Abstract: A method of treating neuropathy in a subject, the method comprising identifying a subject who has neuropathy; and administering to the subject a pharmaceutical composition comprising one of inorganic nitrite and a pharmaceutically acceptable salt thereof.

Abstract: Pneumonia due to the fungus Pneumocystis jirovecii is a life-threatening infection that occurs in immunocompromised patients. The inability to culture the organism as well as the lack of a sequenced genome has hindered antigen discovery that could be useful in developing effective vaccines, therapeutic antibodies and diagnostic methods. A method of surface proteomics of Pneumocystis murina that reliably detects surface proteins that are conserved in Pneumocystis jirovecii is described. In particular, eight identified P. murina surface proteins are described. Methods of eliciting immune responses against the identified proteins, generating therapeutic antibodies against the identified proteins, as well as diagnostic methods based on the identified peptides are described.

Abstract: Systems, methods, and non-transitory computer-readable storage media for a fast power network simulator. A system configured per this disclosure can use identify a power network, the power network comprising generators, transmission lines, and loads, and receive a model of the power network. The model of the power network can include: models of the generators modeled as differential equations, and models of the transmission lines and the loads modeled as algebraic equations. The system can convert, via a processor, the algebraic equations of the models of the transmission lines and the loads to additional differential equations, then combine, via the processor, the differential equations and the additional differential equations, to yield combined differential equations. The system can then iteratively solve linear equations, via the processor, associated with the combined differential equations, to yield solutions, and output the solutions as part of a power simulation of the power network.

Abstract: Chimeric double peptide vaccines are disclosed, useful for inducing active immunity against Candida fungal infections. The chimeric peptide comprises an Fba peptide and an Met6 peptide, covalently linked to one another, with or without an intermediate linker. Fba and Met6 are cell surface components of Candida. When used as a vaccine, the chimeric double peptide vaccine induces stronger protective immunity against fungal infection than does the Fba peptide alone, or the Met6 peptide alone, or a mixture (not covalently linked) of the two peptides.

Abstract: Compositions are described comprising an amount of a toxicant comprising a compound of the formula HNR1R2, or a salt thereof, wherein R1 and R2 are independently hydrogen, a substituted or unsubstituted C4-C6-cycloalkyl group or a substituted or unsubstituted C6-C12-aryl group; wherein the amount of the toxicant is sufficient to control termites. Methods for controlling termites using such compositions are also described.

Abstract: The present disclosure describes systems, methods, and apparatuses utilizing pointer acceleration system modeling. In one exemplary method, among others, such a method obtains, a closed loop pointer acceleration system model, in which the closed loop pointer acceleration system model is based on (1) a model describing user pointing motions integrated with (2) a model of pointer acceleration motions under operational conditions; obtains values for system parameters that include pointer acceleration profile parameters and operational condition parameters; and determines a set of pointer trajectories for a given acceleration profile having the pointer acceleration profile parameters and operational condition parameters.

Abstract: An intervention for sleep disorders comprises collagen, a gelatin peptide, or the amino acid glycine; L-theanine; lactucopicrin, deoxylactucopicrin, or another lactucopicrin derivative; hyaluronic acid; epigallocatechin gallate; and quinic acid. The intervention helps regulate pro-inflammatory biomarkers that are often associated with insomnia development and progression. These biomarkers include cytokines and enzymes associated with tryptophan degradation. Inhibition of these enzymes and cytokines improves tryptophan availability and sleep quality, and allows individuals to sleep better with fewer side effects. The novel composition promotes high-quality, deep sleep.

Abstract: A method of treating a condition of in a human patient comprising pharmacologically activating a translocator protein of 18 kDa (TSPO), wherein the condition is one of a chronic methamphetamine addiction, a medical consequence of methamphetamine use; a behavioral consequence of methamphetamine use, an HIV associated cognitive motor disorder, an HIV-associated neurodegenerative disorder, and a neuroinflammatory response.

Abstract: Embodiments of the present invention include methods for increasing off-chip bandwidth. The method includes designing a circuit of switchable pins, replacing a portion of allocated pins of a processor with switchable pins, connecting the processor to a memory interface configured to switch the switchable pins between a power mode and a signal mode, providing a metric configured to identify which of the power mode and the signal mode is most beneficial during 1 millisecond intervals, and switching the switchable pins to signal mode during intervals where the signal mode provides more benefit than the power mode.

Abstract: A medical device comprising a structure formed of polyvinyl alcohol.

Abstract: Mass spectrometry systems and methods including ionization devices are provided. The ionization device includes either a gas pulse valve or a piezoelectric striker. The ionization device is configured to direct force to the back of a substrate, where an analyte of interest is deposited on the front of the substrate. The impact ionizes the analyte and the ions are directed into a mass spectrometer for analysis.

Abstract: Various embodiments disclosed relate to a method of forming a polypeptide. The method includes contacting a first amino acid-derived N-thiocarboxyanhydrosulfide monomer as a crystalline solid with a polymerization initiator (e.g., in an alkane suspension) to give a polypeptide product. The method further includes contacting the polypeptide product with a second amino acid-derived N-thiocarboxyanhydrosulfide monomer in an alkane suspension.

Abstract: A wedge for on-line inspection of a weld includes a wedge body defining a coolant channel and at least one couplant channel, and a coolant input port in fluid connection with a first end of the coolant channel. The wedge body has a surface for disposing a phased array ultrasonic transducer comprising an array of ultrasonic elements. The coolant channel is formed in proximity to the surface for disposing the phased array ultrasonic transducer such that coolant flowing through the coolant channel maintains the phased array ultrasonic transducer below a predetermined temperature without obstructing the array of ultrasonic elements.

Abstract: The present invention relates to methods of treating overweight or obesity, reducing fat, sugar, and food intake, and reducing body weight or body weight gain in a subject using geranium oil or orlistat mouthwash, or a combination of both.

Abstract: Embodiments of the present invention include apparatuses and methods for performing remote experiments in real-time. The method includes sending requests to perform remote experiments for a desired configuration to a first and second facility. The desired configuration may include a first and second configuration. The method includes running a first remote experiment in real-time at the first facility to obtain a first output variable. The first facility may include the first configuration with a first input variable. The method includes simultaneously running a second remote experiment in real-time at a second facility to obtain a second output variable. The second facility may include the second configuration with a second input variable. The first output variable may be set as the second input variable to mimic the desired configuration. The method includes obtaining experimental results of the desired configuration via the first and second input and output variables.

Abstract: Embodiments of the present invention are directed to the oral administration of Bryostatins for the treatment of neuro-degenerative disease.

Abstract: Compositions and methods are described herein for transdifferentiation of multipotent stromal cells into cells that can express insulin.

Abstract: The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2?). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.

Abstract: Transformed plants are disclosed with enhanced resistance to abiotic stresses, such as salt stress, water stress, or temperature stress. Also disclosed are vectors useful for making such transformed plants, and methods of transforming plants to enhance resistance to abiotic stresses, such as salt stress, water stress, or temperature stress. For example, the Spartina alterniflora ADF gene SaADF2 enhances resistance when transformed into rice Oryza sativa. Transgenic rice plants that expressed higher levels of Spartina ADF were more resistant to salt, drought, and cold. There was improved growth, higher photosynthesis, and increased grain yield as compared to wild-type (WT) rice.

Abstract: Modulation of inward potassium ion conductance with structurally diverse small-molecules in the arthropod salivary gland induces arthropod salivary gland failure that results in a reduction or elimination in the ability of the arthropod to feed. Administering Kir channel inhibitors reduces food intake, increases feeding time, reduces salivary gland secretion, induces mortality, and reduces transmission of vector-borne pathogens. Kir channel inhibitors induce these adverse effects in ticks, mosquitoes, horn flies, and aphids.