Abstract: Described herein are devices and methods for simultaneously expressing amyloid precursor protein and TonB protein. These devices and methods increase the production of these two proteins while also minimizing costs, making the proteins more widely accessible for medical research purposes, including the development of diagnostic tests for numerous diseases associated with elevated production of amyloid proteins. The amyloid precursor protein and TonB produced by the devices and methods described herein, as well as the devices themselves, can be used in experiments designed to model the interactions between metals and amyloids such as ?-amyloid that are characteristic of numerous diseases such as Alzheimer's. Finally, provided herein are diagnostic tests that can detect Alzheimer's disease in samples from patients; the tests are sensitive enough to identify diseases such as Alzheimer's even at pre-clinical stages, before the appearance of symptoms.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing fundus images using fundus image processing machine learning models. One of the methods includes obtaining a model input comprising one or more fundus images, each fundus image being an image of a fundus of an eye of a patient; processing the model input using a fundus image processing machine learning model, wherein the fundus image processing machine learning model is configured to process the model input comprising the one or more fundus image to generate a model output; and processing the model output to generate health analysis data.

Abstract: An electrochemical cell according to various aspects of the present disclosure includes a positive electrode, a negative electrode, a separator, and an electrolyte. The positive electrode includes a positive electroactive material. The positive electroactive material includes a phospho-olivine compound. The negative electrode includes lithium metal. The separator is between the positive electrode and the negative electrode. The separator is electrically insulating and ionically conductive. The electrolyte includes a ternary salt and a solvent. The ternary salt includes LiPF6, LiFSI, and LiClO4.

Abstract: A system in accordance with present embodiments includes an amusement park system having one or more hardware components and a controller. The controller includes a memory device having a game layer and a software layer stored thereon. The game layer includes game logic, and the software layer includes a game API communicatively coupled to the game layer, a wrapper API communicatively coupled to the game API, and multiple wrappers communicatively coupled to the wrapper API. The controller further includes a processor configured to execute instructions to cause the processor to receive a signal indicative of a change in the hardware components, and, based on the signal indicative of the change in the hardware components, communicate with the hardware components via a wrapper to receive an input from the hardware components, or drive operation of the hardware components.

Abstract: Methods for delivering a replacement heart valve include advancing a delivery system through a femoral vein and into the atrium of a heart, wherein the delivery system includes an outer sheath assembly, a mid shaft assembly and an inner assembly. The outer sheath assembly and the mid shaft assembly are adapted to retain the replacement heart valve in a radially compacted state over the inner assembly. The outer sheath assembly is retracted to allow a plurality of distal anchors to self-expand while a portion of the replacement heart valve remains retained in a compacted state by the mid shaft assembly. The distal anchors are positioned to engage one or more native leaflets and the retained portion of the replacement heart valve is then released and allowed to fully expand for implanting the replacement heart valve within the native valve.

Abstract: The technology relates to detecting and responding to emergency vehicles. This may include using a plurality of microphones to detect a siren noise corresponding to an emergency vehicle and to estimate a bearing of the emergency vehicle. This estimated bearing is compared to map information to identify a portion of roadway on which the emergency vehicle is traveling. In addition, information identifying a set of objects in the vehicle's environment as well as characteristics of those objects is received from a perception system is used to determine whether one of the set of objects corresponds to the emergency vehicle. How to respond to the emergency vehicle is determined based on the estimated bearing and identified road segments and the determination of whether one of the set of objects corresponds to the emergency vehicle. This determined response is then used to control the vehicle in an autonomous driving mode.

Abstract: A semiconductor device includes a region of semiconductor material of a first conductivity type and having a first major surface. A body region of a second conductivity type opposite to the first conductivity type is in the region of semiconductor material. The body region includes a stripe region; a first segment in the stripe region and having a first peak dopant concentration, a first depth into the region of semiconductor material, and a first length along the first major surface; and a second segment in the stripe region laterally adjacent to the first segment, adjacent to the first major surface, and having a second peak dopant concentration, a second depth into the region of semiconductor material, and a second length along the first major surface. A source region of the first conductivity type is in the first segment but not in at least part of the second segment.

Abstract: A machine for distributing material from a package of compressed loosefill insulation material is provided. The machine includes a chute having an inlet end and an outlet end. The inlet end is configured to receive compressed loosefill insulation material. A lower unit has a shredding chamber configured to receive the compressed loosefill insulation material from the outlet end of the chute. The shredding chamber includes a plurality of shredders configured to condition the loosefill insulation material. The shredders include a shredder shaft and a plurality of vane assemblies. The vane assemblies are oriented such that adjacent vane assemblies are offset from each other by an angle of about 45° to about 75°. A discharge mechanism receives the loosefill insulation material exiting the shredding chamber and distributes the loosefill insulation material into an airstream and a blower is configured to provide the airstream flowing through the discharge mechanism.

Abstract: A method builds a regression model for predicting processing times for federated queries using a variety of data sources. The method includes obtaining federated queries (e.g., from benchmarks), and generates a plurality of federated query plans for each federated query. Each federated query plan corresponds to executing a respective federated query using a respective data source as the federation engine. The method includes forming feature vectors for each federated query plan based on cost estimations for executing the respective federated query plan and cost estimations for data transfer. The method further includes training a regression model, using the feature vectors for the plurality of federated query plans, to predict runtimes for executing federated queries using the variety of data sources as a federation engine. Some implementations use the trained regression model to determine a suitable federation engine for a given federated query.

Abstract: Methods, systems, apparatuses, and computer program products are provided for altering the behavior of an electronic personal assistant based on a situation associated with a mobile device. A situation is sensed with a plurality of sensors to generate sensor data. A situation score is calculated based on the sensor data. Behavior of an electronic personal assistant is altered based on the calculated situation score. In one aspect, the situation is a driving situation in which a driver drives a vehicle on a roadway. In such case, a driving situation score is calculated based on the sensor data, and behavior of the electronic personal assistant is altered based on the calculated driving situation score, such as suspending interactions by the electronic personal assistant with the driver to avoid the driver being distracted.

Abstract: A method and apparatus are provided for determining whether a driving environment has changed relative to previously stored information about the driving environment. The apparatus may include an autonomous driving computer system configured to detect one or more vehicles in the driving environment, and determine corresponding trajectories for those detected vehicles. The autonomous driving computer system may then compare the determined trajectories to an expected trajectory of a hypothetical vehicle in the driving environment. Based on the comparison, the autonomous driving computer system may determine whether the driving environment has changed and/or a probability that the driving environment has changed, relative to the previously stored information about the driving environment.

Abstract: A vehicle component, and a method and tool for forming the component are provided. First and second tools with first and second surfaces, respectively, are provided. The first tool is translated along a first axis towards the second tool such that the first and second surfaces cooperate to define a mold cavity configured to form an accessory mount feature with an aperture. The second surface is configured to form an integrated rib extending outwardly from an upper surface of the mount feature to a planar bearing surface surrounding the aperture with the planar bearing surface oriented at an acute angle relative to the upper surface. The first axis is substantially parallel to the upper surface.

Abstract: The present invention relates to augmenting the effects of adoptive T cell therapy, such as TVAX Immunotherapy, using adjunct treatment with an oncolytic virus, such as a vaccinia virus, to treat various types of cancer or other proliferative disorders. Immunomodulatory compounds can be used to further augment to effects of the therapy.

Abstract: A modular wash/sanitation rack assembly having a wall support, a plurality of channels, a gear rack mount, and a gear support. The plurality of channels includes at least two wall support channels.

Abstract: Methods and systems for facilitating group payment are disclosed. In one embodiment, a group payment system is configured to execute instructions to perform operations that include receiving, from a first computing device, a request to create a group payment event and, in response, providing to the first computing device a first interface associated with the group payment event. The operations further include receiving, from a second computing device, a request to join the group payment event and, in response, providing a second interface to the second computing device. The operations further include receiving, from the first and/or second computing devices, messages associated with the group payment event and modifying the first and second interfaces to display the messages. The operations further include receiving, from the first and/or second computing devices, financial contributions for the group payment event and modifying the first and second interfaces to display the financial contributions.

Abstract: A spiral wound header ring is provided. The spiral wound header ring comprises at least one outer fabric layer and at least one spiral of inner fabric and rubber. The spiral wound header ring further may have a sealing surface that extends from a rearward facing surface to the forward facing annular, radially extending, surface.

Abstract: Copies of a distributed ledger with multiple blocks are stored on multiple computing devices. A first computing device coming into proximity with a particular object triggers generation of a new block to the distributed ledger, the new block identifying changes to an inventory of objects of the object type and including a hash of a previous block of the distributed ledger. The new block is optionally verified before it is appended onto the distributed ledger and transmitted out to each of the multiple computing devices so that each copy of the distributed ledger includes the new block.

Abstract: A device includes a light guide and at least one in-coupling element configured to couple an image light into the light guide. The device also includes a first out-coupling element configured to couple a first portion of the image light out of the light guide as a plurality of first output lights. The device further includes a second out-coupling element spaced apart from the first out-coupling element by a distance and configured to couple a second portion the image light out of the light guide as a plurality of second output lights. The second output lights are substantially non-overlapping with the first output lights.

Abstract: A process to produce a protein concentrate from grain, specifically barley protein concentrate (BPC) through mechanical and biochemical intervention while producing multiple sugar streams as co-products. The resulting BPC preferably contains 54%-95% protein derived exclusively from the enzymatically processed barley and has a pH>5.0. The BPC may contain approximately 10% oil, less than 5% crude fiber, less than 1% residual glucose, and less than 0.5% phytic acid. The BPC contains no ethanol, organic acid, fermentation products, or microbial cells or cell mass. No fermentation occurs in the production of the BPC. The BPC has unique applications in formulations for aquaculture or livestock feed, and other pet food as well as for food formulations intended for human consumption. The sugar co-products, including glucose, have applications in industry and science and are particularly suitable for use as feedstocks for fermentation processes, livestock feeds, or biochemical conversion processes.

Abstract: An example mounting apparatus for a wireless communication node may comprise: a first weighting-element enclosure having a first set of connectors that extend from the first weighting-element enclosure; a second weighting-element enclosure having a second set of connectors that extend from the second weighting-element enclosure, and wherein the first weighting-element enclosure is connected to the second weighting-element enclosure via two joints that are disposed between the first set of connectors and the second set of connectors; a post that is affixed to either the first weighting-element enclosure or the second weighting-element enclosure; one or more communication-equipment enclosures that are each attached to the post and are each adapted to house respective equipment for the wireless communication node; and at least a first support strut that is connected between the post and a first one of the two joints disposed between the first weighting-element enclosure and the second weighting-element enclosure