Abstract: The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.

Abstract: A vibration reducing system for securing a first member to a second member is disclosed comprising a vibration mat spaces the first member from the second member and reduces vibration therebetween. A fastener secures the first member to the second member. A resilient member is interposed between the first member and the fastener for reducing vibration between the first member and the second member through the fastener.

Abstract: A closure device for sealing an atrial septal defect is provided. The closure device includes a distal closure portion and a proximal closure portion. The distal closure portion includes a distal membrane covering a plurality of distal fingers that extend in a distal plane. The proximal closure portion includes a proximal membrane covering a plurality of proximal fingers that extend in a proximal plane. The closure device also includes a waist section extending axially between the plurality of distal fingers and the plurality of proximal fingers. The distal closure portion is configured to sealingly engage one of the left or right side of a septal wall, the proximal closure portion is configured to sealingly engage the other of the left or right side of the septal wall, and the waist section is configured to be positioned and centered in an atrial septal defect between the left and the right septal wall.

Abstract: A syringe assembly includes a syringe and a tamper evident cap disposed over a Luer connection of the syringe, the tamper evident cap having a main body that defines a proximal end defining an opening, a distal end opposite the proximal end, an outer surface, and an inner surface opposite the outer surface that defines a passage to receive a tip cap and the Luer connection, where the tamper evident cap is spaced from the tip cap. The main body defines a frangible connection between the proximal and distal ends thereof. The frangible connection can break under a force applied to the distal end of the tamper evident cap such that the proximal end of the tamper evident cap remains engaged with the syringe when the frangible connection breaks. An RFID tag is disposed on the syringe and has an integrated circuit and an antenna configured to send/receive signals between an RFID reader.

Abstract: Methods and systems are provided for managing cabin conditions. A fogging metric can be determined. A control signal is generated based on the fogging metric. The system facilitates modification to the operation control of the at least one climate control device based on the control signal. Such a response can correspond to control of a target evaporator temperature of an HVAC system. The target evaporator temperature can be adjusted within a continuous range of available temperatures. As such, the operation of the evaporator can be adjustably tailored to the needs of addressing a fog factor while also maximizing efficiency of the overall system.

Abstract: Systems and methods for operating a hybrid vehicle having an internal combustion engine are presented. In one example, the internal combustion engine is operated in a speed control mode and torque of an electric machine is adjusted so that a possibility of an engine speed controller saturating may be reduced.

Abstract: The subject invention provides compositions comprising solvents and surfactants, as well as their use in improving oil and/or gas production. In some embodiments, the compositions comprise chemical or synthetic solvents and/or surfactants. In other embodiments, the compositions comprise biological components, such as microorganisms and/or their growth by-products. The subject invention can be used to dissolve, disperse and/or emulsify paraffin precipitates and/or deposits; prevent and/or inhibit paraffin deposition; remove rust deposits and prevent corrosion associated therewith; inhibit bacterial growth and/or biofilm formation; and to enhance oil recovery.

Abstract: Aspects disclosed include hardware micro-fused memory (e.g., load and store) operations. In one aspect, a hardware micro-fused memory operation is a single atomic memory operation performed using a plurality of data register operands, for example a load pair or store pair operation. The load pair or store pair operation is treated as two separate operations for purposes of renaming, but is scheduled as a single micro-operation having two data register operands. The load or store pair operation is then performed atomically.

Abstract: In accordance with some embodiments, a physical game element such as a wagering chip or a playing card may be utilized to implement a promotion scheme on an electronic game table (e.g., using RFID or optical imaging technology). During a game it may be determined whether the element is associated with special functionality (e.g., entitles the player to a payout multiplier, special payout table, bonus prize or other benefit). The special functionality may have been previously associated with the element or associated with the element during the game (e.g., dynamically and/or randomly). In accordance with some embodiments a player is not able to readily discern the special functionality by a physical inspection of the physical game element and is only notified of the special functionality once the physical game element is used in a qualifying action (e.g., during a wager at an electronic game table).

Abstract: Methods and apparatuses are described for automatic intelligent query suggestion for information retrieval applications. A server a) determines candidate intents associated with user input text received from a remote device, including applying a trained intent classification model to the user input text to predict candidate intents. The server b) calculates a likelihood value for each of the candidate intents. The server c) compiles a list of suggested queries based upon the candidate intents and associated likelihood values. The server d) identifies a subset of the list of suggested queries for display on the remote device. Upon detecting an update to the user input text at the remote device, the server repeats steps a) to d) using the updated user input text, or upon detecting a selection of one of the suggested queries at the remote device, the server retrieves content responsive to the selected query.

Abstract: Systems, including methods and apparatus, for growing viable monoclonal colonies, identifying them as monoclonal after their viability has been demonstrated, and picking and placing them into a target environment. The methods may include plating cells at low density in a well, capturing at a first time shortly after plating a series of vertically spaced-apart images of the well showing locations of the cells, capturing at a second, later time images of the same well showing locations of candidate cell colonies, determining a likelihood that the candidate colonies are monoclonal based on information in the first set of images, and, based on the likelihood, picking candidate colonies using a picking head for transfer to a target environment.

Abstract: A conduit coupling assembly having an arcuate clamp ring having first and second longitudinal edges, a spanner configured to extend across a longitudinal ring gap between the first and second longitudinal edges, a connecting assembly configured to tighten the spanner and clamp ring to the fluid conduit from a non-actuated position to a tightened position, an arcuate gasket configured to be positioned between the clamp ring and spanner on an outer side of the gasket and the fluid conduit on an inner side of the gasket, and the gasket comprising a spanner recess in the outer side of the gasket configured to receive at least a portion of the spanner.

Abstract: Electronic Article Surveillance in which a radio frequency identification (RFID) interrogation signal is transmitted, over a first window of time, into an RFID interrogation zone of the EAS system. A plurality of response signals are detected from a first RFID tag of the EAS system responding to the interrogation signal. Over a second window of time overlapping at least in part with the first window of time, image data is captured within a field of view. The field of view and the RFID interrogation zone overlap to form a zone of interest. Movement of a non-tag object is characterized during the first window of time based on the image data. Whether the first RFID tag is associated with the characterized non-tag object is determined based on a comparison of the detected plurality of response signals and the characterized movement of the non-tag object.

Abstract: A composite barrel layer for a bat including a fiber pre-preg layer with repetitive folds generally forming part triangle shapes incorporated into a fiber reinforced composite layer of the barrel portion of the bat.

Abstract: A cinematography battery includes a housing and a mounting assembly. The mounting assembly is disposed at least partially within the housing and includes a body and a block. The body is configured to move relative to the housing. The block is operably coupled to the body and is configured to move relative to the body. At least a portion of the mounting assembly is configured to selectively engage a battery mount to couple the battery to the battery mount.

Abstract: Methods to predict end of streaming media using a prediction model are disclosed herein. An example apparatus includes at least one memory, instructions in the apparatus, and processor circuitry to execute the instructions to generate a prediction model using a mean value of a bandwidth of a transmission of a streaming media to a user device and an amplitude of the streaming media, and identify an end of a streaming media session when an output of the prediction model satisfies a threshold.

Abstract: The techniques disclosed herein provide low power, efficient systems, devices and circuits that detect facial movements of a user of a Mixed Reality (MR) device. An example battery operated system includes a pulse driver that generates pulse signals at a set frequency, while operated below the battery voltage. An LC filter receives the pulse signals and generates a transient response based on a capacitance value associated with an antenna. The capacitance of the antenna varies responsive to facial movements of the user based on the varying distance of the antenna to the users skin. A coupling capacitor AC couples the output of the LC filter to other system components, where the AC coupled output of the LC filter includes a detected signal amplitude and a detected signal phase of the LC filter responsive to facial movements of the user.

Abstract: A method of and system for implementing a safe deployment of a first feature in a computing environment is carried out by receiving registration information for the first feature, the registration information including a second feature on which the first feature depends or a feature type on which the first feature depends. Based on the second feature or the feature type, a target build version that meets dependency requirements of the second feature or the feature type is then identified before obtaining a list of build versions for a plurality of computing devices in the computing environment. From among the plurality of computing devices, one or more computing devices that have build versions that meet the target build version are then identified before marking the identified computing devices as being available for deployment of the feature and advancing deployment of the feature to those computing devices.

Abstract: In one embodiment, a system includes first host machines implementing a public-cloud computing environment, wherein at least one of the first host machines includes a resource manager that provides a public-cloud resource interface through which one or more public-cloud clients interact with one or more virtual machines, and second host machines implementing a private-cloud computing environment, wherein at least one of the second host machines includes one or more private-cloud virtual machines, wherein at least one of the first host machines further includes a private-cloud VM resource provider through which the resource manager interacts with the private-cloud virtual machines, wherein the VM resource provider translates requests to perform virtual machine operations from a public-cloud-resource interface to a private-cloud virtual machine interface, and the private-cloud virtual machines perform the requested virtual machine operations in response to receiving the translated requests from the VM resource

Abstract: Techniques for determining levels of interactions amongst entities in a group are provided. A plurality of mobile electronic devices detect signal data indicating when pairs of devices are proximate to one another. A receiver receives the detected signal data, and a data structure representing a contact network is generated based on the received detected signal data. Based on the contact network, a first metric is generated comprising a quantification of an average number of other entities in the contact network with which an entity in the contact network will have interactions in a predetermined amount of time. Based on the contact network, a second metric is generated comprising a quotient comprising of a size of a component of the contact network divided by an overall network size of the contact network. Based on the first and second metric, a level of interaction amongst entities in the group is determined.