop control, in order to elevate the fill level height (6) of the liquid (3), and/or that an apparatus is provided whose volume is increasable, in particular under open- and/or closed-loop control, in order to elevate the fill level height.

Abstract: The invention relates to an apparatus (10) for sectioning histological samples, which encompasses a sectioning unit (18), a sample holder (14), and a drive unit (16) for moving the sample holder (14) relative to the sectioning unit (18) in order to section the sample (12). Also provided is a cooling unit (20), for cooling at least a sub-region of the sample holder (14), which encompasses a compressor for compressing a refrigerant, a capillary tube (25) for delivering the liquefied refrigerant from the compressor (22) to the sample holder (14), and a return line (28) for returning the refrigerant from the sample holder (14) to the compressor (22). At least a sub-region (32) of the capillary tube (25) is embodied in a spiral shape.

Abstract: An apparatus for holding a tissue sample having a retaining member with a first tissue engaging surface and at least one biasing element. The first tissue engaging surface is moveably attached to the retaining member. The apparatus also has a base comprising a second tissue engaging surface which is configured to engage the retaining member to form an interior area with the first and second tissue engaging surfaces facing each other. The apparatus also has a retracting member connected to the retaining member which is configured to retract the first tissue engaging surface and compress the biasing element to form a gap between the tissue sample and one of the first tissue engaging surface and the second tissue engaging surface.

Abstract: The invention relates to an apparatus for treatment of histological samples. The apparatus includes at least a working station, in which the sample gets into contact with a liquid reagent. Further, the apparatus includes a purification device, which blows off at least a part of the reagent adhering to the sample and/or the sample holding arrangement by means of a gas flow, or which sucks off at least a part of the reagent adhering to the sample and/or a sample holding arrangement.

Abstract: An apparatus for holding a tissue sample including a retaining member having a first tissue engaging surface and at least one biasing element, the first tissue engaging surface being moveably attached to the retaining member by said biasing element; and a base having a second tissue engaging surface and configured to engage the retaining member to form an interior area with the first and second tissue engaging surfaces facing each other, wherein the at least one biasing element urges the first tissue engaging surface toward the second tissue engaging surface to retain the tissue sample therebetween in the interior area.

Abstract: The invention relates to a processor for working on histological samples. The processor has an inlet for the insertion of a fixing container, particularly a closed fixing container, with the samples located in the latter.

Abstract: A method for treating a tissue sample including placing at least one tissue sample on an cassette which has: a retaining member, a base and at least one biasing element; placing the at least one tissue sample in the tissue cassette; attaching the base and the retaining member to retain the tissue sample; processing the tissue sample in the tissue cassette with one or more solvents; and embedding the tissue sample in a paraffin to form an portion of paraffin in which the tissue sample is embedded in the tissue cassette, wherein the embedding comprises adding molten paraffin to the interior area of the tissue cassette and allowing the paraffin to become solid.

Abstract: The invention provides a method for detaching and/or isolating a histological sample that is adhering to another sample and/or to the inside of a cassette, for example as a result of solidification of an embedding medium within a cassette. The sample is immobilized in a sample receiving chamber above a first fill level of a liquid that is suitable for counteracting the adhesion; and that the fill level of the liquid is then elevated at least until said level reaches the sample. An apparatus according to the present invention that can be used for carrying out the method comprises a sample receiving chamber and an adjusting chamber, the adjusting chamber being connected to the sample receiving chamber in such a way that a change in the fill level height of the liquid in the sample receiving chamber is producible by changing the pressure existing in the adjusting chamber.