Patents Assigned to Lexicon Pharmaceuticals, Inc.
  • SOTAGLIFLOZIN FOR IMPROVING LEFT ATRIAL FUNCTION
    Publication number: 20240100013
    Abstract: This invention relates to sotagliflozin for use in methods of improving left atrial function, of treating and/or preventing atrial cardiomyopathy, and treating and/or preventing atrial fibrillation, and to compounds and pharmaceutical compositions useful therein.
    Type: Application
    Filed: January 4, 2022
    Publication date: March 28, 2024
    Applicant: Lexicon Pharmaceuticals, Inc.
    Inventors: Felix HOHENDANNER, Frank HEINZEL
  • COMPOUNDS AND METHODS FOR TREATING SPASTICITY
    Publication number: 20230330074
    Abstract: Provided herein are methods of treating and preventing spasticity in a patient in need thereof.
    Type: Application
    Filed: April 12, 2023
    Publication date: October 19, 2023
    Applicant: Lexicon Pharmaceuticals, Inc.
    Inventors: Suma GOPINATHAN, Praveen TYLE, Qi Melissa YANG
  • Compounds and methods for treating viral infections
    Patent number: 11730723
    Abstract: Provided herein are methods of treating, managing and/or preventing viral infections.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: August 22, 2023
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Suma Gopinathan, Praveen Tyle, Qi Melissa Yang
  • Pyrazolo[1,5]pyrimidine-based compounds and methods of their use to treat viral infections
    Patent number: 11666575
    Abstract: Provided herein are methods of treating, managing and/or preventing viral infections. A particular method comprises administering to a subject in need thereof an effective amount of an adaptor associated kinase 1 inhibitor of the formula wherein R1, R2 and R3 are defined herein.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: June 6, 2023
    Assignee: LEXICON PHARMACEUTICALS, INC.
    Inventors: Suma Gopinathan, Praveen Tyle, Qi Melissa Yang
  • Antibodies that bind Notum Pectinacetylesterase
    Patent number: 11059907
    Abstract: Antibodies that neutralize Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting the bone.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: July 13, 2021
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Robert Joseph Brommage, Jr., Xiao Feng, Seokjoo Hong, Gregory Landes, Jeff Liu, David George Potter, David Reed Powell
  • Crystalline solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide and methods of their synthesis
    Patent number: 10968192
    Abstract: Methods of preparing, and solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide, and salts, solvates and cocrystals thereof, are disclosed.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: April 6, 2021
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Mark Stephen Bednarz, Kuangchu Dai, Jeffrey Manning Eckert, Ngiap-Kie Lim, Lauren Sirois, Wenxue Wu, Matthew Mangzhu Zhao
  • ANTIBODIES THAT BIND NOTUM PECTINACETYLESTERASE
    Publication number: 20190241677
    Abstract: Antibodies that neutralize Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting the bone.
    Type: Application
    Filed: February 15, 2019
    Publication date: August 8, 2019
    Applicant: Lexicon Pharmaceuticals, Inc.
    Inventors: Robert Joseph Brommage, JR., Xiao Feng, Seokjoo Hong, Gregory Landes, Jeff Liu, David George Potter, David Reed Powell
  • Inhibitors of sodium glucose transporter 1 for constipation
    Patent number: 10106569
    Abstract: Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: October 23, 2018
    Assignee: Lexicon Pharmaceutical, Inc.
    Inventors: Kenneth Gordon Carson, Nicole Cathleen Goodwin, Bryce Alden Harrison, David Brent Rawlins, Eric Strobel, Brian Zambrowicz
  • Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
    Patent number: 9862724
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: January 9, 2018
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Michael Walter Gardyan, Michael Alan Green, Godwin Kumi, Yulian Zhang
  • Inhibitors of sodium glucose cotransporter 1
    Patent number: 9688710
    Abstract: Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: June 27, 2017
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Kenneth Gordon Carson, Nicole Cathleen Goodwin, Bryce Alden Harrison, David Brent Rawlins, Eric Strobel, Brian Zambrowicz
  • Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use
    Patent number: 9682982
    Abstract: The adaptor associated kinase 1 (AAK1) inhibitor 3-methyloxetan-3-yl-4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate: and pharmaceutically acceptable salts and solid forms thereof are disclosed. Compositions comprising the compound and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by AAK1 activity are also disclosed.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: June 20, 2017
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Godwin Kumi
  • 4H-thieno[3,2-C]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use
    Patent number: 9624238
    Abstract: Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: April 18, 2017
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Joseph Barbosa, Kenneth Gordon Carson, Michael Walter Gardyan, Jason Patrick Healy, Qiang Han, Ross Mabon, Praveen Pabba, James Tarver, Jr., Kristen M. Terranova, Ashok Tunoori, Xiaolian Xu
  • Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
    Patent number: 9403832
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: August 2, 2016
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Kenneth Gordon Carson, Giovanni Cianchetta, Michael Alan Green, Godwin Kumi, Alan Main, Yulian Zhang, Glenn Gregory Zipp
  • Sodium glucose co-transporter inhibitors and methods of their use
    Patent number: 9365602
    Abstract: Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: June 14, 2016
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Bryce Alden Harrison, Spencer David Kimball, Ross Mabon, David Brent Rawlins
  • ANTIBODIES THAT BIND NOTUM PECTINACETYLESTERASE
    Publication number: 20160152731
    Abstract: Antibodies that neutralize Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting the bone.
    Type: Application
    Filed: November 25, 2015
    Publication date: June 2, 2016
    Applicant: Lexicon Pharmaceuticals, Inc.
    Inventors: Robert Joseph Brommage, JR., Xiao Feng, Seokjoo Hong, Gregory Landes, Jeff Liu, David George Potter, David Reed Powell
  • Inhibitors of sodium glucose cotransporter 1
    Patent number: 9200025
    Abstract: Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: December 1, 2015
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Kenneth Gordon Carson, Nicole Cathleen Goodwin, Bryce Alden Harrison, David Brent Rawlins, Eric Strobel, Brian Zambrowicz
  • Methods of treating diabetes
    Patent number: 9067962
    Abstract: Solid forms of anhydrous (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol are disclosed, in addition to methods of their use in the treatment of various diseases and disorders.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: June 30, 2015
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Susan Margaret De Paul, Anett Perlberg, Matthew Mangzhu Zhao
  • Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use
    Patent number: 8969565
    Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: March 3, 2015
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Kenneth Gordon Carson, Giovanni Cianchetta, Michael Alan Green, Godwin Kumi, Zhi Liang, Ying Jade Liu, Alan Main, Yulian Zhang, Gregory Glenn Zipp
  • Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
    Patent number: 8946415
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: February 3, 2015
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Kenneth Gordon Carson, Giovanni Cianchetta, Michael Alan Green, Godwin Kumi, Alan Main, Yulian Zhang, Gregory Glenn Zipp
  • INHIBITORS OF SODIUM GLUCOSE COTRANSPORTER 1
    Publication number: 20140309178
    Abstract: Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.
    Type: Application
    Filed: November 18, 2013
    Publication date: October 16, 2014
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: Kenneth Gordon CARSON, Nicole Cathleen GOODWIN, Bryce Alden HARRISON, David Brent RAWLINS, Eric STROBEL, Brian ZAMBROWICZ