Patents Assigned to Leuven Research & Development
  • Imidazo[4,5-d]pyrimidines, their uses and methods of preparation
    Patent number: 7790730
    Abstract: The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one compound having the general formula (A): wherein U is N or C; X is selected from C1-C10 alkylene, C2-10 alkenylene or C2-10 alkynylene, where each may include one or more intrachain heteroatoms selected from O, S, or NR11, provided any such heteroatom is not adjacent to the N in the ring; R3 is selected from aryl, aryloxy, arylthio, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl-N(R10)—, or heterocycle, where each said substituent is optionally substituted with at least one R17, provided that for cycloalkenyl the double bond is not adjacent to a nitrogen; and the other substituents are described in the specification.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: September 7, 2010
    Assignees: Gilead Sciences, Inc., K.U. Leuven Research & Development
    Inventors: Choung U. Kim, Johan Neyts, David A. Oare, Gerhard Puerstinger
  • Episomal fusion gene
    Patent number: 7776534
    Abstract: The present invention relates to an episomal structure expressing a functional oncogene, whereby said oncogene is a fusion gene of two chromosomal gene fragments. More specifically, the invention relates to a NUP214-ABL1 fusion product, important in the development of T-cell acute lymphoblastic leukemia, to methods to detect the fusion and to methods to prevent the oncogenic activity of said fusion product.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: August 17, 2010
    Assignees: VIB VZW, K.U. Leuven Research and Development
    Inventors: Jan Cools, Anne Hagemeijer, Peter Marynen
  • Pyridazine compound and use thereof
    Patent number: 7754720
    Abstract: A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating compound (1) are provided.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: July 13, 2010
    Assignees: Gilead Sciences, Inc., K.U. Leuven Research & Development, Gerhard Puerstinger
    Inventors: Steven S. Bondy, Terrence C. Dahl, David A. Oare, Reza Oliyai, Winston C. Tse, Vahid Zia
  • Antithrombotic therapy with antibodies binding to the A3 domain of von Willebrand factor (VWF)
    Patent number: 7754215
    Abstract: The present invention clearly demonstrates that vWF-collagen interaction, via the A3 domain of vWF, plays an important role in acute platelet-dependent arterial thrombus formation and that blocking the A3 domain in a vWF-collagen interaction can induce complete abolition of thrombus formation in the injured and stenosed baboon femoral arteries. Accordingly, an antibody or an antigen recognizing fragment thereof binding specifically to the A3 domain of vWF or an epitope thereof can be used for the prevention of acute arterial thrombotic syndromes or to manufacture medicines to for the prevention of acute arterial thrombotic syndromes.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: July 13, 2010
    Assignee: K.U. Leuven Research & Development
    Inventors: Hans Deckmyn, Nancy Cauwenberghs, Karen Vanhoorelbeke
  • Crystalline mesoporous oxide based materials useful for the fixation and controlled release of drugs
    Patent number: 7749521
    Abstract: The invention describes a new class of crystalline silica material having two levels or porosity and structural order. At the first level, building units are nanoslabs of uniform size having zeolite framework. At the second structural level, nanoslabs are assembled, e.g. linked through their corners, edges or faces following patterns imposed by interaction with cationic surfactant or triblock copolymer molecules. After evacuation of these molecules, microporosity is obtained inside the nanoslabs, and a precise mesoporosity between the nanoslabs depending on the tiling pattern of the zeolite nanoslabs, as evidenced by X-ray diffraction. These materials are useful for the fixation of biologically active species, such as poorly soluble drugs.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: July 6, 2010
    Assignee: K.U. Leuven Research & Development
    Inventors: Johan Adriaan Martens, Christine Eva Antonia Kirschhock, Sebastien Philippe Brigitte Kremer, Alexander Jan Maria Herman Eugeen Aerts, Guy Van Den Mooter, Jan Van Humbeeck
  • VITAMIN D3 ANALOGUES FOR THE PREVENTION AND TREATMENT OF BONE DISORDERS
    Publication number: 20100160455
    Abstract: Novel vitamin D analogues are useful for making pharmaceutical compositions for the prevention or treatment of bone disorders such as osteoporosis
    Type: Application
    Filed: March 4, 2010
    Publication date: June 24, 2010
    Applicants: K.U. LEUVEN RESEARCH AND DEVELOPMENT, UNIVERSITEIT GENT
    Inventors: Roger Bouillon, Annemieke Verstuyf, Pierre De Clercq, Maurits Vandewalle
  • NOVEL PYRIDAZINE COMPOUND AND USE THEREOF
    Publication number: 20100152444
    Abstract: A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating compound (1) are provided.
    Type: Application
    Filed: February 18, 2010
    Publication date: June 17, 2010
    Applicants: Gilead Sciences, Inc., K.U. Leuven Research & Development, Gerhard Puerstinger
    Inventors: Steven S. Bondy, Terrenc C. Dahl, David A. Oare, Reza Oliyai, Winston C. Tse, Vahid Zia
  • Vitamin Danalogues for the prevention and treatment of bone disorders
    Patent number: 7704986
    Abstract: Novel vitamin D analogues are useful for making pharmaceutical compositions for the prevention or treatment of bone disorders such as osteoporosis.
    Type: Grant
    Filed: October 17, 2005
    Date of Patent: April 27, 2010
    Assignees: K.U. Leuven Research and Development, Universiteit Gent
    Inventors: Roger Bouillon, Annemieke Verstuyf, Pierre De Clercq, Maurits Vandewalle
  • NOVEL NUCLEOTIDE ANALOGUES AS PRECUSOR MOLECULES FOR ANTIVIRALS
    Publication number: 20100099869
    Abstract: This invention relates to a purine or pyrimidine phosphonate compound of formula (I) or pharmaceutically acceptable salt thereof; wherein B, X, and R1-R3 are as defined in classes and subclasses herein. These compounds may be used as antiviral precursors. The invention also relates to therapeutic compositions of these compounds and their use for the preparation of a medication for testing and/or preventing a viral infection in a patient. The invention also provides methods for making these compounds. In particular, the invention provides an H-phosphinate precursor intermediate of formula (II) wherein B is a purine or pyrimidine base as defined herein and R1 is selected from the group comprising a hydrogen atom, and a methyl, ethyl, hydroxymethyl, hydroxyethyl and C1-6haloalkyl group.
    Type: Application
    Filed: November 8, 2007
    Publication date: April 22, 2010
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE DE LA MEDITERRANEE, K.U. LEUVEN RESEARCH & DEVELOPMENT
    Inventors: Bruno Canard, Karine Alvarez, Karine Barral, Jean-Louis Romette, Johan Neyts, Jan Balzarini
  • PROCESS FOR PRODUCING SINTERED POROUS MATERIALS
    Publication number: 20100074787
    Abstract: The invention provides a process of making porous structures or materials, including the colloidal processing (e.g. slip casting, pressure casting, tape casting or electrophoretic deposition) of solid particle emulsions to form a green body that can be directly sintered without a de-binding step.
    Type: Application
    Filed: June 27, 2006
    Publication date: March 25, 2010
    Applicant: K.U. LEUVEN RESEARCH & DEVELOPMENT
    Inventors: Bram NEIRINCK, Jozef VLEUGELS, Jan FRANSAER, Omer VAN DER BIEST
  • NOVEL PYRIDAZINE COMPOUND AND USE THEREOF
    Publication number: 20100063059
    Abstract: A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections. Methods of making and formulating compound (1) are provided.
    Type: Application
    Filed: July 6, 2007
    Publication date: March 11, 2010
    Applicants: Gilead Sciences, Inc., K. U. Leuven Research & Development
    Inventors: Steven S. Bondy, Terrence C. Dahl, David A. Oare, Reza Oliyai, Winston C. Tse, Vahid Zia
  • Sealing process inspection device
    Patent number: 7673498
    Abstract: In a first object the present invention provides a method for the inspection of the quality of the sealing of a packages and more specifically the method of the present invention allows the on-line inspection of the air-tightness of a package. Said method comprising the following steps of (i) acquiring the noise signal generated by the sealing equipment during the sealing of the package, (ii) analyzing the signal in order to determine the values of at least one physical parameter characterizing the noise signal and (iii) deciding on the quality of the sealing by comparing the determined value to a reference value for said physical parameter.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: March 9, 2010
    Assignee: K.U. Leuven Research and Development
    Inventors: Josse De Baerdemaeker, Bart De Ketelaere, Bram Kamers
  • Particle size reduction of bioactive compounds
    Patent number: 7666307
    Abstract: The invention provides a method for reducing the average size of biologically active compound particles or agglomerates suspended in a fluid by flowing one or more times said fluid having biologically active compound particles or agglomerates suspended therein through one or more magnetic fields to reduce the average size of a substantial portion of the biologically active compound particles or agglomerates by at least 25%. This method may be incorporated into a process for manufacturing a 10 biologically active compound formulation.
    Type: Grant
    Filed: August 25, 2004
    Date of Patent: February 23, 2010
    Assignee: K.U. Leuven Research & Development
    Inventors: Guy Van Den Mooter, Johan Martens, Jan Nuyens
  • SILK FIBRE COMPOSITES
    Publication number: 20100040816
    Abstract: The present invention provides silk fibre reinforced composite materials comprising a thermoplastic polymer matrix, which are relatively light, whilst having a high impact resistance. The silk fibre reinforced composite materials of the present invention allow for an optimal dissipation of the impact energy such that they have a penetration resistance higher than 20 J per mm of plate thickness, more preferably more than 30 J per mm, most preferably more than 40 J per mm. Due to the high impact resistance of the fibrous composite material according to the present invention, panels or shells comprising such composites are particularly useful for the manufacture of objects, which in the course of their life cycle are subject to shocks or at risk of penetration.
    Type: Application
    Filed: March 26, 2007
    Publication date: February 18, 2010
    Applicant: K.U. LEUVEN RESEARCH AND DEVELOPMENT
    Inventors: Ignace Verpoest, Aart Willem Van Vuure, Nedda El Asmar, Jan Vanderbeke
  • Imidazo 4,5-c pyridine compounds and methods of antiviral treatment
    Patent number: 7648998
    Abstract: The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening ofcompounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: January 19, 2010
    Assignees: K.U. Leuven Research & Development, Gilead Sciences, Inc.
    Inventors: Steven S. Bondy, Eric Davis Dowdy, Choung U. Kim, David A. Oare, Johan Neyts, Vahid Zia, Gerhard Pürstinger
  • CRYSTALLINE MESOPOROUS OXIDE BASED MATERIALS USEFUL FOR THE FIXATION AND CONTROLLED RELEASE OF DRUGS
    Publication number: 20100008990
    Abstract: The invention describes a new class of crystalline silica material having two levels of porosity and structural order. At the first level, building units are nanoslabs of uniform size having zeolite framework. At the second structural level, nanoslabs are assembled, e.g. linked through their corners, edges or faces following patterns imposed by interaction with cationic surfactant or triblock copolymer molecules. After evacuation of these molecules, microporosity is obtained inside the nanoslabs, and a precise mesoporosity between the nanoslabs depending on the tiling pattern of the zeolite nanoslabs, as evidenced by X-ray diffraction. These materials are useful for the fixation of biologically active species, such as poorly soluble drugs.
    Type: Application
    Filed: July 6, 2009
    Publication date: January 14, 2010
    Applicant: K.U. Leuven Research & Development
    Inventors: Johan Adriaan Martens, Christine Eva Antonia Kirschhock, Sebastien Philippe Brigitte Kremer, Alexander Jan Maria Herman Eugeen Aerts, Guy Van Den Mooter, Jan Van Humbeeck
  • Zeolite-Like Membranes from Nano-Zeolitic Particles
    Publication number: 20090318282
    Abstract: A silicate-based microporous ceramic molecular sieve membrane zeolite-like properties with an ordered stack of nanometre-sized slab-shaped building blocks having zeolite framework. A method for producing a membrane does not involve a hydrothermal treatment step, hence avoiding the formation of zeolite crystals.
    Type: Application
    Filed: October 19, 2006
    Publication date: December 24, 2009
    Applicants: VLAAMSE INSTELLING VOOR TECHNOLOGISH ONDERZOEK N.V. (VITO), K.U. LEUVEN RESEARCH & DEVELOPMENT
    Inventors: Anita Buekenhoudt, Pierre Jacobs, Ivo Vankelecom, Johan Martens
  • Recognition and localisation of pathologic animal and human sounds
    Publication number: 20090312660
    Abstract: A system and method are described for combining the respiratory status (e.g. amount and type of cough) with the localization of organisms having the respiratory status in real time. The organisms are able to suffer from a respiratory complaint, i.e. they have lungs such as mammals especially farm animals and humans. In particular the present invention is advantageous for animals and humans who are exposed to closed confinements such as pens, cages, aircraft, public places where humans are in close proximity to each other.
    Type: Application
    Filed: June 17, 2008
    Publication date: December 17, 2009
    Applicants: BIORICS NV, K.U. LEUVEN RESEARCH & DEVELOPMENT
    Inventors: Marcella Guarino, Sara Ferrari, Annamaria Costa, Federica Borgonovo, Daniel Berckmans, Jean-Marie Aerts, Mitchell Silva, Vasileios Exadaktylos, Toon Leroy
  • ENHANCING SOLUBILITY AND DISSOLUTION RATE OF POORLY SOLUBLE DRUGS
    Publication number: 20090311325
    Abstract: The present invention relates generally to use of a polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer), such as Kollicoat IR, in the formulation of solid dispersions of low aqueous solubility and dissolution rate bioactive compound and, more particularly to a system and method for improving the solubility and dissolution rate of such low aqueous solubility and dissolution rate bioactive compound, in particular the drug of low aqueous solubility, such as a BCS Class II or Class IV drug compounds.
    Type: Application
    Filed: April 10, 2007
    Publication date: December 17, 2009
    Applicant: K.U.LEUVEN RESEARCH AND DEVELOPMENT
    Inventors: Sandrien Janssens, Guy Van Den Mooter
  • Method for preparing emulsions
    Patent number: 7629390
    Abstract: The invention relates to a method and a system for the emulsification of a pre-mix of two or more immiscible liquids by flowing or circulating one or more times said pre-mix through one or more magnetic fields.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: December 8, 2009
    Assignee: K.U. Leuven Research & Development
    Inventors: Jan Nuyens, Johan Martens