Patents Assigned to Lexicon Pharmaceuticals, Inc.
  • METHODS OF REDUCING THE RISK OF CARDIOVASCULAR EVENTS IN PATIENTS WITH LEFT VENTRICULAR HYPERTROPHY
    Publication number: 20250114323
    Abstract: Methods of reducing the risk of cardiovascular events in patients with left ventricular hypertrophy without hypertension are disclosed. Preferred methods comprise the administration of a therapeutically effective amount of the dual SGLT1/2 inhibitor sotagliflozin.
    Type: Application
    Filed: October 3, 2024
    Publication date: April 10, 2025
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventor: Michael John Davies
  • METHODS OF TREATING TYPE 1 DIABETES AND KIDNEY DISEASE
    Publication number: 20250108032
    Abstract: Methods of using a sodium glucose cotransporter 2 (SGLT2) inhibitor to treat type 1 diabetes, improve cardiovascular health, slow kidney function decline, reduce the risk of cardiovascular death, and reduce the risk of hospitalization for heart failure while minimized adverse events such as diabetic ketoacidosis and severe hypoglycemia are disclosed. In preferred methods, the SGLT2 inhibitor is sotagliflozin. Methods of prescribing and administering sotagliflozin are also disclosed.
    Type: Application
    Filed: September 26, 2024
    Publication date: April 3, 2025
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventor: Michael John Davies
  • USE OF SOTAGLIFLOZIN FOR THE TREATMENT OF PATIENTS WITH TYPE 1 DIABETES MELLITUS
    Publication number: 20240226125
    Abstract: The invention relates to the use of sotagliflozin to improve glycemic control in adults with type 1 diabetes mellitus with a Body Mass Index (BMI) ?27 kg/m2.
    Type: Application
    Filed: March 22, 2024
    Publication date: July 11, 2024
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: Phillip BANKS, Sangeeta SAWHNEY
  • SOTAGLIFLOZIN FOR IMPROVING LEFT ATRIAL FUNCTION
    Publication number: 20240100013
    Abstract: This invention relates to sotagliflozin for use in methods of improving left atrial function, of treating and/or preventing atrial cardiomyopathy, and treating and/or preventing atrial fibrillation, and to compounds and pharmaceutical compositions useful therein.
    Type: Application
    Filed: January 4, 2022
    Publication date: March 28, 2024
    Applicant: Lexicon Pharmaceuticals, Inc.
    Inventors: Felix HOHENDANNER, Frank HEINZEL
  • COMPOUNDS AND METHODS FOR TREATING SPASTICITY
    Publication number: 20230330074
    Abstract: Provided herein are methods of treating and preventing spasticity in a patient in need thereof.
    Type: Application
    Filed: April 12, 2023
    Publication date: October 19, 2023
    Applicant: Lexicon Pharmaceuticals, Inc.
    Inventors: Suma GOPINATHAN, Praveen TYLE, Qi Melissa YANG
  • Compounds and methods for treating viral infections
    Patent number: 11730723
    Abstract: Provided herein are methods of treating, managing and/or preventing viral infections.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: August 22, 2023
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Suma Gopinathan, Praveen Tyle, Qi Melissa Yang
  • Pyrazolo[1,5]pyrimidine-based compounds and methods of their use to treat viral infections
    Patent number: 11666575
    Abstract: Provided herein are methods of treating, managing and/or preventing viral infections. A particular method comprises administering to a subject in need thereof an effective amount of an adaptor associated kinase 1 inhibitor of the formula wherein R1, R2 and R3 are defined herein.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: June 6, 2023
    Assignee: LEXICON PHARMACEUTICALS, INC.
    Inventors: Suma Gopinathan, Praveen Tyle, Qi Melissa Yang
  • Antibodies that bind Notum Pectinacetylesterase
    Patent number: 11059907
    Abstract: Antibodies that neutralize Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting the bone.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: July 13, 2021
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Robert Joseph Brommage, Jr., Xiao Feng, Seokjoo Hong, Gregory Landes, Jeff Liu, David George Potter, David Reed Powell
  • Crystalline solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide and methods of their synthesis
    Patent number: 10968192
    Abstract: Methods of preparing, and solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide, and salts, solvates and cocrystals thereof, are disclosed.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: April 6, 2021
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Mark Stephen Bednarz, Kuangchu Dai, Jeffrey Manning Eckert, Ngiap-Kie Lim, Lauren Sirois, Wenxue Wu, Matthew Mangzhu Zhao
  • ANTIBODIES THAT BIND NOTUM PECTINACETYLESTERASE
    Publication number: 20190241677
    Abstract: Antibodies that neutralize Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting the bone.
    Type: Application
    Filed: February 15, 2019
    Publication date: August 8, 2019
    Applicant: Lexicon Pharmaceuticals, Inc.
    Inventors: Robert Joseph Brommage, JR., Xiao Feng, Seokjoo Hong, Gregory Landes, Jeff Liu, David George Potter, David Reed Powell
  • Inhibitors of sodium glucose transporter 1 for constipation
    Patent number: 10106569
    Abstract: Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: October 23, 2018
    Assignee: Lexicon Pharmaceutical, Inc.
    Inventors: Kenneth Gordon Carson, Nicole Cathleen Goodwin, Bryce Alden Harrison, David Brent Rawlins, Eric Strobel, Brian Zambrowicz
  • Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
    Patent number: 9862724
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: January 9, 2018
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Michael Walter Gardyan, Michael Alan Green, Godwin Kumi, Yulian Zhang
  • Inhibitors of sodium glucose cotransporter 1
    Patent number: 9688710
    Abstract: Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: June 27, 2017
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Kenneth Gordon Carson, Nicole Cathleen Goodwin, Bryce Alden Harrison, David Brent Rawlins, Eric Strobel, Brian Zambrowicz
  • Inhibitors of adapter associated kinase 1, compositions comprising them, and methods of their use
    Patent number: 9682982
    Abstract: The adaptor associated kinase 1 (AAK1) inhibitor 3-methyloxetan-3-yl-4-(3-(2-methoxypyridin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate: and pharmaceutically acceptable salts and solid forms thereof are disclosed. Compositions comprising the compound and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by AAK1 activity are also disclosed.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: June 20, 2017
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Godwin Kumi
  • 4H-thieno[3,2-C]chromene-based inhibitors of Notum Pectinacetylesterase and methods of their use
    Patent number: 9624238
    Abstract: Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: April 18, 2017
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Joseph Barbosa, Kenneth Gordon Carson, Michael Walter Gardyan, Jason Patrick Healy, Qiang Han, Ross Mabon, Praveen Pabba, James Tarver, Jr., Kristen M. Terranova, Ashok Tunoori, Xiaolian Xu
  • Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
    Patent number: 9403832
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: August 2, 2016
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Kenneth Gordon Carson, Giovanni Cianchetta, Michael Alan Green, Godwin Kumi, Alan Main, Yulian Zhang, Glenn Gregory Zipp
  • Sodium glucose co-transporter inhibitors and methods of their use
    Patent number: 9365602
    Abstract: Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: June 14, 2016
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Bryce Alden Harrison, Spencer David Kimball, Ross Mabon, David Brent Rawlins
  • ANTIBODIES THAT BIND NOTUM PECTINACETYLESTERASE
    Publication number: 20160152731
    Abstract: Antibodies that neutralize Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting the bone.
    Type: Application
    Filed: November 25, 2015
    Publication date: June 2, 2016
    Applicant: Lexicon Pharmaceuticals, Inc.
    Inventors: Robert Joseph Brommage, JR., Xiao Feng, Seokjoo Hong, Gregory Landes, Jeff Liu, David George Potter, David Reed Powell
  • Inhibitors of sodium glucose cotransporter 1
    Patent number: 9200025
    Abstract: Inhibitors of sodium glucose cotransporter 1 (SGLT1), compositions comprising them, and methods of their use to treat diseases and disorders such as diabetes are disclosed. Particular compounds are of the formula: the various substituents of which are defined herein.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: December 1, 2015
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Kenneth Gordon Carson, Nicole Cathleen Goodwin, Bryce Alden Harrison, David Brent Rawlins, Eric Strobel, Brian Zambrowicz
  • Methods of treating diabetes
    Patent number: 9067962
    Abstract: Solid forms of anhydrous (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol are disclosed, in addition to methods of their use in the treatment of various diseases and disorders.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: June 30, 2015
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Susan Margaret De Paul, Anett Perlberg, Matthew Mangzhu Zhao