Patents Assigned to Lifeline Scientific, Inc.
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Patent number: 8323954Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: GrantFiled: March 29, 2011Date of Patent: December 4, 2012Assignee: Lifeline Scientific, Inc.Inventors: David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Douglas Schein
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Patent number: 8318415Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: GrantFiled: October 22, 2010Date of Patent: November 27, 2012Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J Steibel, Richard Fraser, Stanley Harris, Douglas Schein, Christopher G. Curtis
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Publication number: 20120276519Abstract: Disclosed is a cannula including a first clamping portion, a second clamping portion and a force applying portion configured to apply at least two different clamping forces across the first clamping portion and the second clamping portion when the cannula is in a closed state. The first clamping portion includes a first gear, the second clamping portion includes a second gear, and the first gear and the second gear are in meshing engagement.Type: ApplicationFiled: April 29, 2011Publication date: November 1, 2012Applicant: LIFELINE SCIENTIFIC, INC.Inventors: David Kravitz, Christopher Steinman, David Pettinato
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Publication number: 20120276620Abstract: Disclosed is portable organ transportation system including a mobile cart and an organ container. At least one of the mobile cart and the organ container include a latch for releasably attaching the organ container to the mobile cart. The organ container may be a portable organ preservation device or a portable organ perfusion apparatus.Type: ApplicationFiled: April 29, 2011Publication date: November 1, 2012Applicant: Lifeline Scientific, Inc.Inventors: David Kravitz, Aaron Randall Ferber, Ross Lockwood, Rodney Hal Monson, Evan David Shapiro
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Publication number: 20120277687Abstract: Disclosed is a cannula including a first circumferential portion, a second circumferential portion, and a seal with a first clamping surface. The first circumferential portion and the second circumferential portion are configured to mutually cooperate to support a circumference of vasculature, and form a second clamping surface. The first clamping surface and the second clamping surface are configured to cooperate to secure an end of the vasculature.Type: ApplicationFiled: April 29, 2011Publication date: November 1, 2012Applicant: LIFELINE SCIENTIFIC, INC.Inventors: David Kravitz, Christopher Steinman, David Pettinato
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Publication number: 20120277681Abstract: A cannula includes a first circumferential portion, a second circumferential portion, and a seal with a first clamping surface. The first circumferential portion and the second circumferential portion are configured to mutually cooperate to support a circumference of vasculature, and form a second clamping surface. The first clamping surface and the second clamping surface are configured to cooperate to secure an end of the vasculature.Type: ApplicationFiled: October 27, 2011Publication date: November 1, 2012Applicant: LIFELINE SCIENTIFIC, INC.Inventors: David Kravitz, Christopher Steinman, David Pettinato
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Patent number: 8268612Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: GrantFiled: August 10, 2011Date of Patent: September 18, 2012Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Douglas Schein, Dickon Isaacs
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Patent number: 8268547Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off.Type: GrantFiled: October 25, 2005Date of Patent: September 18, 2012Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz
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Publication number: 20120148542Abstract: Methods for perfusing one or more organs, tissues or the like (hereinafter “organs”) with a composition comprising at least one complement inhibitor to sustain, maintain or improve the viability of the organs before and/or during transplantation.Type: ApplicationFiled: December 9, 2011Publication date: June 14, 2012Applicant: LIFELINE SCIENTIFIC, INC.Inventor: David KRAVITZ
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Publication number: 20120015343Abstract: Methods of isolating cellular products, such as pancreatic islets, may be used in diabetes research and therapeutic transplantation. The methods may involve providing a donor tissue having desired cells and undesired cells, perfusing the donor tissue with a perfusion solution, developing edema during perfusion of the donor tissue to form a swelled tissue, and separating the desired cells from undesired cellular material to obtain a cellular product. The methods may also include disrupting the tissue, and separating the desired cells from undesired cellular material to obtain the cellular product. The methods may result in an increased yield of cellular product that retains sufficient functional integrity to be useful as a transplantation resource.Type: ApplicationFiled: July 15, 2011Publication date: January 19, 2012Applicants: CELL & TISSUE SYSTEMS, INC., LIFELINE SCIENTIFIC, INC.Inventors: Michael J. TAYLOR, Simona C. BAICU, David KRAVITZ
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Publication number: 20110300612Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: August 10, 2011Publication date: December 8, 2011Applicant: LIFELINE SCIENTIFIC, INC.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein
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Publication number: 20110300613Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: August 10, 2011Publication date: December 8, 2011Applicant: LIFELINE SCIENTIFIC, INC.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Santley Harris, Douglas Schein
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Publication number: 20110300614Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: August 10, 2011Publication date: December 8, 2011Applicant: LIFELINE SCIENTIFIC, INC.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein
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Publication number: 20110300611Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: August 10, 2011Publication date: December 8, 2011Applicant: LIFELINE SCIENTIFIC, INC.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein
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Publication number: 20110183310Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: March 29, 2011Publication date: July 28, 2011Applicant: LIFELINE SCIENTIFIC, INC.Inventors: David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Douglas Schein
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Publication number: 20110129908Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: January 21, 2011Publication date: June 2, 2011Applicant: LIFELINE SCIENTIFIC, INC.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaccs, Douglas Schein
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Patent number: D655063Type: GrantFiled: April 29, 2011Date of Patent: February 28, 2012Assignee: Lifeline Scientific, Inc.Inventors: David Kravitz, Aaron Randall Ferber, Ross Lockwood, Rodney Hal Monson, Evan David Shapiro
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Patent number: D664261Type: GrantFiled: January 11, 2012Date of Patent: July 24, 2012Assignee: Lifeline Scientific, Inc.Inventors: David C. Kravitz, Peter Demuylder, Brian Otts, Stephan Merkle, Jeremiah P. O'Leary, Christopher E. Svensrud
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Patent number: D671653Type: GrantFiled: April 29, 2011Date of Patent: November 27, 2012Assignee: Lifeline Scientific, Inc.Inventors: David Kravitz, Aaron Randall Ferber, Ross Lockwood, Rodney Hal Monson, Evan David Shapiro
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Patent number: D672466Type: GrantFiled: April 29, 2011Date of Patent: December 11, 2012Assignee: Lifeline Scientific, Inc.Inventors: David Kravitz, Aaron Randall Ferber, Ross Lockwood, Rodney Hal Monson, Evan David Shapiro