Abstract: The invention relates to methods for treating cancer in a patient comprising subcutaneously administering a PD-1 antagonist, e.g., an anti-PD-1 antibody, or antigen binding fragment thereof, (e.g. pembrolizumab), in specific amounts to the patient. In some embodiments, the administration occurs about every three weeks. In some embodiments, the amount of anti-PD-1 antibody, or antigen binding fragment thereof, is about 280 mg to about 450 mg. In certain embodiments, the PD-1 antagonist is pembrolizumab, or an antigen binding fragment thereof. Also provided are compositions and kits formulated for subcutaneous administration comprising a dosage of an anti-PD-1 antibody, or antigen-binding fragment thereof, and uses thereof for treating cancer.

Abstract: A ladder includes a first and second assembly, each including a pair of spaced apart rails and a set of rungs coupled to and extending between the spaced apart rails. A pair of brackets slidably receive a pair of the spaced apart rails. A pair of protrusions extend from those spaced apart rails and are movable into a pair of slots defined by a pair of retainers coupled with the other pair of spaced apart rails. The protrusions are movable into the slots while the ladder is in a step ladder configuration at a nonzero angle between the first and second assemblies, such as by moving the pair of retainers from a locking position to an unlocked position as the rails bearing the protrusions longitudinally slide relative to the pair of brackets. The ladder may also have spreaders with limited movement while collapsed and spaced apart rung retainers.

Abstract: Disclosed herein is a wellbore casing corrosion measurement tool, including a sensor assembly and control circuitry. The control circuitry is configured to energize selected components of the sensor assembly to produce multiple electromagnetic fields that are arranged about a circumference of the sensor assembly to induce eddy currents in at least one wellbore casing string, and detect magnetic fields resulting from the eddy currents in the at least one wellbore casing string via the sensor assembly, said magnetic fields being indicative of a state of the at least one wellbore casing string.

Abstract: A method for manufacturing packaging comprises the steps of: temperature conditioning one or more selected portions of at least one preform; and blowing and/or stretching the at least one temperature conditioned preform into a blow mold to form a container including an offset neck finish. Containers, packaging systems and packaging products are disclosed.

Abstract: An illustrative micro-puree machine is provided. The micro-puree machine includes a base unit including a coupling interface arranged to couple with a detachably connectable processing container. The coupling interface includes a mixing shaft configured to extend into the processing container. A drip tray couplable to the base unit below the processing container when the processing container is coupled to the coupling interface. The drip tray is configured to receive food material that leaks from the processing container while coupled to the coupling interface.

Abstract: A vehicular autonomous preference system includes a plurality of sensors positioned within a cabin of a vehicle, and data processing hardware including a memory storing a user profile that includes user preferences and a trainable preference model that includes a model trainer. The data processing hardware is configured to execute the model trainer in response to sensor data received from one or more of the plurality of sensors to update the user preferences in the user profile. The data processing hardware is also configured to adjust ambient controls of the vehicle based on the trainable preference model and the updated user preferences.

Abstract: Brake mounts for bicycles are described herein. The brake mounts are for coupling a brake caliper to a bicycle. An example brake mount includes a bracket having a first side and a second side opposite the first side. The bracket has bores to receive fasteners to couple the brake caliper to the bracket. The brake mount includes a sleeve extending from the first side of the bracket. An opening extends through the sleeve and the bracket. The opening is to receive an axle of a hub assembly of the bicycle. The sleeve is to extend into an axle opening in a frame of the bicycle. A distal end of the sleeve is threaded. The brake mount also includes a nut to be threadably coupled to the distal end of the sleeve when the sleeve is inserted into the axle opening in the frame e.

Abstract: Examples of the disclosure provide a seatback for a vehicle seat, in particular an aircraft seat, comprising a seatback structure that includes a rear side having a partially circumferential outer edge and a recess which is partially surrounded by the outer edge. The recess is configured to retain a panel at least partially arranged within the recess and at least partially covered by the outer edge. The panel is detachable retained to and/or in the recess and is configured as an interchangeable and customized part.

Abstract: A garment hanger assembly comprising a multi-layered corrugated paper hanger body and a removable wire hook is disclosed. The multi-layered corrugated paper hanger body can be used with various removable hooks and has at least one layer that is oriented at substantially a 90° angle corrugation relative to an adjacent layer of corrugated paper. The removable wire hook can be used with various paper hanger bodies and has a horizontal extension that is configured to engage a hanger body when the wire hook is removably attached thereto.

Abstract: A method includes training, using an un-supervised learning technique, an auxiliary ASR model based on a first set of un-transcribed source task speech utterances to determine a first task vector, training, using the un-supervised learning technique, the auxiliary ASR model based on a second set of un-transcribed speech utterances to determine a second task vector, and training, using the un-supervised learning technique, the auxiliary ASR model based on un-transcribed target task speech utterances to determine a target task vector. The method also includes determining a first correlation between the first and target task vectors, determining a second correlation between the second and target task vectors, and adapting parameters of a trained primary ASR model based on the first and second source task vectors and the first and second correlations to teach the primary ASR model to learn how to recognize speech associated with the target task.

Abstract: A method executed by a computing device includes identifying a contingency-action token (CAT) of an object distributed ledger that meets minimum CAT requirements. The method further includes determining whether to select the CAT based on an evaluation of the CAT with regards to an evaluation profile. When selecting the CAT the method further includes to producing a selected CAT and determining reassignment information for the selected CAT. The method further includes updating the selected CAT utilizing the reassignment information for the CAT to produce an updated CAT. The method further includes causing generation of a new block affiliated with the updated CAT via a blockchain of the object distributed ledger, where the new block includes the updated CAT.

Abstract: A vehicle to load inverter module (V2LIM) based onboard charger (OBC). The V2LIM based OBC may include an alternating current to direct current (AC/DC) converter having an AC/DC input and an AC/DC output, a direct current to direct current (DC/DC) converter having a DC/DC input and a DC/DC output, and a direct current to alternating current (DC/AC) converter having a DC/AC input and a DC/AC output, and a controller configured for controlling the AC/DC converter, the DC/DC converter, and the DC/AC converter according to a split-phase load powering mode.

Abstract: Techniques for lock state based on a trigger condition are described and may be implemented to transition a mobile device to a locked state based on various conditions. For instance, a mobile device receives transmission of cloud content and transmits the cloud content to a connected remote display device for output. A trigger condition occurs based on the transmission of the cloud content, such as a decrease in data transmission related to the cloud content. The mobile device can transition to a locked state based at least in part on the trigger condition.

Abstract: The present invention is a dietary supplement geared toward improvement of mental wellbeing, comprising Alpha-glycerylphosphorylcholine (commonly known as “A-GPC”), Methylliberine, Phosphatidylserine, Caffeine, and Theacrine. It has been found that the foregoing ingredients, when combined, have a synergistic effect that exceeds the contributions of the individual ingredients and provides a robust and effective brain supplement.

Abstract: The present disclosure provides distributed power and fault management systems. In one example embodiment, a single power transmitter is coupled to a plurality of power receiver devices via a low-ohmic connection. Each power receiver device is configured to provide local power, and to communicate power input information with the transmitter. The transmitter is configured to sum the power input of each receiver and compare the sum to an output power to determine fault conditions that may be present in the system.

Abstract: In general, the subject matter described in this specification can be embodied in methods, systems, and program products for receiving user input that defines a search query, and providing the search query to a server system. Information that a search engine system determined was responsive to the search query is received at a computing device. The computing device is identified as in a first state, and a first output mode for audibly outputting at least a portion of the information is selected. The first output mode is selected from a collection of the first output mode and a second output mode. The second output mode is selected in response to the computing device being in a second state and is for visually outputting at least the portion of the information and not audibly outputting the at least portion of the information. At least the portion of information is audibly output.

Abstract: Systems and methods for representing two-dimensional representations as three-dimensional avatars are provided herein. In some examples, one or more input video streams are received. A first subject, within the one or more input video streams, is identified. Based on the one or more input video streams, a first view of the first subject is identified. Based on the one or more input video streams, a second view of the first subject is identified. The first subject is segmented into a plurality of planar object. The plurality of planar objects are transformed with respect to each other. The plurality of planar objects are based on the first and second views of the first subject. The plurality of planar objects are output in an output video stream. The plurality of planar objects provide perspective of the first subject to one or more viewers.

Abstract: Methods and technologies are disclosed for the sketch efficient estimation of large-scale multi-sets in distributed, stream-oriented environments. Sketch updates are idempotent and commutative, to support duplicate set elements and varying element sequences. They are also mergeable to support distributed sketch recording. The recording process uses stepwise approximated geometric distributions, efficiently generated from NLZ values of received sketch updates, by using only multiplications with powers of two and integer additions. Sketch registers are subdivided into a portion storing an observed max update value for the register, and a portion storing set of flag bits indicating observed next smaller update values for the register. A Max Likelihood base sketch data evaluation, based on the assumption of statistically independent sketch registers is proposed.

Abstract: A system and method in at least one embodiment provides the means for conditioning batteries for increased battery capacity, battery runtime, reduced battery temperature while charging, and/or reduced battery temperature while in use, using current generated from a generator.

Abstract: Systems, methods, and devices include a wearable device to stimulate or analyze biological systems or implantable objects. The system includes a substrate material and a plurality of acoustic actuators disposed on the substrate material. The plurality of acoustic actuators are operable to generate an acoustic stimulation signal directed to a target area. The system also includes a plurality of acoustic sensors disposed on the substrate material and operable to receive an acoustic response signal from the target area. Furthermore, a plurality of electrical electrodes disposed on the substrate material are operable to generate an electrical stimulation signal directed to the target area and receive an electrical response from the target area. The substrate material forms a sleeve or a cuff, a glove, a head cap, a back harness, a waist binder, a torso binder, and/or an abdominal binder.