Abstract: The present disclosure provides apparatuses and methods for measuring sub-epidermal moisture as an indication of tissue viability and providing information regarding the location of a boundary of non-viable tissue.
Type:
Grant
Filed:
March 11, 2022
Date of Patent:
May 6, 2025
Assignee:
BBI MEDICAL INNOVATIONS, LLC
Inventors:
Martin F. Burns, Sara Barrington, Graham O. Ross
Abstract: The present invention relates to compounds of formula (I) a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment of conditions having an association with TRPC5 containing ion channels. R1, R2, R3, R4 and R5 have meanings given in the description.
Type:
Grant
Filed:
December 10, 2019
Date of Patent:
May 6, 2025
Assignees:
Boehringer Ingelheim International GmbH, Hydra Biosciences, LLC
Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, Cy, Cz, R1, R2, R3, R4, R2a, Ry, Rz, and the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.
Type:
Grant
Filed:
May 3, 2023
Date of Patent:
May 6, 2025
Assignee:
Merck Sharp & Dohme LLC
Inventors:
Indu Bharathan, Symon Gathiaka, Yongxin Han, Xiaoshen Ma, Ryan D. Otte, David L. Sloman, Thomas H. Graham, Timothy Henderson, Elisabeth Hennessy, Anandan Palani
Abstract: An electronic lock includes a housing, and a locking system within the housing. The locking system includes electronics and a lock. More particularly, the housing contains therein, a controller and at least one electronic input device electrically coupled to the controller, where the controller causes the lock to transition between a locked position to an unlocked position responsive to input from the electronic input device.
Abstract: The present invention relates to transgenic ornamental fish, as well as methods of making such fish by germ cell transplantation techniques. Also disclosed are methods of establishing a population of such transgenic fish and methods of providing them to the ornamental fish industry for the purpose of marketing.
Type:
Grant
Filed:
November 13, 2019
Date of Patent:
May 6, 2025
Assignee:
GloFish, LLC
Inventors:
Alan Blake, Richard Crockett, Aidas Nasevicius
Abstract: A tying system or mechanism with at least one lace and a fastener element can be used with a boxing glove or a shoe to allow a user to secure the at least one lace around the boxing glove or shoe without a second person and/or without tying a knot. The tying mechanism can include a back-to-back hook and loop of a fastener element and can include or more locking mechanisms to anchor free ends of the one or more laces at the eyelets of the boxing glove or shoe. The tying mechanism can generate a force that is radial or lateral to a gap defined by flaps of the boxing glove or shoes.
Abstract: Software systems and methods convert algorithms and software codes into time affecting linear pathways (TALPs) via decomposition and convert paired Input/Output (I/O) datasets into TALPs via Value Complexity polynomials. Generated TALPs can be enhanced through merging with other TALPs. TALPs can be grouped by matching the outputs of the TALP-associated prediction polynomials with some set of given criteria into families and cross-families that are useful in a new type of software optimization that allows for output values of grouped TALPs to be modeled, pooled, discretized and optimized to enhance goals or meet user goals.
Type:
Grant
Filed:
October 24, 2024
Date of Patent:
May 6, 2025
Assignee:
C SQUARED IP HOLDINGS LLC
Inventors:
Scott Andrew Smith, Christopher Graham Smith, Kevin David Howard
Abstract: A network is programmed to, based on a service function policy, determine a first service function chain of services to apply to outbound packets of a first type that arrive at a serving gateway; upon classifying a first outbound packet arriving at the serving gateway as the first type based on an identifier of the first outbound packet, route the first outbound packet to the services of the first service function chain; map the identifier to the first type such that the mapping is accessible by the packet gateway; determine a second service function chain of the same services to apply to inbound packets of the first type that arrive at a packet gateway; and upon classifying a first inbound packet arriving at the packet gateway as the first type based on the mapped identifier, route the first inbound packet to the services of the second service function chain.
Abstract: A connector configured to interface with a wall and to secure a wire passing through the wall. The connector having first and second portions with integral channels adapted to grasp the wire and insulation provided about the wire. The connector is secured to the wall with at least one nut that operatively interconnects to threads on the connector.
Abstract: Methods and systems to improve coupling and cohesion of at least one educational program are provided. In some examples, the methods and systems include at least one educational program, where the at least one educational program comprises a first application programming interface (API) that is configured to be coupled to a second API of an internet enabled electronic device in a restricted state and partially decoupled in an unrestricted state.
Abstract: Methods and systems are provided for an insulation system of a stator. In one example, a method may include receiving images of the stator at a processor of a computing system and processing the images by converting the images to one or more of cluster-only images and binary masks. The images may be fed to an artificial intelligence (AI) model to obtain one or more of varnish estimates and void estimates to generate a training dataset which may be used to train a deep learning tool to estimate varnish fill percentages from the images and display the varnish fill percentages at a display device.
Type:
Grant
Filed:
October 3, 2022
Date of Patent:
May 6, 2025
Assignee:
Ford Global Technologies, LLC
Inventors:
Robert Schroeter, Seth Avery, Chris Wolf, Jackson Lenz, Boratha Tan
Abstract: A method of providing information related to a charge status of an electric vehicle includes monitoring, with a system controller in communication with an electrical system within the vehicle, information related to a charge status of the vehicle, and, displaying, with the system controller, for a person in proximity of the vehicle, information related to a charge status of the vehicle.
Type:
Grant
Filed:
August 11, 2023
Date of Patent:
May 6, 2025
Assignee:
GM GLOBAL TECHNOLOGY OPERATIONS LLC
Inventors:
Manoj Kumar Sharma, Michael Alan Losh, Donald K. Grimm
Abstract: A disposable insertion instrument for inserting an implant includes a handle assembly, a drive assembly, and a plunger assembly. The drive assembly comprises an inner shaft and a spring received within an outer sleeve. A locking pin and drive lobes on the inner shaft cooperate to reversibly lock the drive assembly in a retracted position. A medical implant may be attached to the instrument via an adapter located at a distal end of the drive assembly. Following use for insertion of the medical implant into a patient, the disposable insertion instrument may be discarded.
Type:
Grant
Filed:
May 2, 2023
Date of Patent:
May 6, 2025
Assignee:
Spinal Simplicity, LLC
Inventors:
Jeff Slover, Adam Frock, Todd Moseley, Jeffrey David Lee, Christian Aragonez, Adam Rogers, Melissa Frock
Abstract: A filter cleaning system including filter cleaning apparatus including a tubular mast rotatingly disposed on a support rod. One or more filter retainers adapted to retain a filter can be disposed on the tubular mast. A filter disposed on the tubular mast can rotate about the support rod. A fluid stream can be directed on the filter to clean the filter rotating about the support rod.
Abstract: A foam-based seating furniture with an enclosure is provided. The foam-based seating furniture includes main body, a cutout opening formed in the main body, fitted fabric configured to encase the main body, and a removable nesting insert configured to friction fit within the cutout opening. The removable nesting insert can be inserted into the cutout opening, or removed, to provide a myriad of seating arrangements. The main body can be provided in a variety of geometries, including a square with a square removable nesting insert, a circle with a base and a circular removable nesting insert, and a hexagon having a circular nesting insert.
Abstract: A valve member, and related assemblies, systems, and methods, for a high-power pump may include a valve body having a valve head. The valve head may have a seal engaging surface positioned to receive a valve seal. The seal engaging surface may have a first axial position relative to a valve body axis. The valve head further may have a cavity at least partially defining a cavity interior. The cavity interior may extend between a cavity opening and a cavity end. The cavity interior may extend from the cavity opening at a second axial position spaced from the first axial position of the seal engaging surface and at least partially through the first axial position to the cavity end at a third axial position, thereby to reduce mass of the valve member and substantially maintain the strength of the valve head.
Abstract: Various embodiments of the present technology may provide methods and systems for position stabilization. The methods and systems for position stabilization may be integrated within an electronic device. An exemplary system may include a driver circuit responsive to a gyro sensor and a feedback signal from an actuator. The driver circuit may be configured to calibrate a gain applied to a drive signal based on the posture of the electronic device.
Abstract: A method of dosing multiple drugs for an individual patient, by collecting data from the individual patient including drugs to be taken by the patient and genetic testing information, analyzing the individual patient data in view of dosing criteria established based on outside patient data, and determining doses of multiple drugs for each drug taken by the individual patient. A logic engine for dosing multiple drugs, including an algorithm stored on non-transitory computer readable media for collecting outside data to establish criteria for dosing multiple drugs to an individual patient and storing the outside data and individual patient data in a database, analyzing the individual patient data in view of criteria established from the outside data, and determining a dose for each drug to be taken.
Type:
Grant
Filed:
April 14, 2021
Date of Patent:
May 6, 2025
Assignee:
OptimDosing LLC
Inventors:
David Inwald, Kenneth I. Kohn, Laura S. Dellal, Caitlin Joline Brown
Abstract: A method to create a battery cell is provided. The method includes, within a vacuum or an inert atmosphere, utilizing an etching process to remove a passivation layer from a primary surface of a solid electrolyte. The method further includes applying a surface coating to the primary surface. The method further includes, within the battery cell, disposing the solid electrolyte including the surface coating between an anode and a cathode.