Patents Assigned to Louisiana State University and Agricultural and Mechanical College
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Publication number: 20220412990Abstract: The invention relates to methods of cardiovascular imaging and/or measurement of blood markers for detecting, diagnosing and/or prognosing cardiac or myocardial microbleeds, especially in subject with hypertension and cardiovascular diseases. Treatment methods are also provided for subjects identified, diagnosed, prognosed, or detected with cardiac or myocardial microbleeds. In some embodiments, the subject has hypertension-induced microbleeds, but has not had a myocardial infarction or reperfusion therapy.Type: ApplicationFiled: October 30, 2020Publication date: December 29, 2022Applicants: CEDARS-SINAI MEDICAL CENTER, BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventors: Rohan DHARMAKUMAR, Joseph FRANCIS
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Publication number: 20220409637Abstract: Therapeutics and methods of treating COVID-19 in a patient in need thereof comprising administering a pharmaceutically effective dose of a therapeutic, wherein the therapeutic contains an ACE2 externalizer, and the ACE2 externalizer is one of diminazene, diminazene aceturate, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, or prodrug thereof.Type: ApplicationFiled: September 6, 2022Publication date: December 29, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Johnathan Steven ALEXANDER, Christopher KEVIL, Mansoureh BARZEGAR, Ana Maria DRAGOI
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Patent number: 11534442Abstract: The present disclosure provides compositions comprising a lyn kinase activator and TRPM8 agonist, and to methods of: reducing blood glucose levels, weight gain, or fat depot levels; treating metabolic syndrome, Syndrome X, obesity, prediabetes, type II diabetes, type I diabetes; treating hypercholesterolemia, hypertension, coronary heart disease, diabetic neuropathy, lipodystrophy, diabetic retinopathy, erectile dysfunction, kidney disease, dyslipidemia, dyslipoproteinemia, a peroxisome proliferator activated receptor-associated disorder, septicemia, a thrombotic disorder, or pancreatitis; inducing the beiging of adipocytes; and preventing pancreatic beta cell degeneration.Type: GrantFiled: August 19, 2020Date of Patent: December 27, 2022Assignees: Melior Pharmaceuticals I, Inc., Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Andrew G. Reaume, Weina Cong, Frank Greenway, Ann Coulter
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Publication number: 20220403080Abstract: A UV-curable and recyclable thermoset shape memory polymer is provided. The polymer includes a vitrimer-based monomer and a photoinitiator. The vitrimer-based monomer includes a first unit rendering a high chain stiffness upon polymerization of the monomer, and a second photopolymerizable unit for photopolymerization of the monomer under a UV irradiation. The polymer has high strength, high stiffness, high recovery stress, high energy storage, reasonable recycling efficiency, and is printable using SLA with high resolution.Type: ApplicationFiled: May 5, 2022Publication date: December 22, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Ang Li, Guoqiang LI
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Patent number: 11529355Abstract: This invention is directed to compositions, methods and kits that can be used for the treatment or amelioration of pain and fever.Type: GrantFiled: May 17, 2021Date of Patent: December 20, 2022Assignees: The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Alcala de Henares, South Rampart Pharma, LLCInventors: Nicolas Bazan, Hernan Bazan, Julio Alvarez-Builla Gomez, Dennis Paul, Carolina Burgos Garcia
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Publication number: 20220380808Abstract: Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.Type: ApplicationFiled: May 6, 2022Publication date: December 1, 2022Applicants: University of Florida Research Foundation, Incorporated, Board of Supervisors of Louisiana State University & Agricultural & Mechanical CollegeInventors: David C. Bloom, Alfred S. Lewin, Donna M. Newmann, Zachary L. Watson, Sonal Sanjeev Tuli, Gregory Scott Schultz
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Patent number: 11497775Abstract: This invention is directed to compositions and methods for treating a condition of the heart. In an embodiment, the invention is directed to a method of treating a subject in need thereof, wherein the method comprises ablating at least one nerve of the renal artery of the subject; and administering to the subject a therapeutically effective amount of cells.Type: GrantFiled: February 1, 2019Date of Patent: November 15, 2022Assignee: THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventors: David J. Lefer, David J. Polhemus
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Patent number: 11493515Abstract: This invention comprises compositions and methods to detect and treat gastrointestinal diseases.Type: GrantFiled: February 4, 2019Date of Patent: November 8, 2022Assignee: THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventors: Sunyoung Kim, Zeromeh Gerber, Duna Penn, Carl Sabottke, Rebecca Buckley
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Patent number: 11490570Abstract: Various examples of methods and systems are provided for increasing productivity of one or more photosynthetic cultures via self-powered energy output systems. In one example, a system includes a waterproof casing and an energy output module enclosed within the waterproof casing. The waterproof casing is configured to be neutrally buoyant in an enclosure comprising the one or more photosynthetic cultures. In another example, a method includes placing a self-powered energy output system within an enclosure, the self-powered energy output system being neutrally buoyant within the enclosure. The method further includes causing turbulence within the enclosure, and the self-powered energy output system harvests energy to power the self-powered energy output system via the turbulence within the enclosure.Type: GrantFiled: January 14, 2020Date of Patent: November 8, 2022Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventors: Maria Teresa Gutierrez-Wing, Jin-Woo Choi
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Patent number: 11488740Abstract: A phase contrast X-ray imaging system includes: an illumination source adapted to illuminate a region of interest; a diffraction grating adapted to receive illumination from the illuminated region of interest, the diffraction grating comprising a spatial structure having a first periodicity superimposed with a second periodicity that is different from the first periodicity; and a detector adapted to detect illumination passing through the diffraction grating, wherein the spatial structure is defined by varying height and/or pitch, and wherein the spatial structure imparts a first phase dependence based on the first periodicity and an additional phase dependence based on the second periodicity on the illumination passing through the diffraction grating.Type: GrantFiled: November 13, 2020Date of Patent: November 1, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Joyoni Dey, Narayan Bhusal, Leslie Butler, Jonathan P. Dowling, Kyungmin Ham, Varshni Singh
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Patent number: 11488420Abstract: Methods of estimating tribological damage described herein include examples where varying power is applied between surfaces engaged in frictional contact. Calculations evaluate power consumed at the relevant frictional contact and temperature values may be gathered to supplement the calculated power. Instantaneous and cumulative assessments of damage are calculated based on that information. Measurements or calculations of electrical power may be used as part of the damage assessment.Type: GrantFiled: May 29, 2020Date of Patent: November 1, 2022Assignee: Board af Supervisors af Louisiana State University and Agricultural and Mechanical CollegeInventors: Michael M. Khonsari, Lijesh Koottaparambil
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Publication number: 20220330398Abstract: The absorbance or emission wavelength of composite materials comprising a transition metal doped shell disposed over a rare earth doped core and a functionalizable group on the surface of the transition metal doped shell can change upon subjection to a carboxylic acid. This method of changing the absorbance or emission wavelength of a composite material can be used to identify counterfeit currency using an ink comprising a composite material.Type: ApplicationFiled: April 14, 2022Publication date: October 13, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventor: James Anthony Dorman
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Patent number: 11464740Abstract: Methods and monodisperse glass microsphere composites comprising a porous wall hollow-glass microsphere; a cargo of a therapeutic is loaded inside of the porous wall hollow-glass microsphere; and a first shell fully encapsulating the porous wall hollow-glass microsphere and capping pores in the walls, retaining the cargo inside of the porous wall hollow-glass microsphere.Type: GrantFiled: April 29, 2020Date of Patent: October 11, 2022Assignees: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE, MUSC FOUNDATION FOR RESEARCH DEVELOPMENT, APPLIED RESEARCH CENTER, INC.Inventors: Paul M. Weinberger, George Wicks, William D. Hill
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Patent number: 11458142Abstract: This invention is directed to compositions, methods and kits that can be used for the treatment or amelioration of pain.Type: GrantFiled: March 12, 2018Date of Patent: October 4, 2022Assignees: The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Alcala De Henares, South Rampart Pharma, LLCInventors: Nicolas Bazan, Hernan Bazan, Julio Alvarez-Builla, Dennis Paul, Carolina Burgos
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Publication number: 20220280618Abstract: The present invention is directed to antibodies binding to and neutralizing Candida and methods for use thereof.Type: ApplicationFiled: July 28, 2020Publication date: September 8, 2022Applicants: The Administrators of the Tulane Educational Fund, The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Autoimmune Technologies, LLCInventors: Russell B. WILSON, Hong XIN, James E. ROBINSON
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Publication number: 20220273702Abstract: Therapeutics and methods of treating COVID-19 comprising in a patient comprising administering to the patient an effective dose of a pharmacologic composition containing a first therapeutic; wherein the first therapeutic is a hydrogen sulfide (H2S) donor, or a salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analogs thereof. According to a further embodiment the H2S donor is one of include diallyl trisulfide (DATS), diallyl disulfide (DADS), sodium sulfide, acillin, sugammadex, sulfanilamide, disulfram, sulfonamide, a sulfinate, a sulfoxide, a persulfide, a polysulfide, and a sulfone. According to a further embodiment the pharmacologic composition further contains a second therapeutic, wherein the second therapeutic is a nitrite, or a salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analogs thereof. According to a further embodiment wherein the nitrite is an inorganic nitrite.Type: ApplicationFiled: February 25, 2022Publication date: September 1, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Gopi K. Kolluru, Christopher KEVIL, Paari DOMINIC, Anthony Wayne ORR
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Publication number: 20220241401Abstract: The present invention provides vaccines for treating or preventing a herpes simplex virus infection and methods of using and making the vaccine. Further provided are recombinant herpes simplex virus genomes, recombinant viruses, and immunogenic compositions.Type: ApplicationFiled: December 14, 2021Publication date: August 4, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventor: Konstantin G. Kousoulas
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Publication number: 20220243040Abstract: Disclosed herein is a self-healing asphalt binder composition comprising i) an asphalt binder, ii) an oxetane substituted polysaccharide, and iii) a polyurethane, as well as asphalts comprising said self-healing asphalt binder and an asphalt mixture. Also disclosed are methods of making the self-healing asphalt binder.Type: ApplicationFiled: January 31, 2022Publication date: August 4, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Sharareh Shirzad, Marwa M. Hassan
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Publication number: 20220233743Abstract: A composition for wound healing, comprising an amount of a macrophage proresolving polarizer, wherein the amount is effective to promote wound healing. The composition includes wherein the macrophage proresolving polarizer is lipin-1. The composition includes wherein the composition includes one, two, or three of IL-4, apoptotic cells (ACs), and AC derived lipids. The composition includes wherein the macrophage proresolving polarizer is a lipin-1 transcriptional coregulatory activity promoter. The composition includes, wherein the lipin-1 transcriptional coregulatory activity promoter is an inhibitor of lipin-1 macrophage pro-inflammatory responses enzymatic activity. A method for promoting wound healing, comprising contacting a wound on a skin of a mammal with the composition. A kit comprising one or more containers including the composition in sterile packaging.Type: ApplicationFiled: December 14, 2020Publication date: July 28, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Matthew WOOLARD, Robert SCHILKE, Cassidy BLACKBURN
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Patent number: 11392734Abstract: Embodiments of the present invention include apparatuses and methods for performing remote experiments in real-time. The method includes sending requests to perform remote experiments for a desired configuration to a first and second facility. The desired configuration may include a first and second configuration. The method includes running a first remote experiment in real-time at the first facility to obtain a first output variable. The first facility may include the first configuration with a first input variable. The method includes simultaneously running a second remote experiment in real-time at a second facility to obtain a second output variable. The second facility may include the second configuration with a second input variable. The first output variable may be set as the second input variable to mimic the desired configuration. The method includes obtaining experimental results of the desired configuration via the first and second input and output variables.Type: GrantFiled: November 22, 2019Date of Patent: July 19, 2022Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventor: Paulo J. Waltrich