Abstract: Bentonite (or other clay) water-based drilling fluids incorporating functionalized cellulose nanocrystals are disclosed. Cellulose nanocrystals are modified with tailored surface charges or tailored levels of salt-tolerant polymer grafting, and combined with bentonite (or other clay) nanoplatelets in an aqueous suspension. Thermal performance of drilling fluids can also be enhanced by surface grafting of thermally functional polymers onto cellulose nanocrystals.
Type:
Grant
Filed:
October 31, 2018
Date of Patent:
June 8, 2021
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: The present invention relates in part to a method of fabricating graphene structures from graphene oxide by reducing the graphene oxide on a patterned substrate. The invention also relates in part to graphene structures produced using said method and electrodes and capacitors comprising said graphene structures.
Type:
Application
Filed:
February 8, 2021
Publication date:
June 3, 2021
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: A vaccine is disclosed that promotes CD4+ T cell-independent host defense mechanisms to defend against infection by fungi such as Pneumocystis spp. The vaccine may be used to prevent or to treat fungal infections. The novel vaccine can provide protective immunity, even for immunocompromised individuals such as HIV patients having reduced levels of CD4+ T cells.
Type:
Application
Filed:
May 13, 2020
Publication date:
May 20, 2021
Applicants:
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College
Inventors:
Jay K. Kolls, Michael Zheng, Karen Norris, Heather Kling
Abstract: This invention is directed to compositions, methods and kits that can be used for the treatment or amelioration of pain and fever.
Type:
Grant
Filed:
January 9, 2020
Date of Patent:
May 18, 2021
Assignees:
The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, University of Alcala De Hernares, South Rampart Pharma, LLC
Inventors:
Nicolas Bazan, Hernan Bazan, Julio Alvarez-Builla Gomez, Dennis Paul, Carolina Burgos Garcia
Abstract: Disclosed are methods of, and assay and kits for, detecting and diagnosing methods of detecting, diagnosing, vulnerable carotid artery disease capable of becoming acutely symptomatic using the levels of Resolvin D1 (RvD1), docosahexaenoic acid (DHA), and arachidonic acid (AA). Also disclosed are methods of treating carotid artery disease and methods of identifying agents for use in the treatment of carotid artery disease.
Type:
Grant
Filed:
June 22, 2018
Date of Patent:
May 18, 2021
Assignees:
OCHSNER HEALTH SYSTEM, THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURE AND MECHANICAL COLLEGE, THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
Inventors:
Hernan A. Bazan, Yan Lu, Song Hong, Zhide Fang, Bokkyoo Jun, Thomas C. Woods
Abstract: The herbicide-tolerant rice cultivar designated ‘CL272’ and its hybrids and derivatives are disclosed. CL272 is a novel, herbicide-resistant, early maturing, semidwarf, medium-grain rice cultivar with improved yield and improved disease resistance. This invention also pertains to methods for producing a hybrid or new variety by crossing the rice variety ‘CL272’ with another rice line, one or more times. This invention allows for single-gene converted plants of ‘CL272.’ This invention also provides regenerable cells for use in tissue culture of rice plant ‘CL272.’ The present invention provides a method for treating rice.
Type:
Grant
Filed:
May 31, 2017
Date of Patent:
May 18, 2021
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: The herbicide-tolerant rice cultivar designated ‘CL153’ and its hybrids and derivatives are disclosed. CL153 is a novel, herbicide-resistant, high yielding, early maturing, semidwarf, long-grain rice cultivar with excellent grain yield, good grain quality, and produces plans with very good resistance to blast disease. This invention also pertains to methods for producing a hybrid or new variety by crossing the rice variety ‘CL153’ with another rice line, one or more times. This invention allows for single-gene converted plants of ‘CL153.’ This invention also provides regenerable cells for use in tissue culture of rice plant ‘CL153.’ The present invention provides a method for controlling weeds in the vicinity of rice.
Type:
Grant
Filed:
May 31, 2017
Date of Patent:
May 18, 2021
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: A UV-curable and recyclable thermoset shape memory polymer is provided. The polymer includes a vitrimer-based monomer and a photoinitiator. The vitrimer-based monomer includes a first unit rendering a high chain stiffness upon polymerization of the monomer, and a second photopolymerizable unit for photopolymerization of the monomer under a UV irradiation. The polymer has high strength, high stiffness, high recovery stress, high energy storage, reasonable recycling efficiency, and is printable using SLA with high resolution.
Type:
Application
Filed:
April 30, 2019
Publication date:
April 29, 2021
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: Products and methods for treating cancer in a human patient comprising administering to the patient therapeutically effective amount of a first pharmaceutically active agent, wherein the first pharmaceutically active agent is one of an isothiocyanatostilbene and a pharmacologically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, or a combination thereof.
Type:
Grant
Filed:
August 15, 2016
Date of Patent:
April 20, 2021
Assignees:
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY, BOARD OF SUPERVISORS FOR THE UNIVERSITY OF LOUISIA
Inventors:
Alana Lea Gray, James Cardelli, David Thomas Coleman, Khalid El-Sayed, Mohamed M. Mohyeldin
Abstract: Provided herein are green alga Cia8 polypeptides and the polynucleotides that encode them. Also provided herein are transformed cells and transgenic plants that include one or more of the polynucleotides and/or polypeptides provided herein.
Type:
Grant
Filed:
June 20, 2017
Date of Patent:
April 20, 2021
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
James V. Moroney, Marylou C. Machingura, Joanna N. Bajsa-Hirschel
Abstract: A method is disclosed for making palatable methionine-restricted foods, to deliver a methionine-restricted diet to human or veterinary patients. A protein or a food product containing protein is partially oxidized, preferably with ozone, to oxidize nearly all of the methionine and cysteine. After oxidation, tryptophan and lysine are optionally added back since they tend to be oxidized also. Optionally, a small amount of methionine is also added back so that the final methionine is within a preferred range of about 0.85 to about 1.8 gram methionine per 100 gram total protein, preferably about 1.2 gram per 100 gram total protein.
Type:
Application
Filed:
December 16, 2020
Publication date:
April 8, 2021
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
John W. Finley, Thomas Gettys, Frank L. Greenway
Abstract: A method of generating one of podocyte progenitor cells and neural stem/progenitor cells comprising the steps of collecting a urine specimen from a patient; centrifuging the urine specimen; and removing the one of podocyte progenitor cells and neural stem/progenitor cells.
Type:
Grant
Filed:
December 21, 2018
Date of Patent:
April 6, 2021
Assignee:
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY
Abstract: A load dissipating arthroplasty prosthesis comprising a shell, an articular device extending into the shell through a collar defined in the sell, a head and neck portion of the articular device extending from the collar, a shaft portion of the articular device extending into the shell, and a plurality of shock absorbing arcuate linkers spacing and allowing limited movement between the shell and the articular device.
Type:
Grant
Filed:
October 16, 2018
Date of Patent:
March 30, 2021
Assignee:
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY
Inventors:
Gulshan Neville Sunavala-Dossabhoy, Kevin McCarthy
Abstract: A method of treating cancer or a precancer condition in a mammal comprising administering a therapeutically effective amount of a homovanillyl sinapate analog or pharmacologically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analog thereof, or a combination thereof.
Type:
Grant
Filed:
January 13, 2017
Date of Patent:
March 30, 2021
Assignee:
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY
Inventors:
James Allen Cardelli, Ana-Maria Dragoi, Khalid El-Sayed, Mohamed M. Mohyeldin
Abstract: Methods and compositions are disclosed for delivering lutein or other antioxidant to target tissues such as the eye, in bioactive form, while protecting the antioxidant from degradation. The antioxidant is encapsulated in nanoparticles comprising a protein such as zein or a polymer such as poly(lactic-co-glycolic acid) (PLGA). Preferably a surfactant is associated with the nanoparticles as well, further helping to protect the antioxidant. After the nanoparticles are administered to the target tissue, bioactive antioxidant is released to the tissue over time. Optionally, the nanoparticles are admixed with a thermosensitive, bioadhesive gel to promote slow release of antioxidant. The methods and compositions are useful for treating or preventing conditions such as age-related macular degeneration or cataracts.
Type:
Grant
Filed:
April 30, 2019
Date of Patent:
March 23, 2021
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Cristina M. Sabliov, Carlos E. Astete, Ede Bodoki, Oliviu Vostinaru, Ovidiu Ciprian Samoil{hacek over (a)}, Elena Dinte
Abstract: The low temperature cracking and high temperature rutting of polymer-modified asphalt concrete pavement can be reduced. The composite includes asphalt and at least one polymer that expands at low temperature, triggered by cooling-induced tensile stress, to reduce thermal cracking. The composite includes at least one polymer that expands at high temperature, so that the composite recovers after compression induced by traffic loading at higher temperatures, thereby reducing rutting. The system reduces thermal stress, and reduces or even eliminates thermal cracking and rutting. Shape memory polymers (SMPs) are used to improve asphalt compositions so that they better resist both thermal cracking and rutting. The SMP(s) can be incorporated into the asphalt, or a portion of fine aggregates can be replaced with SMP particles or SMP fibers, or aggregate replacement and asphalt modification can be combined.
Type:
Grant
Filed:
March 12, 2019
Date of Patent:
March 23, 2021
Assignee:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: Methods for temporary fracture isolation are provided. An existing fracture is treated with a chemical diverter. The chemical diverter is exposed to conditions causing it to expand, plugging the fracture. A new fracture can be created through the application of pressure and fluid, without disrupting the plugged fracture. The chemical diverter can then be removed through biodegradation or the application of a solvent to reopen the first fracture.
Type:
Grant
Filed:
July 20, 2018
Date of Patent:
March 23, 2021
Assignee:
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY
Abstract: Embodiments of the present application are directed toward a focusing Schlieren technique that is capable of adding color-coded directional information to the visualization of density gradients. Other advantages of the technique can include that it does not require manual calibration, has a simple design and is sensitive enough to be used in compact experimental setups. Certain embodiments include the use of a color-coded source image that replaces the conventional source grid. The technique may benefit from a computer-controlled digital background, which is used for both illumination and display of color-coded source images.
Type:
Application
Filed:
November 11, 2020
Publication date:
March 18, 2021
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Abstract: A composition and method for killing feral hogs: a bait that is attractive to hogs is mixed with a lethal amount of sodium nitrite, along with sufficient base to inhibit decomposition of the sodium nitrite. At sufficiently high pH, encapsulation of the sodium nitrite is not required to inhibit decomposition. In the absence of substantial decomposition, the sodium nitrite itself is not aversive to the pigs, and may even enhance acceptance of the baits by the pigs. Optionally, an anti-emetic compound is added to the mixture to reduce the likelihood the bait will be vomited. Optionally, an additional toxicant such as luteolin is added to the mixture.
Type:
Application
Filed:
August 24, 2020
Publication date:
March 11, 2021
Applicant:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventors:
Glen Gentry, John Pojman, Baylen Thompson