Patents Assigned to Loyola University Chicago
  • Patent number: 10856835
    Abstract: Phantoms for use in calibrating a dual energy imaging system and methods for their use. The phantoms include a body having at least first and second portions arranged in a through-thickness direction of the body. The first portion defines an anterior surface of the body and contains a first material simulating soft tissue and a second material simulating bone. The second portion contains a third material simulating lung tissue and at least a first object embedded in the third material and formed of a fourth material simulating tumor tissue. The first and second portions of the body are configured such that the second material in the first portion superimposes the first object in the second portion in the through-thickness direction of the body relative to the anterior surface thereof.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: December 8, 2020
    Assignee: Loyola University Chicago
    Inventors: John C. Roeske, Rakesh Patel, Maksat Haytmyradov
  • Patent number: 10829526
    Abstract: Methods of treating autoimmune diseases, such as vitiligo, by using compositions comprising DNA encoding a variant inducible heat shock protein 70 (HSP70i) having a mutation in the dendritic cell binding region thereof (HSP70i435-447) or an isolated variant gene product in the form of HSP70i with a modification in the dendritic cell activating region thereof (HSP70i435-447).
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: November 10, 2020
    Assignee: LOYOLA UNIVERSITY OF CHICAGO
    Inventors: I. Caroline Le Poole, Jose Alejandro Guevara, Andrew Zloza
  • Patent number: 10794898
    Abstract: Methods for identifying a compound that alters fluorescence resonance energy transfer (FRET) of a protein. The methods include use of a genetically engineered cell that includes a target protein. The target protein includes one or more heterologous domains. In one embodiment, a target protein includes two heterologous domains, and in another embodiment, the target protein includes a heterologous domain and the cell further includes a second protein that includes a heterologous domain. A heterologous domain may include a chromophore or an amino acid to which a fluorescent dye attaches. The fluorescence lifetime of one or more chromophore, one or more fluorescent dye, or the combination thereof, is measured after contacting the cell with a compound A difference between the fluorescence lifetime in the presence of the test compound and the fluorescence lifetime in the absence of the test compound indicates that the test compound alters the FRET of the target protein.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: October 6, 2020
    Assignees: Regents of the University of Minnesota, Loyola University Chicago
    Inventors: David D. Thomas, Simon Joseph Gruber, Razvan L. Cornea, Gregory David Gillispie, Kurt C. Peterson, Seth Louis Robia
  • Patent number: 10751398
    Abstract: Compositions and treatments for inducing tumor regression by activating inflammasomes in tumor cells and tumor-associated cells. A tumor in a subject is treated by administering a composition to the subject that activates inflammasomes in cells of the tumor and thereby causes tumor cell pyroptosis and tumor regression.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: August 25, 2020
    Assignee: Loyola University Chicago
    Inventors: Liang Qiao, Zhenyu Zhong, Yougang Zhai
  • Patent number: 10626087
    Abstract: Indoline and tetrahydroquinoline sulfonyl compounds that can inhibit DapE and/or bacterial metallo-?-lactamases (“MBLs”), such as NDM-1 are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the compounds disclosed herein.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: April 21, 2020
    Assignees: LOYOLA UNIVERSITY OF CHICAGO, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Daniel Paul Becker, Cory Reidl, Maxwell Moore, Tahirah K. Heath, Walter Fast
  • Patent number: 10597655
    Abstract: Methods for modulating T-type calcium channel activity without directly targeting the T-type calcium channels are provided that include modulating kelch-like protein 1 (KLHL1) levels in a subject by providing a small hairpin RNA (shRNA) that targets a KLHL1 gene, and then administering the shRNA to the subject in an amount sufficient to modulate KLHL1 gene expression. The KLHL1 level directly effects current activity in T-type calcium channels and therefore modulation of KLHL1 gene expression indirectly modulates current activity in T-type calcium channels. The methods may be implemented with, for example, an shRNA molecule suitable for modulating a KLHL1 level in the subject which may be provided as a plasmid encoding the shRNA molecule or an adeno-associated virus vector encoding the shRNA molecule. Methods of identifying compounds that modulate current activity in T-type calcium channels by determining an effect of the compound on KLHL1 gene expression are also provided.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: March 24, 2020
    Assignee: Loyola University Chicago
    Inventors: Erika Sofia Piedras-Renteria, Jody Lee Martin
  • Patent number: 10479972
    Abstract: One aspect of the invention provides a sample chamber for use in the dynamic imaging of cells. In one embodiment, the chamber includes a holding mechanism for positioning the cells against a viewing window in the chamber. A housing is positioned against the viewing window to define the closed chamber. The housing may include access ports allowing for the perfusion of fluid through the chamber, the control of the internal temperature of the chamber and the micromanipulation and electrical stimulation of the cells.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: November 19, 2019
    Assignees: RUSH UNIVERSITY MEDICAL CENTER, LOYOLA UNIVERSITY CHICAGO
    Inventors: Eduardo Rios, Peter Caron, Pieter deTombe, Carlo Manno
  • Publication number: 20190315740
    Abstract: Disclosed are compounds of formula (I) and formula (II): (I) (II) wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.
    Type: Application
    Filed: October 13, 2017
    Publication date: October 17, 2019
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, Loyola University of Chicago
    Inventors: Wenwei Huang, Hao Li, Wei Sun, Xiuli Huang, Paresma R. Patel, Hangmao Sun, Wei Zheng, Xiao Lu, Philip E. Sanderson, Myunghoon Kim, Meghan J. Orr, Gregory J. Tawa, Kim C. Williamson
  • Patent number: 10385040
    Abstract: Indoline sulfonamide compounds that can inhibit DapE and/or bacterial metallo-?-lactamases (MBLs), such as NDM-1, are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the indoline sulfonamide compounds disclosed herein.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: August 20, 2019
    Assignees: LOYOLA UNIVERSITY OF CHICAGO, MARQUETTE UNIVERSITY
    Inventors: Daniel Paul Becker, Richard C. Holz, Tahirah K. Heath, Cory Reidl, Anna Starus
  • Patent number: 10375955
    Abstract: Methodologies, formulations, and kits suitable for decontaminating environments containing bacterial spores by degrading the spores. Formulations contain papain and at least one germinant. Methods for killing bacterial spores include contacting the spores with the formulation for a duration sufficient to initiate germination of the bacterial spores. The spores are then killed with the papain in the formulation, or are rendered by the papain susceptible to being killed by a reagent.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: August 13, 2019
    Assignee: Loyola University Chicago
    Inventor: Adam Driks
  • Publication number: 20190231821
    Abstract: Disclosed herein are T cell receptors (TCRs) capable of binding an antigen expressed by renal cell carcinoma cells. In some examples, the TCRs include an ? chain (such as SEQ ID NO: 2) and a ? chain (such as SEQ ID NO: 3). Also disclosed herein are vectors including nucleic acids encoding the disclosed TCR ? and/or ? chains. Further disclosed are modified T cells expressing the TCRs. In some examples, the modified T cells are prepared by transducing T cells with a vector including nucleic acids encoding the TCR ? chain and the TCR ? chain. In some embodiments, methods include treating a subject with RCC, by obtaining a population of T cells, transducing the population of T cells with a vector including a nucleic acids encoding the TCR ? chain and the TCR ? chain, and administering a composition comprising the modified T cells to the subject.
    Type: Application
    Filed: June 30, 2017
    Publication date: August 1, 2019
    Applicants: The United States of America, as represented by the Secretary, Dept. of Health and Human Services, Loyola University of Chicago
    Inventors: Richard W. Childs, Michael I. Nishimura, Elena A. Cherkasova
  • Patent number: 10299745
    Abstract: A traceable device and procedure suitable for investigating gastrointestinal motility disorders by measuring transit time of the device as it is passed through the gastrointestinal tract of a patient. The device includes a core material configured to be imaged with a gamma imaging process and optionally also an x-ray imaging process, and a sealing material substantially insoluble in gastrointestinal fluids and fully encapsulating the core material.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: May 28, 2019
    Assignee: Loyola University of Chicago
    Inventor: Robert Hans Wagner
  • Patent number: 10049772
    Abstract: In a method, a user at a client device may be provided with a user interface having user interactive controls, including a control to enable selection from among a plurality of disease groups. Each disease group may correspond to a respective set of two or more individual disease codes. A user selection of a disease group of interest may be detected. The set of individual disease codes corresponding to the disease group of interest may be used to identify a set of encounters associated with a patient cohort. The user may be provided with an indication of a number of unique patients in the patient cohort, a number of patients in the cohort having particular characteristic(s), a total number of encounters in the set of encounters associated with the cohort, and/or a number of encounters, in the set of encounters associated with the cohort, having particular encounter characteristic(s).
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: August 14, 2018
    Assignees: LOYOLA UNIVERSITY OF CHICAGO, LOYOLA UNIVERSITY MEDICAL CENTER
    Inventors: Ronald N. Price, Jr., Susan Zelisko, Daniel Valdez, Jack Moy
  • Patent number: 10047377
    Abstract: Methods for modulating T-type calcium channel activity without directly targeting the T-type calcium channels are provided that include modulating kelch-like protein 1 (KLHL1) levels in a subject by providing a small hairpin RNA (shRNA) that targets a KLHL1 gene, and then administering the shRNA to the subject in an amount sufficient to modulate KLHL1 gene expression. The KLHL1 level directly effects current activity in T-type calcium channels and therefore modulation of KLHL 1 gene expression indirectly modulates current activity in T-type calcium channels. The methods may be implemented with, for example, an shRNA molecule suitable for modulating a KLHL1 level in the subject which may be provided as a plasmid encoding the shRNA molecule or an adeno-associated virus vector encoding the shRNA molecule. Methods of identifying compounds that modulate current activity in T-type calcium channels by determining an effect of the compound on KLHL1 gene expression are also provided.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: August 14, 2018
    Assignee: Loyola University of Chicago
    Inventors: Erika Sofia Piedras-Renteria, Jody Lee Martin
  • Patent number: 9991444
    Abstract: Surface-modified organic semiconductors and methods for making surface-modified organic semiconductors are disclosed. More particularly, surface-modified thin films are provided, the surface-modified thin films comprising a first layer comprising a polyaromatic organic semiconductor and a surface layer in direct contact with the first layer, the surface layer comprising an addition reaction product of the polyaromatic organic semiconductor with, for example, a dienophile, wherein the first layer is substantially free of the addition reaction product of the organic semiconductor with the dienophile. Also provided are surface-modified single crystals comprising a core comprising a polyaromatic organic semiconductor and a coating in direct contact with the core, the coating comprising, for example, an addition reaction product of the polyaromatic organic semiconductor with a dienophile, wherein the core is substantially free of the addition reaction product of the organic semiconductor with the dienophile.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: June 5, 2018
    Assignee: LOYOLA UNIVERSITY OF CHICAGO
    Inventors: Jacob W. Ciszek, Brittni A. Qualizza, Srividya Prasad
  • Patent number: 9326955
    Abstract: Methods and combination pharmaceuticals for treating bronchospastic medical conditions by utilizing the electrophysiology of proteinacious channels in lipid membranes of mammalian cells. The combination pharmaceuticals include at least one ?-adrenergic receptor agonist, and at least one composition adapted to effect the electrophysiology of Kv7 potassium channels of a lipid membrane of an airway smooth muscle cell. The pharmaceutical may be administered to a living body in a therapeutic amount sufficient to activate the Kv7 potassium channels of an airway smooth muscle cell.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: May 3, 2016
    Assignee: Loyola University Chicago
    Inventor: Kenneth L. Byron
  • Publication number: 20160008127
    Abstract: Systems and methods for medializing a paralyzed vocal cord are disclosed. In some embodiments, an apparatus includes a lateral portion, a medial portion, and a strut coupled to the lateral and the medial portions. Either the medial portion or the lateral portion can be adjustable in two dimensions which are not parallel to the length of the strut, which can also be adjustable. In some embodiments, the medial portion and/or the lateral portion can each comprise two adjustable arms and a base member which has a curvilinear configuration.
    Type: Application
    Filed: March 4, 2014
    Publication date: January 14, 2016
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Loyola University Chicago
    Inventors: James J. Jaber, Steven Charous, Peter Wipf, Christopher Siviy, April J. Chambers
  • Patent number: 9029139
    Abstract: Methods for generating and using omentum cells, and particularly stromal cells and/or omentum stem cells, in medical treatments such as tissue repair and regeneration to facilitate healing from traumatic injury to an abdominal organ, and immune modulation treatments such as suppression of immune responses and inflammation and prevention of tissue fibrosis. According to one aspect, a medical procedure is performed on a patient that involves harvesting omental tissue from the patient, and then transferring the omental tissue to an organ of the patient. At least a portion of the harvested omental tissue may be activated prior to transferring the omental tissue to the organ. Alternatively, the transferred omental tissue may comprise non-lymphoid cells isolated from the omentum tissue and obtained by homogenizing at least a portion of the harvested omental tissue.
    Type: Grant
    Filed: March 24, 2010
    Date of Patent: May 12, 2015
    Assignee: Loyola University of Chicago
    Inventors: Makio Iwashima, Robert Love, Rudolf Karl Braun, Perianna Sethupathi, Katherine Lathrop Knight
  • Publication number: 20140341935
    Abstract: A vaccine and method of treatment suitable for treating autoimmune diseases, such as Vitiligo, by using variant peptides representing a sequence of amino acids found in heat shock protein 70. The vaccine includes a peptide derived from inducible heat shock protein 70 and a plasmid containing a full inducible heat shock protein 70 DNA sequence encoding the peptide.
    Type: Application
    Filed: August 30, 2012
    Publication date: November 20, 2014
    Applicant: Loyola University Chicago
    Inventors: I. Caroline Le Poole, Jose Alejandro Guevara-Patino, Andrew Zloza
  • Publication number: 20140243579
    Abstract: An imaging process capable of selectively enhancing visualization of soft tissues, for example, a tumor. The imaging process includes producing a hard tissue-enhanced image of a body containing both soft and hard tissues, wherein the hard tissue-enhanced image contains images of the hard tissues that are enhanced relative to the soft tissues. A radiographic image of the body and the soft and hard tissues thereof are then obtained, after which a weighted subtraction algorithm is performed between the radiographic image and the hard tissue-enhanced image to produce a soft tissue-enhanced image in which imaging of the soft tissues is enhanced relative to the hard tissues. The hard tissue-enhanced image may be produced by obtaining first and second initial radiographic images of the body including the soft and hard tissues, and then performing a weighted subtraction algorithm on the first and second initial radiographic images to produce the hard tissue-enhanced image.
    Type: Application
    Filed: February 27, 2014
    Publication date: August 28, 2014
    Applicant: Loyola University Chicago
    Inventors: John C. Roeske, Jason P. Luce, Tracy Sherertz