Abstract: The present invention relates to a novel quinolone compound having an excellent antibacterial activity. More specifically, the present invention relates to 7-(4-aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4 -oxo-1, 4-dihydro-1,8-naphthyridine-3-carboxylic acid represent by the following formula: ##STR1## or its isomer.
Type:
Grant
Filed:
April 4, 1997
Date of Patent:
July 7, 1998
Assignee:
LG Chemical Ltd.
Inventors:
Chang Yong Hong, Young Kwan Kim, Se Ho Kim, Jay Hyok Chang, Hoon Choi, Do Hyun Nam, Ae Ri Kim, Jin Hwa Lee, Ki Sook Park
Abstract: A microparticle having a particle size ranging from 0.5 to 300 .mu.m, which is prepared by dissolving an antigen or a mixture of antigens in an aqueous solution, adding a water-soluble substance thereto, and removing water to obtain a core particle and coating the core particle with a biodegradable polymer; and a single-shot vaccine formulation prepared by dispersing the microparticles in an injection medium.
Type:
Grant
Filed:
March 11, 1996
Date of Patent:
May 19, 1998
Assignee:
LG Chemical Ltd.
Inventors:
Hyeon-Kook Lee, Jung-Hwan Park, Nam-Sok Choi, Myung-Jin Kim, Soo-Hyeon Kim
Abstract: The present invention relates to a novel selective thrombin inhibitor having the following formula (I), which is also effective by oral administration: ##STR1## in which R.sup.1 represents acetyl substituted with aryl or aryloxy, or represents sulfonyl substituted with substituted or unsubstituted aryl or N-containing heterocyclic group,X represents a group of formula ##STR2## R.sup.2 and R.sup.3 independently of one another represent hydrogen; cycloalkyl substituted or unsubstituted with carboxyl or alkoxycarbonyl; arylalkyloxy; hydroxy; or lower alkyl substituted or unsubstituted with carboxyl, alkoxycarbonyl or hydroxy, orR.sup.2 and R.sup.3 together with nitrogen atom to which they are attached can form a piperidine group substituted with carboxyl or alkoxycarbonyl,R.sup.4 represents hydrogen, lower alkyl or lower alkoxy,R.sup.
Type:
Grant
Filed:
January 16, 1996
Date of Patent:
May 5, 1998
Assignee:
LG Chemical Ltd.
Inventors:
Yeong Soo Oh, Sang Soo Kim, Sang Yeul Hwang, Mi Kyung Yun, Seong Ryul Hwang, Seong Won Hong, Yong Hee Lee, Yi Na Jeong, Koo Lee, You Seung Shin
Abstract: The present invention relates to a sustained-release formulation of an animal growth hormone and a process for preparation thereof, comprising a step to produce solid pellets by mixing an animal growth hormone and an excipient in accordance with a direct tabletting method and a step to coat the pellets with a film comprising a biodegradable polymer and a poloxamer. The thus obtained formulation has small initial drug release, and shows a continuous and uniform effect when administered. Further, the formulation of the present invention may be produced economically in a large scale.
Abstract: The present invention relates to a novel quinolone compound having an excellent antibacterial activity. More specifically, the present invention relates to a novel quinoline(naphthyridine)carboxylic acid derivative represented by the following formula (I), which has an 4-aminomethyl-3-oximepyrrolidine substituent on 7-position of the quinolone nucleus and shows a superior antibacterial activity in contrast to the known quinolone antibactrial agents having a weak activity against gram-positive bacterial strains and also has a broad antibacterial spectrum and a highly improved pharmacokinetic property: ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Q are defined as described in the specification.
Type:
Grant
Filed:
January 30, 1997
Date of Patent:
December 16, 1997
Assignee:
LG Chemical Ltd.
Inventors:
Chang Yong Hong, Young Kwan Kim, Jay Hyok Chang, Se Ho Kim, Hoon Choi, Do Hyun Nam, Jin Hwan Kwak, Yi Na Jeong, Jeong In Oh, Mu Yong Kim
Abstract: The present invention relates to a novel quinolone compound having an excellent antibacterial activity. More specifically, the present invention relates to a novel quinoline(naphthyridine)carboxylic acid derivative represented by the following formula (I), which has an 4-aminomethyl-3-oximepyrrolidine substituent on 7-position of the quinolone nucleus and shows a superior antibacterial activity in contrast to the known quinolone antibacterial agents having a weak activity against gram-positive bacterial strains and also has a broad antibacterial spectrum and a highly improved pharmacokinetic property: ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Q are defined as described in the specification.
Type:
Grant
Filed:
June 15, 1995
Date of Patent:
May 27, 1997
Assignee:
LG Chemical Ltd.
Inventors:
Chang Y. Hong, Young K. Kim, Jay H. Chang, Se H. Kim, Hoon Choi, Do H. Nam, Jin H. Kwak, Yi N. Jeong, Jeong I. Oh, Mu Y. Kim