Patents Assigned to LTS Lohmann
  • Patent number: 9763879
    Abstract: A control release and abuse-resistant opiate drug delivery oral wafer or edible oral film dosage to treat pain and substance abuse is provided. The drug delivery oral wafer or edible oral film dosage includes a controlled release layer containing enteric-release beads dispersed in a polymer matrix. The enteric-release beads are formed from a therapeutic amount of an opioid agonist and/or pharmaceutically acceptable salt thereof and a sub-therapeutic amount of opioid antagonist and/or pharmaceutically acceptable salt thereof coated or encapsulated in an enteric-release polymer. The controlled release polymer matrix dissolves or disintegrates following administration or consumption of the oral wafer or edible oral film, releasing the enteric-release beads to be swallowed, with subsequent absorption of the active ingredients within the patient's intestines.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: September 19, 2017
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventor: Michael Li
  • Patent number: 9717853
    Abstract: A cylinder-piston unit of a needle-free injector, with at least one cylinder accommodating an injection solution, at least one piston, and an adhesive coating arranged in the area of the free end face of the cylinder. The cylinder has a bottom portion, on which a discharge tube is arranged. An adhesive disc, which is displaceable in the direction of the center line of the cylinder-piston unit between an installation position and an application position, is arranged on the discharge tube and/or on the bottom portion. The adhesive disc has an adhesive coating on each of the two end faces. In the installation position, the discharge tube can be sealed off in the adhesive disc. In the application position, the front edge of the discharge nozzle lies in the plane of the front adhesive coating or protrudes beyond this plane by at least 0.5 mm.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: August 1, 2017
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventor: Rudolf Matusch
  • Patent number: 9717698
    Abstract: A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer-based layer which is remote from the skin with a rate of application of at least 80 g/m2, and an adhesive skin-contact layer which is adjacent to the polymer-based layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2. The at least one active pharmaceutical ingredient is present in both the polymer-based layer remote from the skin and the skin-contact layer.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: August 1, 2017
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael Horstmann, Walter Mueller
  • Publication number: 20170182060
    Abstract: The invention relates to the use of semi-fluorinated alkanes, in particular mixed with ethanol, as solubilising agents, permeation promoters and/or enhancers for lipophilic and/or poorly skin-permeable pharmaceutical agents that are administered via a transdermal therapeutic system (TTS), and to corresponding TTSs containing such substances.
    Type: Application
    Filed: May 7, 2015
    Publication date: June 29, 2017
    Applicant: LTS Lohmann Therapie-Systeme AG
    Inventors: Sandra WIEDERSBERG, Bernhard GÜNTHER, Dieter SCHERER
  • Patent number: 9687445
    Abstract: A control release and abuse-resistant opiate drug delivery oral wafer or edible oral film dosage to treat pain and substance abuse is provided. The drug delivery oral wafer or edible oral film dosage includes a controlled release layer containing enteric-release beads dispersed in a polymer matrix. The enteric-release beads are formed from a therapeutic amount of an opioid agonist and/or pharmaceutically acceptable salt thereof and a sub-therapeutic amount of opioid antagonist and/or pharmaceutically acceptable salt thereof coated or encapsulated in an enteric-release polymer. The controlled release polymer matrix dissolves or disintegrates following administration or consumption of the oral wafer or edible oral film, releasing the enteric-release beads to be swallowed, with subsequent absorption of the active ingredients within the patient's intestines.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: June 27, 2017
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventor: Michael Hsin Chwen Li
  • Patent number: 9637293
    Abstract: A childproof packaging for individual doses, in particular for preparations for administration in film form, wherein the packaging constitutes a bag produced by sealing, which has a covering layer which is provided at each side of the packaging with local weak points which do not touch the edge of the packaging, wherein the local weak points form a cohesive pattern which runs around the individual dose in an arc or a curve and overlaps an angular region of at least 90° when considered from the main area of the individual zone. The local weak points have a start area and an end area which have a Y configuration when the local weak points on each side of the packaging are superposed.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: May 2, 2017
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: Markus Krumme, Grace A. Behrend, Stephen J. Dodd
  • Publication number: 20170105945
    Abstract: Transdermal therapeutic system for the transdermal administration of rotigotine containing an therapeutically effective amount of rotigotine base in a self-adhesive layer structure, comprising A) a backing layer, and B) a rotigotine-containing biphasic layer, the bi phasic layer having a) an outer phase having a composition comprising 75% to 100% of a polymer or a polymer mixture, and b) an inner phase having a composition comprising rotigotine base, wherein the inner phase forms dispersed deposits in the outer phase, and wherein the inner phase comprises i. rotigotine base, and ii.
    Type: Application
    Filed: May 20, 2015
    Publication date: April 20, 2017
    Applicants: LTS Lohmann Therapie-Systeme AG, UCB Pharma GmbH
    Inventors: Marc Emgenbroich, Elke Klein, Heike Kluth
  • Patent number: 9616045
    Abstract: The invention relates to transdermal therapeutic systems (TTS) comprising a backing, a reservoir layer containing at least one pharmaceutical active ingredient, and an adhesive. Said transdermal therapeutic systems are characterised in that they are able to continuously adhere to the surface of the skin over a long period of time. During said long period of time, a) there is at least one time interval during which the TTS adhering to the surface of the skin is intensively exposed to water, and b) the active ingredient is transdermally released. The invention also relates to a method for the continuous transdermal release of at least one pharmaceutical active ingredient over a long period of time.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: April 11, 2017
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Thomas Hille, Lothar Deurer
  • Publication number: 20170088327
    Abstract: A method for producing a tightly sealed bag packaging and to a tightly sealed bag packaging having at least one perforation and a receiving area surrounded by a plate-shaped edge region for the inert packaging of a product containing active ingredients, wherein the bag packaging comprises cover films or cover film segments bounding the receiving area and forming the edge region. The cover films or cover film segments are each provided with a channel system having at least one channel. The channel system crosses the part of the cover film or the cover film segment covering the receiving area. At one end, each channel is provided with a branching into two channel branches, Furthermore, a slit is arranged between the two channel branches, interrupting a peripheral edge of the bag packaging.
    Type: Application
    Filed: September 17, 2016
    Publication date: March 30, 2017
    Applicant: LTS LOHMANN THERAPIE-SYSTEM AG
    Inventor: MARKUS KRUMME
  • Publication number: 20170079932
    Abstract: Use of an additive in a transdermal therapeutic system with an active agent-containing layer in the form of a biphasic layer having a hydrophilic inner phase and a hydrophobic outer phase, wherein the inner phase comprises the additive and an active agent dissolved therein, wherein the additive has a higher affinity to water than to the active agent, for the control of the permeation rate of the active agent in a manner which is independent from its concentration in the biphasic layer, wherein the maintenance of the permeation rate is proportional to the amount of active agent in the biphasic layer.
    Type: Application
    Filed: May 20, 2015
    Publication date: March 23, 2017
    Applicants: LTS Lohmann Therapie-Systeme AG, UCB Pharma GmbH
    Inventors: Marco Emgenbroich, Johannes Josef Leonhard, Hans-Michael Wolff
  • Patent number: 9597852
    Abstract: A method for producing childproof, highly inert individual dose packagings for transdermal therapeutic systems or film-like forms of administration in the form of a sealing edge bag that can be peeled back with a complete surrounding and continuous sealing surface, comprising two packaging elements, that are arranged on top of each other and form the upper side and the bottom side of a bag containing the product, wherein at least one layer of the packaging material elements is a metal layer and at least one packaging material element a film laminate with at least three-layer design; and the outer layer of the at least three-layer film laminate comprises at least one line-shaped weakening that is not touching the edge of the packaging on the upper and bottom side and the line-shaped weakening has a reduced resistance to tear for opening the packaging.
    Type: Grant
    Filed: July 18, 2015
    Date of Patent: March 21, 2017
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventor: Markus Krumme
  • Patent number: 9597287
    Abstract: An edible oral film strip dosage form containing an unpalatable acidic active pharmaceutical ingredient, particularly ketoprofen, and an ion exchange resin as a primary taste masking agent, along with an optional alkaline agent and further optionally containing one or more secondary taste masking agents is provided. The edible oral film strip dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). The inventive dosages minimize or completely mask the bitterness, burning sensation and throat irritation associated with many acidic active pharmaceutical ingredients. Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: March 21, 2017
    Assignee: LTS Lohmann Therapic-Systeme AG
    Inventors: Michael Hsin Chwen Li, Markus Krumme
  • Patent number: 9599220
    Abstract: A cylinder-piston unit, with at least one cylinder accommodating an injection solution and having an outlet opening, and with at least one piston. The cylinder, or a component mounted upstream of the cylinder, has an end face from which, during correct emptying of the cylinder-piston unit, a short cannula protrudes, which has an outlet opening at its free end. The outlet opening has a surface with a border which has a point near the bottom or an edge near the bottom. The point near the bottom or the edge near the bottom lies 0.15-0.3 mm away from the end face or the front-most point or edge thereof. A cylinder-piston unit is developed which is intended for a disposable injector and which is suitable for virtually painless penetration of the human skin, among other reasons for the administration of highly viscous injection solutions.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: March 21, 2017
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventor: Rudolf Matusch
  • Publication number: 20170046504
    Abstract: A device and a method for determining a suitability of an active ingredient to be applied transdermally or transmucosally. In particular, a system that includes: at least one input device for inputting at least one designation of an active ingredient; a database for storing a plurality of data at least relating to the active ingredient; a computing unit for assessing a suitability of the active ingredient to be applied transdermally and/or transmucosally while taking into consideration data entered via the input device and/or data stored in the database; and an output device for displaying the assessed suitability.
    Type: Application
    Filed: February 24, 2015
    Publication date: February 16, 2017
    Applicant: LTS Lohmann Therapie-Systeme AG
    Inventors: Hanshermann Franke, Patrick Mohr, René Eifler, Marius Bauer
  • Patent number: 9526736
    Abstract: The present invention relates to a transdermal therapeutic system for applying the active ingredient norelgestromin onto the skin, optionally in combination with estrogens. It further relates to the use of such systems for hormonal contraception, and for hormone replacement therapy.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: December 27, 2016
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Frank Theobald, René Eifler
  • Publication number: 20160339223
    Abstract: A microneedle system and method for production thereof. From a board a web grating is produced which has a plurality of grating nodes each defined by three apertures and which has web grating wedges. The microneedle system comprising a board and a plurality of openings delimited circumferentially by a web grating, having at each opening at least one web grating wedge having a needle-shaped tip which projects from the board and which is oriented at least approximately normal to the board. Web grating wedges having needle-shaped tips protrude into each aperture from at least three different directions. In order to produce openings, at least all the web grating wedges which protrude into an aperture are bent by a punch and the needle-shaped tips thereof are oriented normal to the plane of the web grating. At least two web grating wedges are arranged at each opening.
    Type: Application
    Filed: August 8, 2016
    Publication date: November 24, 2016
    Applicant: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventors: SEBASTIAN SCHERR, KARSTEN HEUSER
  • Patent number: 9493285
    Abstract: A method for producing a tightly sealed bag packaging and to a tightly sealed bag packaging having at least one perforation and a receiving area surrounded by a plate-shaped edge region for the inert packaging of a product containing active ingredients, wherein the bag packaging comprises cover films or cover film segments bounding the receiving area and forming the edge region. The cover films or cover film segments are each provided with a channel system having at least one channel. The channel system crosses the part of the cover film or the cover film segment covering the receiving area. At one end, each channel is provided with a branching into two channel branches, Furthermore, a slit is arranged between the two channel branches, interrupting a peripheral edge of the bag packaging.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: November 15, 2016
    Assignee: LTS LOHMANN THERAPIE-SYSTEME AG
    Inventor: Markus Krumme
  • Publication number: 20160324799
    Abstract: A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer-based layer which is remote from the skin with a rate of application of at least 80 g/m2, and an adhesive skin-contact layer which is adjacent to the polymer-based layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2. The at least one active pharmaceutical ingredient is present in both the polymer-based layer remote from the skin and the skin-contact layer.
    Type: Application
    Filed: July 21, 2016
    Publication date: November 10, 2016
    Applicant: LTS Lohmann Therapie-Systeme AG
    Inventors: Michael HORSTMANN, Walter Mueller
  • Patent number: 9486417
    Abstract: A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups: a) terpenes, b) cyclic glucitol ethers, c) medium-chain triglycerides of capric and caprylic acid and/or of linoleic acid; and d) longer-chain alcohols having a chain length of 8 or more carbon atoms.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: November 8, 2016
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Andreas Koch, Christoph Schmitz, Rolf Pracht, Mohammad Sameti
  • Patent number: 9488409
    Abstract: The present invention relates to methods by which to produce sheet-like, wafer-like or film-like forms of drugs, confectionery, other food, cosmetics and the like for oral application or intake. The present invention is more particularly directed to the thermal treatment of carrier materials used in the production of such sheet-like, wafer-like or film-like forms. The thermal treatment removes contaminating or undesired substances from the carrier material.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: November 8, 2016
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Detlev Neuland, Wolfgang Schaefer, Peter Schwarz