Patents Assigned to Leuven Research & Development
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Publication number: 20140079741Abstract: Treatment of a fungal biofilm on implants is via a combination of drugs and/or via the implant pre-treatment with one drug or via the combination of drugs.Type: ApplicationFiled: March 19, 2012Publication date: March 20, 2014Applicant: KATHOLIEKE UNIVERSITEIT LEUVEN KU LEUVEN RESEARCH & DEVELOPMENTInventors: Anna Bink, Bruno Cammue, Johan Martens, Bram Neirinck, Karin Thevissen, Jozef Vleugels
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Patent number: 8670619Abstract: A method for operating on images is described for interest point detection and/or description working under different scales and with different rotations, e.g. for scale-invariant and rotation-invariant interest point detection and/or description.Type: GrantFiled: April 17, 2012Date of Patent: March 11, 2014Assignees: Toyota Motor Europe NV, K.U. Leuven Research & Development, Eidgenoessische Technische Hochschule ZurichInventors: Ryuji Funayama, Hiromichi Yanagihara, Luc Van Gool, Tinne Tuytelaars, Herbert Bay
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Patent number: 8658616Abstract: Compounds having the general formula (I): are provided which have enhanced inhibitory potency and are thus useful in methods of prophylaxis or treatment of a viral infection such as hepatitis C virus. The compounds are phosphoramidate derivatives of nucleoside compounds derived from bases such as adenine and guanine. The glycoside moiety of the nucleoside compound can be substituted at the ss-2? position with methyl and the phosphoramidate group can be 1-naphthyl linked by —O— to the P atom. These compounds can be administered as pharmaceutical compositions, and methods for their preparation are also provided.Type: GrantFiled: November 23, 2007Date of Patent: February 25, 2014Assignees: University College Cardiff Consultants Limited, K.U. Leuven Research and DevelopmentInventors: Christopher McGuigan, Plinio Perrone, Johan Neyts
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Patent number: 8569488Abstract: A crystalline compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating crystalline compound (1) are provided.Type: GrantFiled: December 23, 2011Date of Patent: October 29, 2013Assignees: Gilead Sciences, Inc., K.U. Leuven Research & DevelopmentInventors: Eric D. Dowdy, Kenneth M. Kent, Norma J. Tom, Vahid Zia
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Patent number: 8569487Abstract: A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections. Methods of making and formulating compound (1) are provided.Type: GrantFiled: July 6, 2007Date of Patent: October 29, 2013Assignees: Gilead Sciences, Inc., K.U. Leuven Research & DevelopmentInventors: Steven S. Bondy, Terrence C. Dahl, David A. Oare, Reza Oliyai, Winston C. Tse, Vahid Zia
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Publication number: 20130245606Abstract: A hydrogel based occlusion system, a method for occluding vessels, appendages or aneurysms, and a method for hydrogel synthesis are disclosed. The hydrogel based occlusion system includes a hydrogel having a shrunken and a swollen state and a delivery tool configured to deliver the hydrogel to a target occlusion location. The hydrogel is configured to permanently occlude the target occlusion location in the swollen state. The hydrogel may be an electro-activated hydrogel (EAH) which could be electro-activated with a delivery system to control the degree of swelling/shrinking.Type: ApplicationFiled: March 15, 2013Publication date: September 19, 2013Applicants: UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK, UNIVERSITEIT GENT, TECHNISCHE UNIVERSITEIT DELFT, RAMOT AT TEL-AVIV UNIVERSITY, LTD., KATHOLIEKE UNVIVERSITEIT LEUVEN - KU LEUVEN RESEARCH & DEVELOPMENT, INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZWInventors: Frank Albert STAM, Nathan JACKSON, Peter DUBRUEL, Kehinde ADESANYA, Anika EMBRECHTS, Eduardo MENDES, JR., Hurcules Pereira NEVES, Paul HERIJGERS, Peter VERBRUGGHE, Yosi SHACHAM, Leeya ENGEL, Viacheslav KRYLOV
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Patent number: 8501709Abstract: The invention is directed to phosphonate nucleosides comprising a phosphonalkoxy-substituted five-membered, saturated or unsaturated, oxygen-containing ring coupled to a heterocyclic nucleobase such as a pyrimidine or purine base, as well as pharmaceutical compositions thereof. These compounds, which can be described by general formula (II), are useful for the treatment of retroviral infection, e.g., HIV (Human Immunodeficiency Virus) infection in a mammal. The invention also features synthetic intermediates for the preparation of phosphonate nucleosides.Type: GrantFiled: November 8, 2011Date of Patent: August 6, 2013Assignee: K.U.Leuven Research & DevelopmentInventors: Piet Herdewijn, Christophe Pannecouque, Tongfei Wu, Erik De Clercq
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Patent number: 8470826Abstract: The present invention relates to an episomal structure expressing a functional oncogene, whereby said oncogene is a fusion gene of two chromosomal gene fragments. More specifically, the invention relates to a NUP214-ABL1 fusion product, important in the development of T-cell acute lymphoblastic leukemia, to methods to detect the fusion and to methods to prevent the oncogenic activity of said fusion product.Type: GrantFiled: June 15, 2010Date of Patent: June 25, 2013Assignees: VIB VZW, K.U. Leuven Research and DevelopmentInventors: Jan Cools, Anne Hagemeijer, Peter Marynen
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Patent number: 8450318Abstract: Molecules having a spacer unit, linker and recognition unit(s) are used for the treatment of various diseases, disorders and conditions. The compounds are useful in treating infectious diseases and diseases, disorders or conditions related thereto. Further, the methods for treating diseases, disorders or conditions involve recognition and binding of carbohydrate structures.Type: GrantFiled: March 18, 2008Date of Patent: May 28, 2013Assignees: K.U. Leuven Research and DevelopmentInventors: Monika Mazik, Jan Balzarini
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Publication number: 20130096079Abstract: A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH2, Y is O, S or NH, Z is O, S or CH2, R1 is C1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl, and one of R2 and R3 is OH, and the other of R3 and R2 is a neutral, non-polar amino acid moiety, or a pharmaceutically acceptable salt or hydrate thereof. Said neutral, non-polar amino acid moiety R2 or R3 may be (IV): in which R4, R5, R6 and R7 are each independently H or C1-2 alkyl. In preferred embodiments, one of R2 or R3 is valine, leucine, isoleucine or alanine, particularly valine.Type: ApplicationFiled: November 30, 2012Publication date: April 18, 2013Applicants: K.U. LEUVEN RESEARCH AND DEVELOPMENT, UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITEDInventors: University College Cardiff Consultants Limited, K.U. Leuven Research and Development
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Patent number: 8329664Abstract: A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH2, Y is O, S or NH, Z is O, S or CH2, R1 is C1-6 alkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl, and one of R2 and R3 is OH, and the other of R3 and R2 is a neutral, non-polar amino acid moiety, or a pharmaceutically acceptable salt or hydrate thereof. Said neutral, non-polar amino acid moiety R2 or R3 may be (IV): in which R4, R5, R6 and R7 are each independently H or C1-2 alkyl. In preferred embodiments, one of R2 or R3 is valine, leucine, isoleucine or alanine, particularly valine.Type: GrantFiled: May 9, 2007Date of Patent: December 11, 2012Assignees: University College Cardiff Consultants Limited, K.U. Leuven Research and DevelopmentInventors: Christopher McGuigan, Jan Balzarini, Marco Migliore
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Patent number: 8329727Abstract: The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.Type: GrantFiled: October 13, 2009Date of Patent: December 11, 2012Assignees: Gilead Sciences, Inc., K.U. Leuven Research & DevelopmentInventors: Steven S. Bondy, Eric Davis Dowdy, Choung U. Kim, David A. Oare, Johan Neyts, Vahid Zia, Gerhard Pürstinger
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Publication number: 20120283303Abstract: The present invention relates to the use of N-aminoimidazole or N-aminoimidazole thione derivatives as cytoprotective compounds in vitro and in vivo and for the treatment or prevention of cell death mediated disorders and/or GSK-3 mediated disorders or processes.Type: ApplicationFiled: April 30, 2012Publication date: November 8, 2012Applicant: K.U.LEUVEN RESEARCH AND DEVELOPMENTInventors: Christophe Pannecouque, Wim Robberecht, Miguel Stevens
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Patent number: 8263612Abstract: Pyrrolo[2,3-c]pyridine or pyrrolo[3,2-c]pyridine compounds having the general formula (A), wherein the dashed lines, X, Y and R1 through R5 are as defined in the specification. The compounds are useful in the prophylaxis or treatment of viral infections.Type: GrantFiled: December 14, 2007Date of Patent: September 11, 2012Assignees: Gilead Sciences, Inc., K.U. Leuven Research & DevelopmentInventors: Steven S. Bondy, David A. Oare, Gerhard Puerstinger
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Patent number: 8258126Abstract: Novel vitamin D analogues are useful for making pharmaceutical compositions for the prevention or treatment of bone disorders such as osteoporosis.Type: GrantFiled: March 4, 2010Date of Patent: September 4, 2012Assignees: K.U. Leuven Research & Development, Universiteit GentInventors: Roger Bouillon, Annemieke Verstuyf, Pierre De Clercq, Maurits Vandewalle
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Patent number: 8242087Abstract: This invention relates to novel phosphate-modified nucleosides, and methods for producing them, being useful for the prevention or treatment of a viral infection in a mammal, and for preparing oligonucleotides by DNA/RNA polymerase-dependent amplification, e.g. PCR.Type: GrantFiled: August 27, 2009Date of Patent: August 14, 2012Assignee: K.U.Leuven Research & DevelopmentInventors: Olga Adelfinskaya, Piet Herdewijn
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Patent number: 8236756Abstract: The present invention provides a new prodrug technology and new prodrugs in order to increase the solubility, to modulate plasma protein binding or to enhance the biovailability of a drug. In the present invention the prodrugs are conjugates of a therapeutic compound and a peptide (eg tetrapeptide or hexapeptide) wherein the conjugate is cleavable by dipeptidyl-peptidases, more preferably by CD26, also known as DPPIV (dipeptidyl aminodipeptidase IV). The present invention furthermore provides a method of producing the prodrugs, to enhance brain and lymphatic delivery of drugs and/or to extend drug half-lives in plasma.Type: GrantFiled: May 10, 2004Date of Patent: August 7, 2012Assignees: Consejo Superior de Investigaciones Clentificas (CSIC), K.U. Leuven Research & DevelopmentInventors: Jan Balzarini, Maria José Camarasa Ríus, Sonsoles Velázquez Díaz
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Patent number: 8193157Abstract: The field of the invention relates to the use of carbohydrate binding compounds as a medicine, their use to treat or prevent viral infections, their use to manufacture a medicine to treat or prevent viral infections and their use in a vaccination strategy. The present invention relates to the use of said compounds to manufacture a medicine to treat or prevent viral infections of subjects, more in particular infections with viruses having glycosilated envelop proteins such as Retroviridae (i.e. Lentivirinae), like HIV (human immunodeficiency virus), Flaviviridae, like HCV (hepatitis C virus), Hepadnaviridae, like HBV (hepatitis B virus), Coronaviridae, like SARS corona virus, and Orthomyxoviridae, like influenza A, B or C.Type: GrantFiled: September 21, 2006Date of Patent: June 5, 2012Assignees: K.U.Leuven Research & Development, Technische Universität Carolo Wilhelmina Zu BraunschweigInventors: Jan Balzarini, Monika Mazik
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Patent number: 8172788Abstract: By present invention it has been found that hypothermia decreases adhesion formation more specifically pneumoperitoneum-enhanced adhesion formation. A cooling system has been designed to reduce the peritoneal cavity temperature during surgery, while maintaining at all times a 100% relative humidity in order to prevent desiccation, and a regulatory unit designed to condition the insufflated gas to achieve this while minimalising the necessary cooling. This is a new method for more effectively preventing adhesion though cooling while preventing desiccation. In mice it was demonstrated that factors such as environmental temperature, anaesthesia, ventilation and pneumoperitoneum can be used to influence body temperature in order to prevent adhesion formation.Type: GrantFiled: June 1, 2005Date of Patent: May 8, 2012Assignee: K. U. Leuven Research and DevelopmentInventors: Philippe Koninckx, Thomas Koninckx
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Publication number: 20120108601Abstract: A crystalline compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating crystalline compound (1) are provided.Type: ApplicationFiled: December 23, 2011Publication date: May 3, 2012Applicants: Gilead Sciences, Inc., Gerhard Puerstinger, K.U. Leuven Research & DevelopmentInventors: Eric D. Dowdy, Kenneth M. Kent, Norma J. Tom, Vahid Zia