Abstract: Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.
Type:
Grant
Filed:
June 17, 2015
Date of Patent:
November 29, 2016
Assignee:
LifeCell Corporation
Inventors:
Hui Xu, Wenquan Sun, Hua Wan, Rick T. Owens
Abstract: Devices and methods for tissue transfer are described where a cannula may be inserted into the breast of a subject at one of several points of entry. Insertion of the cannula into the breast may be accomplished by using a guidance system to distinguish between tissue types. Once desirably positioned, the cannula may be withdrawn from the breast while automatically (or manually) injecting the fat in multiple deposits of adipose tissue or fat such that the deposited fat remains within the tract formed by the withdrawn cannula. Multiple tracts of the deposited fat may be injected within the breast until the breast has been desirably remodeled and/or augmented.
Type:
Grant
Filed:
January 16, 2013
Date of Patent:
September 20, 2016
Assignee:
LifeCell Corporation
Inventors:
Joseph Rimsa, Brian J. Domecus, Christopher S. Jones, Paul James Lingane
Abstract: Devices and methods for removal of animal hair are provided. The devices and methods can include one or more rotating bodies that form pinch regions for mechanical removal of animal hair.
Abstract: The present disclosure provides an implantable medical device comprising a composite graft material including a first biologic component, such as an acellular tissue matrix, and a second non-biologic component.
Type:
Grant
Filed:
September 14, 2012
Date of Patent:
August 23, 2016
Assignee:
LifeCell Corporation
Inventors:
Jason Park, Aaron Barere, Christopher T. Wagner, Robert Kiefer, E. Skott Greenhalgh
Abstract: The invention provides tissue repair compositions and methods of making the tissue repair compositions. Also featured are methods of treatment using the tissue repair compositions and articles of manufacture that include the tissue repair compositions.
Abstract: A variety of compositions and methods for removing hair from animal skin are disclosed. The methods can include heating the skin and applying force to the skin to remove hair. The methods can further include applying an adhesive comprising a wax and a resin to the skin, allowing the adhesive to solidify, and applying force to the adhesive.
Abstract: The present disclosure provides tissue products produced from adipose-containing tissues, as well as methods for producing such tissue products. The tissue products can include decellularized and partially de-fatted tissues. In addition, the present disclosure provides systems and methods for using such products.
Abstract: Devices and methods for treating an abdominal incision or hernia are described. An implant for the restoration or prophylactic treatment of an abdominal wall comprises an elongate element and at least one sheet connected to the elongate element along a longitudinal axis of the elongate element. The elongate element is positioned along the line of incision, and the at least one sheet is secured to the abdominal muscles surrounding the incision.
Abstract: The present invention provides for an implantable medical device comprising a hybrid composite material including a first biological component such as an acellular tissue matrix and a second non-biological component for strengthening the device after implantation.
Type:
Grant
Filed:
May 9, 2007
Date of Patent:
May 17, 2016
Assignee:
LifeCell Corporation
Inventors:
David J. McQuillan, John R. Harper, Christopher T. Wagner, E. Skott Greenhalgh
Abstract: Devices and methods for tissue transfer are described where a cannula may be inserted into the breast of a subject at one of several points of entry. Insertion of the cannula into the breast may be accomplished by using a guidance system to distinguish between tissue types. Once desirably positioned, the cannula may be withdrawn from the breast while automatically (or manually) injecting the fat in multiple deposits of adipose tissue or fat such that the deposited fat remains within the tract formed by the withdrawn cannula. Multiple tracts of the deposited fat may be injected within the breast until the breast has been desirably remodeled and/or augmented.
Type:
Grant
Filed:
February 10, 2012
Date of Patent:
April 19, 2016
Assignee:
LifeCell Corporation
Inventors:
Geoffrey C. Gurtner, Michael H. Rosenthal, Brian J. Domecus, Darin Gittings, Kinman Hong
Abstract: The present disclosure provides devices and methods for harvesting and processing tissue from patients for grafting. The devices can include a tissue collection chamber for ascetically collecting, processing, and/or re-implanting adipose tissue.
Type:
Grant
Filed:
May 15, 2013
Date of Patent:
March 8, 2016
Assignee:
LifeCell Corporation
Inventors:
Sangwook Park, Jerome Connor, Aaron M. Barere
Abstract: Elongated and high aspect ratio tissue treatment products are provided. Methods of making and using the tissue treatment products are also provided. The tissue treatment products can be used as implants that conform to the site of implantation and resist migration away from their implantation site in vivo.
Type:
Grant
Filed:
January 17, 2013
Date of Patent:
March 1, 2016
Assignee:
LifeCell Corporation
Inventors:
Timothy Roock, Nathaniel Bachrach, Benjamin T. Kibalo
Abstract: A method of producing a modified acellular tissue matrix (mATM) from an acellular tissue matrix (ATM), where the mATM has a reduced stretchiness relative to the ATM, without substantially compromising its associated structural or functional integrity. The method includes providing an acellular tissue matrix (ATM) and exposing the ATM to elastase for a period of time.
Abstract: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix.
Type:
Grant
Filed:
September 5, 2013
Date of Patent:
January 19, 2016
Assignee:
LifeCell Corporation
Inventors:
Yi Chen, Hui Xu, Li Ting Huang, Wenquan Sun, Hua Wan
Abstract: Tissue matrices having anti-microbial properties are provided. In certain embodiments, the tissue matrices include cationic anti-microbial agents that form a stable bond with the tissue matrices without adversely affecting the biologic properties of the tissue matrices.
Abstract: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix.
Abstract: The present disclosure provides a variety of methods and compositions useful for making, sterilizing, and preserving tissues. The disclosure also features the acellular tissue matrices made by the methods.
Type:
Grant
Filed:
December 31, 2009
Date of Patent:
October 6, 2015
Assignee:
LifeCell Corporation
Inventors:
Wendell Sun, Jerome Connor, Qing-Qing Qiu, Rick Owens