Abstract: Tribenzo-1,4,7-triazacyclononane and derivatives thereof having a formula (I) are disclosed. Methods of making tribenzo-1,4,7-triazacyclononane and related compounds also are disclosed.
Type:
Grant
Filed:
August 14, 2009
Date of Patent:
May 8, 2012
Assignee:
Loyola University of Chicago
Inventors:
Daniel P. Becker, Andria M. Panagopoulos, Marlon R. Lutz, Jr.
Abstract: Methods of utilizing the arrestin-2/sTAM-1 complex as a therapeutic target. The methods include treating cells of a living organism to mediate an interaction between arrestin-2 and STAM-1 adapter protein molecules, wherein the interaction is characterized by the arrestin-2 adapter protein molecule directly binding to the STAM-2 adapter protein molecule. Pharmacological agents can be identified for therapeutic uses by determining whether the pharmacological agent disrupts the interaction between the arrestin-2 and STAM-1 adapter protein molecules.
Abstract: The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
Type:
Grant
Filed:
April 9, 2007
Date of Patent:
March 6, 2012
Assignee:
Loyola University Chicago
Inventors:
Liang Qiao, Wei Shi, Yujun Huang, Jianzhong Liu
Abstract: Methods for generating and using omentum cells, and particularly stromal cells and/or omentum stem cells, in medical treatments such as tissue repair and regeneration to facilitate healing from traumatic injury to an abdominal organ, and immune modulation treatments such as suppression of immune responses and inflammation and prevention of tissue fibrosis. According to one aspect, a medical procedure is performed on a patient that involves harvesting omental tissue from the patient, and then transferring the omental tissue to an organ of the patient. At least a portion of the harvested omental tissue may be activated prior to transferring the omental tissue to the organ. Alternatively, the transferred omental tissue may comprise non-lymphoid cells isolated from the omentum tissue and obtained by homogenizing at least a portion of the harvested omental tissue.
Type:
Application
Filed:
March 24, 2010
Publication date:
April 7, 2011
Applicant:
LOYOLA UNIVERSITY CHICAGO
Inventors:
Makio Iwashima, Robert Love, Rudolf Karl Braun, Perianna Sethupathi, Katherine Lathrop Knight
Abstract: A catalytic composition for the enzymatic conversion of nitriles to amides is disclosed. The composition contains a polymer gel and a nitrile hydratase (NHase). Also disclosed are methods of producing an amide from a nitrile using the catalytic composition.
Type:
Application
Filed:
August 13, 2010
Publication date:
February 17, 2011
Applicants:
LOYOLA UNIVERSITY OF CHICAGO, The Trustees of Hamilton College
Abstract: The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
Type:
Application
Filed:
August 25, 2008
Publication date:
January 20, 2011
Applicant:
LOYOLA UNIVERSITY OF CHICAGO
Inventors:
Lutz Gissmann, Jian Zhou, Martin Muller, Jeanette Painstil
Abstract: Methods and therapeutic strategies utilizing proteinacious channels in lipid membranes of mammalian cells. The methods entail administering a pharmaceutical to a lipid membrane of a mammalian cell, and then determining the effect of the pharmaceutical on the electrophysiology of at least one proteinacious channel of the lipid membrane, wherein the proteinacious channel is a Kv7 potassium channel and/or a L-type calcium channel of an airway smooth muscle cell (ASMC). The method can be used to identify pharmaceuticals that may be used to treat asthmatic and other bronchospastic conditions that can lead to airway obstruction, or to perform drug screening to assess potential risk of pharmaceuticals.
Abstract: Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.
Abstract: A method of inducing stable and functional Tregs from human umbilical cord blood and adult blood without requiring the expansion of pre-existing Tregs. The method utilizes CD14+ monocyte cells present in or isolated from cord blood or adult blood to induce functional Tregs from T cells, and particularly T cells that express CD4+, which may also be obtained from cord blood or adult blood. The developed Tregs are long-lasting and maintain their suppressive functions.
Abstract: Methods and therapeutic strategies utilizing proteinacious channels in lipid membranes of mammalian cells. The methods entail administering a pharmaceutical to a lipid membrane of a mammalian cell, and then determining the effect of the pharmaceutical on the electrophysiology of at least one vascular proteinacious channel of the lipid membrane, wherein the vascular proteinacious channel is a vascular Kv7 potassium channel and/or a vascular L-type calcium channel. The method can be used to identify pharmaceuticals that may be used to treat hypertension and/or vasospastic conditions, or to perform drug screening to assess potential cardiovascular risk of pharmaceuticals.
Type:
Application
Filed:
October 30, 2009
Publication date:
May 6, 2010
Applicant:
Loyola University Chicago
Inventors:
Kenneth L. Byron, Lioubov I. Brueggemann
Abstract: Tribenzo-1,4,7-triazacyclononane and derivatives thereof having a formula (I) are disclosed. Methods of making tribenzo-1,4,7-triazacyclononane and related compounds also are disclosed.
Type:
Application
Filed:
August 14, 2009
Publication date:
February 18, 2010
Applicant:
LOYOLA UNIVERSITY OF CHICAGO
Inventors:
Daniel P. Becker, Andria M. Panagopoulos, Marlon R. Lutz, JR.
Abstract: Methods for preparing self-aldol condensation products of prenyl aldehyde (3-methyl-2-butenal) by use of an amine catalyst under weakly acidic conditions at temperatures of 10° C. or higher are disclosed. Methods are disclosed for the selective formation of ?-1,2-adducts and ?-1,2-adducts of prenyl aldehyde, and for the formation of specialty compositions useful in the flavor and fragrance industries.
Abstract: The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
Type:
Grant
Filed:
February 21, 2006
Date of Patent:
August 26, 2008
Assignee:
Loyola University of Chicago
Inventors:
Lutz Gissmann, Jian Zhou, Martin Muller, Jeanette Painstil
Abstract: Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.
Abstract: The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
Type:
Grant
Filed:
February 17, 2005
Date of Patent:
April 17, 2007
Assignee:
Loyola University Chicago
Inventors:
Liang Qiao, Wei Shi, Yujun Huang, Jianzhong Liu
Abstract: A facile synthesis of symmetric esters of C1-C10 alkylenebisphopsphonic acids is disclosed in which a C1-C10 alkylenebis(phosphonic dichloride) is reacted with an alcohol in the presence of a catalytic amount of 1H-tetrazole and a base in an aprotic solvent to form a first reaction mixture. The first reaction mixture is maintained for a time period sufficient to form a C1-C10 alkylenebis(chloro ester phosphonate) that is reacted under basic conditions with an excess of a hydroxylated compound to form a second reaction mixture that is itself maintained for a time period sufficient to form a C1-C10 alkylenebis(ester phosphonate) partial ester, homoleptic tetraester or mixed tetraester. The material so formed can be recovered or used as is.
Type:
Grant
Filed:
April 5, 2002
Date of Patent:
June 21, 2005
Assignee:
Loyola University of Chicago
Inventors:
Albert W. Herlinger, Dominique C. Stepinski
Abstract: The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
Type:
Application
Filed:
July 1, 2003
Publication date:
October 14, 2004
Applicant:
Loyola University of Chicago
Inventors:
Lutz Gissmann, Jian Zhou, Martin Muller, Jeanette Painstil
Abstract: The glutamic acid residue of corticotropin-releasing hormone analogs have had the position 20 amino acid residue replaced with a D-amino acid moiety. The resulting CRH analogs do not significantly lower blood pressure but have anti-proliferative actions in cell culture and inhibit experimental cancer growth in animals (mice and rats). Novel applications of such analogs are described, such as to inhibit abnormal cell proliferation for conditions such as cancer, including melanoma, and for inflammatory dermatoses, such as psoriasis.
Type:
Grant
Filed:
November 19, 2001
Date of Patent:
October 12, 2004
Assignees:
The Regents of the University of California, Loyola University of Chicago
Abstract: The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
Type:
Grant
Filed:
September 6, 2001
Date of Patent:
July 29, 2003
Assignee:
Loyola University of Chicago
Inventors:
Lutz Gissmann, Jian Zhou, Martin Muller, Jeanette Painstil