Abstract: The present disclosure provides methods of screening for a sortilin binding antagonist. In some embodiments, the methods include incubating an agent with a sortilin protein and a sortilin ligand, where the sortilin protein and sortilin ligand are each attached to a member of a fluorescence donor/acceptor pair, exciting the fluorescence donor of the fluorescence donor/acceptor pair, and detecting fluorescence emitted by the fluorescence donor at a second wavelength and fluorescence emitted by the fluorescence acceptor at a third wavelength. A decrease in the ratio of the fluorescence emitted by the fluorescence acceptor at the third wavelength to the fluorescence emitted by the fluorescence donor at the second wavelength, as compared to the ratio in the absence of the agent, indicates that the agent is a sortilin binding antagonist.

Abstract: An electrical connector assembly can include a plug connector mountable to a planar substrate and a receptacle connector configured to receive a plurality of cables and that can mate with the plug connector. The plug connector may include a first inline terminal row and a second inline terminal row exposed on a mounting face to conductively contact the planar substrate. The receptacle connector can include a plurality of terminals having termination ends aligned in common wafer plane that can be conductively terminated with the plurality of cables. The plug connector and the electrical connector are configured to establish electrical channels from the termination ends coplanar with the common wafer plan to the first and second inline terminal rows.

Abstract: Disclosed is an article of clothing that includes a front side, a back side, a first side between the front side and the back side, and a second side between the front side and the back side that is opposite from the first side. Further, the article includes a flexible webbing that traverses a semi-circumferential path on the article, wherein the semi-circumferential path extends at least: (i) from a first, visible point where the front side meets the first side; (ii) in between an external layer of the backside attached to an inner layer of the backside; and (iii) to a second, visible point where the second side meets the front side. Further still, the article includes a fixed ring located where the front side meets the first side, whereby the article provides hands-free stability to a wearer when a pulling object is attached to the flexible webbing.

Abstract: An animal wellness notification system includes an attachment body configured to securely engage with an ear of the animal; an elongated temperature probe secured to the attachment body and configured to extend within the ear of the animal; a housing secured to the attachment body; a power module electrically connect to and configured to provide power to (or recharge) at least one other element of the animal wellness notification system; a computer disposed within the housing and operably associated with the temperature probe; and a notification device in data communication with the computer, the notification device being configured to provide notice if a temperature of the animal goes beyond a determined.

Abstract: A vehicle includes a chassis, a cab coupled to the chassis, a prime mover coupled to the chassis and positioned at least one of beneath or behind the cab, and an accessory drive. The accessory drive includes an accessory and connecting shaft. The accessory is positioned forward of a front of the cab such that the accessory is spaced from the prime mover. The connecting shaft extends from the prime mover, past the front of the cab, and to the accessory. The connecting shaft is positioned to facilitate driving the accessory with the prime mover.

Abstract: A steering column for autonomous vehicles includes a powered actuator controlling rotation of a lower column, an inner column, and an upper column that is movable relative to the lower and inner columns. Rotation of the lower column relative to the upper column moves the upper column lengthwise. A powered lock rotatably interconnects the inner and lower columns when in a first position, and locks the inner column to a base when in a second position. In an autonomous mode, the upper column is stowed, the powered lock is in the first position, and the motor inhibits rotation of the lower column. In a manual mode, the upper column is extended, the powered lock is in the second position, and a sensor detects an angular position of the upper column.

Abstract: According to certain aspects of the disclosure, non-transitory computer readable media, systems and methods are disclosed for creating and executing test scenarios for automated testing of web pages. A computer system, for example, may perform operations including: recording one or more actions performed by a user on a web page, the one or more actions resulting in a web page element being displayed in the web browser application, recording an identifier of the web page element, in response to detecting a user input indicating a selection of the web page element, and recording a characteristic of the web page element; and generating, by the testing extension, a test scenario specifying a testable outcome resulting from the one or more actions, the testable outcome being an occurrence of an element having the identifier and the characteristic.

Abstract: A method for execution by a query processing system includes receiving a query request from a requesting entity. Query cost data is generated based on the query request by utilizing a query pricing scheme. Minimum query cost compliance data is generated for the query request based on determining whether the minimum query cost data complies with a minimum query cost rule. When the minimum query cost compliance data indicates the minimum query cost data complies with the minimum query cost rule a query result is generated based on facilitating execution of the query by executing at least one query function of the query against a database system, and the query result is transmitted to the requesting entity. When the minimum query cost compliance data indicates the query cost data does not comply with the minimum query cost rule, the query result is not transmitted to the requesting entity.

Abstract: Systems and methods including one or more processors and one or more non-transitory storage devices storing computing instructions configured to run on the one or more processors and perform acts of storing, for each respective customer of one or more customers, respective customer information in a customer database; predicting, using a machine learning lifetime value (LTV) update model, a respective LTV for each respective customer of the one or more customers; determining an online advertisement for each respective customer of the one or more customers using the respective LTV, as predicted, for each respective customer of the one or more customers; and coordinating displaying the online advertisement for at least a portion of the one or more customers. Other embodiments are disclosed herein.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for obtaining, by a first sequence-training speech model, a first batch of training frames that represent speech features of first training utterances; obtaining, by the first sequence-training speech model, one or more first neural network parameters; determining, by the first sequence-training speech model, one or more optimized first neural network parameters based on (i) the first batch of training frames and (ii) the one or more first neural network parameters; obtaining, by a second sequence-training speech model, a second batch of training frames that represent speech features of second training utterances; obtaining one or more second neural network parameters; and determining, by the second sequence-training speech model, one or more optimized second neural network parameters based on (i) the second batch of training frames and (ii) the one or more second neural network parameters.

Abstract: A method for measuring health metrics of a user is provided. A base of an electronic device is attached to the skin of the user. A housing of the electronic device is attached to the base, such that (i) the housing is secured to the base, and (ii) a window of the housing is positioned outside an opening in the base. One or more sensors within the housing generates first physiological data associated with the health metrics of the user through the housing window and the base opening. Second physiological data associated with the health metrics of the user is generated using a set of electrodes positioned outside of the housing. The set of electrodes are coupled to the base, and the set of electrodes facilitate movement of electrical signals between the skin of the user and a sensor printed circuit board within the housing of the electronic device.

Abstract: Manufacturing processes leverage process steps used during CMOS formation to form one or more additional type(s) of devices on the same substrate used for the CMOS formation, and at least partially in parallel with the CMOS formation processes. A first layer of implant wells may be formed at a first depth in a substrate using a first mask, and then a second layer of implant wells may be formed at a second, more shallow depth, using a second mask. CMOS devices that are part of a CMOS platform may be formed using some of the wells, while peripheral devices may be formed using remaining wells.

Abstract: A method and system for managing domain name system (DNS) name servers using virtual name servers is disclosed. A plurality of virtual name servers are mapped to a plurality of actual name servers of the DNS. Each actual name server stores at least one record identifying a domain and an Internet Protocol (IP) address of a computer hosting that domain. Information is received from a monitoring service computer identifying which actual name servers are unhealthy and which actual name servers are healthy. Based on this information, the mapping of each virtual name server that is mapped to an unhealthy actual name server is updated to map to one of the healthy actual name servers.

Abstract: Aspects of the present disclosure include systems and methods for automatically scanning a network for network devices, retrieving and storing device information associated with any identified network devices, and updating records of a DNS based on the retrieved device information. The updated records of the DNS may include the IP address of a given network device and a device name that is automatically generated from the retrieved device information using a set of naming rules applied to the device information. Accordingly, subsequent queries including the device names may be submitted to the DNS to retrieve the corresponding IP addresses. The resulting device names generated by applying the naming rules may be based on, among other things, logical or physical properties of the network devices.

Abstract: The tongue includes a shaft, the shaft being hollow. The shaft includes a first end and a second end, the first end defining a first opening with a first radius of curvature, and the second end defining a second opening with a second radius of curvature. The first radius of curvature is larger than the second radius of curvature. The shaft defines at least one injection port that traverses through an inner surface of the shaft. A first plate is connected to the shaft. The first plate includes an engaging structure configured to mount the tongue onto a lower plate and align the shaft with a groove defined by the lower plate. The rod forming apparatus includes the tongue. The method installs the tongue onto the rod forming apparatus.

Abstract: The present invention relates to processes for preparing refrigerant blends comprising one or more purified hydrofluorocarbon compounds, wherein the one or more hydrofluorocarbon compounds have been recovered from one or more refrigeration, air conditioning or heat pump systems, and purified.

Abstract: This document relates to an optical device that uses a mirror scanning system as part of a display engine, where images generated by the mirror scanning system can be propagated through a waveguide or other such optical assembly to a user's eye. The mirror scanning system can utilize a magnetic assembly, where the mirror of the scanning system can be held in place magnetically instead of using support structures such as torsion bars or beams. Actuators can then be actuated to control the tilt of the mirror by way of magnetic fields, providing a greater field of movement for the optical element and enabling a spherical scan area to be produced.

Abstract: Disclosed herein are system, method, and computer program product embodiments for determining an appropriate FPGA for a particular computer program. An embodiment operates by a central processing unit's counter identifying a plurality of workload properties in processing a computer program, wherein the central processing unit is part of a first computer architecture. The central processing unit then sends the workload properties to a controller trained to identify a field-programmable gate array (FPGA) module based on the plurality of workload properties. The central processing unit thereafter receives a recommended FPGA module from the controller and implements the recommended FPGA module in a computer architecture for processing the computer program, whereby the second computer architecture is able to perform the computer program more efficiently than the first computer architecture.

Abstract: None of the existing quantum programming languages provide specialized support for programming patterns such as conditional-adjoint or adjoint-via-conjugation. As a result, compilers of these languages fail to exploit the optimization opportunities mentioned in this disclosure. Further, none of the available quantum programming languages provide support for automatic translation of circuits using clean qubits to circuits that use idle qubits. Thus, the resulting circuits oftentimes use more qubits than would be required. Embodiments of the disclosed technology, thus allow one to run said circuits on smaller quantum devices. Previous multiplication circuits make use of (expensive) controlled additions. Embodiments of the disclosed technology employ multipliers that work using conditional-adjoint additions, which are cheaper to implement on both near-term and large-scale quantum hardware. The savings lie between 1.5 and 2× in circuit depth for large number of qubits.

Abstract: A pitch board game includes a board made of drop stitch inflatable material. The board, prior to inflation, is light weight, compact and easily carried from location to location. When inflated, the board is comparable in strength and hardness to solid wooden board. The game itself is played like the game “cornhole,” as bean bags are tossed by players onto the upper surface of the board, which is propped up at an acute angle. Bags landing on the surface count one point, and bags landing in a hole in the board count three points.