Abstract: Devices and methods for treating defects in connective tissue are provided along with methods for making such devices. The devices can include acellular arterial tissue matrices that facilitate regrowth of the damaged tissue.
Abstract: Methods of forming a composition for treatment, compositions for treatment, and methods of treatment with the compositions are provided. The methods can include coating a synthetic material substrate with a biologic material. A portion of the biologic material can be acid-swelled.
Type:
Grant
Filed:
June 9, 2017
Date of Patent:
May 19, 2020
Assignee:
LifeCell Corporation
Inventors:
Hui Xu, Sean Collins, Li Ting Huang, Hua Wan, Yi Chen
Abstract: The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices including combinations of different tissue types. The combination can harness various properties of the different tissues to provide improved composite structures with desired mechanical and/or biologic properties.
Type:
Grant
Filed:
June 30, 2017
Date of Patent:
May 5, 2020
Assignee:
LifeCell Corporation
Inventors:
Sangwook Park, Hui Xu, Aaron Barere, Israel Jessop, Mrinal Shah, Nathaniel Bachrach
Abstract: Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.
Type:
Grant
Filed:
September 6, 2018
Date of Patent:
April 7, 2020
Assignee:
LifeCell Corporation
Inventors:
Hui Xu, Wenquan Sun, Hua Wan, Rick T. Owens
Abstract: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating select portions of a tissue matrix with a cross-linking agent and/or a proteolytic enzyme to produce a tissue matrix with variable mechanical and/or biological properties.
Type:
Grant
Filed:
January 30, 2017
Date of Patent:
February 25, 2020
Assignee:
LifeCell Corporation
Inventors:
Gary Monteiro, Christopher T. Wagner, Neil L. Rodriguez, Aubrey Irene Delossantos
Abstract: Tissue processing devices are provided. The tissue processing devices can be used to process and transport tissue in a closed and continuous environment. The devices can be used for adipose tissue transfer, including autologous fat grafting.
Type:
Grant
Filed:
December 21, 2018
Date of Patent:
February 4, 2020
Assignee:
LIFECELL CORPORATION
Inventors:
Kai-Roy Wang, Aaron Barere, Evan J. Friedman, Sangwook Park
Abstract: The present disclosure provides devices and methods for harvesting and processing tissue from patients for grafting. The devices can include a tissue collection chamber for ascetically collecting, processing, and/or re-implanting adipose tissue.
Type:
Grant
Filed:
April 9, 2019
Date of Patent:
February 4, 2020
Assignee:
LIFECELL CORPORATION
Inventors:
Sangwook Park, Jerome Connor, Aaron Barere
Abstract: Devices and methods for processing animal or human tissue are provided. The devices may include a rod having a central axis and configured to simultaneously rotate around the central axis and move along the central axis. The device can further include a group of blades which are attached to the rod and positioned proximate the rigid support surface.
Abstract: The present disclosure relates to tissue matrix products. The products can includes tissue matrices that have holes or perforations located at certain positions to improve certain in vivo functions without substantial loss of strength or other important properties.
Abstract: A vascular graft for treatment of diseased or damaged blood vessels is disclosed. The graft comprises a sheet of acellular tissue matrix with an intact basement membrane. The graft is formed by wrapping the sheet into a tube and securing the edges of the sheet together. The acellular tissue matrix facilitates tissue ingrowth and remodeling of the graft with host cells.
Type:
Grant
Filed:
August 24, 2010
Date of Patent:
January 7, 2020
Assignee:
LifeCell Corporation
Inventors:
Hui Xu, Cunqi Cui, Joshua Czeczuga, Jared Lombardi
Abstract: Devices and methods for processing animal or human tissue are provided. The devices may include a vacuum surface to secure the tissue in place and an apparatus for removing fat or other material from the tissue. The apparatus can include one or more blades and/or a fluid jet system.
Abstract: Devices and methods for treating an abdominal incision or hernia are described. An implant for the restoration or prophylactic treatment of an abdominal wall comprises an elongate element and at least one sheet connected to the elongate element along a longitudinal axis of the elongate element. The elongate element is positioned along the line of incision, and the at least one sheet is secured to the abdominal muscles surrounding the incision.
Abstract: Systems, devices, and methods of the present disclosure assist with management of tubes and hoses during surgical procedures. The systems, devices, and methods provide for the proper opening and closing of tubes to facilitate performance of steps in a surgical procedure. Systems, devices, and methods of the present disclosure control fluid delivery to and from a medical device, including devices for tissue processing and cleaning.
Type:
Grant
Filed:
August 28, 2017
Date of Patent:
November 12, 2019
Assignee:
LifeCell Corporation
Inventors:
Evan Friedman, Israel James Jessop, Kai-Roy Wang, Aaron Barere, Brendan P. Collins, Derek Hugger, Christopher Labak, Scott Woodruff
Abstract: Devices and methods for treating or repairing openings in an body wall are provided. The devices and methods can include acellular tissue matrices. The tissue matrices can be positioned within the abdominal opening and can be used to close the opening.
Type:
Grant
Filed:
February 17, 2011
Date of Patent:
October 22, 2019
Assignee:
LifeCell Corporation
Inventors:
Eric Stevenson, Wendell Sun, Aaron Barere
Abstract: A lab processing device is provided. The device may include a container with an open side, a sash located on the open side and an airflow sensor to measure airflow to or from the interior volume of the container. The device can include a light source configured to be enabled or disabled depending on the location of the sash or measurements of the airflow sensor.
Type:
Grant
Filed:
May 26, 2015
Date of Patent:
October 8, 2019
Assignee:
LifeCell Corporation
Inventors:
Vasant Shah, Michael Kuehne, Joseph Junio, Jr., Russell Saputo, Ronojit Sudhir Adyanthaya
Abstract: The present application relates to use of transglutaminases to treat various products, including medical devices such as tissue grafts, tissue matrices or other tissue-derived materials, and synthetics. The transglutaminases can be applied to the medical devices to provide advantages such as adhesion resistance or abrasion resistance.
Type:
Grant
Filed:
January 29, 2018
Date of Patent:
September 17, 2019
Assignee:
LifeCell Corporation
Inventors:
Yi Chen, Sean Collins, Li Ting Huang, Eric Stec, Hui Xu
Abstract: The invention provides tissue repair compositions and methods of making the tissue repair compositions. Also featured are methods of treatment using the tissue repair compositions and articles of manufacture that include the tissue repair compositions.