Abstract: The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (VIIIg): wherein: R2=H or Me; R3=H or Me; R4=Alkyl; R5=O-Alkyl; and Alkyl=aliphatic C1-C4 alkyl. The present disclosure further provides methods of making compounds of general formula (VIIIg), compositions comprising a therapeutically effective amount of a compound of general formula (VIIIg), and methods of treating or preventing pain in a subject by administering (e.g., topically applying) compositions comprising an effective amount of a compound of general formula (VIIIg) to the subject.

Abstract: An adjustable automobile subframe alignment fixture for inspecting a subframe includes one or more bases; one or more rails, connected to the one or more bases, having indexing positions to accommodate multiple sized subframes; and one or more connection points, adjustably mounted on the one or more rails, configured to receive risers and/or jigs for adjusting to a geometry of the subframe and allowing structural integrity of the subframe to be determined. If the geometry of the subframe matches the geometry of the fixture, the subframe is structurally sound. If the geometry of the subframe fails matches the geometry of the fixture, the subframe lacks structural integrity.

Abstract: A change to a first version of source code of an application that is running with a debugger attached is identified, resulting in a second version of the source code. It is determined whether the change occurred with corresponding software suspended or not. The change is applied to the software without restarting the software, based on applying the change using edit and continue (EnC) when the change occurred with the software suspended, or applying the change using hot reload when the change occurred with the software not suspended. Subsequently, the software is suspended, and debug state is presented. The presentation includes presenting the second version of the source code after EnC, or after hot reload and when the software is suspended in an updated memory entity; or presenting the first version of the source code after hot reload and when the software is suspended in a stale memory entity.

Abstract: A pupil-replicating lightguide includes a slab of transparent material, a switchable out-coupling grating for out-coupling portions of image light to propagate towards an eyebox, and a switchable tracking grating for redirecting tracking light carrying an eye image towards an eye tracking camera. One of the two gratings may be turned ON while the other is turned OFF, in a time-sequential manner, allowing the combined use of the pupil-replicating lightguide for carrying image light and eye tracking light.

Abstract: A hybrid-fabric apparatus comprises a black box memory configured to store a plurality of behavior metrics and an anomaly agent coupled to the black box. The anomaly agent determines a baseline vector corresponding to nominal behavior of the fabric, wherein the baseline vector comprises at least two different behavior metrics that are correlated with each other. The anomaly agent disaggregates anomaly detection criteria into a plurality of anomaly criterion to be distributed among network nodes in the fabric, the anomaly detection criteria characterizing a variation from the baseline vector, and each of the plurality of anomaly criterion comprising a function of a measured vector of behavior metrics. The variation can be calculated based on a variation function applied to a vector of measured behavior metrics having elements corresponding to member elements of the baseline vector. Anomaly criterion statuses calculated by at least some of the network nodes are aggregated.

Abstract: A document re-finding system generates embeddings for concept clips provided by a user, the concept clips defining a concept for searching for content of interest to the user in a plurality of documents previously seen by the user. The re-finding system determines semantic relationships between the concept and document clips, related to respective document among the plurality of documents, based on the concept embedding and embeddings generated for the document clips. A graphical user interface depicting the semantic relationships is rendered to the user and is operable to enable re-finding a document, among the plurality of documents, having the content of interest to the user.

Abstract: In some implementations, a monitoring device may receive configuration information associated with an extract, transform, load (ETL) pipeline that includes one or more data sources and one or more data sinks. The monitoring device may generate, based on the configuration information, lineage data related to a data flow from the one or more data sources to the one or more data sinks in the ETL pipeline. The monitoring device may generate one or more predicted quality metrics associated with the ETL pipeline using a machine learning model. The monitoring device may generate a visualization in which multiple nodes are arranged to indicate the data flow from the one or more data sources to the one or more data sinks and further in which the one or more predicted quality metrics are encoded within the visualization.

Abstract: The disclosure provides a system, for designing and developing immersion cooling in data centers. The system includes an internet technology (IT) tank that houses a computing device immersed in a two phase coolant; an aisle, in which the immersion tank is disposed, that captures a first vaporized portion of the two phase coolant escaped from the immersion tank; a condenser that transforms the first vaporized portion of the two phase coolant that escaped from the immersion tank into a first liquid portion of the two phase coolant; a second condenser captures and condenses a second portion of vapor; and a liquid distributor manages the cooling fluid and coolant fluid for the IT tank and two condensers.

Abstract: Described are light emitting diode (LED) devices comprising a plurality of mesas defining pixels, each of the mesas comprising semiconductor layers, an N-contact material in a space between each of the plurality of mesas, a dielectric material which insulates sidewalls of the P-type layer and the active region from the metal. A multilayer composite film is on the P-type layer, the multilayer composite film comprising: a current spreading layer on the P-type layer, the current spreading layer having a first portion and a second portion; a dielectric layer on the second portion of the current spreading layer; a via opening defined by sidewalls in the dielectric layer and the first portion of the current spreading layer; and a P-contact layer in the via opening on the first portion of the current spreading layer, the sidewalls in the dielectric layer, and on at least a portion of the dielectric layer.

Abstract: A battery with a generally cuboid body with a top face. A cylindrical terminal extending from a center of the top face, a top of the cylindrical terminal provided with electrical contacts. A left tab and a right tab provided extending from the top face proximate a left end and a right end of the top face, respectively. A peripheral portion of each of the left and the right tabs forming a retaining groove extending from the top face; and an inward facing portion of the peripheral portion of each of the left and the right tabs facing the cylindrical terminal provided with an arc radius centered upon the center of the top face. The battery interconnectable with a range of electronic devices via a range of vectors and/or mechanics.

Abstract: A fuel cell system has a fuel cell stack including a plurality of fuel cells and an anode injector system, and a controller programmed. The controller, responsive to an amplitude of cyclic changes in voltage of at least some of the fuel cells exceeding a threshold, a frequency of the cyclic changes being within a predetermined range of a frequency associated with the anode injector system, and the voltage being less than a predetermined value, disables the fuel cell stack.

Abstract: Systems and methods for operating an engine that includes an exhaust system with a carbonaceous soot trap described. In one example, a carbonaceous soot load estimate for the carbonaceous soot trap is performed when a differential pressure sensor is degraded. The carbonaceous soot estimate may be performed when the engine is not rotating.

Abstract: A “while away” canvas is described herein. A client computing device detects that a page that comprises search results is displayed on a display of the client computing device, wherein the search results were identified based upon a query received from the client computing device. The client computing device subsequently detects that focus of the user has left the page. Upon detecting that focus of the user has returned to the page, the client computing device updates the page to include the “while away” canvas, which identifies additional search results (based upon the query) that were published after the page that comprises the search results was initially displayed.

Abstract: A system can include a processor and a computer-readable storage device storing instructions which, when executed by the processor, cause the processor to perform operations. The operations can include receiving an identification of a local device having a control module that manages a reader component and a locking mechanism and transmitting an authorized list to the local device that identifies authorized users that can gain access to the local device via the locking mechanism through interacting with the reader component. The control module on the local device can manage multiple functions of the local device including management of the reader component and the locking mechanism.

Abstract: A wound care device for delivering topical oxygen therapy, negative pressure wound therapy, and a low intensity vacuum therapy for treatment of a wound. The wound care device may include an oxygen supply mea, an oxygen consuming mea, a vacuum pump and motor, a pressure sensor, and a power supply and electronic controls. A dressing may be connected to the wound care device for administering topical continuous oxygen therapy and simultaneous negative pressure wound therapy to a wound. A canister or exudate trap may be positioned between the dressing and the vacuum supply port of the vacuum pump to collect and store exudates from the wound. The canister may be combined with the dressing.

Abstract: A chromatographic cassette includes a cassette including a chamber, chromatographic media disposed within the cassette chamber, a distribution network fluidly coupled to the chromatographic media and an inlet port and an outlet port coupled to the distribution network. A hyper-productive chromatography technique includes providing a scalable and stackable chromatographic cassette, loading a sample to be processed, operating the scalable chromatographic cassette having an adsorptive chromatographic bed having a volume greater than 0.5 liter by establishing a flow at a linear velocity greater than 500 cm/hr with a residence time of the loading step of less than one minute.

Abstract: An apparatus includes a communication device affixed to or placed within a transport container. The apparatus further includes processing circuitry configured to initiate display, via the communication device, of first routing information indicating a first destination along a geographic route from a first location to a second location and to, in response to a condition indicating movement of the container from the first location to an intermediate location, initiate display, via the at least one communication device, of second routing information indicating a second destination or a final destination that is different than the first destination.