Abstract: There are described novel dispersible cimetidine tablets containing 30 to 90% by weight of one of the polymorphous modifications of cimetidine A, B or C, 5 to 55% by weight of one or more disintegrationg agents, 0.05 to 5.0% by weight of a surfactant, such as sodium lauryl sulphate together with other common adjuvants. The process for the manufacture of dispersible cimetidine tablets is effected on the basis of known methods by granulating the ingredients and by compressing the granulate to tablets. Dispersible tablets disintegrate when brought in contact with water at room temperature within less than 1 minute to yield a fine dispersion, which facilitates the oral application. Therefore such tablets are particularly suitable for certain groups of patients, especially for the aged and children. Dispersible tablets containing cimetidine excell by their improved rate of dissolution and good bioavailability.

Abstract: There are described novel dispersible tablets of dihydroergotoxine or of acid addition salts thereof, containing 0.1 to 4% by weight of dihydroergotoxine or its acid addition salts, 4 to 60% by weight of one or more disintegrating agents, 0.8 to 10% by weight of an organic acid and, optionally, 0.2 to 2% by weight of an antioxidizing agent together with other common adjuvants. The process for the manufacture of dispersible tablets of dihydroergotoxine and of acid addition salts thereof is carried out on the basis of known methods by granulating the ingredients and by compressing the granulate to tablets. Dispersible tablets disintegrate within less than 1 minute when brought in contact with water at room temperature to yield a fine dispersion, which facilitates the oral application. Therefore such tablets are particularly suitable for the aged. Dispersible tablets containing dihydroergotoxine or acid addition salts thereof excell by their improved rate of dissolution and good bioavailability.

Abstract: A new and simple process for the preparation of crystalline cimetidine (N-cyano-N'-methyl-N"-{2/(5-methyl-1H-imidazole-4-yl)methylthio/ethyl}guan idine) is described, wherein cimetidine is obtained by reacting O-ethyl-S-(4-methylimidazolyl-5-methyl)dithiocarbonate hydrobromide with N-cyano-N'-methyl-N"-(2-chloroethyl)guanidine in an aqueous methylamine solution at a temperature between room temperature and the reflux temperature of the reaction mixture, whereupon the desired compound is separated.Cimetidine is a valuable drug in the therapy of the ulcer disease.

Abstract: A new, technologically easily feasible process for the preparation of 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, comprising a partrial hydrolysis of dimethyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate in an inert organic solvent at a temperature between room temperature and the reflux temperature of the reaction mixture with an aqueous solution of alkali hydroxide and the reaction of the obtained 3-methoxycarbonyl-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-5-car boxylic acid either with N-(2-hydroxyethyl)-N-benzyl-methylamine in the presence or absence of an organic solvent in the presence of N,N'-dicyclohexylcarbodiimide at a temperature of between 25.degree. and 120.degree. C. or with N-(2-haloethyl)-N-benzyl-methylamine in the presence of an inert organic solvent and of a proton acceptor at a temperature of between 25.degree. and 140.degree. C.

Abstract: A new, technologically easily feasible process for the preparation of 4(5)-methyl-5(4)-thiomethyl imidazole of the formula ##STR1## and of acid addition salts thereof is described, wherein 4(5)-methyl-5(4)-bromomethyl imidazole hydrobromide is reacted in an aqueous medium at room temperature with potassium O-ethyl dithiocarbonate to the intermediate O-ethyl-S-(4-methylimidazolyl-5-methyl) dithiocarbonate, which is hydrolyzed at the reflux temperature under nitrogen atmosphere with an aqueous HBr or HCl solution to 4(5)-methyl-5(4)-thiomethyl imidazole hydrobromide or hydrochloride resp.The compound is a valuable starting material in the synthesis of cimetidine, a well-known drug in the therapy of the ulcer disease.

Abstract: In the process for preparing 4-(2'-nitrophenyl-2,6-dimethyl)-3,5-dicarbmethoxy-1,4-dihydropyridine of the formula ##STR1## 2-nitrobenzaldehyd-diacetate, methyl acetoacetate and ammonia are reacted in the presence of an inert organic solvent, such as methanol, and in the presence or absence of an organic base, such as pyridine, at a temperature of between 20.degree. and 150.degree. C. The compound is a valuable medicine for the treatment of angina pectoris.

Abstract: Medicine containing salts of ergotaminine, ergosinine, ergocryptinine, ergocristinine, and ergocorninine and use for treating arterial hypertension, heart insufficiency, heart arrhythmia or cephalalgia.

Abstract: Sodium alumoglucoheptonate, process of preparing from sodium glucoheptonate and sodium aluminate, and use of sodium alumoglucoheptonate as a sequestering agent.

Abstract: Preparation of 4-(n-hexadecylamino)-benzoic acid or salt thereof employing as catalyst quaternary ammonium or phosphonium salt.

Abstract: Sodium alumoglucoheptonate, process of preparing from sodium glucoheptonate and sodium aluminate, and use of sodium alumoglucoheptonate as a sequestering agent.

Abstract: Process for preparing 2-(3-benzoylphenyl)-propionic acid or salt thereof which includes methylating 3-benzoyl-phenyl acetonitrile or an alkoxide thereof in the presence of neutral non-cyclic ligands with an open polyether chain.

Abstract: A process for the preparation of N-substituted esters of 9,10-dihydrolysergic acids of the formula: ##STR1## wherein R.sub.1 is an alkyl group of 1-5 carbon atoms, an alkenyl group of 2-5 carbon atoms or a cycloalkyl group of 3-5 carbon atoms,R.sub.2 is hydrogen or an alkoxy group of 1-3 carbon atoms andX' is hydrogen or halogen,characterized in that esterified 9,10-dihydrolysergic acids of the formula: ##STR2## wherein R is hydrogen or a hydrolyzable organic group,X' is hydrogen or halogen, andR.sub.2 has the meaning as stated above,are reacted with a compound of the formula:R.sub.1 Y (III)whereinR.sub.1 has the meaning as stated above,Y is halogen or sulphate,in the presence of a catalyst for phase transition in the presence of aqueous alkali medium in an inert organic solvent immiscible with water, and certain novel esters obtained thereby.

Abstract: 2-Bromoergosine of the formula: ##STR1## and acid addition salts thereof. The acid addition salts are employed in the treatment of arterial hypertension and of heart arrythmias.

Abstract: A process for the preparation of 2-(3-benzoylphenyl)propionic acid or salt thereof wherein 3-benzoylphenyl acetonitrile or an alkoxide thereof is reacted with a methylating agent and wherein the mixture obtained is hydrolized to thereby provide the desired acid.

Abstract: A process of preparing ##STR1## by reacting 4-thiomethyl-5-methyl imidazole with N-cyano-N'-methyl-N"-(2-chloroethyl) guanidine in a two-phase system under the conditions of phase transfer catalysis.

Abstract: A process for preparing 2-(3-benzoylphenyl)-propionic acid which includes treating 1-(3-benzoylphenyl)-propine with a thallium (III) salt in a lower alkanol to obtain 2-(3-benzoylphenyl)-propionic ester, and hydrolyzing the ester.

Abstract: 1-(3-Benzoylphenyl)-propine represented by the formula: ##STR1## useful as an intermediate is provided.

Abstract: Preparation of .beta.-methyldigoxin in the presence of dimethyl formamide, an inert solvent, methyl ester of a sulphuric acid, and strontium hydroxide.

Abstract: A new variety of carnation plant distinguished by a continuous and profuse production of medium sized flowers having a generally orange coloration borne on long, strong flower stems growing raceme on strong main stems of about one meter in length, the plant being of the spray type with a vigorous and rapid growth rate with strong stem character and with abundant foliage.

Abstract: A new carnation cultivar distinguished by its continuous and profuse production of very pleasing, bright pink blossoms of medium size, borne raceme with more than three per stem on medium strong peduncles of medium length, the plant being a tall, spray type with a vigorous, rapid and sturdy growth habit and an average height of about one meter.