Patents Assigned to Lonza AG
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Patent number: 9970017Abstract: The present invention relates to the production of heterologous polypeptides in a recombinant bacterial host cell, wherein the bacterial host cell is rendered unable to deactivate the promoter controlling the expression of the heterologous polypeptide in the absence of an inducer.Type: GrantFiled: October 10, 2016Date of Patent: May 15, 2018Assignee: Lonza AGInventors: Marian Wenzel, Josef Altenbuchner, Christoph Kiziak
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Patent number: 9962678Abstract: A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).Type: GrantFiled: June 28, 2016Date of Patent: May 8, 2018Assignee: LONZA AGInventors: Dominique Roberge, Nikolaus Bieler, Bertin Zimmermann, Rainald Forbert
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Publication number: 20170137830Abstract: The present invention relates to the production of heterologous polypeptides in a recombinant bacterial host cell, wherein the bacterial host cell is rendered unable to deactivate the promoter controlling the expression of the heterologous polypeptide in the absence of an inducer.Type: ApplicationFiled: October 10, 2016Publication date: May 18, 2017Applicant: Lonza AGInventors: Marian Wenzel, Josef Altenbuchner, Christoph Kiziak
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Patent number: 9551018Abstract: The present invention relates to the production of optically pure secondary amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.Type: GrantFiled: June 16, 2015Date of Patent: January 24, 2017Assignee: LONZA AGInventors: Karen Robins, Uwe Scheuer, Matthias Hohne
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Patent number: 9375698Abstract: A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).Type: GrantFiled: July 14, 2014Date of Patent: June 28, 2016Assignee: Lonza AGInventors: Dominique Roberge, Nikolaus Bieler, Bertin Zimmermann, Rainald Forbert
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Patent number: 9302243Abstract: A continuous reaction micro-reactor of modular structure comprises, arranged along a back-to-front stacking axis thereof, a first frame means, a reaction unit, and a second frame means, wherein said reaction unit comprises a process fluid channel system for continuous reaction of a plurality of feeds or reactants flowing into said reaction unit to form at least one product flowing out of said reaction unit, and a heat exchange fluid channel system for adjusting the temperature environment of said process fluid channel system, said first and second frame means are each formed as a flange, and said first and second frame means are alpressed towards each other by a plurality of tensioning means arranged along and within an outer circumference of said first and second frame means and enclosing said reaction unit.Type: GrantFiled: May 12, 2010Date of Patent: April 5, 2016Assignee: LONZA AGInventor: Norbert Josef Kockmann
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Patent number: 9279128Abstract: Vectors expressible in a host that is the rhaBAD promoter region of the L-rhamnose operon operably linked to a transcriptional unit that is: a) a nucleic acid sequence which is heterologous to the host, and b) a prokaryotic signal sequence operably linked to the nucleic acid sequence. The prokaryotic signal sequence is selected from signal peptides of periplasmatic binding proteins for sugars, amino acids, vitamins and ions. The expression of the nucleic acid sequence is controlled by the promoter region. The vector is used for the regulated heterologous expression of a nucleic acid sequence in a prokaryotic host. This is an isolated and purified nucleic acid sequence expressible in a host is the promoter region of the L-rhamnose operon. There is a method for producing a polypeptide in a host using the vector.Type: GrantFiled: October 14, 2011Date of Patent: March 8, 2016Assignee: LONZA AGInventors: Johann Brass, Christoph Kiziak, Joachim Klein, Ralf Ostendorp
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Patent number: 9163247Abstract: The present invention relates to a vector expressible in a prokaryotic host and a nucleic acid sequence comprising a mannose-inducible promoter of the mannose operon of Bacillus subfiles wherein the vector and nucleic acid sequence, respectively, can be suitably used for transforming a host cell for expression of a heterologous nucleic acid sequence coding a polypeptide in, in particular, high cell density fermentation.Type: GrantFiled: August 2, 2010Date of Patent: October 20, 2015Assignee: Lonza AGInventors: Tianqi Sun, Josef Altenbuchner, Christoph Kiziak
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Patent number: 9074228Abstract: The present invention relates to the production of optically pure secondary amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.Type: GrantFiled: February 13, 2007Date of Patent: July 7, 2015Assignee: LONZA AGInventors: Karen Robins, Uwe Bornscheuer, Matthias Höhne
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Patent number: 9040480Abstract: A new method of synthesizing GLP-1 peptide is devised.Type: GrantFiled: April 29, 2013Date of Patent: May 26, 2015Assignee: LONZA AGInventors: Oleg Werbitzky, Stéphane Varray, Matthieu Giraud, Carsten Meininghaus
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Patent number: 9023296Abstract: A method of manufacturing a target reactor having a flow-channel system in which a plurality of reactants continuously flowing into said target reactor are mixed and interconvert to form a target volumetric flow-rate (f2) of a product continuously flowing out of said target reactor, wherein the smallest hydraulic diameter (dh2) of said target reactor is calculated based on the relationship d h ? ? 2 = d h ? ? 1 ? ( f 2 f 1 ) 3 - n 7 - n in a turbulent or transitional turbulent flow, wherein n is a non-integer number with 1>n?0, between the corresponding smallest hydraulic diameter (dh1) of a standard reactor having the same fluidic type of flow-channel system, f1 is a standard volumetric flow-rate of said standard reactor carrying out the same interconversion, and f2 is said target volumetric flow-rate.Type: GrantFiled: May 12, 2010Date of Patent: May 5, 2015Assignee: Lonza AGInventors: Dominique Roberge, Norbert Kockmann, Michael Gottsponer, Markus Eyholzer
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Patent number: 8962865Abstract: A process is disclosed for the preparation of a compound of formula and/or an addition salt of a proton acid, wherein R1 and R2 independently represent alkyl, cycloalkyl, aryl or aralkyl, each aryl or aralkyl being optionally further substituted with alkyl, alkoxy and/or halogen.Type: GrantFiled: July 25, 2013Date of Patent: February 24, 2015Assignee: Lonza AGInventors: Dominique Michel, Rudolf Fuchs
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Publication number: 20140322105Abstract: A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).Type: ApplicationFiled: July 14, 2014Publication date: October 30, 2014Applicant: Lonza AGInventors: Dominique Roberge, Nikolaus Bieler, Bertin Zimmermann, Rainald Forbert
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Patent number: 8728750Abstract: The present invention relates to the production of optically active amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.Type: GrantFiled: September 6, 2007Date of Patent: May 20, 2014Assignee: Lonza AGInventors: Karen Robins, Uwe Bornscheuer, Matthias Höhne
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Publication number: 20130324699Abstract: A new method of synthesizing GLP-1 peptide is devised.Type: ApplicationFiled: April 29, 2013Publication date: December 5, 2013Applicant: LONZA AGInventor: Lonza AG
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Publication number: 20130310574Abstract: A process is disclosed for the preparation of a compound of formula and/or an addition salt of a proton acid, wherein R1 and R2 independently represent alkyl, cycloalkyl, aryl or aralkyl, each aryl or aralkyl being optionally further substituted with alkyl, alkoxy and/or halogen.Type: ApplicationFiled: July 25, 2013Publication date: November 21, 2013Applicant: Lonza AGInventors: Dominique Michel, Rudolf Fuchs
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Patent number: 8577622Abstract: The present invention relates to processes for the screening, preparation and characterization of (R)-selective ?-transaminases, to transaminases obtained thereby and their uses in various transamination processes.Type: GrantFiled: August 13, 2010Date of Patent: November 5, 2013Assignee: Lonza AGInventors: Matthias Hoehne, Uwe Bornscheuer, Karen Robins, Sebastian Schaetzle
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Patent number: 8558014Abstract: A process is disclosed for the preparation of a compound of formula and/or an addition salt of a proton acid, wherein R1 and R2 independently represent alkyl, cycloalkyl, aryl or aralkyl, each aryl or aralkyl being optionally further substituted with alkyl, alkoxy and/or halogen. The process involves reacting a mixture comprising a methyl ketone of formula and a compound of formula H2N—R2 (V) and/or an addition salt of proton acid, and formaldehyde in the presence of a solvent selected from the group consisting of water, aliphatic alcohols, cycloaliphatic alcohols and mixtures thereof, and optionally a proton acid to afford a ?-amino ketone of formula and/or an addition salt of a proton acid, and reducing the carbonyl group of said ?-amino ketone to afford a compound of formula I, and/or an addition salt of a proton acid wherein the first step is carried out at a pressure above 1.5 bar.Type: GrantFiled: August 25, 2010Date of Patent: October 15, 2013Assignee: Lonza AGInventors: Dominique Michel, Rudolf Fuchs
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Publication number: 20130259768Abstract: A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).Type: ApplicationFiled: May 22, 2013Publication date: October 3, 2013Applicant: LONZA AGInventors: Dominique Roberge, Nikolaus Bieler, Bertin Zimmermann, Rainald Forbert
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Patent number: 8512653Abstract: A micro-reactor system assembly comprises a stack of at least n process modules (1-6), wherein n is an integer equal to or greater than 1, made from a rigid first material and comprising at least one reactive fluid passage (1A, 1B, 2A, 3A, 6A) for accommodating and guiding a reactive fluid, and at least n+1 heat exchange modules (7, 8) made from a ductile second material other than said first material and comprising at least one heat exchange fluid passage (7A, 8A) for accommodating and guiding a heat exchange fluid, wherein each process module (1-6) is sandwiched between two adjacent heat exchange modules (7, 8).Type: GrantFiled: March 29, 2012Date of Patent: August 20, 2013Assignee: Lonza AGInventors: Dominique Roberge, Nikolaus Bieler, Bertin Zimmermann, Rainald Forbert