Patents Assigned to Louisiana State University and Agricultural and Mechanical College
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Patent number: 11384019Abstract: High-strength concrete-like FG blends and methods for producing them are described. The blend includes FG, hydraulic cement, additional alkali material, and pozzolanic material. The blend further includes an admixture used in the formulation of concrete. The blend further includes an aggregate. The aggregate is a coarse aggregate or a fine aggregate.Type: GrantFiled: November 12, 2020Date of Patent: July 12, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Michele Barbato, Yasser Bigdeli, Maria Teresa Gutierrez-Wing, Charles Davis Lofton
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Patent number: 11376573Abstract: Methods of preparing an acidic catalyst are disclosed that include heating a metal halide to produce a vapor phase metal halide, contacting an initial support material with the vapor phase metal halide in a reaction vessel causing a first chemical reaction and producing an intermediate acidic catalyst, contacting the intermediate acidic catalyst with HBr causing a second chemical reaction and producing an acidic catalyst product which is both more acidic than the intermediate acidic catalyst and more acidic than the initial support material.Type: GrantFiled: February 14, 2020Date of Patent: July 5, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: James J. Spivey, Kunlun Ding, Swarom Kanitkar
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Publication number: 20220193105Abstract: The presently disclosed invention relates to products and methods of treating cancer in a patient comprising administering to the patient a pharmaceutically therapeutic dose of a chemotherapeutic, or any pharmaceutically acceptable salt, solvate, or prodrug thereof, conjugated to a nanocarrier. According to a further embodiment, the chemotherapeutic has a primary (10) amine (—NH2) group in within a pharmaceutical structure of the chemotherapeutic structure. According to a further embodiment, the chemotherapeutic is one of a platinum-based pharmaceutical and an Anthracycline family pharmaceutical. According to a further embodiment, the chemotherapeutic is one of gemcitabine, methotrexate, cisplatin, oxaliplatin, doxorubicin, daunorubicine, idarubicine, and epirubicine. According to a further embodiment, the chemotherapeutic is either attached to the nanocarrier by means that includes covalent bonds or is attached by means that does not included covalent bonds.Type: ApplicationFiled: March 1, 2021Publication date: June 23, 2022Applicants: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Shenuarin BHUIYAN, Mohuddin QUADAIR
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Patent number: 11357191Abstract: The herbicide-tolerant rice cultivar designated “PVL01” and its hybrids and derivatives are disclosed. The present invention provides a method for producing rice, wherein said rice is tolerant to a quizalofop herbicide or tolerant to a tepraloxdyim herbicide; wherein said rice belongs to any of (a) variety “PVL01” or (b) a hybrid, derivative, or progeny of “PVL01”. Further provided are methods for producing a hybrid or a new variety by crossing the rice variety “PVL01” with another rice line, one or more times. In another embodiment, this invention allows for single-gene converted plants of “PVL01”. In another embodiment, this invention provides regenerable cells for use in tissue culture of rice plant “PVL01”.Type: GrantFiled: June 19, 2018Date of Patent: June 14, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventor: Steven D. Linscombe
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Patent number: 11358901Abstract: A composition comprising thermoset polymer, shape memory polymer to facilitate macro scale damage closure, and methods for molecular scale healing are provided. The composition can resolve structural defects by a bio-mimetic close-then heal process. In use, the shape memory polymer can provide molecular scale healing in a structural defect. The methods for molecular scale healing can include heating a composition including a thermoplastic such as fibers, particles or spheres to a level at or above the thermoplastic's melting point, then cooling of the composition below the melting temperature of the thermoplastic. The compositions have the ability to close macroscopic defects repeatedly even if another wound/damage occurs in a previously healed/repaired area.Type: GrantFiled: April 17, 2020Date of Patent: June 14, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Guoqiang Li, Harper Meng
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Patent number: 11357085Abstract: The absorbance or emission wavelength of composite materials comprising a transition metal doped shell disposed over a rare earth doped core and a functionalizable group on the surface of the transition metal doped shell can change upon subjection to a carboxylic acid. This method of changing the absorbance or emission wavelength of a composite material can be used to identify counterfeit currency using an ink comprising a composite material.Type: GrantFiled: September 25, 2018Date of Patent: June 7, 2022Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventor: James Anthony Dorman
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Patent number: 11351273Abstract: Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to therapeutic nucleic acids, for example therapeutic ribozymes, that are useful for inhibiting viral reactivation in a subject.Type: GrantFiled: June 21, 2017Date of Patent: June 7, 2022Assignees: Board Of Supervisors Of Louisiana State University & Agricultural & Mechanical College, University of Florida Research Foundation, IncorporatedInventors: David C. Bloom, Alfred S. Lewin, Donna M. Neumann, Zachary L. Watson, Sonal Sanjeev Tuli, Gregory Scott Schultz
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Patent number: 11351628Abstract: A wedge for on-line inspection of a weld includes a wedge body defining a coolant channel and at least one couplant channel, and a coolant input port in fluid connection with a first end of the coolant channel. The wedge body has a surface for disposing a phased array ultrasonic transducer comprising an array of ultrasonic elements. The coolant channel is formed in proximity to the surface for disposing the phased array ultrasonic transducer such that coolant flowing through the coolant channel maintains the phased array ultrasonic transducer below a predetermined temperature without obstructing the array of ultrasonic elements.Type: GrantFiled: February 9, 2017Date of Patent: June 7, 2022Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventors: Daniel J. Huggett, Mohammad W. Dewan, Muhammad A. Wahab, Thunshun W. Liao, Ayman M. Okeil
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Publication number: 20220169508Abstract: The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2?). The pharmaceutical compositions of the invention are useful, for example, for treating or reducing pain, improving symptoms of a microvascular disease, and improving nerve conduction velocity.Type: ApplicationFiled: February 14, 2022Publication date: June 2, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Amol SOIN, Christopher KEVIL, Kyle CHAN, Anthony GIORDANO
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Publication number: 20220163541Abstract: The presently disclosed invention relates to a method of diagnosing Multiple Sclerosis (MS) in a patient comprising obtaining a sample from the patient, determining a level of one or more H2S generating enzymes in the sample from the patient, and diagnosing the patient with MS when the level of the one or more H2S generating enzymes is one of at least 15% higher or lower than a control level for the one or more H2S generating enzymes, and at least 10% higher or lower than a control level for the one or more H2S generating enzymes.Type: ApplicationFiled: November 26, 2021Publication date: May 26, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Johnathan Steven ALEXANDER, Christopher KEVIL, Elizabeth DISBROW, Karen Y. STOKES, J. Winny YUN, Pooja VEERAREDDY, Urska Cvek
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Patent number: 11331492Abstract: Methods and apparatus are disclosed relating to the stimulating of tissue including nerve tissue based on combinations of capacitors and resistors. Application and removal of voltage to an electrical circuit is taught as part of a method of creating voltage waveforms for nerve and other tissue with such waveforms creating neural signals. The electrical apparatus taught may, include a first electrical node grounded through a first resistor; a second electrical node grounded through a second resistor; a first capacitor connected to both the first electrical node and the second electrical node; a second capacitor separating the second electrical node from a biological grounding point and direct current sources connected to the two nodes.Type: GrantFiled: April 29, 2020Date of Patent: May 17, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Jose A. Parodi Amaya, Edward F Austin, Jin-Woo Choi
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Patent number: 11332565Abstract: A UV-curable and recyclable thermoset shape memory polymer is provided. The polymer includes a vitrimer-based monomer and a photoinitiator. The vitrimer-based monomer includes a first unit rendering a high chain stiffness upon polymerization of the monomer, and a second photopolymerizable unit for photopolymerization of the monomer under a UV irradiation. The polymer has high strength, high stiffness, high recovery stress, high energy storage, reasonable recycling efficiency, and is printable using SLA with high resolution.Type: GrantFiled: April 30, 2019Date of Patent: May 17, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Ang Li, Guoqiang Li
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Publication number: 20220117937Abstract: The present invention discloses methods of inhibiting biofilm formation, increasing bacteriocidal activity within a biofilm, treating bacteria within a biofilm, or remediating a biofilm in or on a subject, comprising administering to the subject an effective amount of a compound according to Formula I: wherein R1-5 are defined herein.Type: ApplicationFiled: October 15, 2021Publication date: April 21, 2022Applicants: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Kansas, Oklahoma State UniversityInventors: Mario Rivera, Huili Yao, Richard A. Bunce, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Kate Eshelman, Achala N.D. Punchi Hewage, Scott Lovell, Anabel Soldano
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Patent number: 11285191Abstract: Disclosed are compositions and methods for stimulating immune responses. More particularly, these compositions and methods involve the use of an inhibitor of IL-25 function and an immune stimulator that stimulates an immune response to a target antigen for stimulating protective or therapeutic immune responses to a target antigen. The compositions and methods of the present invention are particularly useful in the prevention and treatment of infections and cancers.Type: GrantFiled: July 26, 2017Date of Patent: March 29, 2022Assignee: THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGEInventors: Ronald James Jackson, Charani Ranasinghe
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Publication number: 20220071642Abstract: The presently disclosed invention relates to devices and methods for conducting bone surgery on an animal using a bone surgery tool comprising a base, a fixed arm fixed to the base, the fixed arm including a shoulder and a jaw, a sliding arm releasably fixable to the base, the sliding arm including a head that receives an implant and a cartridge in a slot, the method comprising hooking the bone with the jaw, moving the head toward the jaw capturing the bone, accessing the bone with a drill through cartridge bores in the cartridge, and drilling holes, accessing the bone with a self-shearing screw attached to a screw driver through cartridge bores in the cartridge, and attaching the implant to the bone, and moving the head away from the jaw releasing the bone.Type: ApplicationFiled: December 3, 2020Publication date: March 10, 2022Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Giovanni Francesco SOLITRO, R. Shane BARTON, Johnathan Steven ALEXANDER
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Publication number: 20220072324Abstract: A device, system and method for creating pulsed electric fields with good uniformity are provided. The electric fields occupy a large volume, suitable for placing a human or animal patient. A device for generating the electric fields is provided, which comprises one or more toroidally or cylindrically shaped magnetic core(s) wound with electrical wires, which, when pulsed with electrical currents, generate an electric field of high uniformity in the interior region of the toroidal or cylindrical cores. These electric field pulses, when used in conjunction with pharmacological agent, destroy cancer cells through a process called Targeted Osmotic Lysis.Type: ApplicationFiled: December 2, 2019Publication date: March 10, 2022Applicants: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, The Phantom Laboratory, IncorporatedInventors: Dennis J. Paul, Harry J. Gould, Richard Philip Mallozzi
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Patent number: 11266834Abstract: An electro-acupuncture (EA) system and method for performing EA on a patient are provided. The EA system comprises a wearable neurostimulator device, at least a first pair of electrically-conductive acupuncture needles and a system controller. The wearable neurostimulator device comprises a casing, an EA circuit mechanically coupled to the casing, and an attachment device mechanically coupled to the casing and adapted to removably secure the wearable neurostimulator device to the patient. The first pair of electrically-conductive acupuncture needles is mechanically coupled to the casing and electrically coupled to the EA circuit. The system controller is in communication with the EA circuit of the wearable neurostimulator device via a communication link and controls the EA circuit to cause the EA circuit to output an output voltage selected by the system controller at a frequency selected by the system controller.Type: GrantFiled: September 27, 2019Date of Patent: March 8, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Jin-Woo Choi, Jose Aquiles Parodi Amaya, Ronald Koh
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Patent number: 11267756Abstract: Engineered Cementitious Composites (ECC) and cement products including Engineered Cementitious Composites are provided. The ECC can include cement, sugar cane bagasse ash, and fiber. The sugar cane bagasse ash can be processed to provide a partial cement or sand replacement in ECCs and cement products.Type: GrantFiled: April 2, 2020Date of Patent: March 8, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Gabriel Andres Arce, Marwa Hassan, Hassan Noorvand, Tyson Rupnow, Michele Barbato
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Patent number: 11268959Abstract: Methods, compositions, devices, and kits are described herein that are useful for detecting BoHV-1 infection in animals and/or for distinguishing animals that may benefit from administration of BoHV-1 tmv vaccine.Type: GrantFiled: June 9, 2020Date of Patent: March 8, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventor: Shafiqul Islam Chowdhury
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Patent number: 11246896Abstract: A conditionally replicating adenovirus were generated that can specifically replicate and express therapeutic genes in neuroendocrine tumors. The promoter-specific expression of the adenoviruses is regulated upstream by an INSM1 (insulinoma-associated-1) promoter that is silent in normal adult tissues but active in developing neuroendocrine cells and neuroendocrine tumors. By placing the I NSM 1-promoter with an insulator and two copies of neuronal restrictive silencer elements in an adenoviral vector, the construct can retain tumor specificity and drive expression of a mutated adenovirus E1A gene (?24E1A) and the herpes simplex virus thymidine kinase gene. The I NSM1-promoter-driven viruses could replicate specifically in the I NSM1-positive cells and I NSM1-specific HSV-tk expression in combination with ganciclovir treatment displayed dose-dependent tumor cell-specific killing in insulinomas.Type: GrantFiled: October 28, 2016Date of Patent: February 15, 2022Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Michael Lan, Mary Breslin