Patents Assigned to LTS Lohmann
  • Polyvinylpyrrolidone For The Stabilization Of A Solid Dispersion Of The Non-Crystalline Form Of Rotigotine
    Publication number: 20180263921
    Abstract: The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.
    Type: Application
    Filed: May 17, 2018
    Publication date: September 20, 2018
    Applicants: UCB Pharma GmbH, LTS Lohmann Therapie-Systeme AG
    Inventors: Hans-Michael WOLFF, Christoph ARTH, Luc QUERE, Walter MÜLLER
  • Transdermal therapeutic system with electronic component
    Patent number: 10046151
    Abstract: Transdermal therapeutic systems are described which have at least one electronic component, as well as methods for producing this type of transdermal therapeutic systems.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: August 14, 2018
    Assignee: LTS Lohmann Therapie-Systeme, AG
    Inventors: Wolfgang Laux, Beatrix Platt, Nico Reum
  • Transdermal Delivery System Including an Interface Mediator
    Publication number: 20180221300
    Abstract: Transdermal therapeutic system for the transdermal administration of a systemically active agent comprising a self-adhesive layer structure, comprising A) a backing layer, and B) a dried biphasic layer, the dried biphasic layer having a) an outer phase having a composition comprising 75% to 100% of a polymer or polymer mixture, and b) an inner phase having a composition comprising at least one active agent, wherein the inner phase forms dispersed deposits in the outer phase, and c) 0.1% to 3.5% of an interface mediator with a kinematic viscosity of from 10 cSt to 100 000 cSt at 25° C., and and C) optionally an additional skin contact layer.
    Type: Application
    Filed: May 20, 2015
    Publication date: August 9, 2018
    Applicants: LTS LOHMANN Therapie-Systeme AG, UCB Pharma GmbH
    Inventors: Marco Emgenbroich, Johannes Josef Leonhard, Kristina Kassner, Aurélia Lappert
  • Self-adhesive film for teeth
    Patent number: 10039711
    Abstract: Monolayered or multilayered, film-shaped, pressure-sensitive adhesive preparations for application in the oral region and a process for manufacturing such preparations. The preparations contain at least one polymethyl vinyl ether-maleic acid anhydride copolymer, polyvinyl acetate and/or at least one copolymer of the polyvinyl acetate with vinyl alcohol esters of fatty acids, as well as at least one cosmetic and/or pharmaceutical active substance.
    Type: Grant
    Filed: October 6, 2005
    Date of Patent: August 7, 2018
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Petra Botzem, Wolfgang Laux
  • Transdermal therapeutic system comprising an adhesive layer method for siliconizing the back layer of the system and use of said back layer
    Patent number: 10034841
    Abstract: The invention generally relates to a transdermal therapeutic system which comprises a backing layer, an adhesive layer, a polymer layer and a removable protective layer. The adhesive layer is an organosiloxane layer that is anchored to the backing layer by siliconization.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: July 31, 2018
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Walter Müller, Johannes Leonhard
  • Dual-chamber cylinder-piston unit for the lyophilisation, storage, reconstitution and application of injection solutions for an injector, and method for filling the cylinder-piston unit
    Patent number: 10022500
    Abstract: A method for filling a cylinder/piston unit (1) for a needle-free injector comprising a chamber (3) arranged in a cylinder (2), for receiving an injection solution (4), a front wall (5) having at least one nozzle borehole or an outlet element (6), and a second piston (7) arranged to move in the chamber. The chamber (3) is made in two parts with a first chamber (8) and a concentric second chamber (9) having a smaller cross section than the first chamber. A first piston (10) closes the first chamber (8) and the second piston closes the second chamber (9). The second piston comprises at least one flow channel (16) or the first chamber comprises at least one closable, axially oriented freeze-drying channel (34), and the second chamber (9) comprises at least one axially oriented flow channel (36), on the respective rear ends of the chambers (8, 9).
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: July 17, 2018
    Assignee: LTS LOHMANN THERAPIE—SYSTEME AG
    Inventor: Rudolf Matusch
  • POLYVINYLPYRROLIDONE FOR THE STABILIZATION OF A SOLID DISPERSION OF THE NON-CRYSTALLINE FORM OF ROTIGOTINE
    Publication number: 20180147154
    Abstract: The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.
    Type: Application
    Filed: January 31, 2018
    Publication date: May 31, 2018
    Applicants: UCB Pharma GmbH, LTS Lohmann Therapie-Systeme AG
    Inventors: Hans-Michael Wolff, Christoph Arth, Luc Quere, Walter Müller
  • Electrically-Heatable Plaster
    Publication number: 20180125723
    Abstract: An electrically-heatable plaster that comprises a self-adhesive skin contact layer, an electrically-conductive textile fabric in which electrically-conductive fibres are in contact with one another, as a heating element, and optionally at least one active substance, as well as to a method for production and the use of same for local heat therapy and/or transdermal application of active substances.
    Type: Application
    Filed: April 8, 2016
    Publication date: May 10, 2018
    Applicant: LTS Lohmann Therapie-Systeme AG
    Inventor: Peter KLAFFENBACH
  • Wafer And Capsule Formulations With Enhanced Dissolution Rates For Fenofibrate
    Publication number: 20180092979
    Abstract: The invention relates to developing a novel water and capsule formulation using fenofibrate which is difficult to dissolve and control its release rate in vitro. For example, the invention relates to the creation of capsules and wafers comprising: fenofibrate, a surfactant, a carrier wax, a film former, a plasticizer, and optionally a super disintegrant or other ingredients. The invention further relates to the process of forming such capsules and wafers.
    Type: Application
    Filed: November 21, 2017
    Publication date: April 5, 2018
    Applicant: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Li, Markus Krumme
  • Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine
    Patent number: 9925150
    Abstract: The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: March 27, 2018
    Assignees: LTS Lohmann Therapie-Systeme AG, UCB Pharma GmbH
    Inventors: Hans-Michael Wolff, Christoph Arth, Luc Quere, Walter Müller
  • DISPOSABLE INJECTOR WITH INCREASED TRIGGERING RELIABILITY
    Publication number: 20180056000
    Abstract: A disposable injector with a piston actuation ram is mounted in a housing, is loaded by a spring energy accumulator and can be unlocked by a displaceable trigger device. The piston actuation ram can be supported by a tensioning rod mounted in the housing. The trigger device comprises a trigger ring displaceable relative to the housing. The tensioning rod can be supported directly or indirectly by a bearing surface of the trigger ring. The bearing surface encloses an angle of between ten degrees and forty five degrees with the longitudinal direction of the disposable injector. The point of the angle lies offset with respect to the trigger ring in the triggering direction of the disposable injector. A disposable injector with increased trigger reliability is developed.
    Type: Application
    Filed: October 25, 2017
    Publication date: March 1, 2018
    Applicant: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: SARA FORGHANI, UWE WORTMANN, KARSTEN HEUSER, HEIKO SPILGIES
  • SINGLE-USE INJECTOR HAVING A RELEASE ASSEMBLY UNIT FOR SIMPLIFIED ASSEMBLY
    Publication number: 20180056001
    Abstract: A single-use injector having a plunger actuator which is mounted in a housing, which is loaded by a spring energy store, and which can be unlocked by a movable release device. The plunger actuator can be supported by a traction rod mounted in the housing. The movable release device includes a casing housing. The casing housing includes an upper shell and a lower shell, the separation line of which is oriented in the longitudinal direction of the single-use injector. The casing housing has a cornerless cross-section deviating from a circular shape. The housing is anti-rotationally centered in the casing housing.
    Type: Application
    Filed: October 25, 2017
    Publication date: March 1, 2018
    Applicant: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: SARA FORGHANI, KARSTEN HEUSER, SEBASTIAN SCHERR, UWE WORTMANN
  • Transdermal therapeutic system for the administration of peptides
    Patent number: 9895319
    Abstract: The invention relates to a transdermal therapeutic system (TTS), which is suited for the administration of a peptide to a patient through skin treated with ablation. The transdermal therapeutic system includes a back layer and an active substance-containing layer that contains at least one peptide and a carrier substance, preferably as a textile web material.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: February 20, 2018
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Horstmann, Gerd Hoffmann, Sandra Wiedersberg
  • Transdermal therapeutic system with pressure generating device
    Patent number: 9895521
    Abstract: A transdermal therapeutic system with a system support, at least one advancing element which is embedded into the system support, and at least one active ingredient reservoir which can be elastically deformed at least in some regions and which is embedded into the advancing element. On the application side of the transdermal therapeutic system, the system support surrounds the advancing element, and the advancing element surrounds the active ingredient reservoir. The advancing element comprises a swelling body which can be expanded by means of a liquid intake. The system support is designed to be rigid at least in some regions. A transdermal therapeutic system is developed which enhances the effect of the advancing element.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: February 20, 2018
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventor: Patrick Mohr
  • DISPOSABLE INJECTOR HAVING A SOUND-PROOFING LAYER
    Publication number: 20180021516
    Abstract: A disposable injector comprising a housing, a spring-loaded piston-actuating plunger arranged in the housing and able to be released by a trigger unit. A cylinder-piston unit comprising a cylinder and a piston that is positioned at a distance from the piston-actuating plunger. A closed layer made on an elastically-deformable material surrounds the piston-actuating plunger in at least some sections and projects beyond same in the trigger direction, resulting in a disposable injector that will not alarm a patient during use thereof.
    Type: Application
    Filed: October 2, 2017
    Publication date: January 25, 2018
    Applicant: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: THORSTEN SICHTERMANN, UWE WORTMANN
  • Wafer and capsule formulations with enhanced dissolution rates for fenofibrate
    Patent number: 9849184
    Abstract: The invention relates to developing a novel water and capsule formulation using fenofibrate which is difficult to dissolve and control its release rate in vitro. For example, the invention relates to the creation of capsules and wafers comprising: fenofibrate, a surfactant, a carrier wax, a film former, a plasticizer, and optionally a super disintegrant or other ingredients. The invention further relates to the process of forming such capsules and wafers.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: December 26, 2017
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Li, Markus Krumme
  • Wafer Comprising Steroid Hormones
    Publication number: 20170348321
    Abstract: The invention relates to a pharmaceutical composition in the form of a system in film form for transmucosal administration of steroid hormones. An administration system for steroid hormones which dissolves in the mouth and which releases with a high bioavailability is disclosed. The administration system in film form dissolves in the mouth preferably in a period of less than 30 min, and the steroid hormone entering the bloodstream transmucosally from the administration system leads to a rapid rise in the concentration in the blood. It is thus possible to achieve a maximum concentration of this steroid hormone in the blood in a period of less than 60 min after administration.
    Type: Application
    Filed: August 23, 2017
    Publication date: December 7, 2017
    Applicant: LTS Lohmann Therapie-Systeme AG
    Inventors: Markus Krumme, Albert Radlmaier, Sescha General, Michael Dittgen, Keith Jensen
  • Transdermal therapeutic system having controlled active substance flow comprising a basic reacting oxide
    Patent number: 9833418
    Abstract: The present invention relates to transdermal therapeutic systems that include an occlusive back layer impervious to an active substance, a single or multilayer matrix, and a peelable protective film. The matrix or at least one of the matrix layers includes a pharmaceutical active substance or a plurality of pharmaceutical active substances in the form of at least one pharmaceutically consumable salt thereof and a pharmaceutically consumable, alkaline reacting oxide.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: December 5, 2017
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: René Eifler, Regine Kaufmann, Patrick Mohr
  • DEXAMETHASONE ORAL FILM
    Publication number: 20170304319
    Abstract: The present invention relates to an oral film consisting essentially of dexamethasone and hydroxypropyl methylcellulose, wherein the concentration of dexamethasone is 30% w/w or more and the concentration of hydroxypropyl methylcellulose is between 35 and 70% w/w based on total dry matter.
    Type: Application
    Filed: November 4, 2015
    Publication date: October 26, 2017
    Applicants: ACUCORT AB, LTS LOHMANN THERAPIE-SYSTEME AG
    Inventor: Bengt Arvid WESTRIN
  • Wafer comprising steroid hormones
    Patent number: 9763960
    Abstract: The invention relates to a pharmaceutical composition in the form of a system in film form for transmucosal administration of steroid hormones. An administration system for steroid hormones which dissolves in the mouth and which releases with a high bioavailability is disclosed. The administration system in film form dissolves in the mouth preferably in a period of less than 30 min, and the steroid hormone entering the bloodstream transmucosally from the administration system leads to a rapid rise in the concentration in the blood. It is thus possible to achieve a maximum concentration of this steroid hormone in the blood in a period of less than 60 min after administration.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: September 19, 2017
    Assignee: LTS Lohmann Theraple-Systeme AG
    Inventors: Markus Krumme, Albert Radlmaier, Sascha General, Michael Dittgen, Keith Jensen