Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.
Type:
Grant
Filed:
January 19, 2012
Date of Patent:
May 14, 2013
Assignee:
Liquidia Technologies, Inc.
Inventors:
Jason P. Rolland, Benjamin Maynor, Robert Lyon Henn
Abstract: A polarizer including a substrate sheet configured with grid elements on at least a first surface, wherein the grid elements have a height to width aspect ratio of at least 1.5:1, and metal coupled with the grid elements, wherein the metal comprises a height to width aspect ratio greater than the aspect ratio of the grid elements of the substrate.
Type:
Application
Filed:
August 17, 2010
Publication date:
August 16, 2012
Applicant:
LIQUIDIA TECHNOLOGIES, INC
Inventors:
Xiansheng Meng, Zhilian Zhou, Douglas Mar, Ginger Rothrock, Paul Drzaic
Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.
Type:
Application
Filed:
January 19, 2012
Publication date:
July 26, 2012
Applicant:
Liquidia TEchnologies, Inc.
Inventors:
Jason P. Rolland, Benjamin Maynor, Robert L. Henn
Abstract: An engineered aerosol particle for use in aerosol applications is provided. The engineered aerosol particle comprises a fabricated nanoparticle body member being non-spherical. The fabricated nanoparticle body member is configured to provide at least one of auto-rotation, tumbling, or lift when entrained in an airstream to thereby increase settling time of the fabricated nanoparticle body member. An associated method is also provided.
Type:
Application
Filed:
July 13, 2010
Publication date:
May 10, 2012
Applicants:
LIQUIDIA TECHNOLOGIES, INC., THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Inventors:
Philip Desimone, Benjamin Maynor, Mary Napier, Jonathan Pillai, Joseph M. Desimone, Will Patrick, Kyle Laaker, Hanjun Zhang
Abstract: A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.
Type:
Grant
Filed:
December 4, 2006
Date of Patent:
March 6, 2012
Assignee:
Liquidia Technologies, Inc.
Inventors:
Jason P. Rolland, Benjamin Maynor, Robert L. Henn
Abstract: A delivery system for local drug delivery to a target site of internal body tissue is provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site of internal body tissue. A counter electrode is in electrical communication with the source electrode, and is configured to cooperate with the source electrode to form a localized electric field proximate to the target site. A reservoir is configured to be disposed such that the reservoir is capable of interacting with the localized electric field. The reservoir is configured to carry a cargo capable of being delivered to the target site when exposed to the localized electric field. Associated methods are also provided.
Type:
Application
Filed:
February 25, 2010
Publication date:
December 15, 2011
Applicants:
LIQUIDIA TECHNOLOGIES, INC., THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Inventors:
Joseph Desimone, Mary Napier, Jonathan Pillai, James Byrne, Lukas Miller Roush, Jen Jen Yeh, Matt Parrott
Abstract: A system including a mold having a fluoropolymer wherein the mold defines a plurality of cavities having a predetermined shape and a cross-sectional dimension less than about 100 micrometers; a roller; a surface in cooperation with the roller to form a nip point configured to receive the mold, wherein the nip point is further configured to receive a substantially liquid composition and accelerate entry of the substantially liquid composition into the cavity.
Type:
Application
Filed:
June 8, 2011
Publication date:
December 8, 2011
Applicant:
Liquidia Technologies, Inc.
Inventors:
Robert Lyon HENN, Alex ERMOSHKIN, Kyle Matthew Benjamin HENN, Benjamin MAYNOR, Jason ROLLAND, Robert PRAINO
Abstract: A system including a mold having a fluoropolymer wherein the mold defines a plurality of cavities having a predetermined shape and a cross-sectional dimension less than about 100 micrometers; a roller; a surface in cooperation with the roller to form a nip point configured to receive the mold, wherein the nip point is further configured to receive a substantially liquid composition and accelerate entry of the substantially liquid composition into the cavity.
Type:
Grant
Filed:
October 13, 2008
Date of Patent:
July 12, 2011
Assignee:
Liquidia Technologies, Inc.
Inventors:
Robert Henn, Alex Ermoshkin, Kyle Henn, Benjamin Maynor
Abstract: A polymer composite includes a polymer and an additive encased in the polymer, wherein the additive includes a plurality of isolated particles where each particle of the plurality of particles has a substantially predetermined three dimensional shape and is substantially oriented with respect to each other in a predetermined two dimensional array.
Type:
Application
Filed:
November 15, 2007
Publication date:
August 26, 2010
Applicants:
The University of North Carolona at Chapel Hill, Liquidia Technologies, Inc.
Inventors:
Joseph M. DeSimone, Robert Lyon Henn, Janine Nunes, Libin Du
Abstract: A nanoarray includes a fluoropolymer array defining a plurality of cavities where each cavity has a predetermined shape and is less than about 5 micrometers in a broadest cross-sectional dimension. The nanoarray also includes a composition discretely contained in each cavity, where the composition includes a linking group for coupling with a modifying group. The nanoarray can be fabricated from fluoropolyether or perfluoropolyether.
Abstract: A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.
Type:
Application
Filed:
December 3, 2009
Publication date:
July 8, 2010
Applicant:
Liquidia Technologies, Inc.
Inventors:
Alexander Ermochkine, Derek Schorzman, Jacob Sprague
Abstract: A plurality of nanoparticles, a structure assembled therefrom, a method of forming the structure, including a plurality of particles where each particle of the plurality of particles is configured with a substantially predetermined shape and a largest dimension less than about 100 micrometers, and where each particle of the plurality of particles includes an opening through the particle.
Type:
Application
Filed:
August 30, 2007
Publication date:
March 4, 2010
Applicant:
Liquidia Technologies, Inc.
Inventors:
Joseph M. Desimone, Robert L. Henn, Jake Sprague
Abstract: Micro and/or nano-particles are fabricated in micro and/or nano-scale cavities of replicate molds for cosmetic applications. The micro and/or nano-particles can be fabricated for inclusion in cosmetic composition or fabricated from cosmetic ingredients.
Abstract: A medical device includes a textured surface having a predetermined nanostructure, wherein the nanostructure is less than about 500 nanometers in a broadest dimension. The textures nanostructure surface reduces friction between the medical device and biological tissue.
Type:
Application
Filed:
January 4, 2007
Publication date:
October 8, 2009
Applicant:
Liquidia Technologies, Inc.
Inventors:
Lloyd M. Robeson, Ginger Denison Rothrock
Abstract: A medical device including a body portion configured and dimensioned to be associated with a vessel of a patient and a responsive component associated with the body portion wherein the responsive component is switchable between a first configuration and a second configuration.