Patents Assigned to Life Technologies AS
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Patent number: 11952495Abstract: The present disclosure provides for compounds of Formula (I), its corresponding compounds of Formula (II) or salts thereof and their use as fluorogenic pH sensors.Type: GrantFiled: October 11, 2021Date of Patent: April 9, 2024Assignee: Life Technologies CorporationInventors: Yi-Zhen Hu, Aimei Chen, Daniel Beacham, Chrisgen Vonnegut, Krishnamurthy Nacharaju
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Patent number: 11951474Abstract: The invention provides a passive fluidics circuit for directing different fluids to a common volume, such as a reaction chamber or flow cell, without intermixing or cross contamination. The direction and rate of flow through junctions, nodes and passages of the fluidics circuit are controlled by the states of upstream valves (e.g. opened or closed), differential fluid pressures at circuit inlets or upstream reservoirs, flow path resistances, and the like. Free diffusion or leakage of fluids from unselected inlets into the common outlet or other inlets at junctions or nodes is prevented by the flow of the selected inlet fluid, a portion of which sweeps by the inlets of unselected fluids and exits the fluidics circuit by waste ports, thereby creating a barrier against undesired intermixing with the outlet flow through leakage or diffusion.Type: GrantFiled: June 21, 2021Date of Patent: April 9, 2024Assignee: Life Technologies CorporationInventors: Jonathan Schultz, David Marran
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Patent number: 11946100Abstract: The present application provides a microdroplet container and a method for manufacturing the same, a method for spreading microdroplets, a microdroplet-generating kit, a temperature-controlling device, an oil phase composition for microdroplet generating and a method for treating the same. The temperature controlling device includes a flexible circuit board a heating substrate, and multiple semiconductor electric couples. The semiconductor electric couples are disposed between the flexible circuit board and a first surface of the heating substrate, and are connected to each other.Type: GrantFiled: January 24, 2019Date of Patent: April 2, 2024Assignee: SNIPER (SUZHOU) LIFE TECHNOLOGY CO., LTD.Inventor: Guang-Ji Sheng
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Patent number: 11946859Abstract: The method of analyzing absorbance of one or more liquid samples (3) arranged in the wells (2) of a microplate (1) comprises the steps of setting a desired wavelength falling within the wavelength range of 380 nm-750 nm for absorbance measurement (101), illuminating the samples (3) using electromagnetic radiation having a bandwidth of at most 20 nm around the set wavelength (102), measuring radiant flux transmitted through each sample (3) (103), on the basis of measured radiant flux values, determining an absorbance value for each sample (3) (104), and visualizing the absorbance values on a display (12) as a matrix comprising a plurality of cells (23), each cell (23) corresponding to a well (2) of the microplate (1) (105). The set wavelength is used as an input for determining the visual properties of the cells (23).Type: GrantFiled: July 26, 2022Date of Patent: April 2, 2024Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Adyary Fallarero, Marika J. Raitio, Tommi Suvanto, Katja Eklin
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Patent number: 11944975Abstract: A thermal cycler system comprises a sample block configured to receive a sample holder configured to receive a plurality of samples; an adaptor configured to surround a periphery of the sample block; and a drip pan configured to surround a periphery of the adaptor. The drip pan comprises one or more ejector mechanisms and one or more openings, the one or more ejector mechanisms configured to respectively extend through the one or more openings into contact with the sample holder in a state of the sample holder received by the sample block and the adaptor surrounding the periphery of the sample block.Type: GrantFiled: December 29, 2022Date of Patent: April 2, 2024Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Zeqi Tan, Wuh Ken Loh, Siew Yin Lee, Kuan Moon (Bernard) Boo
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Patent number: 11944945Abstract: A fluid mixing system includes a flexible bag having a first end, an opposing second end, and an interior surface bounding a compartment; a retainer coupled to the second end of the flexible bag, the retainer having a retention cavity formed thereon that communicates with the compartment of the flexible bag; and an elongated member having a first end rotatably coupled to the first end of the flexible bag and an opposing second end freely disposed within the retention cavity of the retainer so that the second end of the elongated member can rotate within the retention cavity relative to the retainer.Type: GrantFiled: November 27, 2020Date of Patent: April 2, 2024Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Jeremy K. Larsen, Clinton C. Staheli, Brandon M. Knudsen
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Publication number: 20240102003Abstract: The present disclosure describes oligonucleotide-tethered nucleotides, methods of making them, and methods of using them. The oligonucleotide-tethered nucleotides comprise, in some embodiments, a nucleotide linked to an oligonucleotide of from about 3 to about 100 nucleotides in length. These oligonucleotide-tethered nucleotides can be used to label a plurality of different types of nucleic acids in a plurality of different situations with a known oligonucleotide, which can serve as a barcode in some embodiments. The resulting oligonucleotide-labeled nucleic acids oligo-nucleotides can be used in a variety of nucleic acid sequencing methods.Type: ApplicationFiled: June 30, 2023Publication date: March 28, 2024Applicants: Thermo Fisher Scientific Baltics UAB, Life Technologies CorporationInventors: Arvydas Lubys, Inga Cikotiene, Zana Kapustina, Arturas Berezniakovas, Justina Sulgaite, Simona Zeimyte, Mark Andersen, Michael Allen, Sihong Chen
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Patent number: 11940371Abstract: The present disclosure provides apparatuses, systems, and methods for performing particle analysis through flow cytometry at comparatively high event rates and for gathering high resolution images of particles.Type: GrantFiled: December 21, 2022Date of Patent: March 26, 2024Assignee: Life Technologies CorporationInventors: Gregory Kaduchak, Michael Ward
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Patent number: 11920191Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.Type: GrantFiled: January 18, 2021Date of Patent: March 5, 2024Assignee: Life Technologies CorporationInventors: Mingsong Chen, Kuan Moon Boo, Tiong Han Toh, Mauro Aguanno, Soo Yong Lau, Huei Yeo, Wei Fuh Teo
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Patent number: 11918191Abstract: A conception aid for assisting in natural conception may include a platform configured for placement in a vaginal canal, wherein the platform comprises one or more capturing elements configured to collect semen. A method of aiding conception may include providing a conception aid device including one or more capturing elements, collecting semen with the one or more capturing elements wherein the one or more capturing elements is configured to contain the collected semen on the device, and positioning the device in a vaginal canal.Type: GrantFiled: May 17, 2022Date of Patent: March 5, 2024Assignee: HANNAH LIFE TECHNOLOGIES PTE, LTD.Inventors: Prusothman Sina Raja, Chee Keong Tee, Vivek Murali, Zongyuan Xu, Shruthi Pandi Chelvam
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Patent number: 11913066Abstract: Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.Type: GrantFiled: January 26, 2022Date of Patent: February 27, 2024Assignee: Life Technologies CorporationInventors: Robert Green, Dennis Wang, Julio Mulero, Robert Lagace
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Publication number: 20240058714Abstract: The present invention discloses a multi-functional toy comprising: a flexible shell comprising a receiving cavity, an opening communicating with the receiving cavity, and a locking portion provided around the opening; a seat is mounted on the opening and protrudes into the receiving cavity; the seat comprises a clamping groove formed by being recessed and an upper clamping wall and a lower clamping wall forming the clamping groove; the locking portion protrudes into the clamping groove; the upper clamping wall protrudes into the receiving cavity; the lower clamping wall is exposed to the flexible shell; and the lamp holder further comprises a plurality of fasteners penetrating upwards successively through the lower clamping wall and the locking portion.Type: ApplicationFiled: May 10, 2023Publication date: February 22, 2024Applicant: Guangdong Time Life Technology Co., Ltd.Inventor: Longcai XU
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Patent number: 11904321Abstract: A container includes a lower portion and a lid to connect with the lower portion. The lid includes a fluidic interface, a swing bar, and a counter structure disposed on an opposite side of the fluidic interface relative to the swing bar. The fluidic interface includes a first liquid port, a second liquid port, a gas port, and a seal ring disposed around the first liquid port, the second liquid port, and the gas port, the first liquid port disposed along a center axis of the container.Type: GrantFiled: May 28, 2020Date of Patent: February 20, 2024Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Mark Reed, Rui Zheng
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Patent number: 11905558Abstract: A sequencing system includes an automated sequencing instrument adapted to determine variant calls for one or more extracted polynucleotide samples with a performance of at least 98.5% raw read accuracy and a run time in a range of 5 hours to 14 hours to determine variant calls for 4 extracted polynucleotide samples using a targeted assay with one DNA pool per sample and an average amplicon size in a range of 100 to 120 bases.Type: GrantFiled: August 14, 2020Date of Patent: February 20, 2024Assignee: Life Technologies CorporationInventors: Mark Reed, Chiu Tai Andrew Wong, David Marran
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Patent number: 11905557Abstract: According to various embodiments described herein, a microfluidics-chip based purification device and system for Sanger-sequencing reactions is provided. The device and system allow for the introduction into a sequencing system of a cartridge containing purification technologies specific to the sequencing contaminants or sequencing method where the simplified purification solution of a cartridge allows automation of the sample purification process, reduced consumption of purification reagents, and consistency in sampling by reducing the sampling errors and artifacts. These various embodiments therefore solve the need for a microfluidics-chip-based, Sanger-sequencing reaction purification system for CE devices. The microfluidic chips described can be used as a PCR chip by reorganizing the on-chip reagents, reaction wells and work flow steps.Type: GrantFiled: March 5, 2021Date of Patent: February 20, 2024Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Swati Goyal, Achim Karger, Peter Ma, S. Jeffrey Rosner, Ian Walton, Jonathan Wang, Michael Wenz
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Patent number: 11906724Abstract: Apparatuses, systems and methods for generating color video with a monochrome sensor include the acts of (i) selectively energizing each of a plurality of light sources in a sequence, (ii) capturing a monochrome image of the illuminated sample at a monochrome sensor at each stage of the sequence, and (iii) generating a color video from the monochrome images. The sequence can have a series of stages with each stage of the sequence corresponding to activation of a different wavelength of light from the light sources to illuminate a sample. Generating the monochrome video can include the acts of compiling a plurality of monochrome images captured at the monochrome sensor with a single light source into a series of monochrome video frames comprising the monochrome video.Type: GrantFiled: May 6, 2022Date of Patent: February 20, 2024Assignee: Life Technologies CorporationInventors: Marc Berretta, Jason Mecham, Frank Metting, Jonathan Paullin, Paul Boeschoten, Erik Persmark, Eric Altendorf
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Patent number: 11899029Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.Type: GrantFiled: November 17, 2022Date of Patent: February 13, 2024Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Kristopher Barbee, Maximilian Carpino, Ray Wheeling, Nicholas Peter Bajka
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Publication number: 20240042062Abstract: This disclosure relates to the field of fluorescent dyes, and in particular, compositions and methods for increasing fluorescent signals and the reduction of fluorescent quenching.Type: ApplicationFiled: October 16, 2023Publication date: February 8, 2024Applicants: Life Technologies Corporation, Pierce Biotechnology, Inc.Inventors: Surbhi Desai, Marie Christine Nlend, Kyle Gee, Matthew Baker, Robert Aggeler, Scott Sweeney, Aleksey Rukavishnikov, Shih-Jung Huang
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Patent number: D1016098Type: GrantFiled: March 12, 2021Date of Patent: February 27, 2024Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Nephi D. Jones, Jason D. Brown
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Patent number: D1021947Type: GrantFiled: April 19, 2022Date of Patent: April 9, 2024Assignee: Life Technologies CorporationInventors: Sean Zimmerman, Scott Rickes