Patents Assigned to Loyola University Chicago
  • Patent number: 11779603
    Abstract: Disclosed herein are T cell receptors (TCRs) capable of binding an antigen expressed by renal cell carcinoma cells. In some examples, the TCRs include an ? chain (such as SEQ ID NO: 2) and a ? chain (such as SEQ ID NO: 3). Also disclosed herein are vectors including nucleic acids encoding the disclosed TCR ? and/or ? chains. Further disclosed are modified T cells expressing the TCRs. In some examples, the modified T cells are prepared by transducing T cells with a vector including nucleic acids encoding the TCR ? chain and the TCR ? chain. In some embodiments, methods include treating a subject with RCC, by obtaining a population of T cells, transducing the population of T cells with a vector including a nucleic acids encoding the TCR ? chain and the TCR ? chain, and administering a composition comprising the modified T cells to the subject.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: October 10, 2023
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Loyola University of Chicago
    Inventors: Richard W. Childs, Michael I. Nishimura, Elena A. Cherkasova
  • Patent number: 11753408
    Abstract: Disclosed are compounds of formula (I) and formula (II): wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: September 12, 2023
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Loyola University of Chicago
    Inventors: Wenwei Huang, Hao Li, Wei Sun, Xiuli Huang, Paresma R. Patel, Hangmao Sun, Wei Zheng, Xiao Lu, Philip E. Sanderson, Myunghoon Kim, Meghan J. Orr, Gregory J. Tawa, Kim C. Williamson
  • Patent number: 11684667
    Abstract: Coronaviruses, vaccines comprising the same, and methods for preventing disease. One embodiment of such includes a live, attenuated coronavirus comprising a variant replicase gene encoding polyproteins comprising a non-structural protein (nsp)-15, the replicase gene encoding the nsp15 and causes any change, including mutations and/or deletions, that affects the stability or activity of the nsp15.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: June 27, 2023
    Assignee: LOYOLA UNIVERSITY OF CHICAGO
    Inventors: Susan Baker, Xufang Deng
  • Patent number: 11590226
    Abstract: Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase (“MMP”) inhibitors and agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: Formula (I) wherein the substituents are as described.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: February 28, 2023
    Assignee: LOYOLA UNIVERSITY OF CHICAGO
    Inventors: Daniel Paul Becker, Marlon Ray Lutz, Jr.
  • Patent number: 11227385
    Abstract: Methods for classifying and measuring orientations of objects, as nonlimiting examples, implants utilizing two-dimensional radiographs. One such method determines a three-dimensional orientation of an object based on its area projected onto a two-dimensional image and known or measured geometry. Another such method provides an automated solution to computationally determine the orientation and characterizing features of an implant based on two-dimensional radiographs. Orientations and characteristics of one or more objects in the vicinity of an object of interest may also be determined.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: January 18, 2022
    Assignee: Loyola University Chicago
    Inventors: Michael Patrick Murphy, Cameron James Killen, Karen Wu
  • Publication number: 20210246137
    Abstract: Disclosed are compounds of formula (I) and formula (II): wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.
    Type: Application
    Filed: April 22, 2021
    Publication date: August 12, 2021
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, Loyola University of Chicago
    Inventors: Wenwei Huang, Hao Li, Wei Sun, Xiuli Huang, Paresma R. Patel, Hangmao Sun, Wei Zheng, Xiao Lu, Philip E. Sanderson, Myunghoon Kim, Meghan J. Orr, Gregory J. Tawa, Kim C. Williamson
  • Patent number: 11085939
    Abstract: Disclosed herein is a method for quantifying phosphatidylethanol (“PEth”), a direct ethanol biomarker, from a blood sample using gas chromatography mass spectrometry. The method disclosed herein is useful for diagnosing acute and chronic alcohol abuse.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: August 10, 2021
    Assignee: LOYOLA UNIVERSITY OF CHICAGO
    Inventors: James Vincent DeFrancesco, Majid Afshar
  • Patent number: 11065096
    Abstract: Medical procedures and devices suitable for reducing the risk of embolic cerebrovascular events, including but not limited to cardioembolic stroke, that result from emboli entering the right or left common carotid artery. The invention uses a combination of intracranial flow diverting stent technologies and carotid stent technologies to achieve clinical objectives of embolic stroke prevention without thromboembolic and/or vascular stenosis complication. Such a stent has struts that generate high radial forces for endothelial apposition, and a mesh with interstices sufficiently small to prevent clinically significant-sized embolic material from passing therethrough from the common carotid artery into the internal carotid artery, but sufficiently large to enable blood and small clinically insignificant-sized embolic material to pass therethrough from the common carotid artery into the internal carotid artery.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: July 20, 2021
    Assignee: Loyola University Chicago
    Inventor: Daniel Heiferman
  • Patent number: 11021469
    Abstract: Indoline sulfonamide compounds that can inhibit DapE and/or bacterial metallo-?-lactamases (MBLs), such as NDM-1, are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the indoline sulfonamide compounds disclosed herein.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: June 1, 2021
    Assignees: LOYOLA UNIVERSITY OF CHICAGO, Board of Regents, The University of Texas System
    Inventors: Daniel Paul Becker, Tahirah K. Heath, Cory Reidl, Walter Fast
  • Patent number: 10988472
    Abstract: Disclosed are compounds of formula (I) and formula (II): (I) (II) wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: April 27, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Loyola University of Chicago
    Inventors: Wenwei Huang, Hao Li, Wei Sun, Xiuli Huang, Paresma R. Patel, Hangmao Sun, Wei Zheng, Xiao Lu, Philip E. Sanderson, Myunghoon Kim, Meghan J. Orr, Gregory J. Tawa, Kim C. Williamson
  • Patent number: 10856835
    Abstract: Phantoms for use in calibrating a dual energy imaging system and methods for their use. The phantoms include a body having at least first and second portions arranged in a through-thickness direction of the body. The first portion defines an anterior surface of the body and contains a first material simulating soft tissue and a second material simulating bone. The second portion contains a third material simulating lung tissue and at least a first object embedded in the third material and formed of a fourth material simulating tumor tissue. The first and second portions of the body are configured such that the second material in the first portion superimposes the first object in the second portion in the through-thickness direction of the body relative to the anterior surface thereof.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: December 8, 2020
    Assignee: Loyola University Chicago
    Inventors: John C. Roeske, Rakesh Patel, Maksat Haytmyradov
  • Patent number: 10829526
    Abstract: Methods of treating autoimmune diseases, such as vitiligo, by using compositions comprising DNA encoding a variant inducible heat shock protein 70 (HSP70i) having a mutation in the dendritic cell binding region thereof (HSP70i435-447) or an isolated variant gene product in the form of HSP70i with a modification in the dendritic cell activating region thereof (HSP70i435-447).
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: November 10, 2020
    Assignee: LOYOLA UNIVERSITY OF CHICAGO
    Inventors: I. Caroline Le Poole, Jose Alejandro Guevara, Andrew Zloza
  • Patent number: 10794898
    Abstract: Methods for identifying a compound that alters fluorescence resonance energy transfer (FRET) of a protein. The methods include use of a genetically engineered cell that includes a target protein. The target protein includes one or more heterologous domains. In one embodiment, a target protein includes two heterologous domains, and in another embodiment, the target protein includes a heterologous domain and the cell further includes a second protein that includes a heterologous domain. A heterologous domain may include a chromophore or an amino acid to which a fluorescent dye attaches. The fluorescence lifetime of one or more chromophore, one or more fluorescent dye, or the combination thereof, is measured after contacting the cell with a compound A difference between the fluorescence lifetime in the presence of the test compound and the fluorescence lifetime in the absence of the test compound indicates that the test compound alters the FRET of the target protein.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: October 6, 2020
    Assignees: Regents of the University of Minnesota, Loyola University Chicago
    Inventors: David D. Thomas, Simon Joseph Gruber, Razvan L. Cornea, Gregory David Gillispie, Kurt C. Peterson, Seth Louis Robia
  • Patent number: 10751398
    Abstract: Compositions and treatments for inducing tumor regression by activating inflammasomes in tumor cells and tumor-associated cells. A tumor in a subject is treated by administering a composition to the subject that activates inflammasomes in cells of the tumor and thereby causes tumor cell pyroptosis and tumor regression.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: August 25, 2020
    Assignee: Loyola University Chicago
    Inventors: Liang Qiao, Zhenyu Zhong, Yougang Zhai
  • Patent number: 10626087
    Abstract: Indoline and tetrahydroquinoline sulfonyl compounds that can inhibit DapE and/or bacterial metallo-?-lactamases (“MBLs”), such as NDM-1 are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the compounds disclosed herein.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: April 21, 2020
    Assignees: LOYOLA UNIVERSITY OF CHICAGO, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Daniel Paul Becker, Cory Reidl, Maxwell Moore, Tahirah K. Heath, Walter Fast
  • Patent number: 10597655
    Abstract: Methods for modulating T-type calcium channel activity without directly targeting the T-type calcium channels are provided that include modulating kelch-like protein 1 (KLHL1) levels in a subject by providing a small hairpin RNA (shRNA) that targets a KLHL1 gene, and then administering the shRNA to the subject in an amount sufficient to modulate KLHL1 gene expression. The KLHL1 level directly effects current activity in T-type calcium channels and therefore modulation of KLHL1 gene expression indirectly modulates current activity in T-type calcium channels. The methods may be implemented with, for example, an shRNA molecule suitable for modulating a KLHL1 level in the subject which may be provided as a plasmid encoding the shRNA molecule or an adeno-associated virus vector encoding the shRNA molecule. Methods of identifying compounds that modulate current activity in T-type calcium channels by determining an effect of the compound on KLHL1 gene expression are also provided.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: March 24, 2020
    Assignee: Loyola University Chicago
    Inventors: Erika Sofia Piedras-Renteria, Jody Lee Martin
  • Patent number: 10479972
    Abstract: One aspect of the invention provides a sample chamber for use in the dynamic imaging of cells. In one embodiment, the chamber includes a holding mechanism for positioning the cells against a viewing window in the chamber. A housing is positioned against the viewing window to define the closed chamber. The housing may include access ports allowing for the perfusion of fluid through the chamber, the control of the internal temperature of the chamber and the micromanipulation and electrical stimulation of the cells.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: November 19, 2019
    Assignees: RUSH UNIVERSITY MEDICAL CENTER, LOYOLA UNIVERSITY CHICAGO
    Inventors: Eduardo Rios, Peter Caron, Pieter deTombe, Carlo Manno
  • Publication number: 20190315740
    Abstract: Disclosed are compounds of formula (I) and formula (II): (I) (II) wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.
    Type: Application
    Filed: October 13, 2017
    Publication date: October 17, 2019
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, Loyola University of Chicago
    Inventors: Wenwei Huang, Hao Li, Wei Sun, Xiuli Huang, Paresma R. Patel, Hangmao Sun, Wei Zheng, Xiao Lu, Philip E. Sanderson, Myunghoon Kim, Meghan J. Orr, Gregory J. Tawa, Kim C. Williamson
  • Patent number: 10385040
    Abstract: Indoline sulfonamide compounds that can inhibit DapE and/or bacterial metallo-?-lactamases (MBLs), such as NDM-1, are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the indoline sulfonamide compounds disclosed herein.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: August 20, 2019
    Assignees: LOYOLA UNIVERSITY OF CHICAGO, MARQUETTE UNIVERSITY
    Inventors: Daniel Paul Becker, Richard C. Holz, Tahirah K. Heath, Cory Reidl, Anna Starus
  • Patent number: 10375955
    Abstract: Methodologies, formulations, and kits suitable for decontaminating environments containing bacterial spores by degrading the spores. Formulations contain papain and at least one germinant. Methods for killing bacterial spores include contacting the spores with the formulation for a duration sufficient to initiate germination of the bacterial spores. The spores are then killed with the papain in the formulation, or are rendered by the papain susceptible to being killed by a reagent.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: August 13, 2019
    Assignee: Loyola University Chicago
    Inventor: Adam Driks