Abstract: Pharmaceutical composition comprising (S)-N-ethyl-3-[1-dimethylamino)ethyl]-N-methyl-phenyl-carbamate in free base or acid addition salt form and an anti-oxidant. Said pharmaceutical compositions may be delivered to a patient using a transdermal delivery device.

Abstract: A process for continuously manufacturing transdermal therapeutic patches having a backing layer, a pressure-sensitive adhesive drug reservoir layer, and a removable protective layer, whereby loss of active substances during fabrication of the patches is minimized, said process being characterized in that, in a tape-like laminate having a pressure-sensitive adhesive backing layer (1) and a removable protective layer (3), single quadrangular pressure-sensitive adhesive drug reservoir sections (2) are inserted one after the other in the longitudinal direction between the layers (2,3); the clearance between said drug reservoir sections remains constant in the longitudinal direction; their width is calculated such that the backing layer (1) and the removable protective layer (3) project beyond both sides of said sections; the pressure-sensitive adhesive backing layer (1) is first cut by punching in such a way that the punching line (1a) surrounds the individual drug reservoir sections (2) at an evident distance fr

Abstract: A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots (14) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix (12).

Abstract: The invention concerns a transdermal application system for antithrombotic therapy and for the prophylaxis against cancer, respectively, containing as active substance acetylsalicylic acid and/or pharmaceutically acceptable salts thereof.

Abstract: A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots (14) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix (12).

Abstract: The invention relates to reservoirs with a delivery surface for the controlled delivery of active substances decreasing over the time of use to solid, liquid or gaseous acceptors and whereby at least at one point of the reservoir a cross-sectional surface of the reservoir is parallel to the delivery surface and smaller in area than the delivery surface. The invention also relates to an apparatus for the controlled delivery of active substances decreasing over the time of use, which has at least one reservoir. At least one active substance to be delivered is active in the technical, human and veterinary medical, cosmetic and pest control sectors.

Abstract: A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots (14) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix (12).

Abstract: A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots (14) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix (12).

Abstract: A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots (14) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix (12).

Abstract: A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots (14) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix (12).

Abstract: This invention relates to a process for the production of a transdermal therapeutic system containing the active substance 17-.beta.-estradiol and optionally further active substances having a laminated structure positioned on a backing layer which is essentially impermeable to active substance and moisture, one or more matrix layers and optionally an adhesive layer, characterized in that at least one of the matrix layers or the adhesive layer contains anhydrous 17-.beta.-estradiol in crystalline form.

Abstract: A transdermal therapeutic system for antithrombotic therapy is disclosed. The system comprises a hydrophobic polymer matrix, acetic anhydride, and acetylsalicylic acid as the only active ingredient.

Abstract: A device for the controlled release of active substances in liquid media from an active substance-containing matrix exhibiting active substance releasing-surfaces has, the active substance releasing surfaces of the matrix covered, at least partially, by an erodible mass of solids; the thickness of the erodible mass across its extent on the active substance releasing-areas is determined by gradients.

Abstract: A transdermal therapeutic system containing the active substance 17-.beta.-estradiol and optionally further active substances has a laminated structure positioned on a backing layer which is essentially impermeable to active substance and moisture, at least one matrix layer and optionally an adhesive layer. The at least one matrix layer or the adhesive layer contains anhydrous 17-.beta.-estradiol in crystalline form.

Abstract: A therapeutic system for supplying active substances to the skin consists of a backing layer remote from the skin, with at least one active substance depot. The depot may consist of a fluid active substance or a fluid composition comprising an active substance delivery control matrix. There is also included an adhesive fixing device for fixing the therapeutic system on the skin. The therapeutic system is characterized in that the active substance depots (14) consist of at least one adjuvant having a supporting and distributing function by being provided with a planar textile material completely surrounded by matrix (12).

Abstract: A scopolamine-containing transdermal therapeutic system in the form of a patch is described whose active substance-containing layers comprise as base polymer copolymers of acrylic acid or methacrylic acid derivatives and scopolamine base in a concentration corresponding to 50-100% of the saturation solubility, preferably 60-100% of the saturation solubility, in the total vehicle formulation.

Abstract: A transdermal therapeutic system exhibiting layered structure consists of a backing layer which is impermeable to active substances, a matrix having water-insoluble basic material and islands (inclusions) divided therein, and a layer controlling the access of cutaneous liquid by means of which the matrix is activatable. Process for the production are described.

Abstract: A presentation which, in the form of a film, permits the individual dosage of drugs, confectionary, other food, cosmetics and the like for oral application or intake. The presentation is characterized by the fact that it comprises a mass of 20 to 60%-wt. of at least a film former, 2 to 40%-wt. of at least a gel former, 0.1 to 35%-wt. of at least an active substance, and up to 40%-wt. of an inert filling agent, being applied on a carrier, or by consisting of a mass having the aforementioned composition but is unsupported. In the production thereof, an intimate mixture of said components is prepared, optionally with the addition of up to 30%-wt. of a polar solvent, and processed to form a homogeneous, spreadable or extrudable mass.

Abstract: The invention relates to a floatable, oral, therapeutic system, in which a lengthening of the gastrointestinal residence time of medicaments and a controlled delivery thereof are achieved by systems, which are specifically lighter than the gastric fluid, float on the latter and can only with difficulty reach the lower-lying pylorus, said system using at least one structural element with cavities or voids, such as foams or hollow bodies.

Abstract: A process is provided for the production of a flat administration form with a dosable portion of drugs or of a flat-shaped device for the dosable release of volatile substances, such as aromatic substances, to the ambient air by using high-volatile or thermolabile dosing media in liquid or semisolid state as the ingredients of the administration form or of the device by means of printing processes. A free-flowing preparation of the ingredients is knife-coated in a measured amount into at least one volumetrically defined cavity of a flat printing block. A substrate to be charged with the ingredients or dosing media, respectively, is gradually led as web-shaped material under web tension over the cavity of the printing block and pressed into the filled cavity by means of a mechanical pressure device whereby the substrate takes up the ingredient from the printing block in a dosed amount.