Patents Assigned to Lexicon Pharmaceuticals, Inc.
  • MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE
    Publication number: 20100081691
    Abstract: This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use in, for example, the treatment of cognitive disorders.
    Type: Application
    Filed: December 8, 2009
    Publication date: April 1, 2010
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: Joseph Barbosa, Li Dong, Cynthia Anne Fink, Jiancheng Wang, G. Gregory Zipp
  • METHODS OF TREATING RHEUMATOID ARTHRITIS
    Publication number: 20100076030
    Abstract: Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed.
    Type: Application
    Filed: December 1, 2009
    Publication date: March 25, 2010
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Lakmal W. Boteju, Kenneth G. Carson, Theodore C. Jessop, Spencer David Kimball
  • Monoclonal antibodies against ANGPTL4
    Patent number: 7655762
    Abstract: Monoclonal antibodies that specifically bind to ANGPTL4 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL4 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: February 2, 2010
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: E-Chiang Lee, Gregory M. Landes, Kyu Chung, Ling Chen, Urvi Desai, David Reed Powell, Seokjoo Hong
  • Imidazole-based compounds, compositions comprising them and methods of their use
    Patent number: 7649098
    Abstract: Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: January 19, 2010
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Lakmal W. Boteju, Kenneth G. Carson, Theodore C. Jessop, Spencer David Kimball
  • HETEROCYCLIC COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE
    Publication number: 20090312375
    Abstract: Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed.
    Type: Application
    Filed: August 24, 2009
    Publication date: December 17, 2009
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Simon D.P. Baugh, Kenneth G. Carson, Theodore C. Jessop, James E. Tarver
  • Heterocyclic compounds, compositions comprising them and methods of their use
    Patent number: 7598280
    Abstract: Heterocyclic compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: October 6, 2009
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Simon D. P. Baugh, Kenneth G. Carson, Theodore C. Jessop, James E. Tarver
  • 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
    Patent number: 7553840
    Abstract: Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: June 30, 2009
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Arokiasamy Devasagayaraj, Haihong Jin, Zhi-Cai Shi, Ashok Tunoori, Ying Wang, Chengmin Zhang
  • Novel Gene Disruptions, Compositions and Methods Relating Thereto
    Publication number: 20090142348
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO844, PRO1131 or PRO5992 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Application
    Filed: May 21, 2007
    Publication date: June 4, 2009
    Applicants: GENENTECH, INC., LEXICON PHARMACEUTICALS, INC.
    Inventors: Frederic de Sauvage, Ellen Filvaroff, Jagath Reddy Junutula, Bobby Joe Payne, Zheng-Zheng Shi, Mary Jean Sparks, Peter Vogel
  • 4-Piperidin-1-yl-7-pyrrolo[2,3-]pyrimidine compounds
    Patent number: 7423043
    Abstract: Substituted 4-piperidin-1-yl-7H-pyrrolo[2,3-D]pyrimidine compounds are disclosed, as well as compositions comprising them and methods of their use for the treatment, prevention and management of various diseases and disorders.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: September 9, 2008
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David Brent Rawlins, Michael Victor Voronkov, Yulian Zhang
  • Knockout animals manifesting hyperlipidemia
    Patent number: 7402730
    Abstract: Genetically engineered cells and animals are described that incorporate a mutated GHP1 allele. Animals that are homozygous for the mutated GHP1 allele are useful for the production of monoclonal antibodies against GHP1.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: July 22, 2008
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Mary Jean Sparks, Wenhu Huang
  • Human kinases and polynucleotides encoding the same, and uses thereof
    Patent number: 7374932
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: December 29, 2004
    Date of Patent: May 20, 2008
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: D. Wade Walke, Erin Hilbun, Gregory Donoho, C. Alexander Turner, Jr., Gwenn Hansen, Hector BeltrandelRio, Isaac Van Sligtenhorst
  • Human metalloprotease and polynucleotides encoding the same
    Patent number: 7374933
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in thereapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: May 20, 2008
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: D. Wade Walke, Nathaniel L. Wilganowski, C. Alexander Turner, Jr.
  • Vectors for making genomic modifications
    Patent number: 7332338
    Abstract: Methods and vectors (both DNA and retroviral) are provided for the construction of a Library of mutated cells. The Library will preferably contain mutations in essentially all genes present in the genome of the cells. The nature of the Library and the vectors allow for methods of screening for mutations in specific genes, and for gathering nucleotide sequence data from each mutated gene to provide a database of tagged gene sequences. Such a database provides a means to access the individual mutant cell clones contained in the Library. The invention includes the described Library, methods of making the same, and vectors used to construct the Library. Methods are also provided for accessing individual parts of the Library either by sequence or by pooling and screening. The invention also provides for the generation of non-human transgenic animals which are mutant for specific genes as isolated and generated from the cells of the Library.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: February 19, 2008
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Brian Zambrowicz, Glenn A. Friedrich, Arthur T. Sands
  • Variants of FAM3C
    Patent number: 7312079
    Abstract: Polynucleotide and polypeptide sequences that encode novel variant FAM3C proteins are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: December 25, 2007
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventor: Yi Hu
  • Thiazolopyrazoles and methods of their use
    Patent number: 7300949
    Abstract: This invention concerns novel thiazolopyrazole compounds and compositions comprising them. Methods of using these compounds for the treatment, prevention and management of various diseases and disorders are also encompassed by the invention.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: November 27, 2007
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Joseph Barbosa, Cynthia A. Fink, Spencer D. Kimball, Hartmuth Kolb, Zhi-Cai Shi, Ashok R. Tunoori
  • Polynucleotides encoding human transporter proteins
    Patent number: 7268222
    Abstract: Novel human ATP binding cassette transporter polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: September 11, 2007
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Marie Harras, Gregory Donoho, C. Alexander Turner, Jr., Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands
  • Human GABA transporter protein and polynucleotides encoding the same
    Patent number: 7229790
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: August 28, 2001
    Date of Patent: June 12, 2007
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Carl Johan Friddle, Brenda Gerhardt, Yi Hu
  • Large scale synthesis of 1,2,4- and 1,3,4-oxadiazole carboxylates
    Patent number: 6951946
    Abstract: Disclosed are efficient and scalable processes for preparing 1,2,4- and 1,3,4-oxadiazole carboxylates from readily available starting materials.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: October 4, 2005
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hartmuth C. Kolb, Ramanaiah C. Kanamarlapudi, Paul F. Richardson
  • Water as promoter in the nucleophilic substitution of chloride
    Patent number: 6891068
    Abstract: Disclosed is a one step method for preparing a ?-substituted sulfide by treating a ?-halosulfide with a nucleophile in water.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: May 10, 2005
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hartmuth C. Kolb, Zhi-Cai Shi, Zhi-Min Wang
  • Modified safe and efficient process for the environmentally friendly synthesis of imidoesters
    Patent number: 6806380
    Abstract: Disclosed is a safe, efficient and environmentally friendly method for preparing imidoesters.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: October 19, 2004
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hartmuth C. Kolb, Ramanaiah C. Kanamarlapudi, Paul F. Richardson, Gaznabi Khan